Synthesis and antiviral activity of N9-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 7, 2011, Pages 2114-2124

  Baszczyňski, Ondřej ^a   Jansa, Petr ^a   Dračínský, Martin ^a   Klepetářová, Blanka ^a   Holý, Antonín ^a   Votruba, Ivan ^a   Clercq, Erik De ^b   Balzarini, Jan ^b   Janeba, Zlatko ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside phosphonates; Antiviral; FPMP; N 6 Methyl AMP aminohydrolase; Purines

Indexed keywords

1 FLUORO 3 (TRITYLOXY)PROPAN 2 OL; 2 AMINO 6 CHLORO 9 [2 [(DIISOPROPOXYPHOSPHORYL)METHOXY] 3 FLUOROPROPYL]PURINE; 2,6 DIAMINO N6 (2 METHOXYETHYL) 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; 2,6 DIAMINO N6 (N,N DIMETHYLAMINOETHYL) 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; 2,6 DIAMINO N6 PROPYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; 2,6 DIAMINO N6,N6 DIMETHYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; 2,6 DIAMINOPURINE DERIVATIVE; 6 CHLORO 9 [2 [(DIISOPROPOXYPHOSPHORYL)METHOXY] 3 FLUOROPROPYL]PURINE; 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL] 6 (PYRROLIDIN 1 YL)PURINE; 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL] N6 METHYLADENINE; 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL] N6 PROPYLADENINE; ADENINE DERIVATIVE; ADENOSINE MONOPHOSPHATE DEAMINASE; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; DIISOPROPYL [[(1 FLUORO 3 HYDROXYPROPAN 2 YL)OXY]METHYL]PHOSPHONATE; DIISOPROPYL [[[1 FLUORO 3 (TOSYLOXY)PROPAN 2 YL]OXY]METHYL]PHOSPHONATE; DIISOPROPYL [[[1 FLUORO 3 (TRITYLOXY)PROPAN 2 YL]OXY]METHYL]PHOSPHONATE; GUANINE DERIVATIVE; N6 (BUTAN 2 YL) 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N6 ALLYL 2,6 DIAMINO 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; N6 BUTYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N6 CYCLOPENTYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N6 CYCLOPROPYL 2,6 DIAMINO 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]PURINE; N6 CYCLOPROPYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N6,N6 DIETHYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N6,N6 DIMETHYL 9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; N9 [3 FLUORO 2 (PHOSPHONOMETHOXY)PROPYL] DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENANTIOMER; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MOLONEY MURINE SARCOMA ONCOVIRUS; MOUSE; NONHUMAN;

2-AMINOPURINE; 3T3 CELLS; ADENINE; ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1; HIV-2; HUMANS; MICE; MICE, INBRED C3H; MOLONEY MURINE SARCOMA VIRUS; PHOSPHONIC ACIDS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS; MOLONEY MURINE SARCOMA VIRUS;

EID: 79953206917     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.050     Document Type: Article

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