Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers

Journal of Psychopharmacology

Volumn 24, Issue 8, 2010, Pages 1217-1221

  Taylor, M J ^a   Norbury, R ^a   Murphy, S ^a   Rudebeck, S ^a   Jezzard, P ^a   Cowen, P J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

citalopram; frontal cortex; glutamate; magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CITALOPRAM; CREATINE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; N ACETYLASPARTIC ACID; PLACEBO;

ADULT; ARTICLE; CINGULATE GYRUS; DRUG EFFECT; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ADULT; CITALOPRAM; DEPRESSIVE DISORDER, MAJOR; FEMALE; FRONTAL LOBE; GLUTAMIC ACID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN UPTAKE INHIBITORS; SOFTWARE; YOUNG ADULT;

EID: 77955136795     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109105679     Document Type: Article

References (32)

1. Auer, DP, Putz, B., Kraft, E., Lipinski, B., Schill, J., Holsboer, F. (2000) Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 47: 305-313.
2. Barker, PB, Soher, BJ, Blackband, SJ, Chatham, JC, Mathews, VP, Bryan, RN (1993) Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed 6: 89-94.
3. Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Ashworth, F., Sule, A., et al. (2007) Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry 61: 806-812.
4. Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Boorman, E., Matthews, PM, et al. (2008) Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. Int J Neuropsychopharmacol 11: 255-260.
5. Bhagwagar, Z., Wylezinska, M., Taylor, M., Jezzard, P., Matthews, PM, Cowen, PJ (2004) Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. Am J Psychiatry 161: 368-370.
6. Bottomley, PA (1987) Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci 508: 333-348.
7. Brooks, WM, Friedman, SD, Stidley, CA (1999) Reproducibility of 1H-MRS in vivo. Magn Reson Med 41: 193-197.
8. Danbolt, NC (2001) Glutamate uptake. Prog Neurobiol 65: 1-105. Eastwood, SL, Burnet, PW, Gittins, R., Baker, K., Harrison, PJ (2001) Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia. Synapse 42: 104-114.
9. First, MB, Spitzer, RL, Gibbon, M., Williams, JBW (1997) Structured Clinical Interview for DSM-IV Axis I disorders - Clinician Version (SCID-CV) American Psychiatric Press, Washington, DC.
10. Harmer, CJ, Mackay, CE, Reid, CB, Cowen, PJ, Goodwin, GM (2006) Antidepressant drug treatment modifies the neural processing of nonconscious threat cues. Biol Psychiatry 59: 816-820.
11. Harmer, CJ, Shelley, NC, Cowen, PJ, Goodwin, GM (2004) Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry 161: 1256-1263.
12. Hasler, G., Neumeister, A., van der Veen, JW, Tumonis, T., Bain, EE, Shen, J., et al. (2005) Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry 58: 969-973.
13. Hasler, G., van der Veen, JW, Tumonis, T., Meyers, N., Shen, J., Drevets, WC (2007) Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 64: 193-200.
14. Hornung, JP (2003) The human raphe nuclei and the serotonergic system. J Chem Neuroanat 26: 331-343.
15. Hurd, R., Sailasuta, N., Srinivasan, R., Vigneron, DB, Pelletier, D., Nelson, SJ (2004) Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med 51: 435-440.
16. Hyder, F., Patel, AB, Gjedde, A., Rothman, DL, Behar, KL, Shulman, RG (2006) Neuronal-glial glucose oxidation and glutamatergicGABAergic function. J Cereb Blood Flow Metab 26: 865-877.
17. Jakab, RL, Goldman-Rakic, PS (1998) 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci U S A 95: 735-740.
18. Jakab, RL, Goldman-Rakic, PS (2000) Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex. J Comp Neurol 417: 337-348.
19. Lentner, C (ed) (1981) Geigy Scientific Tables. Basel: Ciba-Geigy.
20. Malhi, GS, Valenzuela, M., Wen, W., Sachdev, P. (2002) Magnetic resonance spectroscopy and its applications in psychiatry. Aust N Z J Psychiatry 36: 31-43.
21. Mescher, M., Merkle, H., Kirsch, J., Garwood, M., Gruetter, R. (1998) Simultaneous in vivo spectral editing and water suppression. NMR Biomed 11: 266-272.
22. Michael, N., Erfurth, A., Ohrmann, P., Arolt, V., Heindel, W., Pfleiderer, B. (2003) Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression. Psychol Med 33: 1277-1284.
23. Pfleiderer, B., Michael, N., Erfurth, A., Ohrmann, P., Hohmann, U., Wolgast, M., et al. (2003) Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients. Psychiatry Res 122: 185-192.
24. Provencher, SW (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30: 672-679.
25. Sanacora, G., Gueorguieva, R., Epperson, CN, Wu, YT, Appel, M., Rothman, DL, et al. (2004) Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 61: 705-713.
26. Sanacora, G., Zarate, CA, Krystal, JH, Manji, HK (2008) Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov 7: 426-437.
27. Shen, J., Petersen, KF, Behar, KL, Brown, P., Nixon, TW, Mason, GF, et al. (1999) Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc Natl Acad Sci U S A 96: 8235-8240.
28. Taylor, M., Murphy, SE, Selvaraj, S., Wylezinkska, M., Jezzard, P., Cowen, PJ, et al. (2008) Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy. J Psychopharmacol 22: 473-476.
29. Taylor, MJ, Freemantle, N., Geddes, JR, Bhagwagar, Z. (2006) Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 63: 1217-1223.
30. Vanhamme, L., van den Boogaart, A., Van Huffel, S. (1997) Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 129: 35-43.
31. Yildiz-Yesiloglu, A., Ankerst, DP (2006) Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res 147: 1-25.
32. Zhang, Y., Brady, M., Smith, S. (2001) Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20: 45-57.