Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo

Endocrinology

Volumn 152, Issue 4, 2011, Pages 1470-1478

  Boldt, Henning B ^a   Conover, Cheryl A ^a  

^a Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL INVASION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR VASCULARIZATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR II; MICE; MICE, NUDE; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79953171500     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1095     Document Type: Article

References (31)

1. Byun D, Mohan S, Yoo M, Sexton C, Baylink DJ, Qin X 2001 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro. J Clin Endocrinol Metab 86:847-854 (Pubitemid 32207505)
2. Chen BK, Leiferman KM, Pittelkow MR, Overgaard MT, Oxvig C, Conover CA 2003 Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin. J Clin Endocrinol Metab 88:4465-4471 (Pubitemid 37153758)
3. Ortiz CO, Chen BK, Bale LK, Overgaard MT, Oxvig C, Conover CA 2003 Transforming growth factor-β regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts. J Bone Miner Res 18:1066-1072 (Pubitemid 37294944)
4. Boldt HB, Conover CA 2007 Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Res 17:10-18
5. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M 1998 Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351:1393-1396 (Pubitemid 28209997)
6. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M 1998 Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279:563-566 (Pubitemid 28067285)
7. Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X 1999 Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst 91:151-156 (Pubitemid 29042692)
8. Lukanova A, Lundin E, Toniolo P, Micheli A, Akhmedkhanov A, Rinaldi S, Muti P, Lenner P, Biessy C, Krogh V, Zeleniuch-Jacquotte A, Berrino F, Hallmans G, Riboli E, Kaaks R 2002 Circulating levels of insulin-like growth factor-I and risk of ovarian cancer. Int J Cancer 101:549-554
9. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer M J1999 Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGFbinding protein-3. J Natl Cancer Inst 91:620-625
10. Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D 2002 Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62:1030-1035 (Pubitemid 34160283)
11. Wu Y, Cui K, Miyoshi K, Hennighausen L, Green JE, Setser J, Le-Roith D, Yakar S 2003 Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 63:4384-4388 (Pubitemid 36951007)
12. Bates P, Fisher R, Ward A, Richardson L, Hill DJ, Graham CF 1995 Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). Br J Cancer 72:1189-1193
13. Moorehead RA, Sanchez OH, Baldwin RM, Khokha R 2003 Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma. Oncogene 22:853-857 (Pubitemid 36255821)
14. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, García- Echeverría C, Pearson MA, Hofmann F, Anderson KC, Kung AL 2004 Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5:221-230 (Pubitemid 38402114)
15. Diehl D, Hoeflich A, Wolf E, Lahm H 2004 Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. Cancer Res 64:1600-1603 (Pubitemid 38428678)
16. Durai R, Yang SY, Sales KM, Seifalian AM, Goldspink G, Winslet MC2007 Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. Int J Oncol 30:883-888
17. Damon SE, Maddison L, Ware JL, Plymate SR 1998 Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formation. Endocrinology 139:3456-3464 (Pubitemid 28512302)
18. Ryan AJ, Napoletano S, Fitzpatrick PA, Currid CA, O'Sullivan NC, Harmey JH 2009 Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer. Br J Cancer 101:278-286
19. Rho SB, Dong SM, Kang S, Seo SS, Yoo CW, Lee DO, Woo JS, Park SY 2008 Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis. Carcinogenesis 29:2106-2111
20. Bulut I, Coskun A, Ciftci A, Cetinkaya E, Altiay G, Caglar T, Gulcan E 2009 Relationship between pregnancy-associated plasma protein-A and lung cancer. Am J Med Sci 337:241-244
21. Conover CA, Bale LK 2007 Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 6:727-729 (Pubitemid 47400055)
22. Conover CA, Bale LK, Mader JR, Mason MA, Keenan KP, Marler RJ 2010 Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A. J Gerontol A Biol Sci Med Sci 65:590-599
23. Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C 2000 Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem 275:31128-31133
24. Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C 2001 Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin. Biochem J 358:359-367 (Pubitemid 32826352)
25. Qin X, Byun D, Lau KH, Baylink DJ, Mohan S 2000 Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease. Arch Biochem Biophys 379:209-216 (Pubitemid 30637455)
26. Laursen LS, Overgaard MT, Søe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C 2001 Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett 504:36-40 (Pubitemid 32777807)
27. Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB 1996 Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem 271:29483-29488 (Pubitemid 26382669)
28. Conover CA, Hartmann LC, Bradley S, Stalboerger P, Klee GG, Kalli KR, Jenkins RB 1998 Biological characterization of human epithelial ovarian carcinoma cells in primary culture: the insulin-like growth factor system. Exp Cell Res 238:439-449 (Pubitemid 28372832)
29. Tanaka Y, Kobayashi H, Suzuki M, Hirashima Y, Kanayama N, Terao T 2004 Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis. Int J Cancer 109:336-347 (Pubitemid 38252760)
30. Whitley BR, Beaulieu LM, Carter JC, Church FC 2007 Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol Oncol 104:470-479 (Pubitemid 46135652)
31. Jadlowiec J, Dongell D, Smith J, Conover C, Campbell P 2005 Pregnancy-associated plasma protein-A is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick chorioallontoic membrane. Endocrinology 146:3765-3772 (Pubitemid 41175744)