Glycyrrhizin and its metabolite 18β-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes

European Journal of Pharmacology

Volumn 626, Issue 2-3, 2010, Pages 154-158

  Kawakami, Zenji ^a   Ikarashi, Yasushi ^a   Kase, Yoshio ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

18 glycyrrhetinic acid; Astrocyte; Glycyrrhiza; Glycyrrhizin; PKC; Yokukansan

Indexed keywords

CHINESE DRUG; GLUTAMIC ACID; GLYCYCOUMARIN; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; ISOLIQUIRITIGENIN; ISOLIQUITINE; LIQUILITIN APIOSIDE; LIQUIRITIGENIN; LIQUIRITIN; NATURAL PRODUCT; PROTEIN KINASE C; UNCLASSIFIED DRUG; YOKUKANSAN;

AMINO ACID TRANSPORT; ANGELICA; ANGELICA ACUTILOBA; ANIMAL CELL; ARTICLE; ASTROCYTE; ATRACTYLODES; ATRACTYLODES LANCEA; BRAIN CELL; BUPLEURUM; BUPLEURUM FALCATUM; CELL TRANSPORT; CNIDIUM; CNIDIUM OFFICINALE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; ENZYME ACTIVITY; GLYCYRRHIZA URALENSIS; MEDICINAL PLANT; METABOLIC TRANSPORT DISORDER; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PLANT ROOT; PORIA COCOS; PRIORITY JOURNAL; RAT; THIAMINE DEFICIENCY; UNCARIA; UNCARIA RHYNCHOPHYLLA;

ANIMALS; ASTROCYTES; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GLUTAMIC ACID; GLYCYRRHETINIC ACID; GLYCYRRHIZA; GLYCYRRHIZIC ACID; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RATS; THIAMINE DEFICIENCY;

EID: 70649107801     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.046     Document Type: Article

References (31)

1. Abe K., Abe Y., and Saito H. Evaluation of L-glutamate clearance capacity of cultured rat cortical astrocytes. Biol. Pharm. Bull. 23 (2000) 204-207
2. Behrens P.F., Franz P., Woodman B., Lindenberg K.S., and Landwehrmeyer G.B. Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 125 (2002) 1908-1922
3. Cheung N.S., Pacoe C.J., Giardina S.F., John C.A., and Beart P.M. Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, exitotoxic injury in cultured cortical neurones. Neuropharmacol 37 (1998) 1419-1429
4. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
5. Collins G.H. Glial cell changes in the brain stem of thiamine-deficient rats. Am. J. Pathol. 50 (1967) 791-814
6. Conradt M., and Stoffel W. Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation. J. Neurochem. 68 (1997) 1244-1251
7. Gonzalez M.I., Lopez-Colom A.M., and Ortega A. Sodium-dependent glutamate transporter in Muller glial cells: regulation by phorbol esters. Brain Res. 831 (1999) 140-145
8. Han F., Shioda N., Moriguchi S., Qin Z.H., and Fukunaga K. Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism. Neurosci. Lett. 430 (2008) 275-280
9. Harkany T., Ábrahám I., Timmerman W., Laskay G., Tóth B., Sasvári M., Kónya C., Sebens J.B., Korf J., Nyakas C., Zarándi M., Soós K., Penke B., and Luiten P.G.M. β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur. J. Neurosci. 12 (2000) 2735-2745
10. Hattori M., Sakamoto T., Kobashi K., and Namba T. Metabolism of glycyrrhizin by human intestinal flora. Planta Med. 48 (1983) 38-42
11. Hazell A.S., Butterworth R.F., and Hakim A.M. Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency. J. Neurochem. 61 (1993) 1155-1158
12. Hazell A.S., Pannunzio P., Rama Rao K.V., Pow D.V., and Rambaldi A. Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes. Glia 43 (2003) 175-184
13. Ikarashi, Y., Iizuka, S., Imamura, S., Yamaguchi, T., Sekiguchi, K., Kanno, H., Kawakami, Z., Yuzurihara, M., Kase, Y., Takeda, S., 2009. Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol. Pharm. Bull. 32, 1701--1709.
14. Iwasaki K., Satoh-Nakagawa T., Maruyama M., Monma Y., Nemoto M., Tomita N., Tanji H., Fujiwara H., Seki T., Fujii M., Arai H., and Sasaki H. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J. Clin. Psychiatry 66 (2005) 248-252
15. Iwasaki K., Maruyama M., Tomita N., Furukawa K., Nemoto M., Fujiwara H., Seki T., Fujii M., Kodama M., and Arai H. Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. J. Clin. Psychiatry 66 (2005) 1612-1613
16. Juurlink B.H.J., and Walz W. Neural cell culture techniques. In: Boulton A.A., Baker G.B., and Bateson A.N. (Eds). Neuromethods, vol 33 Cell Neurobiology Techniques (1998), Humana Press Inc., Totowa, NJ 53-102
17. Kanai Y., Smith C.P., and Hediger M.A. The elusive transporters with a high affinity for glutamate. Trends Neurosci. 16 (1993) 365-370
18. Kawakami Z., Kanno H., Ueki T., Terawaki K., Tabuchi M., Ikarashi Y., and Kase Y. Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in culture cells. Neurosci. 159 (2009) 1397-1407
19. Kondo K., Shiba M., Nakamura R., Morota T., and Shoyama Y. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Biol. Pharm. Bull. 30 (2007) 1271-1277
20. Langlais P.J., and Zhang S.X. Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. J. Neurochem. 61 (1993) 2175-2182
21. Mollica L., De Marchis F., Spitaleri A., Dallacosta C., Pennacchini D., Zamai M., Agresti A., Trisciuoglio L., Musco G., and Bianchi M.E. Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities. Chem. Biol. 14 (2007) 431-441
22. Murata A., Nakagawasai O., Yamadera F., Oba A., Wakui K., Arai Y., and Tadano T. Dysfunction of serotonergic systems in thiamine-deficient diet fed mice: effect of SSRI on abnormality induced by thiamine deficiency. Jpn. J. Neurolpsychopharmacol. 24 (2004) 93-99
23. Nakagawasai O., Tadano T., Niijima F., Tan-no K., and Kisara K. Immunohistochemical estimation of rat brain somatostatin on avoidance learning impairment induced by thiamine deficiency. Brain Res. Bull. 51 (2000) 47-55
24. O'Brian C.A., Ward N.E., and Vogel V.G. Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid. Cancer Lett. 49 (1990) 9-12
25. Pedrazzi M., Raiteri L., Bonanno G., Patrone M., Ledda S., Passalacqua M., Milanese M., Melloni E., Raiteri M., Pontremoli S., and Sparatore B. Stimulation of excitatory amino acid release from adult mouse brain glia subcellular particles by high mobility group box 1 protein. J. Neurochem. 99 (2006) 827-838
26. Robertson D.M., Wasan S.M., and Skinner D.B. Ultrastructural features of early brain stem lesions of thiamine-deficient rats. Am. J. Pathol. 52 (1968) 1081-1097
27. Roman J., Ritzenthaler J.D., Boles B., Lois M., and Roser-Page S. Lipopolysaccharide induces expression of fibronectin alpha 5 beta 1-integrin receptors in human monocytic cells in a protein kinase C-dependent fashion. Am. J. Physiol., Lung. Cell. Mol. Physiol. 287 (2004) L239-L249
28. Sakamoto R., Okano M., Takena H., and Ohtsuki K. Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro. Biol. Pharm. Bull. 24 (2001) 906-911
29. +-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol. Pharmacol. 53 (1998) 355-369
30. Todd K.G., and Butterworth R.F. In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy. Methods 23 (2001) 55-61
31. Yamamura Y., Kawakami J., Santa T., Kotaki H., Uchino K., Sawada Y., Tanaka N., and Iga T. Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method. J. Pharm. Sci. 81 (1992) 1042-1046