Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter-related molecules

Journal of Comparative Neurology

Volumn 519, Issue 7, 2011, Pages 1219-1257

  Stanić, Davor ^a,b   Mulder, Jan ^a   Watanabe, Masahiko ^c   Hökfelt, Tomas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

7 transmembrane receptor, transmitter coexistence; Colchicine; G protein coupled receptor; Immunohistochemistry; Mapping; Neuropeptide Y; Presynaptic receptor; Y1 receptor; Y2 receptor

Indexed keywords

4 AMINOBUTYRIC ACID; CALBINDIN; GLUTAMATE DECARBOXYLASE 67; METABOTROPIC RECEPTOR 2; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROTRANSMITTER; TYROSINE 3 MONOOXYGENASE; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR GLUTAMATE TRANSPORTER 3;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CONTROLLED STUDY; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOCOMPETENT CELL; MALE; MOUSE; NERVE ENDING; NERVE FIBER; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIKARYON; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEPTUM NUCLEUS;

ANIMALS; BRAIN; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; NEUROPEPTIDE Y; NEUROTRANSMITTER AGENTS; RECEPTORS, NEUROPEPTIDE Y; SYNAPTIC TRANSMISSION;

EID: 79953218075     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22608     Document Type: Article

References (211)

1. Abrahamson EE, Moore RY. 2001. Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections. Brain Res 916: 172-191.
2. Adams JC. 1992. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J Histochem Cytochem 40: 1457-1463.
3. Agnati LF, Zoli M, Strömberg I, Fuxe K. 1995. Intercellular communication in the brain: wiring versus volume transmission. Neuroscience 69: 711-726.
4. Aicher SA, Springston M, Berger SB, Reis DJ, Wahlestedt C. 1991. Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neurosci Lett 130: 32-36.
5. Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, Polak JM. 1983. Neuropeptide Y distribution in the rat brain. Science 221: 877-879.
6. Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino MA, Niijima A, Meguid MM, Kasuga M. 2003. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 124: 1325-1336.
7. Bai FL, Yamano M, Shiotani Y, Emson PC, Smith AD, Powell JF, Tohyama M. 1985. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 331: 172-175.
8. Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD. 1997. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J Neurosci 17: 8927-8936.
9. Bard JA, Walker MW, Branchek TA, Weinshank RL. 1995. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J Biol Chem 270: 26762-26765.
10. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. 2002. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654.
11. Biello SM, Janik D, Mrosovsky N. 1994. Neuropeptide Y and behaviorally induced phase shifts. Neuroscience 62: 273-279.
12. Billington CJ, Briggs JE, Harker S, Grace M, Levine AS. 1994. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol 266(6 Pt 2): R1765-1770.
13. Blomqvist AG, Herzog H. 1997. Y-receptor subtypes-how many more? Trends Neurosci 20: 294-298.
14. Bouchard P, Maurice T, St-Pierre S, Privat A, Quirion R. 1997. Neuropeptide Y and the calcitonin gene-related peptide attenuate learning impairments induced by MK-801 via a sigma receptor-related mechanism. Eur J Neurosci 9: 2142-2151.
15. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
16. Broberger C, Landry M, Wong H, Walsh JN, Hökfelt T. 1997. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66: 393-408.
17. Broberger C, De Lecea L, Sutcliffe JG, Hökfelt T. 1998. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 402: 460-474.
18. Broome M, Hökfelt T, Terenius L. 1985. Peptide YY (PYY)-immunoreactive neurons in the lower brain stem and spinal cord of rat. Acta Physiol Scand 125: 349-352.
19. Broqua P, Wettstein JG, Rocher MN, Gauthier-Martin B, Junien JL. 1995. Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures. Behav Pharmacol 6: 215-222.
20. Brumovsky PR, Shi TJ, Matsuda H, Kopp J, Villar MJ, Hökfelt T. 2002. NPY Y1 receptors are present in axonal processes of DRG neurons. Exp Neurol 174: 1-10.
21. Brumovsky P, Stanic D, Shuster S, Herzog H, Villar M, Hökfelt T. 2005. Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse. J Comp Neurol 489: 328-348.
22. Brumovsky P, Watanabe M, Hökfelt T. 2007. Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury. Neuroscience 147: 469-490.
23. Caberlotto L, Hurd YL. 2001. Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior. Neuropsychopharmacology 25: 91-97.
24. Caberlotto L, Fuxe K, Sedvall G, Hurd YL. 1997. Localization of neuropeptide Y Y1 mRNA in the human brain: abundant expression in cerebral cortex and striatum. Eur J Neurosci 9: 1212-1225.
25. Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL. 1998a. Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain. Neuroscience 86: 167-178.
26. Caberlotto L, Tinner B, Bunnemann B, Agnati L, Fuxe K. 1998b. On the relationship of neuropeptide Y Y1 receptor-immunoreactive neuronal structures to the neuropeptide Y-immunoreactive nerve terminal networks. A double immunolabelling analysis in the rat brain. Neuroscience 86: 827-845.
27. Caberlotto L, Fuxe K, Hurd YL. 2000. Characterization of NPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum. J Chem Neuroanat 20: 327-337.
28. Celio MR. 1990. Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35: 375-475.
29. Chan-Palay V, Allen YS, Lang W, Haesler U, Polak JM. 1985. Cytology and distribution in normal human cerebral cortex of neurons immunoreactive with antisera against neuropeptide Y. J Comp Neurol 238: 382-389.
30. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA, O'Donohue TL. 1985. The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience 15: 1159-1181.
31. Clark JT, Kalra PS, Crowley WR, Kalra SP. 1984. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429.
32. Colmers WF, Lukowiak K, Pittman QJ. 1985. Neuropeptide Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism. Brain Res 346: 404-408.
33. Colmers WF, Lukowiak K, Pittman QJ. 1987. Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J Physiol 383: 285-299.
34. Colmers WF, Lukowiak K, Pittman QJ. 1988. Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J Neurosci 8: 3827-3837.
35. Colmers WF, Klapstein GJ, Fournier A, St-Pierre S, Treherne KA. 1991. Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br J Pharmacol 102: 41-44.
36. Coons AH. 1958. Fluorescent antibody methods. In: Danielli JF, editor. General cytochemical methods. New York: Academic. p 399-422.
37. Cortes R, Ceccatelli S, Schalling M, Hökfelt T. 1990. Differential effects of intracerebroventricular colchicine administration on the expression of mRNAs for neuropeptides and neurotransmitter enzymes, with special emphasis on galanin: an in situ hybridization study. Synapse 6: 369-391.
38. Crawford IL, Connor JD. 1973. Localization and release of glutamic acid in relation to the hippocampal mossy fibre pathway. Nature 244: 442-443.
39. Crowley WR, Tessel RE, O'Donohue TL, Adler BA, Kalra SP. 1985. Effects of ovarian hormones on the concentrations of immunoreactive neuropeptide Y in discrete brain regions of the female rat: correlation with serum luteinizing hormone (LH) and median eminence LH-releasing hormone. Endocrinology 117: 1151-1155.
40. Csiffary A, Görcs TJ, Palkovits M. 1990. Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron microscopic double immunolabeling study. Brain Res 506: 215-222.
41. Dahlström A. 1968. Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat. Eur J Pharmacol 5: 111-113.
42. de Quidt ME, Emson PC. 1986a. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. I. Radioimmunoassay and chromatographic characterisation. Neuroscience 18: 527-543.
43. de Quidt ME, Emson PC. 1986b. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system. II. Immunohistochemical analysis. Neuroscience 18: 545-618.
44. DiMaggio DA, Chronwall BM, Buchanan K, O'Donohue TL. 1985. Pancreatic polypeptide immunoreactivity in rat brain is actually neuropeptide Y. Neuroscience 15: 1149-1157.
45. Doods HN, Krause J. 1991. Different neuropeptide Y receptor subtypes in rat and rabbit vas deferens. Eur J Pharmacol 204: 101-103.
46. Dumont Y, Fournier A, St-Pierre S, Quirion R. 1993. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J Neurosci 13: 73-86.
47. Dumont Y, Fournier A, St-Pierre S, Quirion R. 1996. Autoradiographic distribution of [125I]Leu31, Pro34]PYY and [125I]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands. Synapse 22: 139-158.
48. Dumont Y, Jacques D, Bouchard P, Quirion R. 1998. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J Comp Neurol 402: 372-384.
49. Ekman R, Wahlestedt C, Böttcher G, Sundler F, Håkanson R, Panula P. 1986. Peptide YY-like immunoreactivity in the central nervous system of the rat. Regul Pept 16: 157-168.
50. Eva C, Keinanen K, Monyer H, Seeburg P, Sprengel R. 1990. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett 271: 81-84.
51. Eva C, Oberto A, Sprengel R, Genazzani E. 1992. The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett 314: 285-288.
52. Everitt BJ, Hökfelt T, Terenius L, Tatemoto K, Mutt V, Goldstein M. 1984. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11: 443-462.
53. Fekete C, Kelly J, Mihaly E, Sarkar S, Rand WM, Legradi G, Emerson CH, Lechan RM. 2001. Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology 142: 2606-2613.
54. Fetissov SO, Jacoby AS, Brumovsky PR, Shine J, Iismaa TP, Hökfelt T. 2003a. Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice. Epilepsia 44: 1022-1033.
55. Fetissov SO, Kuteeva E, Hökfelt T. 2003b. Directional cues for arcuate NPY projections are present in the adult brain. Exp Neurol 183: 116-123.
56. Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hökfelt T. 2004. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. J Comp Neurol 470: 256-265.
57. Fetissov SO, Bensing S, Mulder J, Le Maitre E, Hulting AL, Harkany T, Ekwall O, Sköldberg F, Husebye ES, Perheentupa J, Rorsman F, Kämpe O, Hökfelt T. 2009. Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems. J Comp Neurol 513: 1-20.
58. Flood JF, Baker ML, Hernandez EN, Morley JE. 1989. Modulation of memory processing by neuropeptide Y varies with brain injection site. Brain Res 503: 73-82.
59. Freund TF, Buzsaki G. 1996. Interneurons of the hippocampus. Hippocampus 6: 347-470.
60. Fuhlendorff J, Gether U, Aakerlund L, Langeland-Johansen N, Thogersen H, Melberg SG, Olsen UB, Thastrup O, Schwartz TW. 1990. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A 87: 182-186.
61. Furmanski O, Gajavelli S, Lee JW, Collado ME, Jergova S, Sagen J. 2009. Combined extrinsic and intrinsic manipulations exert complementary neuronal enrichment in embryonic rat neural precursor cultures: an in vitro and in vivo analysis. J Comp Neurol 515: 56-71.
62. Fuxe K, Agnati LF (eds.). 1991. Volume transmission in the brain. New York: Raven.
63. Gackenheimer SL, Schober DA, Gehlert DR. 2001. Characterization of neuropeptide Y Y1-like and Y2-like receptor subtypes in the mouse brain. Peptides 22: 335-341.
64. Gall C, Lauterborn J, Isackson P, White J. 1990. Seizures, neuropeptide regulation, and mRNA expression in the hippocampus. Prog Brain Res 83: 371-390.
65. Gamble KL, Paul KN, Karom MC, Tosini G, Albers HE. 2006. Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci 23: 2488-2494.
66. Gehlert DR. 1998. Multiple receptors for the pancreatic polypeptide (PP-fold) family: physiological implications. Proc Soc Exp Biol Med 218: 7-22.
67. Gehlert DR, Chronwall BM, Schäfer MP, O'Donohue TL. 1987. Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization. Synapse 1: 25-31.
68. Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA. 1996. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol 49: 224-228.
69. Gehlert DR, Schober DA, Morin M, Berglund MM. 2007. Co-expression of neuropeptide Y Y1 and Y5 receptors results in heterodimerization and altered functional properties. Biochem Pharmacol 74: 1652-1664.
70. Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL. 1995. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem 270: 26758-26761.
71. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL. 1996. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382: 168-171.
72. Glass MJ, Chan J, Pickel VM. 2002. Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons. J Neurosci Res 67: 753-765.
73. Gobbi M, Gariboldi M, Piwko C, Hoyer D, Sperk G, Vezzani A. 1998. Distinct changes in peptide YY binding to, and mRNA levels of, Y1 and Y2 receptors in the rat hippocampus associated with kindling epileptogenesis. J Neurochem 70: 1615-1622.
74. Goldschmidt RB, Steward O. 1982. Neurotoxic effects of colchicine: differential susceptibility of CNS neuronal populations. Neuroscience 7:695-714.
75. Golombek DA, Biello SM, Rendon RA, Harrington ME. 1996. Neuropeptide Y phase shifts the circadian clock in vitro via a Y2 receptor. Neuroreport 7: 1315-1319.
76. Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El Mestikawy S. 2002. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci 22: 5442-5451.
77. Greber S, Schwarzer C, Sperk G. 1994. Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro. Br J Pharmacol 113: 737-740.
78. Gregor P, Feng Y, DeCarr LB, Cornfield LJ, McCaleb ML. 1996a. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. J Biol Chem 271: 27776-27781.
79. Gregor P, Millham ML, Feng Y, DeCarr LB, McCaleb ML, Cornfield LJ. 1996b. Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett 381: 58-62.
80. Grundemar L. 1997. Multiple receptors and multiple actions. In: Grundemar L, Bloom SR, editors. Neuropeptide Y and drug development. London: Academic Press. p 1-14.
81. Grundemar L, Jonas SE, Morner N, Högestatt ED, Wahlestedt C, Håkanson R. 1992. Characterization of vascular neuropeptide Y receptors. Br J Pharmacol 105: 45-50.
82. Gustafson EL, Smith KE, Durkin MM, Walker MW, Gerald C, Weinshank R, Branchek TA. 1997. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Brain Res Mol Brain Res 46: 223-235.
83. Gutierrez R. 2002. Activity-dependent expression of simultaneous glutamatergic and GABAergic neurotransmission from the mossy fibers in vitro. J Neurophysiol 87: 2562-2570.
84. Gutierrez R. 2005. The dual glutamatergic-GABAergic phenotype of hippocampal granule cells. Trends Neurosci 28: 297-303.
85. Gutierrez R, Romo-Parra H, Maqueda J, Vivar C, Ramirez M, Morales MA, Lamas M. 2003. Plasticity of the GABAergic phenotype of the "glutamatergic" granule cells of the rat dentate gyrus. J Neurosci 23: 5594-5598.
86. Haas HL, Hermann A, Greene RW, Chan-Palay V. 1987. Action and location of neuropeptide tyrosine (Y) on hippocampal neurons of the rat in slice preparations. J Comp Neurol 257: 208-215.
87. Hahn TM, Breininger JF, Baskin DG, Schwartz MW. 1998. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1: 271-272.
88. Hansel DE, Eipper BA, Ronnett GV. 2001. Neuropeptide Y functions as a neuroproliferative factor. Nature 410: 940-944.
89. Hantman AW, van den Pol AN, Perl ER. 2004. Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression. J Neurosci 24: 836-842.
90. Heilig M, Söderpalm B, Engel JA, Widerlöv E. 1989. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berl) 98: 524-529.
91. Heilig M, McLeod S, Brot M, Heinrichs SC, Menzaghi F, Koob GF, Britton KT. 1993. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8: 357-363.
92. Heinrichs SC, Menzaghi F, Koob GF. 1998. Neuropeptide Y-induced feeding and its control. Vitam Horm 54: 51-66.
93. Herkenham M. 1987. Mismatches between neurotransmitter and receptor localizations in brain: observations and implications. Neuroscience 23: 1-38.
94. Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA. 1992. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci U S A 89: 5794-5798.
95. Hökfelt T, Mårtensson R, Björklund A, Kleinau S, Goldstein M. 1984. Distributional maps of tyrosine-hydroxylase-immunoreactive neurons in the rat brain. In: Björklund A, Hökfelt T, editors. Handbook of chemical neuroanatomy, vol. 2. Classical transmitters in the CNS, Part I. Amsterdam: Elsevier. p 277-379.
96. Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C. 1997. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756: 283-286.
97. Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, Beck-Sickinger AG, Gray WP. 2005. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem 93: 560-570.
98. Huhman KL, Albers HE. 1994. Neuropeptide Y microinjected into the suprachiasmatic region phase shifts circadian rhythms in constant darkness. Peptides 15: 1475-1478.
99. Huhman KL, Gillespie CF, Marvel CL, Albers HE. 1996. Neuropeptide Y phase shifts circadian rhythms in vivo via a Y2 receptor. Neuroreport 7: 1249-1252.
100. Inui A. 1999. Neuropeptide Y feeding receptors: are multiple subtypes involved? Trends Pharmacol Sci 20: 43-46.
101. Jimenez-Vasquez PA, Overstreet DH, Mathe AA. 2000. Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effects of electroconvulsive stimuli. J Psychiatr Res 34: 405-412.
102. Jinno S, Kosaka T. 2003. Patterns of expression of neuropeptides in GABAergic nonprincipal neurons in the mouse hippocampus: Quantitative analysis with optical disector. J Comp Neurol 461: 333-349.
103. Johansson JU, Ericsson J, Janson J, Beraki S, Stanić D, Mandic SA, Wikström MA, Hökfelt T, Ögren SO, Rozell B, Berggren PO, Bark C. 2008. An ancient duplication of exon 5 in the snap25 gene is required for complex neuronal development/function. PLoS Genet 4: e1000278.
104. Kalra SP, Kalra PS. 2004. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38: 201-211.
105. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. 1999. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20: 68-100.
106. Kash TL, Winder DG. 2006. Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology 51: 1013-1022.
107. Kasyanov AM, Safiulina VF, Voronin LL, Cherubini E. 2004. GABA-mediated giant depolarizing potentials as coincidence detectors for enhancing synaptic efficacy in the developing hippocampus. Proc Natl Acad Sci U S A 101: 3967-3972.
108. Köhler C, Eriksson LG, Davies S, Chan-Palay V. 1987. Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region. Neurosci Lett 78: 1-6.
109. Kopp J, Nanobashvili A, Kokaia Z, Lindvall O, Hökfelt T. 1999. Differential regulation of mRNAs for neuropeptide Y and its receptor subtypes in widespread areas of the rat limbic system during kindling epileptogenesis. Brain Res Mol Brain Res 72: 17-29.
110. Kopp J, Xu ZQ, Zhang X, Pedrazzini T, Herzog H, Kresse A, Wong H, Walsh JH, Hökfelt T. 2002. Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience 111: 443-532.
111. Krause J, Eva C, Seeburg PH, Sprengel R. 1992. Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol Pharmacol 41: 817-821.
112. Kreutzberg GW. 1969. Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine. Proc Natl Acad Sci U S A 62: 722-728.
113. Krysiak R, Obuchowicz E, Herman ZS. 1999. Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis. Eur J Endocrinol 140: 130-136.
114. Lall GS, Biello SM. 2003. Attenuation of circadian light induced phase advances and delays by neuropeptide Y and a neuropeptide Y Y1/Y5 receptor agonist. Neuroscience 119: 611-618.
115. Lamas M, Gomez-Lira G, Gutierrez R. 2001. Vesicular GABA transporter mRNA expression in the dentate gyrus and in mossy fiber synaptosomes. Brain Res Mol Brain Res 93: 209-214.
116. Larhammar D. 1996. Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept 65: 165-174.
117. Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C. 1992. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem 267: 10935-10938.
118. Larhammar D, Wraith A, Berglund MM, Holmberg SK, Lundell I. 2001. Origins of the many NPY-family receptors in mammals. Peptides 22: 295-307.
119. Larsen PJ, Sheikh SP, Jakobsen CR, Schwartz TW, Mikkelsen JD. 1993. Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur J Neurosci 5: 1622-1637.
120. Lehmann H, Ebert U, Löscher W. 1996. Immunocytochemical localization of GABA immunoreactivity in dentate granule cells of normal and kindled rats. Neurosci Lett 212: 41-44.
121. Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, Chen L, Chen L, Chen TM, Chin MC, Chong J, Crook BE, Czaplinska A, Dang CN, Datta S, Dee NR, Desaki AL, Desta T, Diep E, Dolbeare TA, Donelan MJ, Dong HW, Dougherty JG, Duncan BJ, Ebbert AJ, Eichele G, Estin LK, Faber C, Facer BA, Fields R, Fischer SR, Fliss TP, Frensley C, Gates SN, Glattfelder KJ, Halverson KR, Hart MR, Hohmann JG, Howell MP, Jeung DP, Johnson RA, Karr PT, Kawal R, Kidney JM, Knapik RH, Kuan CL, Lake JH, Laramee AR, Larsen KD, Lau C, Lemon TA, Liang AJ, Liu Y, Luong LT, Michaels J, Morgan JJ, Morgan RJ, Mortrud MT, Mosqueda NF, Ng LL, Ng R, Orta GJ, Overly CC, Pak TH, Parry SE, Pathak SD, Pearson OC, Puchalski RB, Riley ZL, Rockett HR, Rowland SA, Royall JJ, Ruiz MJ, Sarno NR, Schaffnit K, Shapovalova NV, Sivisay T, Slaughterbeck CR, Smith SC, Smith KA, Smith BI, Sodt AJ, Stewart NN, Stumpf KR, Sunkin SM, Sutram M, Tam A, Teemer CD, Thaller C, Thompson CL, Varnam LR, Visel A, Whitlock RM, Wohnoutka PE, Wolkey CK, Wong VY, Wood M, Yaylaoglu MB, Young RC, Youngstrom BL, Yuan XF, Zhang B, Zwingman TA, Jones AR. 2007. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445: 168-176.
122. Levine AS, Morley JE. 1984. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5: 1025-1029.
123. Lin S, Boey D, Couzens M, Lee N, Sainsbury A, Herzog H. 2005. Compensatory changes in [125I]-PYY binding in Y receptor knockout mice suggest the potential existence of further Y receptor(s). Neuropeptides 39: 21-28.
124. Ludwig M, Leng G. 2006. Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci 7: 126-136.
125. Lundberg JM, Hemsén A, Larsson O, Rudehill A, Saria A, Fredholm BB. 1988a. Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction. Eur J Pharmacol 145: 21-29.
126. Lundberg JM, Hemsén A, Rudehill A, Härfstrand A, Larsson O, Sollevi A, Saria A, Hökfelt T, Fuxe K, Fredholm BB. 1988b. Neuropeptide Y- and alpha-adrenergic receptors in pig spleen: localization, binding characteristics, cyclic AMP effects and functional responses in control and denervated animals. Neuroscience 24: 659-672.
127. Lundell I, Statnick MA, Johnson D, Schober DA, Starback P, Gehlert DR, Larhammar D. 1996. The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc Natl Acad Sci U S A 93: 5111-5115.
128. Lynch DR, Walker MW, Miller RJ, Snyder SH. 1989. Neuropeptide Y receptor binding sites in rat brain: differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor heterogeneity. J Neurosci 9: 2607-2619.
129. Malendowicz LK, Markowska A, Zabel M. 1996. Neuropeptide Y-related peptides and hypothalamo-pituitary-adrenal axis function. Histol Histopathol 11: 485-494.
130. Malmström RE, Hökfelt T, Björkman JA, Nihlén C, Byström M, Ekstrand AJ, Lundberg JM. 1998. Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog. Regul Pept 75-76: 55-70.
131. Martel JC, St-Pierre S, Quirion R. 1986. Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides 7: 55-60.
132. McAuley MA, Westfall TC. 1992. Possible location and function of neuropeptide Y receptor subtypes in the rat mesenteric arterial bed. J Pharmacol Exp Ther 261: 863-868.
133. McDermott BJ, Millar BC, Piper HM. 1993. Cardiovascular effects of neuropeptide Y: receptor interactions and cellular mechanisms. Cardiovasc Res 27: 893-905.
134. McDonald AJ, Pearson JC. 1989. Coexistence of GABA and peptide immunoreactivity in non-pyramidal neurons of the basolateral amygdala. Neurosci Lett 100: 53-58.
135. Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T. 1998. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50: 143-150.
136. Michel MC, Wieland T, Tsujimoto G. 2009. How reliable are G-protein-coupled receptor antibodies? Naunyn Schmiedebergs Arch Pharmacol 379: 385-388.
137. Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M. 2006. Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J Neurochem 97: 1431-1446.
138. Miyazaki T, Fukaya M, Shimizu H, Watanabe M. 2003. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Eur J Neurosci 17: 2563-2572.
139. Mody I. 2002. The GAD-given right of dentate gyrus granule cells to become GABAergic. Epilepsy Curr 2: 143-145.
140. Moore RY, Card JP. 1990. Neuropeptide Y in the circadian timing system. Ann N Y Acad Sci 611: 247-257.
141. Moore RY, Gustafson EL, Card JP. 1984. Identical immunoreactivity of afferents to the rat suprachiasmatic nucleus with antisera against avian pancreatic polypeptide, molluscan cardioexcitatory peptide and neuropeptide Y. Cell Tissue Res 236: 41-46.
142. Moore RY, Speh JC, Leak RK. 2002. Suprachiasmatic nucleus organization. Cell Tissue Res 309: 89-98.
143. Morimoto R, Satoh F, Murakami O, Totsune K, Saruta M, Suzuki T, Sasano H, Ito S, Takahashi K. 2008. Expression of peptide YY in human brain and pituitary tissues. Nutrition 24: 878-884.
144. Morris BJ. 1989. Neuronal localisation of neuropeptide Y gene expression in rat brain. J Comp Neurol 290: 358-368.
145. Mugnaini E, Oertel WH. 1985. An atlas of the distribution of the GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry. In: Björklund A, Hökfelt T, editors. Handbook of chemical neuroanatomy, vol. 4. GABA and neuropeptides in the CNS Pt I. Amsterdam: Elsevier. p 436-608.
146. Nakajima M, Inui A, Asakawa A, Momose K, Ueno N, Teranishi A, Baba S, Kasuga M. 1998. Neuropeptide Y produces anxiety via Y2-type receptors. Peptides 19: 359-363.
147. Nakamura M, Aoki Y, Hirano D. 1996. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim Biophys Acta 1284: 134-137.
148. Naveilhan P, Neveu I, Arenas E, Ernfors P. 1998. Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system. Neuroscience 87: 289-302.
149. Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody. Neurosci Lett 202: 197-200.
150. Ohkubo T, Niwa M, Yamashita K, Kataoka Y, Shigematsu K. 1990. Neuropeptide Y (NPY) and peptide YY (PYY) receptors in rat brain. Cell Mol Neurobiol 10: 539-552.
151. Ottersen OP, Storm-Mathisen J. 1984. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique. J Comp Neurol 229: 374-392.
152. Pacheco Otalora LF, Couoh J, Shigamoto R, Zarei MM, Garrido Sanabria ER. 2006. Abnormal mGluR2/3 expression in the perforant path termination zones and mossy fibers of chronically epileptic rats. Brain Res 1098: 170-185.
153. Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E. 2008. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J Clin Invest 118: 149-160.
154. Parker RM, Herzog H. 1998. Comparison of Y-receptor subtype expression in the rat hippocampus. Regul Pept 75-76: 109-115.
155. Parker RM, Herzog H. 1999. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci 11: 1431-1448.
156. Paxinos G, Franklin KBJ. 2001. The mouse brain in stereotaxic coordinates, 2nd ed. London: Academic Press.
157. Pease PC. 1962. Buffered formaldehyde as a killing agent and primary fixative for electron microscopy. Anat Rec 142: 342.
158. Pickel VM, Beck-Sickinger AG, Chan J, Weiland HA. 1998. Y1 receptors in the nucleus accumbens: ultrastructural localization and association with neuropeptide Y. J Neurosci Res 52: 54-68.
159. Redrobe JP, Dumont Y, Quirion R. 2002. Neuropeptide Y (NPY) and depression: from animal studies to the human condition. Life Sci 71: 2921-2937.
160. Roettger VR, Pearson JC, Goldfinger MD. 1989. Identification of gamma-aminobutyric acid-like immunoreactive neurons in the rat cuneate nucleus. Neurosci Lett 97: 46-50.
161. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R. 1995. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem 270: 22661-22664.
162. Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM. 2004. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41: 711-722.
163. Rosier AM, Orban GA, Vandesande F. 1990. Regional distribution of binding sites for neuropeptide Y in cat and monkey visual cortex determined by in vitro receptor autoradiography. J Comp Neurol 293: 486-498.
164. Rostkowski AB, Teppen TL, Peterson DA, Urban JH. 2009. Cell-specific expression of neuropeptide Y Y1 receptor immunoreactivity in the rat basolateral amygdala. J Comp Neurol 517: 166-176.
165. Safiulina VF, Fattorini G, Conti F, Cherubini E. 2006. GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus. J Neurosci 26: 597-608.
166. Sahu A, Kalra SP, Crowley WR, Kalra PS. 1988. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res 457: 376-378.
167. Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Furtinger S, Jenkins A, Cox HM, Sperk G, Hökfelt T, Herzog H. 2002. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci U S A 99: 8938-8943.
168. Sajdyk TJ, Vandergriff MG, Gehlert DR. 1999. Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur J Pharmacol 368: 143-147.
169. Sajdyk TJ, Schober DA, Gehlert DR. 2002a. Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats. Neuropharmacology 43: 1165-1172.
170. Sajdyk TJ, Schober DA, Smiley DL, Gehlert DR. 2002b. Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. Pharmacol Biochem Behav 71: 419-423.
171. Sandler R, Smith AD. 1991. Coexistence of GABA and glutamate in mossy fiber terminals of the primate hippocampus: an ultrastructural study. J Comp Neurol 303: 177-192.
172. Sawchenko PE, Swanson LW, Grzanna R, Howe PR, Bloom SR, Polak JM. 1985. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241: 138-153.
173. Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA. 1997. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature 385: 630-634.
174. Schwarzer C, Sperk G. 1995. Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat. Neuroscience 69: 705-709.
175. Schwarzer C, Sperk G, Samanin R, Rizzi M, Gariboldi M, Vezzani A. 1996. Neuropeptides-immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis. Brain Res Brain Res Rev 22: 27-50.
176. Schwarzer C, Kofler N, Sperk G. 1998. Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy. Mol Pharmacol 53: 6-13.
177. Shaw JL, Gackenheimer SL, Gehlert DR. 2003. Functional autoradiography of neuropeptide Y Y1 and Y2 receptor subtypes in rat brain using agonist stimulated [35S]GTPgammaS binding. J Chem Neuroanat 26: 179-193.
178. Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci 17: 7503-7522.
179. Singec I, Knoth R, Ditter M, Volk B, Frotscher M. 2004. Neurogranin is expressed by principal cells but not interneurons in the rodent and monkey neocortex and hippocampus. J Comp Neurol 479: 30-42.
180. Sloviter RS, Dichter MA, Rachinsky TL, Dean E, Goodman JH, Sollas AL, Martin DL. 1996. Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J Comp Neurol 373: 593-618.
181. Somogyi J, Baude A, Omori Y, Shimizu H, El Mestikawy S, Fukaya M, Shigemoto R, Watanabe M, Somogyi P. 2004. GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. Eur J Neurosci 19: 552-569.
182. Soscia SJ, Harrington ME. 2004. Neuropeptide Y attenuates NMDA-induced phase shifts in the SCN of NPY Y1 receptor knockout mice in vitro. Brain Res 1023: 148-153.
183. St-Pierre JA, Dumont Y, Nouel D, Herzog H, Hamel E, Quirion R. 1998. Preferential expression of the neuropeptide Y Y1 over the Y2 receptor subtype in cultured hippocampal neurons and cloning of the rat Y2 receptor. Br J Pharmacol 123: 183-194.
184. Stanic D, Finkelstein DI, Bourke DW, Drago J, Horne MK. 2003. Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat. Eur J Neurosci 18: 1175-1188.
185. Stanić D, Brumovsky P, Fetissov S, Shuster S, Herzog H, Hökfelt T. 2006. Characterization of neuropeptide Y2 receptor protein expression in the mouse brain. I. Distribution in cell bodies and nerve terminals. J Comp Neurol 499: 357-390.
186. Stanić D, Paratcha G, Ledda F, Herzog H, Kopin A, Hökfelt T. 2008. Peptidergic influences on proliferation, migration and placement of neural progenitors in the adult mouse forebrain. Proc Natl Acad Sci USA 105: 3610-3615.
187. Stanley BG, Leibowitz SF. 1984. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci 35: 2635-2642.
188. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. 1986. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189-1192.
189. Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K, Kaneko T. 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467: 60-79.
190. Tasan RO, Nguyen NK, Weger S, Sartori SB, Singewald N, Heilbronn R, Herzog H, Sperk G. 2010. The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression. J Neurosci 30: 6282-6290.
191. Tatemoto K. 1982. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A 79: 5485-5489.
192. Tatemoto K, Carlquist M, Mutt V. 1982. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296: 659-660.
193. Tschenett A, Singewald N, Carli M, Balducci C, Salchner P, Vezzani A, Herzog H, Sperk G. 2003. Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur J Neurosci 18: 143-148.
194. Uchigashima M, Fukaya M, Watanabe M, Kamiya H. 2007. Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. J Neurosci 27: 8088-8100.
195. Undén A, Bartfai T. 1984. Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex. FEBS Lett 177: 125-128.
196. Undén A, Tatemoto K, Mutt V, Bartfai T. 1984. Neuropeptide Y receptor in the rat brain. Eur J Biochem 145: 525-530.
197. Vezzani A, Sperk G. 2004. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? Neuropeptides 38: 245-252.
198. Vezzani A, Civenni G, Rizzi M, Monno A, Messali S, Samanin R. 1994. Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. Brain Res 660: 138-143.
199. Wahlestedt C, Reis DJ. 1993. Neuropeptide Y-related peptides and their receptors-are the receptors potential therapeutic drug targets? Annu Rev Pharmacol Toxicol 33: 309-352.
200. Wahlestedt C, Yanaihara N, Håkanson R. 1986. Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept 13: 307-318.
201. Walker MC, Ruiz A, Kullmann DM. 2001. Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses. Neuron 29: 703-715.
202. Weber ET, Rea MA. 1997. Neuropeptide Y blocks light-induced phase advances but not delays of the circadian activity rhythm in hamsters. Neurosci Lett 231: 159-162.
203. Weinberg DH, Sirinathsinghji DJ, Tan CP, Shiao LL, Morin N, Rigby MR, Heavens RH, Rapoport DR, Bayne ML, Cascieri MA, Strader CD, Linemeyer DL, MacNeil DJ. 1996. Cloning and expression of a novel neuropeptide Y receptor. J Biol Chem 271: 16435-16438.
204. Weiser T, Wieland HA, Doods HN. 2000. Effects of the neuropeptide Y Y(2) receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices. Eur J Pharmacol 404: 133-136.
205. Wolak ML, DeJoseph MR, Cator AD, Mokashi AS, Brownfield MS, Urban JH. 2003. Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J Comp Neurol 464: 285-311.
206. Woldbye DP, Madsen TM, Larsen PJ, Mikkelsen JD, Bolwig TG. 1996. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res 737: 162-168.
207. Wraith A, Tornsten A, Chardon P, Harbitz I, Chowdhary BP, Andersson L, Lundin LG, Larhammar D. 2000. Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome Res 10: 302-310.
208. Yannielli PC, Brewer JM, Harrington ME. 2004. Blockade of the NPY Y5 receptor potentiates circadian responses to light: complementary in vivo and in vitro studies. Eur J Neurosci 19: 891-897.
209. Young WS 3rd, Kuhar MJ. 1979. A new method for receptor autoradiography: [3H]opioid receptors in rat brain. Brain Res 179: 255-270.
210. Zamboni I, De Martino C. 1967. Buffered picric acid formaldehyde: A new rapid fixative for electron microscopy. J Cell Biol 35: 148A.
211. Zhang X, Bao L, Xu ZQ, Kopp J, Arvidsson U, Elde R, Hökfelt T. 1994. Localization of neuropeptide Y Y1 receptors in the rat nervous system with special reference to somatic receptors on small dorsal root ganglion neurons. Proc Natl Acad Sci U S A 91: 11738-11742.