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Volumn 10, Issue 10, 2002, Pages 1078-1086

The glucocorticoid receptor gene and its association to metabolic syndrome

Author keywords

Gene; Glucocorticoid receptor; Hypertension; Insulin resistance; Mutation

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

EID: 0036777944     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2002.146     Document Type: Review
Times cited : (92)

References (82)
  • 1
    • 0022393794 scopus 로고
    • Primary structure and expression of a functional human glucocorticoid receptor cDNA
    • Hollenberg SM, Weinberger C, Ong ES, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 1985;318:635-41.
    • (1985) Nature , vol.318 , pp. 635-641
    • Hollenberg, S.M.1    Weinberger, C.2    Ong, E.S.3
  • 3
    • 0028283503 scopus 로고
    • Molecular mechanisms of action of steroid/thyroid receptor superfamily members
    • Tsai MJ, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem. 1994;63:451-86.
    • (1994) Annu Rev Biochem , vol.63 , pp. 451-486
    • Tsai, M.J.1    O'Malley, B.W.2
  • 5
    • 0029993518 scopus 로고    scopus 로고
    • The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function
    • Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996;271:9550-9.
    • (1996) J Biol Chem , vol.271 , pp. 9550-9559
    • Oakley, R.H.1    Sar, M.2    Cidlowski, J.A.3
  • 6
    • 0033323794 scopus 로고    scopus 로고
    • Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing
    • Rivers C, Levy A, Hancock J, Lightman S, Norman M. Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing. J Clin Endocrinol Metab. 1999;84:4283-6.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4283-4286
    • Rivers, C.1    Levy, A.2    Hancock, J.3    Lightman, S.4    Norman, M.5
  • 7
    • 0024671996 scopus 로고
    • The glucocorticoid receptor gene is in 5q31-q32
    • Francke U, Foellmer BE. The glucocorticoid receptor gene is in 5q31-q32. Genomics. 1989;4:610-2.
    • (1989) Genomics , vol.4 , pp. 610-612
    • Francke, U.1    Foellmer, B.E.2
  • 8
    • 0025895395 scopus 로고
    • The genomic structure of the human glucocorticoid receptor
    • Encio IJ, Detera-Wadleigh SD. The genomic structure of the human glucocorticoid receptor. J Biol Chem. 1991;266:7182-8.
    • (1991) J Biol Chem , vol.266 , pp. 7182-7188
    • Encio, I.J.1    Detera-Wadleigh, S.D.2
  • 9
    • 0021673241 scopus 로고
    • Structure and regulation of the glucocorticoid hormone receptor
    • Rousseau GG. Structure and regulation of the glucocorticoid hormone receptor. Mol Cell Endocrinol. 1984;38:1-11.
    • (1984) Mol Cell Endocrinol , vol.38 , pp. 1-11
    • Rousseau, G.G.1
  • 10
  • 11
    • 0032524357 scopus 로고    scopus 로고
    • New twists in gene regulation by glucocorticoid receptor: Is DNA binding dispensable?
    • Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 1998;93:487-90.
    • (1998) Cell , vol.93 , pp. 487-490
    • Karin, M.1
  • 12
    • 0031848850 scopus 로고    scopus 로고
    • Recent advances in the study of hsp90 structure and mechanism of action
    • Toft DO. Recent advances in the study of hsp90 structure and mechanism of action. Trends Endocrinol Metab. 1998;9:238-43.
    • (1998) Trends Endocrinol Metab , vol.9 , pp. 238-243
    • Toft, D.O.1
  • 13
    • 0031871101 scopus 로고    scopus 로고
    • Studies with purified chaperones advance the understanding of the mechanism of glucocorticoid receptor-hsp90 heterocomplex assembly
    • Pratt WB, Dittmar KD. Studies with purified chaperones advance the understanding of the mechanism of glucocorticoid receptor-hsp90 heterocomplex assembly. Trends Endocrinol Metab. 1998;9:244-52.
    • (1998) Trends Endocrinol Metab , vol.9 , pp. 244-252
    • Pratt, W.B.1    Dittmar, K.D.2
  • 14
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrinol Rev. 1997;18:306-60.
    • (1997) Endocrinol Rev , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 15
    • 0029618368 scopus 로고
    • Steroid hormone receptors: Many actors in search of a plot
    • Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell. 1995;83:851-7.
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schutz, G.3
  • 16
    • 0343985350 scopus 로고    scopus 로고
    • Transcriptional regulation by steroid hormones
    • Beato M, Chavez S, Truss M. Transcriptional regulation by steroid hormones. Steroids. 1996;61:240-51.
    • (1996) Steroids , vol.61 , pp. 240-251
    • Beato, M.1    Chavez, S.2    Truss, M.3
  • 17
    • 0015139897 scopus 로고
    • Adipose tissue fat cell size and number in relation to metabolism in randomly selected middle-aged men and women
    • Björntorp P, Bengtsson C, Blohme G, et al. Adipose tissue fat cell size and number in relation to metabolism in randomly selected middle-aged men and women. Metabolism. 1971;20: 927-35.
    • (1971) Metabolism , vol.20 , pp. 927-935
    • Björntorp, P.1    Bengtsson, C.2    Blohme, G.3
  • 18
    • 0023718023 scopus 로고
    • The associations between obesity, adipose tissue distribution and disease
    • Björntorp P. The associations between obesity, adipose tissue distribution and disease. Acta Med Scand Suppl. 1988;723: 121-34.
    • (1988) Acta Med Scand Suppl , vol.723 , pp. 121-134
    • Björntorp, P.1
  • 19
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 20
    • 0003112433 scopus 로고    scopus 로고
    • Visceral obesity and the metabolic syndrome
    • Björntorp P, ed. Chichester: John Wiley & Sons;
    • Rusmond R. Visceral obesity and the metabolic syndrome. In: Björntorp P, ed. The International Textbook of Obesity. Chichester: John Wiley & Sons; 2001, pp. 339-50.
    • (2001) The International Textbook of Obesity , pp. 339-350
    • Rusmond, R.1
  • 21
    • 0003725206 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications
    • Geneva, Switzerland: World Health Organization
    • World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Report of a WHO Consultation. Part 1 : Diagnosis and Classification of Diabetes Mellitus. Geneva, Switzerland: World Health Organization; 1999.
    • (1999) Report of a WHO Consultation. Part 1 : Diagnosis and Classification of Diabetes Mellitus
  • 22
    • 0032699817 scopus 로고    scopus 로고
    • General characteristics of the insulin resistance syndrome: Prevalence and heritability. European Group for the study of Insulin Resistance (EGIR)
    • Beck-Nielsen H. General characteristics of the insulin resistance syndrome: prevalence and heritability. European Group for the study of Insulin Resistance (EGIR). Drugs. 1999;58: 7-10.
    • (1999) Drugs , vol.58 , pp. 7-10
    • Beck-Nielsen, H.1
  • 23
    • 0034837376 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality associated with the metabolic syndrome
    • Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683-9.
    • (2001) Diabetes Care , vol.24 , pp. 683-689
    • Isomaa, B.1    Almgren, P.2    Tuomi, T.3
  • 28
    • 0032533899 scopus 로고    scopus 로고
    • Syndrome X and mortality: A population-based study. Risk Factor and Life Expectancy Research Group
    • Trevisan M, Liu J, Bahsas FB, Menotti A. Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group. Am J Epidemiol. 1998;148:958-66.
    • (1998) Am J Epidemiol , vol.148 , pp. 958-966
    • Trevisan, M.1    Liu, J.2    Bahsas, F.B.3    Menotti, A.4
  • 29
    • 0031708579 scopus 로고    scopus 로고
    • Birth weight, adult weight, and girth as predictors of the metabolic syndrome in postmenopausal women: The Rancho Bernardo Study
    • Yarbrough DE, Barrett-Connor E, Kritz-Silverstein D, Wingard DL. Birth weight, adult weight, and girth as predictors of the metabolic syndrome in postmenopausal women: the Rancho Bernardo Study. Diabetes Care. 1998;21:1652-8.
    • (1998) Diabetes Care , vol.21 , pp. 1652-1658
    • Yarbrough, D.E.1    Barrett-Connor, E.2    Kritz-Silverstein, D.3    Wingard, D.L.4
  • 31
    • 0034155234 scopus 로고    scopus 로고
    • Obesity is the key determinant of cardiovascular risk factors in the Hong Kong Chinese population: Cross-sectional clinic-based study
    • Lee ZS, Critchley JA, Chan JC, et al. Obesity is the key determinant of cardiovascular risk factors in the Hong Kong Chinese population: cross-sectional clinic-based study. Hong Kong Med J. 2000;6:13-23.
    • (2000) Hong Kong Med J , vol.6 , pp. 13-23
    • Lee, Z.S.1    Critchley, J.A.2    Chan, J.C.3
  • 32
    • 0026026319 scopus 로고
    • Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
    • Hurley DM, Accili D, Stratakis CA, et al. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest 1991;87:680-6.
    • (1991) J Clin Invest , vol.87 , pp. 680-686
    • Hurley, D.M.1    Accili, D.2    Stratakis, C.A.3
  • 33
    • 0030179298 scopus 로고    scopus 로고
    • Cushing's disease preceded by generalized glucocorticoid resistance: Clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation
    • Karl M, Lamberts SW, Koper JW, et al. Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation. Proc Assoc Am Physicians. 1996;108:296-307.
    • (1996) Proc Assoc Am Physicians , vol.108 , pp. 296-307
    • Karl, M.1    Lamberts, S.W.2    Koper, J.W.3
  • 34
    • 0034845924 scopus 로고    scopus 로고
    • Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance
    • Ruiz M, Lind U, Gafvels M, et al. Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance. Clin Endocrinol (Oxf). 2001; 55:363-71.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 363-371
    • Ruiz, M.1    Lind, U.2    Gafvels, M.3
  • 35
    • 0027217319 scopus 로고
    • A mutation of the glucocorticoid receptor in primary cortisol resistance
    • Malchoff DM, Brufsky A, Reardon G, et al. A mutation of the glucocorticoid receptor in primary cortisol resistance. J Clin Invest. 1993;91:1918-25.
    • (1993) J Clin Invest , vol.91 , pp. 1918-1925
    • Malchoff, D.M.1    Brufsky, A.2    Reardon, G.3
  • 36
    • 0030943735 scopus 로고    scopus 로고
    • Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance
    • Koper JW, Stolk RP, de Lange P, et al. Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. Hum Genet. 1997;99:663-8.
    • (1997) Hum Genet , vol.99 , pp. 663-668
    • Koper, J.W.1    Stolk, R.P.2    De Lange, P.3
  • 37
    • 0030962905 scopus 로고    scopus 로고
    • Differential hormone-dependent transcriptional activation and repression by naturally occurring human glucocorticoid receptor variants
    • de Lange P, Koper JW, Huizenga NA, et al. Differential hormone-dependent transcriptional activation and repression by naturally occurring human glucocorticoid receptor variants. Mol Endocrinol. 1997;11:1156-64.
    • (1997) Mol Endocrinol , vol.11 , pp. 1156-1164
    • De Lange, P.1    Koper, J.W.2    Huizenga, N.A.3
  • 39
    • 0019992376 scopus 로고
    • Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease
    • Chrousos GP, Vingerhoeds A, Brandon D, et al. Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease. J Clin Invest. 1982;69:1261-9.
    • (1982) J Clin Invest , vol.69 , pp. 1261-1269
    • Chrousos, G.P.1    Vingerhoeds, A.2    Brandon, D.3
  • 41
    • 0342501862 scopus 로고    scopus 로고
    • Molecular basis of glucocorticoid-resistant syndromes
    • Werner S, Brönnegard M. Molecular basis of glucocorticoid-resistant syndromes. Steroids. 1996;61:216-21.
    • (1996) Steroids , vol.61 , pp. 216-221
    • Werner, S.1    Brönnegard, M.2
  • 42
    • 0034965716 scopus 로고    scopus 로고
    • Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes
    • Kino T, Chrousos GP. Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes. J Endocrinol. 2001; 169:437-45.
    • (2001) J Endocrinol , vol.169 , pp. 437-445
    • Kino, T.1    Chrousos, G.P.2
  • 45
    • 0030904953 scopus 로고    scopus 로고
    • Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors
    • Dahia PL, Honegger J, Reincke M, et al. Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors. J Clin Endocrinol Metab. 1997;82:1088-93.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1088-1093
    • Dahia, P.L.1    Honegger, J.2    Reincke, M.3
  • 46
    • 0031732319 scopus 로고    scopus 로고
    • Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus
    • Huizenga NA, de Lange P, Koper JW, et al. Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus. J Clin Endocrinol Metab. 1998;83:917-21.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 917-921
    • Huizenga, N.A.1    De Lange, P.2    Koper, J.W.3
  • 47
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med. 1995;332: 1351-62.
    • (1995) N Engl J Med , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 48
    • 0031872236 scopus 로고    scopus 로고
    • Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture
    • Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci. 1998;851:311-35.
    • (1998) Ann NY Acad Sci , vol.851 , pp. 311-335
    • Chrousos, G.P.1
  • 49
    • 0032518022 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators
    • McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338:171-9.
    • (1998) N Engl J Med , vol.338 , pp. 171-179
    • McEwen, B.S.1
  • 50
    • 0026543152 scopus 로고
    • Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
    • Pepin MC, Pothier F, Barden N. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature. 1992;355:725-8.
    • (1992) Nature , vol.355 , pp. 725-728
    • Pepin, M.C.1    Pothier, F.2    Barden, N.3
  • 51
    • 0028894954 scopus 로고
    • Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function
    • Montkowski A, Barden N, Wotjak C, et al. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. J Neuroendocrinol. 1995;7:841-5.
    • (1995) J Neuroendocrinol , vol.7 , pp. 841-845
    • Montkowski, A.1    Barden, N.2    Wotjak, C.3
  • 52
    • 0032842478 scopus 로고    scopus 로고
    • Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    • Tronche F, Kellendonk C, Kretz O, et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999;23:99-103.
    • (1999) Nat Genet , vol.23 , pp. 99-103
    • Tronche, F.1    Kellendonk, C.2    Kretz, O.3
  • 53
    • 0031857940 scopus 로고    scopus 로고
    • Glucocorticoid receptor polymorphism in genetic hypertension
    • Kenyon CJ, Panarelli M, Zagato L, et al. Glucocorticoid receptor polymorphism in genetic hypertension. J Mol Endocrinol. 1998;21:41-50.
    • (1998) J Mol Endocrinol , vol.21 , pp. 41-50
    • Kenyon, C.J.1    Panarelli, M.2    Zagato, L.3
  • 54
    • 0029982833 scopus 로고    scopus 로고
    • Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells
    • Ray DW, Davis JR, White A, Clark AJ. Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells. Cancer Res. 1996;56:3276-80.
    • (1996) Cancer Res , vol.56 , pp. 3276-3280
    • Ray, D.W.1    Davis, J.R.2    White, A.3    Clark, A.J.4
  • 55
    • 0034749107 scopus 로고    scopus 로고
    • The phase-shift mutation in the glucocorticoid receptor gene: Potential etiologic significance of neuroendocrine mechanisms in lupus nephritis
    • Jiang T, Liu S, Tan M, et al. The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis. Clin Chim Acta. 2001;313:113-7.
    • (2001) Clin Chim Acta , vol.313 , pp. 113-117
    • Jiang, T.1    Liu, S.2    Tan, M.3
  • 56
  • 57
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294:2166-70.
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 58
    • 0026615126 scopus 로고
    • An association between a BclI restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women
    • Weaver JU, Hitman GA, Kopelman PG. An association between a BclI restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J Mol Endocrinol. 1992;9:295-300.
    • (1992) J Mol Endocrinol , vol.9 , pp. 295-300
    • Weaver, J.U.1    Hitman, G.A.2    Kopelman, P.G.3
  • 59
    • 0030009852 scopus 로고    scopus 로고
    • Candidate gene approach of familial morbid obesity: Linkage analysis of the glucocorticoid receptor gene
    • Clement K, Philippi A, Jury C, et al. Candidate gene approach of familial morbid obesity: linkage analysis of the glucocorticoid receptor gene, Int J Obes Relat Metab Disord. 1996;20:507-12.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 507-512
    • Clement, K.1    Philippi, A.2    Jury, C.3
  • 60
    • 0031132266 scopus 로고    scopus 로고
    • Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus
    • Buemann B, Vohl MC, Chagnon M, et al. Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res. 1997;5:186-92.
    • (1997) Obes Res , vol.5 , pp. 186-192
    • Buemann, B.1    Vohl, M.C.2    Chagnon, M.3
  • 61
    • 0031732980 scopus 로고    scopus 로고
    • Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects
    • Panarelli M, Holloway CD, Fraser R, et al. Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab. 1998;83:1846-52.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1846-1852
    • Panarelli, M.1    Holloway, C.D.2    Fraser, R.3
  • 62
    • 0034184087 scopus 로고    scopus 로고
    • A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    • Rosmond R, Chagnon YC, Holm G, et al. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res. 2000;8:211-8.
    • (2000) Obes Res , vol.8 , pp. 211-218
    • Rosmond, R.1    Chagnon, Y.C.2    Holm, G.3
  • 63
    • 0034971441 scopus 로고    scopus 로고
    • Glucocorticoid receptor BclI variant is associated with an increased atherogenic profile in response to long-term overfeeding
    • Ukkola O, Rosmond R, Tremblay A, Bouchard C. Glucocorticoid receptor BclI variant is associated with an increased atherogenic profile in response to long-term overfeeding. Atherosclerosis. 2001;157:221-4.
    • (2001) Atherosclerosis , vol.157 , pp. 221-224
    • Ukkola, O.1    Rosmond, R.2    Tremblay, A.3    Bouchard, C.4
  • 64
    • 0025292829 scopus 로고
    • The response to long-term overfeeding in identical twins
    • Bouchard C, Tremblay A, Després JP, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477-82.
    • (1990) N Engl J Med , vol.322 , pp. 1477-1482
    • Bouchard, C.1    Tremblay, A.2    Després, J.P.3
  • 65
    • 0027513378 scopus 로고
    • Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene
    • Karl M, Lamberts SW, Detera-Wadleigh SD, et al. Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene. J Clin Endocrinol Metab. 1993;76:683-9.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 683-689
    • Karl, M.1    Lamberts, S.W.2    Detera-Wadleigh, S.D.3
  • 66
    • 15144360854 scopus 로고    scopus 로고
    • A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo
    • Huizenga NA, Koper JW, De Lange P, et al. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab. 1998;83:144-51.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 144-151
    • Huizenga, N.A.1    Koper, J.W.2    De Lange, P.3
  • 67
    • 0033456160 scopus 로고    scopus 로고
    • Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension
    • Lin RC, Wang WY, Morris BJ. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. Hypertension. 1999;34:1186-92.
    • (1999) Hypertension , vol.34 , pp. 1186-1192
    • Lin, R.C.1    Wang, W.Y.2    Morris, B.J.3
  • 68
    • 0033589793 scopus 로고    scopus 로고
    • High penetrance, overweight, and glucocorticoid receptor variant: Case-control study
    • Lin RC, Wang WY, Morris BJ. High penetrance, overweight, and glucocorticoid receptor variant: case-control study. BMJ. 1999;319:1337-8.
    • (1999) BMJ , vol.319 , pp. 1337-1338
    • Lin, R.C.1    Wang, W.Y.2    Morris, B.J.3
  • 69
    • 0040475897 scopus 로고    scopus 로고
    • Glucocorticoid receptor variant and body mass index
    • Halsall DJ, Luan J, Hales N, Wareham NJ, O'Rahilly S. Glucocorticoid receptor variant and body mass index. BMJ. 2000. http:// www.bmj.com/cgi/eletters/319/7221/1337#9433
    • (2000) BMJ
    • Halsall, D.J.1    Luan, J.2    Hales, N.3    Wareham, N.J.4    O'Rahilly, S.5
  • 70
    • 0035019845 scopus 로고    scopus 로고
    • The N363S polymorphism of the glucocorticoid receptor: Potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus
    • Dobson MG, Redfern CP, Unwin N, Weaver JU. The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. J Clin Endocrinol Metab. 2001;86:2270-4.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2270-2274
    • Dobson, M.G.1    Redfern, C.P.2    Unwin, N.3    Weaver, J.U.4
  • 71
    • 0035901268 scopus 로고    scopus 로고
    • Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: Cohort study
    • Rosmond R, Bouchard C, Björntorp P. Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study. BMJ. 2001; 322:652-3.
    • (2001) BMJ , vol.322 , pp. 652-653
    • Rosmond, R.1    Bouchard, C.2    Björntorp, P.3
  • 72
    • 0034769251 scopus 로고    scopus 로고
    • The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men
    • Echwald SM, Sorensen TI, Andersen T, Pedersen O. The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men. Int J Obes Relat Metab Disord. 2001;25:1563-5.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 1563-1565
    • Echwald, S.M.1    Sorensen, T.I.2    Andersen, T.3    Pedersen, O.4
  • 73
    • 0032962910 scopus 로고    scopus 로고
    • Linkage analysis of glucocorticoid and β2-adrenergic receptor genes with blood pressure and body mass index
    • Takami S, Wong ZY, Stebbing M, Harrap SB. Linkage analysis of glucocorticoid and β2-adrenergic receptor genes with blood pressure and body mass index. Am J Physiol. 1999;276:H1379-H84.
    • (1999) Am J Physiol , vol.276
    • Takami, S.1    Wong, Z.Y.2    Stebbing, M.3    Harrap, S.B.4
  • 74
    • 0029330319 scopus 로고
    • The hypothalamic-pituitary-adrenal axis in obesity
    • Chalew S, Nagel H, Shore S. The hypothalamic-pituitary-adrenal axis in obesity. Obes Res. 1995;3:371-82.
    • (1995) Obes Res , vol.3 , pp. 371-382
    • Chalew, S.1    Nagel, H.2    Shore, S.3
  • 75
    • 0031702647 scopus 로고    scopus 로고
    • Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome
    • Armanini D, Spinella P, Simoncini M, et al. Regulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome. J Endocrinol. 1998;158:435-9.
    • (1998) J Endocrinol , vol.158 , pp. 435-439
    • Armanini, D.1    Spinella, P.2    Simoncini, M.3
  • 76
    • 0032932506 scopus 로고    scopus 로고
    • Enigmas of adrenal androgen and glucocorticoid dissociation in premenopausal onset rheumatoid arthritis
    • Masi AT, Chrousos GP, Bornstein SR. Enigmas of adrenal androgen and glucocorticoid dissociation in premenopausal onset rheumatoid arthritis. J Rheumatol. 1999;26:247-50.
    • (1999) J Rheumatol , vol.26 , pp. 247-250
    • Masi, A.T.1    Chrousos, G.P.2    Bornstein, S.R.3
  • 77
    • 0033012264 scopus 로고    scopus 로고
    • Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression
    • Zobel AW, Yassouridis A, Frieboes RM, Holsboer F. Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatr. 1999;156:949-51.
    • (1999) Am J Psychiatr , vol.156 , pp. 949-951
    • Zobel, A.W.1    Yassouridis, A.2    Frieboes, R.M.3    Holsboer, F.4
  • 79
    • 0032706949 scopus 로고    scopus 로고
    • Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
    • Björntorp P, Holm G, Rosmond R. Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus. Diabetes Med. 1999;16:373-83.
    • (1999) Diabetes Med , vol.16 , pp. 373-383
    • Björntorp, P.1    Holm, G.2    Rosmond, R.3
  • 80
    • 0035208596 scopus 로고    scopus 로고
    • Alterations in the hypothalamic-pituitary-adrenal axis in Metabolic Syndrome
    • Rosmond R, Björntorp P. Alterations in the hypothalamic-pituitary-adrenal axis in Metabolic Syndrome. Endocrinologist. 2001;11:491-7.
    • (2001) Endocrinologist , vol.11 , pp. 491-497
    • Rosmond, R.1    Björntorp, P.2
  • 82
    • 0026574210 scopus 로고
    • Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: A four-corners approach to the identification of genetic determinants of blood pressure
    • Watt GC, Harrap SB, Foy CJ, et al. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J Hypertens. 1992;10: 473-82.
    • (1992) J Hypertens , vol.10 , pp. 473-482
    • Watt, G.C.1    Harrap, S.B.2    Foy, C.J.3


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