Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension

Clinical Genetics

Volumn 64, Issue 5, 2003, Pages 433-438

  Benjafield, A V ^a   Katyk, K ^a   Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Association study; Blood pressure; Chromosome 17; Chromosome 2; Chromosome 4; Endothelin; Essential hypertension; Microsatellite polymorphism; Single nucleotide polymorphism

Indexed keywords

ADENINE; CYTOSINE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; FK 506 BINDING PROTEIN; GUANINE; NITRIC OXIDE; PROTEIN SERINE THREONINE KINASE; TYROSINE;

5' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; AUSTRALIA; BLOOD PRESSURE REGULATION; CAUCASIAN; CHROMOSOME 17; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ESSENTIAL HYPERTENSION; EXON; FEMALE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC LINKAGE; GENETIC TRANSDUCTION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE REPEAT; PARENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RACE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION;

5' UNTRANSLATED REGIONS; AGED; AMINO ACID SUBSTITUTION; BLOOD PRESSURE; COHORT STUDIES; EXONS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ENDOTHELIN; TACROLIMUS BINDING PROTEINS;

EID: 0042092604     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2003.00148.x     Document Type: Article

References (23)

1. Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases. Part I. General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001: 104: 2746-2753.
2. Carretero OA, Oparil S. Essential hypertension. Part I. Definition and etiology. Circulation 2000: 101: 329-335.
3. Jacob HJ. Physiological genetics: application to hypertension research. Clin Exp Pharmacol Physiol 1999: 26: 530-535.
4. Spieker LE, Noll G, Ruschitzka FT, Luscher TF. Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched? Heart Fail Rev 2001: 6: 301-315.
5. Tzourio C, El Amrani M, Poirier O, Nicaud V, Bousser MG, Alperovitch A. Association between migraine and endothelin type A receptor (ETA-231A/G) gene polymorphism. Neurology 2001: 56: 1273-1277.
6. Nicaud V, Poirier O, Behague I et al. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Temoins sur l'Infarctus du Myocarde (ECTIM) Study. Am J Hypertens 1999: 12: 304-310.
7. Charron P, Tesson F, Poirier O et al. Identification of a genetic risk factor for idiopathic dilated cardiomyopathy. Involvement of a polymorphism in the endothelin receptor type A gene. CARDIGENE group. Eur Heart J 1999: 20: 1587-1591.
8. Hasegawa K, Fujiwara H, Doyama K et al. Endothelin-1-selective receptor in the arterial intima of patients with hypertension. Hypertension 1994: 23: 288-293.
9. Wilson FH, Disse-Nicodeme S, Choate KA et al. Human hypertension caused by mutations in WNK kinases. Science 2001: 293: 1107-1112.
10. Wilson FH, Kahle KT, Sabath E et al. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 2003: 100: 680-684.
11. Levy D, DeStefano AL, Larson MG et al. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham heart study. Hypertension 2000: 36: 477-483.
12. Baima J, Nicolaou M, Schwartz F et al. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension 1999: 71: 4-7.
13. Julier C, Delepine M, Keavney B et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet 1997: 6: 2077-2086.
14. Xin HB, Senbonmatsu T, Cheng DS et al. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature 2002: 416:334-338.
15. Morris BJ, Zee RYL, Schrader AP. Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest 1994: 94: 1085-1089.
16. Chambers SM, Morris BJ. Glucagon receptor gene mutation in essential hypertension. Nat Genet 1996: 12: 122.
17. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension 1998: 32: 1094-1097.
18. Hill WG. Estimation of linkage disequilibrium in randomly mating populations. Heredity 1974: 33: 229-239.
19. Weeks DE, Lathrop M. Polygenic disease: methods for mapping complex disease traits. Trends Genet 1995: 11: 513-519.
20. Hilbert P, Lindpainter K, Beckmann JS et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991: 353: 521-529.
21. Jacob HJ, Lindpainter K, Lincoln SE et al. Genetic mapping of a gene causing hypertension in the strokeprone spontaneously hypertensive rat. Cell 1991: 67: 213-224.
22. Monti J, Zimdahl H, Schulz H, Plehm R, Ganten D, Hubner N. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Hypertension 2003: 41: 938-942.
23. Nelson MT, Herrera GM. Molecular physiology: protecting the heart. Nature 2002: 416: 273-274.