Renin, Genes, and beyond: 40 years of molecular discoveries in the hypertension field

Hypertension

Volumn 57, Issue 3 PART 2, 2011, Pages 538-548

  Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PRORENIN; RENIN;

ARTICLE; DNA POLYMORPHISM; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HYPERTENSION; MOLECULAR BIOLOGY; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALS; HYPERTENSION; MOLECULAR BIOLOGY; RENIN;

EID: 79953213270     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.166967     Document Type: Article

References (140)

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36. Morris BJ, Rose BR. Cervical screening in the 21st century: The case for human papillomavirus testing of self-collected specimens. (Review) Clin Chem Lab Med. 2007;45:577-591. (Pubitemid 46709750)
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38. Dallas PB, Flanagan JL, Nightingale BN, Morris BJ. Polymerase chain reaction for fast, nonradioactive detection of high-and low-risk papillomavirus types in routine cervical specimens and in biopsies. J Med Virol. 1989;27:105-111. (Pubitemid 19078719)
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51. Lin RCY, Schyvens CG, Wang Y, Whitworth JA, Morris BJ. Tumor necrosis factor receptor 2 mRNA in rat models of hypertension. Am J Hypertens. 2003;16:685-688. (Pubitemid 36900593)
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55. Smith DL, Law RE, Shaw KJ, Do YS, Hsueh WA, Morris BJ. Proximal 2.6 kb of 5-flanking DNA is insufficient for human renin promoter activity in renin-synthesizing chorio-decidual cells. Biochim Biophys Acta. 1994;1219:465-474.
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59. Ying L-H, Morris BJ, Sigmund CD. Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem. 1997; 272:2412-2420. (Pubitemid 27058530)
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75. Adams DJ, Van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JEJ. ZNF265-A novel spliceosomal protein able to induce alternative splicing. J Cell Biol. 2001;154:25-32. (Pubitemid 34289275)
76. Morris BJ, Plambeck CA, Adams DJ, Van der Weyden L, Medcalf R, Mackay JP. What causes loss of juxtaglomerular cell identity and renin during culture?-Role for ZNF265 binding to cyclin B1 messenger RNA. (Abstract). 19th Scientific Meeting of the International Society for Hypertension, Prague, 23-27 June. J Hypertens. 2002;20(Suppl 4): P0375.
77. Plambeck CA, Kwan AHY, Adams DJ, Westman BJ, Van der Weyden L, Medcalf RL, Morris BJ, Mackay JP. The zinc finger domain from human splicing factor ZNF265 forms a novel fold. J Biol Chem. 2003; 278:22805-22811. (Pubitemid 36830342)
78. Loughlin FE, Mansfield RE, Vaz PM, McGrath AP, Setiyaputra S, Gamsjaeger R, Chen ES, Morris BJ, Guss JM, Mackay JP. The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNAbinding domains that recognize 5- splice site-like sequences. Proc Natl Acad Sci USA. 2009;106:5581-5586.
79. Markus MA, Morris BJ. RBM4: a multifunctional RNA-binding protein. Int J Biochem Cell Biol. 2009;41:740-743.
80. Mangs AH, Speirs HJ, Goy C, Adams DJ, Markus MA, Morris BJ. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic Acids Res. 2006;34:4976-4986. (Pubitemid 44605640)
81. Markus MA, Heinrich B, Raitskin O, Adams DJ, Mangs H, Goy C, Ladomery M, Sperling R, Stamm S, Morris BJ. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Exp Cell Res. 2006;312:3379-3388. (Pubitemid 44380239)
82. Markus MA, Morris BJ. Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties. DNA Cell Biol. 2006;25: 457-464. (Pubitemid 44267066)
83. Morris BJ, Griffiths LR. Frequency in hypertensives of alleles for a RFLP associated with the renin gene. Biochem Biophys Res Comm. 1988;150:219-224. (Pubitemid 18036225)
84. Zee RYL, Ying L-H, Morris BJ, Griffiths LR. Association and linkage analyses of restriction fragment length polymorphisms for the human renin and antithrombin III genes in essential hypertension. J Hypertens. 1991;9:825-830.
85. Morris BJ. Molecular genetics links renin to hypertension. Mol Cell Endocrinol. 1991;75:C13-C18.
86. Morris BJ, Benjafield AV, Lin RC. Essential hypertension: genes and dreams. Clin Chem Lab Med. 2003;41:834-844. (Pubitemid 37010173)
87. Morris BJ. Identification of essential hypertension genes. (Review). J Hypertens. 1993;11:115-120. (Pubitemid 23130562)
88. Morris BJ. Discovery of genes for essential hypertension. In: Ganten D, Lindpaintner K, eds. Molecular Reviews in Cardiovascular Medicine. London, UK: Rapid Science Publishers; 1996:33-48.
89. Morris BJ. Genes for essential hypertension: The first decade of research. In: Frossard PM, Parvez SH, Minami M, Parvez S, Saito H, eds. Progress in Hypertension. Zeist, the Netherlands: VSP International Press; 1999:1-44.
90. Benjafield AV, Wang WYS, Morris BJ. No association of angiotensinconverting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. Am J Hypertens. 2004;17:624-628. (Pubitemid 38844990)
91. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein-3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension. 1998;32:1094-1097.
92. Wang WYS, Zee RYL, Morris BJ. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin Genet. 1997;51:31-34. (Pubitemid 27116896)
93. Kumar NN, Benjafield AV, Lin RCY, Wang WYS, Stowasser M, Morris BJ. Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. J Hypertens. 2003;21:1331-1117.
94. Benjafield AV, Katyk K, Morris BJ. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Clin Genet. 2003;64:433-438. (Pubitemid 37406894)
95. Speirs HJL, Katyk K, Kumar NN, Benjafield AV, Wang WYS, Morris BJ. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. J Hypertens. 2004;22:931-936. (Pubitemid 38680467)
96. Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM. Identification of a novel polymorphism in the 3-UTR of the L-arginine transporter gene, SLC7A1-Contribution to hypertension and endothelial dysfunction Circulation. 2007;115:1269-1274.
97. Ying L-H, Zee RYL, Griffiths LR, Morris BJ. Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension. Biochem Biophys Res Comm. 1991;181:486-492.
98. Zee RYL, Lou Y-k, Morris BJ. 11: Insertion variant in intron 9, but not microsatellite in intron 2, of the insulin receptor gene is associated with essential hypertension. J Hypertens. 1993;11:1283-1288.
99. Lin RCY, Wang WYS, Morris BJ. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. Hypertension. 1999;34:1186-1192. (Pubitemid 30002380)
100. Bennett CL, Schrader AP, Morris BJ. Cross-sectional analysis of Met2353Thr variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun. 1993;197:833-839.
101. Zee RYL, Stephen AL, Iwai N, Morris BJ. Association analyses of SA gene variant in essential hypertensives. Am J Hypertens. 1997;10: 235-242. (Pubitemid 27128265)
102. Wang WYS, Adams DJ, Glenn CL, Morris BJ. The Gly460Trp variant of-adducin is not associated with hypertension in Australian Anglo-Caucasians. Am J Hypertens. 1999;12:632-636.
103. Wang WYS, Glenn CL, Zhang W, Nyholt DR, Morris BJ. Exclusion of angiotensinogen locus in molecular basis of human hypertension: Sibpair linkage and association analyses in Australian Anglo-Caucasians. Am J Med Genet. 1999;87:53-60. (Pubitemid 29522063)
104. Benjafield AV, Iwai N, Ishikawa K, Wang WYS, Morris BJ. Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension. Hypertens Res. 2003;26: 591-595. (Pubitemid 37080790)
105. Speirs HJL, Morris BJ. WNK4 intron 10 polymorphism is not associated with hypertension. Hypertension. 2004;43:766-768. (Pubitemid 38405584)
106. Benjafield AV, Morris BJ. Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. Am J Hypertens. 2000;13:994-998.
107. Nielsen R. Genomics: In search of rare human variants. Nature. 2010; 467:1050-1051.
108. Bansal V, Libiger O, Torkamani A, Schork NJ. Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet. 2010;11:773-785.
109. Chambers SM, Morris BJ. Glucagon receptor gene mutation in essential hypertension. Nat Genet. 1996;12:122.
110. Morris BJ, Jeyasingam CL, Zhang W, Curtain RP, Griffiths LR. Influence of family history on frequency of glucagon receptor Gly40Ser mutation in hypertensive subjects. Hypertension. 1997;30:1640-1641. (Pubitemid 27528117)
111. Bankir L, Martin H, Déchaux M, Ahloulay M. Plasma cAMP: a hepatorenal link influencing proximal reabsorption and renal hemodynamics? Kidney Int. 1997;59(Suppl):S50-S56. (Pubitemid 27252821)
112. Bankir L, Ahloulay M, Devreotes PN, Parent CA. Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol. 282:F376-F392.
113. Brand E, Bankir L, Plouin PF, FS. Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study. Hypertension. 1999;34:15-17. (Pubitemid 29325712)
114. Zee RYL, Lou YK, Griffiths LR, Morris BJ. Association of an insertion/ deletion polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun. 1992; 184:9-15.
115. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L, Ricard S, Tiret P, Amouyel F, Alhenc-Gelas F, Soubrier F. Deletion polymorphism in the gene for angiotensinconverting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641-644.
116. Morris BJ, Zee RY, Schrader AP. Different frequencies of angiotensinconverting enzyme genotypes in older hypertensive individuals. J Clin Invest. 1994;94:1085-1089. (Pubitemid 24286450)
117. Glenn CL, Wang WYS, Morris BJ. Different frequency of inducible nitric oxide synthase genotypes in older essential hypertensives. Hypertension. 1999;33:927-932. (Pubitemid 29186386)
118. Glenn CL, Wang WYS, Benjafield AV, Morris BJ. Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia, and plasma shed receptor. Hum Mol Genet. 2000; 13:1943-1949. (Pubitemid 30642658)
119. Pausova Z, Gaudet D, Gossard F, Bernard M, Kaldunski ML, Jomphe M, Tremblay J, Hudson TJ, Bouchard G, Kotchen TA, Cowley AW, Hamet P. Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. Hypertension. 2005;46:1280-1285. (Pubitemid 43189724)
120. Morris BJ. Dissecting hypertension by obesity identifies a locus at 1p36. Hypertension. 2005;46:1256-1258. (Pubitemid 43189718)
121. Speirs HJL, Wang WYS, Benjafield AV, Morris BJ. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. J Hypertens. 2005;23:1491-1496. (Pubitemid 41104820)
122. Benjafield AV, Wang WYS, Speirs HJL, Morris BJ. Genome-wide scan for hypertension in Sydney sibships: The GENIHUSS Study. Am J Hypertens. 2005;18:828-832. (Pubitemid 40745269)
123. Zee RYL, Griffiths LR, Morris BJ. Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives. Biochem Biophys Res Commun. 1992;189:965-971. (Pubitemid 23032469)
124. Zee RYL, Schrader AP, Robinson BG, Griffiths LR, Morris BJ. Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives. Clin Genet. 1995;47:118-121.
125. Lin RCY, Wang WYS, Morris BJ. High penetrance, overweight, and glucocorticoid receptor variant: case-control study. BMJ. 1999;319: 1337-1338. (Pubitemid 29537504)
126. Lin RCY, Wang XL, Dalziel B, Caterson ID, Morris BJ. Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor Asn363Ser variant. Obesity Res. 2003;11:802-808. (Pubitemid 41151607)
127. Morris BJ, Lin RCY, Wang XL, Dalziel B, Caterson ID. Central obesity is associated with glucocorticoid receptor N363S variant: Big picture sheds light. Obesity Res. 2003;12:1607-1609.
128. Lin RCY, Ericsson JO, Benjafield AV, Morris BJ. Association of-2-adrenoceptor Gln27Glu variant with body weight, but not hypertension. Am J Hypertens. 14:1201-1204.
129. Benjafield AV, Lin RCY, Dalziel B, Gosby AK, Caterson ID, Morris BJ. G-protein-3 subunit gene splice variant in obesity and overweight. Int J Obes. 2001;25:777-780.
130. Benjafield AV, Wang XL, Morris BJ. Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease. J Mol Med. 2001;79:109-115. (Pubitemid 32285335)
131. Lin RCY, Wang XL, Morris BJ. Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension. 2003;41: 404-407. (Pubitemid 36314608)
132. Morris BJ, Glenn CL, Wilcken DEL, Wang XL. Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease. Clin Sci. 2001;100:551-556. (Pubitemid 32434121)
133. Benjafield AV, Glenn CL, Wang XL, Colagiuri S, Morris BJ. TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes. Diab Care. 2001;24:53-757.
134. Morris BJ, Markus MA, Glenn CL, Colagiuri S, Adams DJ, Wang XL. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. J Mol Med. 2002;80: 96-104. (Pubitemid 34169817)
135. Marques FZ, Campain AE, Yang YH, Morris BJ. Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. Hypertension. 2010;56:319-324.
136. Morris BJ, Marques FZ, Campain AE, Yang JE, Davern PJ, Head GA, Tomaszweski M, Zukowska-Szczechowska E, Charchar F. Global alterations in gene expression in essential hypertension and rodent models. High Blood Pressure Research 2010, Washington, DC. 2010(WK06):17. [Abstract].
137. Morris BJ. A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. (Review). J Hypertens. 2005;23:1285-1309. (Pubitemid 40933947)
138. Stefani M, Markus MA, Lin RCY, Pinese M, Dawes IA, Morris B. The effect on resveratrol on a cell model of human aging. Ann NY Acad Sci. 2007;1114:407-418. (Pubitemid 350070370)
139. Morris BJ. How xenohormetic compounds confer health benefits. In: Le Bourg E, Rattan SIS, eds. Mild Stress: Applying Hormesis in Aging Research and Interventions. Amsterdam, The Netherlands: Springer; 2008:115-138.
140. Morris BJ. Calorie restriction mimetics and aging. In: Everitt AV, Rattan S, Le Couteur DG, de Cabo R, eds. Calorie Restriction, Aging and Longevity. Dordrecht, Heidelberg, London, New York: Springer; 2010: 141-175.