Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy

Biological Psychiatry

Volumn 69, Issue 8, 2011, Pages 772-779

  Merkl, Angela ^a,b   Schubert, Florian ^d   Quante, Arnim ^a   Luborzewski, Alexander ^a   Brakemeier, Eva Lotta ^c   Grimm, Simone ^b   Heuser, Isabella ^a   Bajbouj, Malek ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d PHYSIKALISCH TECHNISCHE BUNDESANSTALT   (Germany)

Author keywords

Anterior cingulum; dorsolateral prefrontal cortex; electroconvulsive therapy; glutamate; major depressive disorder; N acetyl aspartate

Indexed keywords

CHOLINE; CREATINE; CREATINE PHOSPHATE; GLUTAMIC ACID; N ACETYLASPARTIC ACID;

ADULT; ANTERIOR CINGULATE; ARTICLE; AUTOBIOGRAPHICAL MEMORY; CELL VIABILITY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; ELECTROCONVULSIVE THERAPY; ENERGY METABOLISM; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; NEUROCHEMISTRY; NEUROPROTECTION; NEUROPSYCHOLOGY; NEUROTRANSMISSION; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STATISTICAL SIGNIFICANCE; TREATMENT RESPONSE;

ADULT; ANALYSIS OF VARIANCE; ASPARTIC ACID; CREATINE; DEPRESSIVE DISORDER, MAJOR; ELECTROCONVULSIVE THERAPY; FEMALE; GLUTAMIC ACID; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MENTAL RECALL; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PHOSPHOCREATINE; PREFRONTAL CORTEX; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VERBAL LEARNING;

EID: 79953203160     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.08.009     Document Type: Article

References (60)

1. H.W. Folkerts, N. Michael, R. Tolle, K. Schonauer, S. Mucke, and H. Schulze-Monking Electroconvulsive therapy vs. paroxetine in treatment-resistant depressiona randomized study Acta Psychiatr Scand 96 1997 334 342 (Pubitemid 27496013)
2. H.A. Sackeim, J. Prudic, M.S. Nobler, L. Fitzsimons, S.H. Lisanby, and N. Payne Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy Brain Stimul 1 2008 71 83 (Pubitemid 351698629)
3. A. Merkl, I. Heuser, and M. Bajbouj Antidepressant electroconvulsive therapy: Mechanism of action, recent advances and limitations Exp Neurol 219 2009 20 26
4. H.A. Sackeim, J. Prudic, R. Fuller, J. Keilp, P.W. Lavori, and M. Olfson The cognitive effects of electroconvulsive therapy in community settings Neuropsychopharmacology 32 2007 244 254 (Pubitemid 44967804)
5. J. Chen, Y. Zhang, M.B. Kelz, C. Steffen, E.S. Ang, L. Zeng, and E.J. Nestler Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: Role of [Delta]FosB J Neurosci 20 2000 8965 8971 (Pubitemid 32042896)
6. T.A. Kosten, M.P. Galloway, R.S. Duman, D.S. Russell, and C. D'Sa Repeated unpredictable stress and antidepressants differentially regulate expression of the Bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures Neuropsychopharmacology 33 2008 1545 1558 (Pubitemid 351684697)
7. J.R. Moffett, B. Ross, P. Arun, C.N. Madhavarao, and A.M. Namboodiri N-acetylaspartate in the CNS: From neurodiagnostics to neurobiology Prog Neurobiol 81 2007 89 131 (Pubitemid 46282272)
8. G. Ende, T. Demirakca, and H. Tost The biochemistry of dysfunctional emotions: Proton MR spectroscopic findings in major depressive disorder Prog Brain Res 156 2006 481 501 (Pubitemid 44466060)
9. G. Sanacora, C.A. Zarate, J.H. Krystal, and H.K. Manji Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders Nat Rev Drug Discov 7 2008 426 437 (Pubitemid 351619114)
10. C.A. Zarate Jr, J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, and D.A. Luckenbaugh A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression Arch Gen Psychiatry 63 2006 856 864 (Pubitemid 44188478)
11. D.P. Auer, B. Putz, E. Kraft, B. Lipinski, J. Schill, and F. Holsboer Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study Biol Psychiatry 47 2000 305 313 (Pubitemid 30109243)
12. B. Pfleiderer, N. Michael, A. Erfurth, P. Ohrmann, U. Hohmann, and M. Wolgast Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients Psychiatry Res 122 2003 185 192 (Pubitemid 36412193)
13. N. Michael, A. Erfurth, P. Ohrmann, V. Arolt, W. Heindel, and B. Pfleiderer Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression Psychol Med 33 2003 1277 1284 (Pubitemid 37265215)
14. G. Hasler, J.W. van der Veen, T. Tumonis, N. Meyers, J. Shen, and W.C. Drevets Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy Arch Gen Psychiatry 64 2007 193 200 (Pubitemid 46220776)
15. A. Milne, G.M. MacQueen, K. Yucel, N. Soreni, and G.B. Hall Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: A proton magnetic resonance spectroscopy study Neuroimage 47 2009 36 41
16. S. Gruber, R. Frey, V. Mlynarik, A. Stadlbauer, A. Heiden, and S. Kasper Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla Invest Radiol 38 2003 403 408 (Pubitemid 36791333)
17. G. Ende, D.F. Braus, S. Walter, W. Weber-Fahr, and F.A. Henn The hippocampus in patients treated with electroconvulsive therapy: A proton magnetic resonance spectroscopic imaging study Arch Gen Psychiatry 57 2000 937 943
18. H.S. Mayberg Positron emission tomography imaging in depression: A neural systems perspective Neuroimaging Clin N Am 13 2003 805 815 (Pubitemid 37445057)
19. H.K. Manji, and R.S. Duman Impairments of neuroplasticity and cellular resilience in severe mood disorders: Implications for the development of novel therapeutics Psychopharmacol Bull 35 2001 5 49
20. T. Frodl, N. Koutsouleris, R. Bottlender, C. Born, M. Jger, and M. Mrgenthaler Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression Mol Psychiatry 13 2008 1093 1101
21. D. Ongur, W.C. Drevets, and J.L. Price Glial reduction in the subgenual prefrontal cortex in mood disorders Proc Natl Acad Sci U S A 95 1998 13290 13295 (Pubitemid 28509564)
22. G. Rajkowska, J.J. Miguel-Hidalgo, J. Wei, G. Dilley, S.D. Pittman, and H.Y. Meltzer Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression Biol Psychiatry 45 1999 1085 1098 (Pubitemid 29236550)
23. G. Rajkowska, G. O'Dwyer, Z. Teleki, C.A. Stockmeier, and J.J. Miguel-Hidalgo GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression Neuropsychopharmacology 32 2007 471 482 (Pubitemid 46106953)
24. H.A. Sackeim The definition and meaning of treatment-resistant depression J Clin Psychiatry 62 suppl 16 2001 10 17
25. M. Hautzinger [The Beck Depression Inventory in clinical practice] Nervenarzt 62 1991 689 696
26. H.A. Sackeim, P. Decina, M. Kanzler, B. Kerr, and S. Malitz Effects of electrode placement on the efficacy of titrated, low-dose ECT Am J Psychiatry 144 1987 1449 1455 (Pubitemid 18009537)
27. C.L.M. Helmstaedter, and S. Lux VLMT-Verbaler Lern und Merkfhigkeitstest 2001 Hogrefe Gttingen, Germany
28. C. Helmstaedter, M. Sonntag-Dillender, C. Hoppe, and C.E. Elger Depressed mood and memory impairment in temporal lobe epilepsy as a function of focus lateralization and localization Epilepsy Behav 5 2004 696 701 (Pubitemid 40392586)
29. K. Schmidtke, and H. Vollmer Retrograde amnesia: A study of its relation to anterograde amnesia and semantic memory deficits Neuropsychologia 35 1997 505 518 (Pubitemid 27144003)
30. F. Schubert, J. Gallinat, F. Seifert, and H. Rinneberg Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla Neuroimage 21 2004 1762 1771 (Pubitemid 38446596)
31. C. Elster, F. Schubert, A. Link, M. Walzel, F. Seifert, and H. Rinneberg Quantitative magnetic resonance spectroscopy: Semi-parametric modeling and determination of uncertainties Magn Reson Med 53 2005 1288 1296 (Pubitemid 40734648)
32. G. Hasler, J.W. van der Veen, T. Tumonis, N. Meyers, J. Shen, and W.C. Drevets Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy Arch Gen Psychiatry 64 2007 193 200 (Pubitemid 46220776)
33. A. Yildiz-Yesiloglu, and D.P. Ankerst Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: A meta-analysis Psychiatry Res 147 2006 1 25 (Pubitemid 44067434)
34. N. Michael, A. Erfurth, P. Ohrmann, V. Arolt, W. Heindel, and B. Pfleiderer Neurotrophic effects of electroconvulsive therapy: A proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression Neuropsychopharmacology 28 2003 720 725
35. P.V. Choudary, M. Molnar, S.J. Evans, H. Tomita, J.Z. Li, and M.P. Vawter Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression Proc Natl Acad Sci U S A 102 2005 15653 15658 (Pubitemid 41528111)
36. A. Pilc, S. Chaki, G. Nowak, and J.M. Witkin Mood disorders: Regulation by metabotropic glutamate receptors Biochem Pharmacol 75 2008 997 1006
37. M.A. Frye, J. Watzl, S. Banakar, J. O'Neill, J. Mintz, and P. Davanzo Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression Neuropsychopharmacology 32 2007 2490 2499 (Pubitemid 350126840)
38. K. Hashimoto, A. Sawa, and M. Iyo Increased levels of glutamate in brains from patients with mood disorders Biol Psychiatry 62 2007 1310 1316 (Pubitemid 350060893)
39. M. Vythilingam, H.C. Charles, L.A. Tupler, T. Blitchington, L. Kelly, and K.R. Krishnan Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: An automated multivoxel proton magnetic resonance spectroscopy study Biol Psychiatry 54 2003 744 750 (Pubitemid 37281391)
40. C.S. Chen, I.C. Chiang, C.W. Li, W.C. Lin, C.Y. Lu, and T.J. Hsieh Proton magnetic resonance spectroscopy of late-life major depressive disorder Psychiatry Res 172 2009 210 214
41. B.D. Ross, S. Bluml, R. Cowan, E. Danielsen, N. Farrow, and J. Tan In vivo MR spectroscopy of human dementia Neuroimaging Clin N Am 8 1998 809 822 (Pubitemid 28532518)
42. M. Walter, A. Henning, S. Grimm, R.F. Schulte, J. Beck, and U. Dydak The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression Arch Gen Psychiatry 66 2009 478 486
43. A. Moreno, B.D. Ross, and S. Bluml Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13) C]glucose infusion J Neurochem 77 2001 347 350 (Pubitemid 32248698)
44. J.F. Clark, A. Doepke, J.A. Filosa, R.L. Wardle, A. Lu, T.J. Meeker, and G.J. Pyne-Geithman N-acetylaspartate as a reservoir for glutamate Med Hypotheses 67 2006 506 512 (Pubitemid 43928324)
45. A. Kumar, Z. Jin, W. Bilker, J. Udupa, and G. Gottlieb Late-onset minor and major depression: Early evidence for common neuroanatomical substrates detected by using MRI Proc Natl Acad Sci U S A 95 1998 7654 7658 (Pubitemid 28293308)
46. S.R. Lamont, A. Paulls, and C.A. Stewart Repeated electroconvulsive stimulation, but not antidepressant drugs, induces mossy fibre sprouting in the rat hippocampus Brain Res 893 2001 53 58 (Pubitemid 32171896)
47. T.M. Madsen, A. Treschow, J. Bengzon, T.G. Bolwig, O. Lindvall, and A. Tingstrom Increased neurogenesis in a model of electroconvulsive therapy Biol Psychiatry 47 2000 1043 1049 (Pubitemid 30336212)
48. R.S. Duman, and V.A. Vaidya Molecular and cellular actions of chronic electroconvulsive seizures J ECT 14 1998 181 193 (Pubitemid 28433914)
49. J.S. Modica-Napolitano, and P.F. Renshaw Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: Implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder Biol Psychiatry 55 2004 273 277 (Pubitemid 38117163)
50. S. Awata, H. Ito, M. Konno, S. Ono, R. Kawashima, H. Fukuda, and M. Sato Regional cerebral blood flow abnormalities in late-life depression: Relation to refractoriness and chronification Psychiatry Clin Neurosci 52 1998 97 105 (Pubitemid 28188987)
51. H.A. Sackeim, E.M. Dillingham, J. Prudic, T. Cooper, W.V. McCall, and P. Rosenquist Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: Short-term efficacy and adverse effects Arch Gen Psychiatry 66 2009 729 737
52. C. Sobin, H.A. Sackeim, J. Prudic, D.P. Devanand, B.J. Moody, and M.C. McElhiney Predictors of retrograde amnesia following ECT Am J Psychiatry 152 1995 995 1001
53. N.C. Patel, M.P. DelBello, K.M. Cecil, K.E. Stanford, C.M. Adler, and S.M. Strakowski Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium J Child Adolesc Psychopharmacol 18 2008 132 139 (Pubitemid 351591441)
54. M. Taylor, R. Norbury, S. Murphy, S. Rudebeck, P. Jezzard, and P. Cowen Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers J Psychopharmacol 24 2009 1217 1221
55. K.G. Rasmussen, M. Mueller, T.A. Rummans, M.M. Husain, G. Petrides, and R.G. Knapp Is baseline medication resistance associated with potential for relapse after successful remission of a depressive episode with ECT? Data from the Consortium for Research on Electroconvulsive Therapy (CORE) J Clin Psychiatry 70 2009 232 237
56. C. Loo, P. Sheehan, M. Pigot, and W. Lyndon A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT J Affect Disord 103 2007 277 281 (Pubitemid 47445782)
57. C.H. Kellner, R. Knapp, M.M. Husain, K. Rasmussen, S. Sampson, and M. Cullum Bifrontal, bitemporal and right unilateral electrode placement in ECT: Randomised trial Br J Psychiatry 196 2010 226 234
58. B. Walder, M. Seeck, and M.R. Tramer Propofol [correction of propfol] versus methohexital for electroconvulsive therapy: A meta-analysis J Neurosurg Anesthesiol 13 2001 93 98 (Pubitemid 32244984)
59. S.V. Eranti, A.J. Mogg, G.C. Pluck, S. Landau, and D.M. McLoughlin Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: A naturalistic comparison study J Affect Disord 113 2009 165 171
60. M.E. Thase, and A.J. Rush When at first you don't succeed: Sequential strategies for antidepressant nonresponders J Clin Psychiatry 58 suppl 13 1997 23 29 (Pubitemid 28011969)