Dehydroevodiamine·HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance

Journal of Neurochemistry

Volumn 74, Issue 1, 2000, Pages 244-253

  Park, Cheol Hyoung ^a   Young Jae, Lee ^c   Sang Hyung, Lee ^b   Choi, Se Hoon ^a   Hye Sun, Kim ^a   Jeong, Sung Jin ^a   Kim, Sung Soo ^d   Suh, Yoo Hun ^b  

^a Neuroscience Research Institute   (South Korea)

^b Seoul National University   (South Korea)

^c Jeju National University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Alzheimer's disease; Brain ischemia; Dehydroevodiamine HCl; Entorhinal cortex; Learning and memory

Indexed keywords

DEHYDROEVODIAMINE; SCOPOLAMINE; ALKALOID; CHOLINESTERASE INHIBITOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN INJURY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; AMNESIA; ANIMAL; AVOIDANCE BEHAVIOR; BRAIN INFARCTION; CELL DEATH; CHEMICALLY INDUCED DISORDER; ENTORHINAL CORTEX; HIPPOCAMPUS; LEARNING; MAZE TEST; MEMORY; NERVE CELL; PATHOLOGY; PSYCHOLOGICAL ASPECT; REACTION TIME; SPRAGUE DAWLEY RAT;

ALKALOIDS; AMNESIA; ANIMALS; AVOIDANCE LEARNING; CELL DEATH; CEREBRAL INFARCTION; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; ENTORHINAL CORTEX; HIPPOCAMPUS; LEARNING; MAZE LEARNING; MEMORY; MUSCARINIC ANTAGONISTS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SCOPOLAMINE;

EID: 0033621563     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0740244.x     Document Type: Article

References (44)

1. Amaral D. G. and Witter M. P. (1995) Hippocampal formation, in The Rat Nervous System (Paxinos G., ed), pp. 443-493. Academic Press, Sydney.
2. Baddeley A. D., Bressi S., Sala S. D., Logie R., and Spinnler H. (1991) The decline of working memory in Alzheimer's disease. Brain 114, 2521-2542.
3. Bartus J. D. and Johnson H. R. (1976) Short-term memory in the rhesus monkey: disruption from the anti-cholinergic scopolamine. Pharmacol. Biochem. Behav. 5, 39-46.
4. Bassant M. H., Jazat-Poindessous F., and Lamour Y. (1996) Effects of metrifonate, a cholinesterase inhibitor, on local cerebral glucose utilization in young and aged rats. J. Cereb. Blood Flow Metab. 16, 1014-1025.
5. Benderson J. B., Pitts L. H., Tsuji M., Nishimura M. C., Davis R. L., and Bartkowski H. M. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of neurologic examination. Stroke 17, 472-476.
6. Bierer L. M., Haroutunian V., Gabriel S., Knott P. J., Carlin L. S., Purohit D. P., Perl D. P., Schmeidler J., Kanof P., and Davis K. L. (1995) Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64, 749-760.
7. Chelliah J., Smith J. D., and Fariss M. W. (1994) Inhibition of cholinesterase activity by tetrahydroaminoacridine and the hemisuccinate esters of tocopherol and cholesterol. Biochim. Biophys. Acta 1206, 17-26.
8. del Zoppo G. J., Wagner S., and Tagaya M. (1997) Trends and future developments in the pharmacological treatment of acute ischaemic stroke. Drugs 54, 9-38.
9. Eckerman D. A., Gordon W. A., Edwards J. D., McPhail R., and Gage M. I. (1980) Effects of scopolamine, pentobarbital, and amphetamine on radial arm maze performance in the rat. Pharmacol. Biochem. Behav. 12, 595-602.
10. Geddes J. W., Monaghan D. T., Cotman C. W., Lott I. T., Kim R. C., and Chui H. C. (1985) Plasticity of hippocampal circuitry in Alzheimer's disease. Science 230, 1179-1181.
11. Giacobini E. (1997) From molecular structure to Alzheimer therapy. Jpn. J. Pharmacol. 74, 225-241.
12. Gionet T. X., Thomas J. D., Warner D. S., Goodlett C. R., Wasserman E. A., and West J. R. (1991) Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats. Stroke 22, 1040-1047.
13. Gómez-Isla T., Price J. L., McKeel D. W. Jr., Morris J. C., Growdon J. H., and Hyman B. T. (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16, 4491-4500.
14. Haji A., Momose Y., Takeda R., Nakanishi S., Horiuchi T., and Arisawa M. (1994) Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa. J. Nat. Prod. 57, 387-389.
15. Hodges H., Sowinski P., Fleming P., Kershaw T. R., Sinden J. D., Meldrum B. S., and Gray J. A. (1996) Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischaemia in rats. Neuroscience 72, 959-988.
16. Kesslak J. P., Korotzer A., Song A., Kamali K., and Cotman C. W. (1991) Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex. Brain Res. 557, 57-63.
17. Levisohn L. F. and Isacson O. (1991) Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Brain Res. 564, 230-244.
18. Loh S. H., Lee A. R., Huang W. H., and Lin C. I. (1992) Ionic mechanisms responsible for the antiarrhythmic action of denydroevodiamine in guinea-pig isolated cardiomyocytes. Br. J. Pharmacol. 106, 517-523.
19. Longa E. Z., Weinstein P. R., Carlson S., and Cummins R. (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84-91.
20. Marx J. L. (1987) Alzheimer's drug trial put on hold. Science 238, 1041-1042.
21. McGeer P. L., McGeer E. Z., Suzuki J., Dolman C. E., and Nagai T. (1984) Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain. Neurology 34, 741-745.
22. Meunier M., Bachevalier J., Mishkin M., and Murray E. A. (1993) Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J. Neurosci. 13, 5418-5432.
23. Miwa C. and Ueki A. (1996) Effects of entorhinal cortex lesion on learning behavior and on hippocampus in the rat. Psychiatry Clin. Neurosci. 50, 223-230.
24. Ni J. W., Ohta H., Matsumoto K., and Watanabe H. (1994) Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats. Brain Res. 653, 231-236.
25. Ni J. W., Matsumoto K., Li H. B., Murakami Y., and Watanabe H. (1995) Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat. Brain Res. 673, 290-296.
26. Park C. H., Kim S. H., Choi W., Lee Y. J., Kang S. S., Kim J. S., and Suh Y. H. (1996) Novel anticholinesterase and antiamnesic activities of dehydroevodiamine-HCl, a constituent of Evodia rutaecarpa. Planta Medico 62, 405-409.
27. Peel D. B. and Baron S. P. (1988) Effects of selection delays on radial maze performance: acquisition and effects of scopolamine. Pharmacol. Biochem. Behav. 29, 143-150.
28. Petito C. K., Feldmann E., Pulsinelli W. A., and Plum F. (1987) Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 37, 1281-1286.
29. Poduri A., Beason-Held L. L., Moss M. B., Rosene D. L., and Hyman B. T. (1995) CA3 neuronal degeneration follows chronic entorhinal cortex lesions. Neurosci. Lett. 197, 1-4.
30. Rawlins J. N. P. and Deacon R. M. J. (1993) Further developments of maze procedures, in Behavioral Neuroscience, Vol. 1: A Practical Approach (Sahgal A., ed), pp. 95-122. IRL Press. Oxford.
31. Rogers R. L., Meyer J. S., Mortel K. F., Mahurin R. K., and Judd B. W. (1986) Decreased cerebral blood flow precedes multi-infarct dementia, but follows senile dementia of Alzheimer type. Neurology 36, 1-6.
32. Sadoshima S., Ibayashi S., Fujii K., Nagao T., Sugimori H., and Fujishima M. (1995) Inhibition of acetylcholinesterase modulates the autoregulation of cerebral blood flow and attenuates ischemic brain metabolism in hypertensive rats. J. Cereb. Blood Flow Metab. 15, 845-851.
33. Selkoe D. J. (1994) Alzheimer's disease; a central role for amyloid. J. Neuropathol. Exp. Neurol. 53, 438-447.
34. Shinjo H., Ueki A., Miwa C., and Morita Y. (1998) Effect of EC lesion on hippocampal cholinergic system in rat in operant learning task as studied by in vivo brain microdialysis. J. Neurol. Sci. 157, 13-18.
35. Siesjö B. K. (1992) Pathophysiology and treatment of focal cerebral ischemia. I. Pathophysiology. J. Neurosurg. 77, 169-184.
36. Tanaka K., Mizukawa K., Ogawa N., and Mori A. (1995) Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus. Neurochem. Res. 20, 663-667.
37. Torre J. C., Fortin T., Park G. A. S., Pappas B. A., and Richard M. T. (1993) Brain blood flow restoration 'rescues' chronically damaged rat CA1 neurons. Brain Res. 623, 6-15.
38. Ueki A., Miwa C., and Miyoshi K. (1994) Impairment in the acquisition of passive and active avoidance learning tasks due to bilateral entorhinal cortex lesions. J. Neurol. Sci. 125, 14-21.
39. Volpe B. T. and Petito C. K. (1985) Dementia with bilateral medial temporal lobe ischemia. Neurology 35, 1793-1797.
40. Watkins P. B., Zimmerman H. J., Knapp M. J., Gracon S. I., and Lewis K. W. (1994) Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 271, 992-998.
41. Whitehouse P. J., Price D. L., Struble R. G., Clark R. W., Coyle J. T., and DeLong M. R. (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215, 1237-1239.
42. Yang H. Y., Li S. Y., and Chen C. F. (1988) Hypotensive effects of dehydroevodiamine, a quinazolinocarboline alkaloid isolated from Evodia rutaecarpa. Asia Pac. J. Pharmacol. 3, 191-196.
43. Yonemori F., Yamada H., Yamaguchi T., Uemura A., and Tamura A. (1996) Spatial memory disturbance after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 16, 973-980.
44. Zola-Morgan S., Squire L. R., Rempel N. L., Glower R. P., and Amaral D. G. (1992) Enduring memory impairment in monkeys after ischemic damage to the hippocampus. J. Neurosci. 12, 2582-2596.