Efficacy of colchicine in patients with primary biliary cirrhosis poorly responsive to ursodiol and methotrexate

American Journal of Gastroenterology

Volumn 98, Issue 1, 2003, Pages 205-208

  Lee, Young Mee ^a   Kaplan, Marshall M ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; COLESTIPOL; COLESTYRAMINE; METHOTREXATE; RIFAMPICIN; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; CASE REPORT; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HUMAN; LIVER BIOPSY; LIVER FUNCTION TEST; LIVER HISTOLOGY; PHOTOTHERAPY; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PRURITUS; SYMPTOMATOLOGY; TREATMENT FAILURE;

ADULT; CHOLAGOGUES AND CHOLERETICS; COLCHICINE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LIVER CIRRHOSIS, BILIARY; METHOTREXATE; MIDDLE AGED; TREATMENT FAILURE; URSODEOXYCHOLIC ACID;

EID: 0037259843     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2003.07182.x     Document Type: Article

References (26)

1. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1996; 335:1570-8 (review).
2. Jorgensen RA, Dickson ER, Hofmann AF, et al. Characterisation of patients with a complete biochemical response to ursodeoxycholic acid. Gut 1995;36:935-8.
3. Leuschner M, Dietrich C, You T, et al. Characterization of patients with primary biliary cirrhosis responding to long term ursodeoxycholic acid therapy. Gut 2000;46:121-6.
4. Degott C, Zafrani ES, Callard P, et al. Histopathogical study of primary biliary cirhhosis and the effect of ursodeoxycholic acid treatment on histology progression. Hepatology 1999;29:1007-12.
5. Poupon RE, Poupon R, Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994; 330:1342-7.
6. Lindor KD, Dickson ER, Baldus WP, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994;106:1284-90.
7. Heathcote EJ, Cauch-Dudek K, Walker V, et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994;19:1149-56.
8. Combes B, Carithers RL, Jr, Maddrey WC, et al. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995;22:759-66.
9. Poupon RE, Lindor KD, Cauch-Dudek K, et al. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997;113:884-90.
10. Goulis J, Leandro G, Burroughs AK. Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: A meta-analysis. Lancet 1999;354:1053-60.
11. Pares A, Caballeris L, Rodes J, et al. Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: Results of a double-blind controlled multicentric trial. J Hepatol 2000;32:561-6.
12. Kaplan M, DeLellis R, Wolfe H. Sustained biochemical and histological remission of primary biliary cirrhosis in response to medical treatment. Ann Intern Med 1997;126:682-8.
13. Munoz S, Carithers RL, Emmerson SS, et al. Absence of pulmonary toxicity in primary biliary cirrhosis (PBC) treated with methotrexate and ursodiol. Hepatology 1998;28:392 (abstract).
14. Kaplan MM, Schmid C, Provenzale D, et al. A prospective trial of colchicine and methotrexate in the treatment of primary biliary cirrhosis. Gastroenterology 1999;117:1-9.
15. Warnes TW. Treatment of primary biliary cirrhosis. Semin Liv Dis 1985;5:228-40.
16. Bodenheimer HC Jr. Schaffner F, Sternlieb I, et al. A prospective clinical trial of D-penicillamine in the treatment of primary biliary cirrhosis. Hepatology 1985;5:1139-42.
17. Vuoristo M, Farkkila M, Karvonen AL, et al. A placebo-controlled trial of primary biliary cirrhosis treatment with colchicine and ursodeoxycholic acid. Gastroenterology 1995; 108:1470-8.
18. Poupon RE, Huet M, Poupon R, et al. A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1996;24:1098-103.
19. Bonis PA, Kaplan MM. The effects of colchicine and methotrexate are additive to ursodeoxycholic acid for patients with primary biliary cirrhosis (PBC) who have responded incompletely to ursodeoxycholic acid. Hepatology 1997;26:438A (abstract).
20. Kaplan MM, Alling DW, Zimmerman HJ, et al. A prospective trial of colchicine for primary biliary cirrhosis. N Engl J Med 1986;315:1448-54.
21. Warnes TW, Smith A, Lee FI, et al. A controlled trial of colchicine in primary biliary cirrhosis. J Hepatol 1987;5:1-7.
22. Shibata J, Fujiyama S, Honda Y, Sato T. Combination therapy with ursodeoxycholic acid and colchicine for primary biliary cirrhosis. J Gastroenterol Hepatol 1992;7:277-82.
23. Almasio P, Floreani A, Chiaramonte M, et al. Multicentre randomized placebo-controlled trial of ursodeoxycholic acid with or without colchicine in symptomatic primary biliary cirrhosis. Aliment Pharmacol Ther 2000;14:1645-52.
24. Xu L, Guo L, Keough A, et al. Isolation and characterization of a novel virus associated with primary biliary cirrhosis. Hepatology 2000;32:297A (abstract).
25. Lee J, Boyer JL. Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis 2000;20:373-84.
26. Kaplan MM. Methotrexate hepatotoxicity and the premature reporting of Mark Twain's death: Both greatly exaggerated. Hepatology 1990;12:784-6.