Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: A new method to evaluate the efficiency of targeted therapy using monoclonal antibodies

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11337-11345

  Gaborit, Nadège ^a,c   Larbouret, Christel ^a   Vallaghe, Julie ^b   Peyrusson, Frédéric ^b   Bascoul Mollevi, Caroline ^c   Crapez, Evelyne ^c   Azria, David ^a,c   Chardès, Thierry ^a   Poul, Marie Alix ^a   Mathis, Gérard ^b   Bazin, Hervé ^b   Pèlegrin, André ^a  

^a INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^b Research Department   (France)

^c CENTRE VAL D AURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-EGFR; ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITIES; CELL LINES; CELL SURFACES; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTORS; ERLOTINIB; HETERODIMERS; IN-VITRO; IN-VIVO; LAPATINIB; MEDIAN SURVIVAL; MONOCLONAL ANTIBODIES (MABS); OVARIAN CARCINOMA CELL; THERAPEUTIC EFFECTS; THERAPEUTIC STRATEGY; TIME-RESOLVED FLUORESCENCE; TR-FRET; TRASTUZUMAB; TUMOR CELL LINES; TYROSINE KINASE INHIBITOR; UNDERLYING MECHANISM;

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; ENERGY TRANSFER; FLUORESCENCE; PHOSPHORYLATION; SURFACE PLASMON RESONANCE; TUMORS;

MONOCLONAL ANTIBODIES;

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; HETERODIMER; LAPATINIB; PERTUZUMAB; TRASTUZUMAB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CELL STRAIN 3T3; CELL SURFACE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; EMBRYO; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MICE; NEOPLASMS; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN MULTIMERIZATION; QUINAZOLINES; RECEPTOR, ERBB-2; RECEPTORS, FIBROBLAST GROWTH FACTOR;

MUS;

EID: 79953176342     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.223503     Document Type: Article

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