Lyophilized flutamide dispersions with polyols and amino acids: Preparation and in vitro evaluation

Drug Development and Industrial Pharmacy

Volumn 37, Issue 4, 2011, Pages 446-455

  Elgindy, Nazik ^a   Elkhodairy, Kadria ^a   Molokhia, Abdullah ^b   Osman Elzoghby, Ahmed ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b Pharco Pharmaceutical Co   (Egypt)

Author keywords

Amino acids; lyophilization; monophase solution; particle size; polyols; surface area and porosity

Indexed keywords

AMINO ACID; ARGININE; DRUG CARRIER; FLUTAMIDE; GLYCINE; MANNITOL; POLYOL;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG FORMULATION; FREEZE DRYING; GAS CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SOLUTION AND SOLUBILITY; TABLET POROSITY; X RAY DIFFRACTION;

AMINO ACIDS; CALORIMETRY, DIFFERENTIAL SCANNING; FLUTAMIDE; FREEZE DRYING; PARTICLE SIZE; POLYMERS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 79953243552     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.522190     Document Type: Article

References (27)

1. Debruyna FMI. (1996). Combined androgen blockade is the treatment of choice for patients with advanced prostate cancer. Eur Urol, 29:34-6.
2. Zuo Z, kwon G, Stevenson B, Diakur J, Wiebe LI. (2000). Hydroxypropyl-b-cyclodextrin-flutamide inclusion complex. I. Formulation, physical characterization and absorption studies using the Caco-2 in vitro model. J Pharm Pharm Sci, 3:220-7.
3. Elgindy N, Elkhodairy K, Molokhia A, Elzoghby A. (2010). Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide. Eur J Pharm Biopharm, 74:397-405.
4. Arias MJ, Ginés JM, Moyano JR, Rabasco AM. (1994). The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene. J Drug Target, 2:45-51. (Pubitemid 24106959)
5. Okonogi S, Oguchi T, Yonemochi E, Puttipipatkhachorn S, Yamamoto K. (1997). Improved dissolution of ofloxacin via solid dispersion. Int J Pharm, 156:175-80. (Pubitemid 27400005)
6. Zajc N, Obreza A, Bele M, Srlil S. (2005). Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method. Int J Pharm, 291:51-8. (Pubitemid 40221996)
7. Nassab PR, Rajkó R, Szabó-Révés P. (2006). Physicochemical characterization of meloxicam-mannitol binary systems. J Pharm Biomed Anal, 41:1191-7. (Pubitemid 44218678)
8. Arias MJ, Moyano JR, Ginés JM. (1998). Study by DSC and HSM of the oxazepam-PEG 6000 and oxazepam-D-mannitol systems: Application to the preparation of solid dispersions. Thermochim Acta, 321:33-41. (Pubitemid 128351777)
9. Gombás Á, Szabó-Révés P, Regdon G Jr, Eros I. (2003). Study of thermal behaviour of sugar alcohols. J Therm Anal Calorim, 73:615-21.
10. Van Drooge DJ, Hinrich WLJ, Frulink HW. (2004). Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent. J Pharm Sci, 93:713-25. (Pubitemid 38332303)
11. Wang Z, Deng Y, Sun S, Zhang X. (2006). Preparation of hydrophobic drugs cyclodextrin complex by lyophilization monophase solution. Drug Dev Ind Pharm, 32:73-83. (Pubitemid 43220916)
12. Arakawa T, Kita Y, Koyama AH. (2008). Solubility enhancement of gluten and organic compounds by arginine. Int J Pharm, 355: 220-3.
13. Mura P, Maestrelli F, Cirri M. (2003). Ternary systems of naproxen with hydroxypropyl-b-cyclodextrin and aminoacids. Int J Pharm, 260:293-302. (Pubitemid 36773926)
14. Umrethia ML, Ghosh PK, Majithiya RJ, Murthy RSR. (2005). A new reverse-phase high performance liquid chromatographic method for determination of flutamide in liposomes, rat blood plasma and tablet dosage forms. Ars Pharm, 46:109-24. (Pubitemid 41285634)
15. Higuchi T, Connors KA. (1965). Phase solubility techniques. Adv Anal Chem Instrum, 4:117-212.
16. Teagarden DL, Baker DS. (2002). Practical aspects of lyophilization using nonaqueous co-solvent systems. Eur J Pharm Sci, 15: 115-33. (Pubitemid 34155373)
17. Rawlinson CF, Williams AC, Timmins P, Grimsey I. (2007). Polymer-mediated disruption of drug crystallinity. Int J Pharm, 336:42-8. (Pubitemid 46566483)
18. Kirk AO, Josh DE, Bo C, Brian DS, Thomas EM, Keith PJ, Robert OW. (2007). Novel ultra-rapid freezing particle engineering process for enhancement of dissolution rates of poorly watersoluble drugs. Eur J Pharm Biopharm, 65:57-67.
19. Goddeeris C, Van den Mooter G. (2008). Free flowing solid dispersions of the anti-HIV drug UC 781 with Poloxamer 407 and a maximum amount of TPGS 1000: Investigating the relationship between physicochemical characteristics and dissolution behaviour. Eur. J Pharm Sci, 35:104-13.
20. Crowley PB, Golovin A. (2005). Cation-pi interactions in protein- protein interfaces. Proteins, 59:231-9.
21. Ni N, Tesconi M, Tabibi SE, Gupta S, Yalkowsky SH. (2001). Use of pure t-butanol as a solvent for freeze drying: A case study. Int J Pharm, 226:39-46. (Pubitemid 32807670)
22. Nagase H, Endo T, Ueda H, Nagai T. (2003). Influence of dry conditions on dehydration of a, a-trehalose dihydrate. STP Pharm Sci, 13:269-75. (Pubitemid 37337354)
23. Williams RO III, Johnson KP, Hu J. (2003). Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: Organic solvent versus organic/aqueous cosolvent systems. Eur J Pharm Sci, 20: 295-303. (Pubitemid 37338535)
24. Sun N, Wei X, Wu B, Chen J, Lu Y, Wu W. (2008). Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique. Powder Technol, 182:72-80. (Pubitemid 351173199)
25. Ginés JM, Arias MJ, Rabasco AM. (1993). Elaboration and dissolution study of solid dispersions triamterene-D-mannitol. Summary of presentations. Congressus Pharmaceuticus Hungaricus IX, Budapest, 19-22 September. p. 85.
26. Leuner C, Dressman J. (2000). Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm, 50:47-60. (Pubitemid 30326688)
27. Craig DQM. (2002). The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm, 231:131-44. (Pubitemid 34033673)