Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy

Critical Care Medicine

Volumn 39, Issue 4, 2011, Pages 643-650

  Hauer, Daniela ^a   Weis, Florian ^a   Papassotiropoulos, Andreas ^c   Schmoeckel, Michael ^a   Beiras Fernandez, Andres ^a   Lieke, Julia ^a   Kaufmann, Ines ^a   Kirchhoff, Fabian ^a   Vogeser, Michael ^a   Roozendaal, Benno ^b   Briegel, Josef ^a   De Quervain, Dominique ^d   Schelling, Gustav ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c Division of Molecular Psychology and Life Sciences Training Facility   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

genetic polymorphism; glucocorticoid receptor gene; outcome; posttraumatic stress disorder; stress; traumatic memories

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCINE; HYDROCORTISONE; MIDAZOLAM; PROPOFOL;

ACUTE HEART FAILURE; ADULT; AGED; ANXIETY DISORDER; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HEART SURGERY; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; INJURY; INTENSIVE CARE; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PHYSICAL CAPACITY; POSTTRAUMATIC STRESS DISORDER; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; QUESTIONNAIRE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; TREATMENT DURATION;

EID: 79953232321     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318206bae6     Document Type: Article

References (47)

1. Wolf OT: HPA axis and memory. Best Pract Res Clin Endocrinol Metab 2003; 17:287-299.
2. Roozendaal B, Quirarte GL, McGaugh JL: Stress-activated hormonal systems and the regulation of memory storage. Ann N Y Acad Sci 1997; 821:247-258. (Pubitemid 27343026)
3. de Quervain DJ, Aerni A, Schelling G, et al: Glucocorticoids and the regulation of memory in health and disease. Front Neuroendocrinol 2009; 30:358-370.
4. Roozendaal B, Quirarte GL, McGaugh JL: Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor-cAMP/PKA system in influencing memory consolidation. Eur J Neurosci 2002; 15:553-560. (Pubitemid 35463674)
5. Kuhlmann S, Wolf OT: Arousal and cortisol interact in modulating memory consolidation in healthy young men. Behav Neurosci 2006; 120:217-223. (Pubitemid 43345121)
6. de Quervain DJ, Roozendaal B, McGaugh JL: Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 1998; 394:787-790. (Pubitemid 28391643)
7. Kuhlmann S, Piel M, Wolf OT: Impaired memory retrieval after psychosocial stress in healthy young men. J Neurosci 2005; 25:2977-2982. (Pubitemid 40389255)
8. Yehuda R, Yang RK, Golier JA, et al: Effect of topiramate on glucocorticoid receptor mediated action. Neuropsychopharmacology 2004; 29:433-439. (Pubitemid 38175161)
9. Yehuda R, Boisoneau D, Lowy MT, et al: Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumaticstress disorder. Arch Gen Psychiatry 1995; 52:583-593.
10. Binder EB, Bradley RG, Liu W, et al: Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. J Am Med Assoc 2008; 299:1291-1305. (Pubitemid 351439075)
11. Cohen H, Zohar J, Gidron Y, et al: Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats. Biol Psychiatry 2006; 59:1208-1218.
12. Schelling G, Richter M, Roozendaal B, et al: Exposure to high stress in the intensive care unit may have negative effects on healthrelated quality-of-life outcomes after cardiac surgery. Crit Care Med 2003; 31:1971-1980. (Pubitemid 36900752)
13. Schelling G, Kilger E, Roozendaal B, et al: Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: A randomized study. Biol Psychiatry 2004; 55:627-633. (Pubitemid 38315037)
14. Weis F, Kilger E, Roozendaal B, et al: Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: A randomized study. J Thorac Cardiovasc Surg 2006; 131:277-282.
15. Duval F, Crocq MA, Guillon MS, et al: Increased adrenocorticotropin suppression after dexamethasone administration in sexually abused adolescents with posttraumatic stress disorder. Ann N Y Acad Sci 2004; 1032: 273-275. (Pubitemid 40298491)
16. van Rossum EF, Binder EB, Majer M, et al: Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry 2006; 59:681-688.
17. Derijk RH, van Leeuwen N, Klok MD, et al: Corticosteroid receptor-gene variants: Modulators of the stress-response and implications for mental health. Eur J Pharmacol 2008; 585:492-501.
18. Kumsta R, Entringer S, Koper JW, et al: Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes. Biol Psychol 2008; 79:179-184.
19. van Rossum EF, Koper JW, van den Beld AW, et al: Identification of the BclI polymorphism in the glucocorticoid receptor gene: Association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 2003; 59:585-592. (Pubitemid 37357618)
20. Huizenga NA, Koper JW, De Lange P, et al: A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998; 83:144-151. (Pubitemid 28498326)
21. Rosmond R: The glucocorticoid receptor gene and its association to metabolic syndrome. Obes Res 2002; 10:1078-1086. (Pubitemid 135688926)
22. Stoll C, Kapfhammer HP, Rothenhäusler HB, et al: Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 1999; 25:697-704. (Pubitemid 29376123)
23. Schelling G, Stoll C, Haller M, et al: Healthrelated quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 1998; 26:651-659. (Pubitemid 28201410)
24. Deja M, Denke C, Weber-Carstens S, et al: Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome. Crit Care 2006; 10:R147.
25. Girard TD, Shintani AK, Jackson JC, et al: Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: A prospective cohort study. Crit Care 2007; 11:R28.
26. Boer KR, van Ruler O, van Emmerik AA, et al: Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: A nomogram. Intensive Care Med 2008; 34:664-674. (Pubitemid 351660081)
27. Eid J, Thayer JF, Johnsen BH: Measuring post-traumatic stress: A psychometric evaluation of symptom- and coping questionnaires based on a Norwegian sample. Scand J Psychol 1999; 40:101-108.
28. Bullinger M: German translation and psychometric testing of the SF-36 Health Survey: Preliminary results from the IQOLA Project. International Quality of Life Assessment. Soc Sci Med 1995; 41:1359-1366.
29. Vogeser M, Briegel J, Jacob K: Determination of serum cortisol by isotope-dilution liquidchromatography electrospray ionization tandem mass spectrometry with on-line extraction. Clin Chem Lab Med 2001; 39:944-947. (Pubitemid 33062244)
30. Kilger E, Weis F, Briegel J, et al: Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med 2003; 31:1068-1074. (Pubitemid 36444415)
31. Wü st S, Van Rossum EF, Federenko IS, et al: Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 2004; 89: 565-573. (Pubitemid 38269859)
32. Ising M, Depping AM, Siebertz A, et al: Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 2008; 28: 389-398.
33. Bachmann AW, Sedgley TL, Jackson RV, et al: Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 2005; 30:297-306. (Pubitemid 39423363)
34. Yehuda R, Cai G, Golier JA, et al: Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol Psychiatry 2009; 66:708-711.
35. McGaugh JL, Roozendaal B: Role of adrenal stress hormones in forming lasting memories in the brain. Curr Opin Neurobiol 2002; 12:205-210. (Pubitemid 34518341)
36. de Quervain DJ, Roozendaal B, Nitsch RM, et al: Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nat Neurosci 2000; 3:313-314. (Pubitemid 30185479)
37. Tollenaar MS, Elzinga BM, Spinhoven P, et al: Immediate and prolonged effects of cortisol, but not propranolol, on memory retrieval in healthy young men. Neurobiol Learn Mem 2009; 91:23-31.
38. Hauer D, Weis F, Krauseneck T, et al: Traumatic memories, post-traumatic stress disorder and serum cortisol levels in long-term survivors of the acute respiratory distress syndrome. Brain Res 2009; 1293:114-120.
39. Schelling G, Stoll C, Kapfhammer HP, et al: The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors. Crit Care Med 1999; 27: 2678-2683. (Pubitemid 30027180)
40. Schelling G, Briegel J, Roozendaal B, et al: The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry 2001; 50:978-985. (Pubitemid 34066490)
41. Aerni A, Traber R, Hock C, et al: Low-dose cortisol for symptoms of posttraumatic stress disorder. Am J Psychiatry 2004; 161: 1488-1490. (Pubitemid 38989105)
42. Weaver JU, Hitman GA, Kopelman PG: An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J Mol Endocrinol 1992; 9:295-300.
43. Buemann B, Vohl MC, Chagnon M, et al: Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res 1997; 5:186-192. (Pubitemid 127702722)
44. van Rossum EF, Lamberts SW: Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 2004; 59:333-357.
45. Binder EB: The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009; 34(Suppl 1):S186-S195.
46. Panarelli M, Holloway CD, Fraser R, et al: Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 1998; 83: 1846-1852. (Pubitemid 28496304)
47. van Rossum EF, Russcher H, Lamberts SW: Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene. Trends Endocrinol Metab 2005; 16:445-450 (Pubitemid 41660860)