Co-expression of neuropeptide Y Y1 and Y5 receptors results in heterodimerization and altered functional properties

Biochemical Pharmacology

Volumn 74, Issue 11, 2007, Pages 1652-1664

  Gehlert, Donald R ^a   Schober, Douglas A ^a   Morin, Michelle ^a   Berglund, Magnus M ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Anxiety; Desensitization; Feeding; GPCR heterodimers; GPCR internalization; Neuropeptide Y

Indexed keywords

1 [3 [1 [2 (4 IODOPHENYL)ETHYL]PIPERIDIN 4 YL]PROPYL] 2 [(PHENOXY)METHYL] 4 [3 (1 PIPERIDINYL)PROPOXY] 1H BENZIMIDAZOLE; 1 NAPHTHALENESULFONIC ACID [4 [(4 AMINO 2 QUINAZOLINYLAMINO)METHYL]CYCLOHEXYLMETHYL]AMIDE; [2 NITROBENZENE 2 SULFONIC ACID [4 (2 NAPHTHYLMETHYLAMINO)METHYL]CYCLOHEXYLMETHYL]AMIDE; ADENYLATE CYCLASE; GREEN FLUORESCENT PROTEIN; LY 366258; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; RENILLA LUCIFERIN 2 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION;

ADENYLATE CYCLASE; ANIMALS; ARGININE; CELL LINE; CELL MEMBRANE; CRICETINAE; CYCLIC AMP; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RESONANCE ENERGY TRANSFER; FORSKOLIN; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES, RENILLA; MACACA MULATTA; MESOCRICETUS; MICROSCOPY, CONFOCAL; NEUROPEPTIDE Y; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RECEPTORS, NEUROPEPTIDE Y; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 35349016873     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.08.017     Document Type: Article

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