Effect of Topiramate on Glucocorticoid Receptor Mediated Action

Neuropsychopharmacology

Volumn 29, Issue 2, 2004, Pages 433-439

  Yehuda, Rachel ^a,b   Yang, Ren Kui ^a   Golier, Julia A ^a   Tischler, Lisa ^a   Liong, Betty ^a   Decker, Kelly ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b 116/A Psychiatry   (United States)

Author keywords

Depression, mononuclear leukocytes; Glucocorticoid receptors; Lysozyme activity; Post traumatic stress disorder; Topiramate

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; TOPIRAMATE;

ACUTE STRESS DISORDER; ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD SAMPLING; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; IC 50; INCUBATION TIME; INJURY; INTERMETHOD COMPARISON; MALE; MONONUCLEAR CELL; NEUROENDOCRINE SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VEIN PUNCTURE;

EID: 0842286559     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300331     Document Type: Article

References (30)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual IV. American Psychiatric Press: Wahington, DC.
2. Berlant J, van Kammen DP (2000). Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report. J Clin Psychiatry 63: 15-20.
3. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS (1995). The development of a Clinician-Administered PTSD Scale. J Trauma Stress 8: 75-90.
4. Carpenter LL, Leon Z, Yasmin S, Price LH (2002). Do obese depressed patients respond to topiramate? A retrospective chart review. J Affect Disord 69: 251-255.
5. Chengappa KN, Rathore D, Levine J, Atzert R, Solai L, Parepally H 1999. Topiramate as add-on treatment for patients with bipolar mania. Bipolar Disord 1: 42-53.
6. De Lorenzo RJ, Sombati S, Coulter DA. (2000). Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. Epilepsia 41: S40-S44.
7. Deutsch SI, Rosse RB, Billingslea EN, Ellack AS, Mastropaolo J (2002). Topiramates antagonizes MK-801 in an animal model of schizophrenia. Eur J Pharmacol 449: 121-125.
8. Gibbs III JW, Sombati S, DeLorenzo RJ, Coulter DA (2000). Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons. Epilepsia 41: S10-S16.
9. Green BL (1996). In: Stamm BH (ed). Trauma History Questionnaire in Measurement of Stress, Trauma, and Adaptation. Sidran: Lutherville, MD.
10. Grunze HC, Normann C, Langosch J, Schaefer M, Amann B, Sterr A (2001). Antimanic efficacy of topiramate in 11 patients in an open trial with an on-off-on design. J Clin Psychiatry 62: 464-468.
11. Jahromi SS, Pelletier MR, McDonald PJ, Khosravani H, Carlen PL 2000. Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models. Brain 87: 20-28.
12. Jette NJ, Marson AG, Hutton JL 2002. Topiramate add-on for drug-resistant partial epilepsy. Cochrane Database System Rev, CD001417.
13. Landfield PW, Eldridge JC 1994. The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: role of dysregulated intraneuronal calcium. Ann NY Acad Sci 74: 308-321.
14. Lee SR, Kim SP, Kim JE (2000). Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils. Neurosci Lett 281: 183-186.
15. Meijer OC, deLange ECM, Breimer DD, Boer AG, deKloet ER (1998). Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139: 1789-1998.
16. Panarelli M, Holloway CD, Mulatero P, Fraser R, Kenyon J (1994). Inhibition of lysozyme synthesis by dexamethasone in human mononuclear leukocytes: an index of glucocorticoid sensitivity. J Clin Endocrinol Metab 78: 872-877.
17. Pariante CM, Miller AH (2001). Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49: 391-404.
18. Privitera MD, Brodie MJ, Mattson RH, Chadwick DW, Neto W, Wang S (2003). EPMN 105 Study Group. Acta Neurol Scand 107: 165-175.
19. Sapolsky RM (1994). The physiological relevance of glucocorticoid endangerment of the hippocampus. Ann NY Acad Sci 746: 294-304.
20. Sapolsky RM. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57: 925-935.
21. Schinkel AH, Wagenaar E, van Deemter L, Mol CAAM, Borst P (1995). Absence of the mdrla P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705.
22. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR (2001). Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry 50: 952-959.
23. Shank RP, Gardocki JF, Streeter AF, Maryanoff BE (2000). An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia 41: S3-S9.
24. Spitzer RL, Williams JBW, Gibbon M (1995). Structured Clinical Interview for DSM-IV (SCID). New York State Psychiatric Institute, Biometrics Research: New York.
25. Yehuda R (2001). Are glucocorticoids responsible for putative hippocampal damage in PTSD? How and when to decide. Hippocampus 11: 85-89.
26. Yehuda R (2002). Current status of cortisol findings in post-traumatic stress disorder. Psychiatr Clin North Am 25: 341-368.
27. Yehuda R, Boisoneau D, Lowy MT, Giller Jr EL (1995). Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 52: 583-593.
28. Yehuda R, Halligan SL, Grossman R, Golier JA, Wong C (2002). The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder. Biological Psychiatry 52: 393-403.
29. Yehuda R, Makotkine I, Ling SG, Singh B, Yang RK (2003). Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone. J Psychiatric Res 34: 471-477.
30. York DA (2000). Effect of topiramate on body weight and body composition of Osborne-Mendel rats fed a high fat diet: alterations in hormones, neuropeptide and uncoupling protein mRNAs. Nutrition 16: 967-975.