Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6685-6696

  Yu, Chao ^a   Sonnen, Andreas F P ^b   George, Roger ^c   Dessailly, Benoit H ^c   Stagg, Loren J ^d   Evans, Edward J ^a   Orengo, Christine A ^c   Stuart, David I ^b   Ladbury, John E ^c,d   Ikemizu, Shinji ^e   Gilbert, Robert J C ^b   Davis, Simon J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTING CELLS; ANTIGEN RECEPTORS; CELL SURFACE PROTEINS; CELL SURFACES; CONFORMATIONAL CHANGE; CYTOTOXIC; CYTOTOXIC T LYMPHOCYTES; ENTROPIC CHANGES; EVOLUTIONARY HISTORY; HOMODIMERS; INDUCED FIT; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; LIGAND INTERACTIONS; LIGAND RECOGNITION; NEW STRUCTURES; RESOLUTION STRUCTURE; RIGID BODY; STRUCTURAL CHANGE; THERMODYNAMIC PARAMETER; TYROSINE KINASE;

AMINO ACIDS; ANTIGENS; CELL MEMBRANES; ENZYMES; GERMANIUM ALLOYS; PHOSPHORYLATION;

LIGANDS;

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTHALPY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THERMODYNAMICS;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; HUMANS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; THERMODYNAMICS;

EID: 79953209723     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182394     Document Type: Article

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