Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5254-5265

  Riese, Matthew J ^a,b   Grewal, Jashanpreet ^a   Das, Jayajit ^c   Zou, Tao ^a   Patil, Vineet ^a   Chakraborty, Arup K ^d,e   Koretzky, Gary A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LEVEL; ACTIVATION THRESHOLDS; CURRENT MODELS; DEGREE OF COMPLEXITY; DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; DIGITAL CONVERSION; ERK ACTIVATION; EXCHANGE FACTORS; FUNCTIONAL RESPONSE; IMMUNE RESPONSE; IN-VITRO; KEY DETERMINANTS; NOVEL STRATEGIES; PHOSPHATIDIC ACIDS; T CELL RECEPTOR; T CELLS;

CELL MEMBRANES; SIGNAL TRANSDUCTION; TUMORS;

GLYCEROL;

DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE ZETA; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME PHOSPHORYLATION; IMMUNOSTIMULATION; IN VITRO STUDY; LIPID METABOLISM; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN LIPID INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TARGET CELL; TUMOR XENOGRAFT;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DIACYLGLYCEROL KINASE; DIGLYCERIDES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LYMPHOMA; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; NEOPLASMS, EXPERIMENTAL; RAS PROTEINS;

EID: 79953141058     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.171884     Document Type: Article

References (46)

1. Rosenberg, S. A., Yang, J. C., and Restifo, N. P. (2004) Nat. Med. 10, 909-915
2. Drake, C. G., Jaffee, E., and Pardoll, D. M. (2006) Adv. Immunol. 90, 51-81
3. Loeser, S., Loser, K., Bijker, M. S., Rangachari, M., van der Burg, S. H., Wada, T., Beissert, S., Melief, C. J., and Penninger, J. M. (2007) J. Exp. Med. 204, 879-891
4. Chiang, J. Y., Jang, I. K., Hodes, R., and Gu, H. (2007) J. Clin. Invest. 117, 1029-1036
5. Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., and Roose, J. P. (2009) Cell 136, 337-351
6. Dower, N. A., Stang, S. L., Bottorff, D. A., Ebinu, J. O., Dickie, P., Ostergaard, H. L., and Stone, J. C. (2000) Nat. Immunol. 1, 317-321
7. Roose, J. P., Mollenauer, M., Ho, M., Kurosaki, T., and Weiss, A. (2007) Mol. Cell. Biol. 27, 2732-2745
8. Boykevisch, S., Zhao, C., Sondermann, H., Philippidou, P., Halegoua, S., Kuriyan, J., and Bar-Sagi, D. (2006) Curr. Biol. 16, 2173-2179
9. Freedman, T. S., Sondermann, H., Friedland, G. D., Kortemme, T., Bar-Sagi, D., Marqusee, S., and Kuriyan, J. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 16692-16697
10. Altan-Bonnet, G., and Germain, R. N. (2005) PLoS Biol. 3, e356
11. Chakraborty, A. K., Das, J., Zikherman, J., Yang, M., Govern, C. C., Ho, M., Weiss, A., and Roose, J. (2009) Sci. Signal. 2, pt2
12. Zhong, X. P., Hainey, E. A., Olenchock, B. A., Jordan, M. S., Maltzman, J. S., Nichols, K. E., Shen, H., and Koretzky, G. A. (2003) Nat. Immunol. 4, 882-890
13. Olenchock, B. A., Guo, R., Carpenter, J. H., Jordan, M., Topham, M. K., Koretzky, G. A., and Zhong, X. P. (2006) Nat. Immunol. 7, 1174-1181
14. Zha, Y., Marks, R., Ho, A. W., Peterson, A. C., Janardhan, S., Brown, I., Praveen, K., Stang, S., Stone, J. C., and Gajewski, T. F. (2006) Nat. Immunol. 7, 1166-1173
15. Mérida, I., Avila-Flores, A., and Merino, E. (2008) Biochem. J. 409, 1-18
16. Topham, M. K., and Prescott, S. M. (2001) J. Cell Biol. 152, 1135-1143
17. Jordan, M. S., Smith, J. E., Burns, J. C., Austin, J. E., Nichols, K. E., Aschenbrenner, A. C., and Koretzky, G. A. (2008) Immunity 28, 359-369
18. Van Kampen, N. G. (1992) Stochastic Processes in Physics and Chemistry, Elsevier/North-Holland, Amsterdam
19. Gillespie, D. (1977) J. Phys. Chem. 81, 2340-2361
20. Weiss, A., Koretzky, G., Schatzman, R. C., and Kadlecek, T. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 5484-5488
21. Franklin, R. A., Tordai, A., Patel, H., Gardner, A. M., Johnson, G. L., and Gelfand, E. W. (1994) J. Clin. Invest. 93, 2134-2140
22. Zehn, D., Lee, S. Y., and Bevan, M. J. (2009) Nature 458, 211-214
23. Hogquist, K. A., Jameson, S. C., Heath, W. R., Howard, J. L., Bevan, M. J., and Carbone, F. R. (1994) Cell 76, 17-27
24. DiSpirito, J. R., and H. Shen, H. (2010) Cell Res. 20, 13-23
25. D'Cruz, L. M., Rubinstein, M. P., and Goldrath, A. W. (2009) Semin. Immunol. 21, 92-98
26. Shamim, M., Nanjappa, S. G., Singh, A., Plisch, E. H., LeBlanc, S. E., Walent, J., Svaren, J., Seroogy, C., and Suresh, M. (2007) J. Immunol. 179, 7233-7243
27. Johnson, K. G., LeRoy, F. G., Borysiewicz, L. K., and Matthews, R. J. (1999) J. Immunol. 162, 3802-3813
28. Simma, O., Zebedin, E., Neugebauer, N., Schellack, C., Pilz, A., Chang-Rodriguez, S., Lingnau, K., Weisz, E., Putz, E. M., Pickl, W. F., Felzmann, T., Müller, M., Decker, T., Sexl, V., and Stoiber, D. (2009) Cancer Res. 69, 203-211
29. Moore, M. W., Carbone, F. R., and Bevan, M. J. (1988) Cell 54, 777-785
30. Goldberg, J., Shrikant, P., and Mescher, M. F. (2003) J. Immunol. 170, 228-235
31. Topham, M. K., Bunting, M., Zimmerman, G. A., McIntyre, T. M., Blackshear, P. J., and Prescott, S. M. (1998) Nature 394, 697-700
32. Luo, B., Prescott, S. M., and Topham, M. K. (2003) J. Cell Biol. 160, 929-937
33. Surh, C. D., and Sprent, J. (2008) Immunity 29, 848-862
34. Ernst, B., Lee, D. S., Chang, J. M., Sprent, J., and Surh, C. D. (1999) Immunity 11, 173-181
35. Goldrath, A. W., and Bevan, M. J. (1999) Immunity 11, 183-190
36. Schluns, K. S., Kieper, W. C., Jameson, S. C., and Lefrançois, L. (2000) Nat. Immunol. 1, 426-432
37. Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, and K. I., Surh, C. D. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8732-8737
38. Zhang, H., and Meadows, G. G. (2005) J. Leukocyte Biol. 78, 1070-1080
39. Posevitz, V., Arndt, B., Krieger, T., Warnecke, N., Schraven, B., and Simeoni, L. (2008) J. Immunol. 180, 1634-1642
40. Norment, A. M., Bogatzki, L. Y., Klinger, M., Ojala, E. W., Bevan, M. J., and Kay, R. J. (2003) J. Immunol. 170, 1141-1149
41. Yi, T., and Lindner, D. (2008) Curr. Oncol. Rep. 10, 114-121
42. Lorenz, U. (2009) Immunol. Rev. 228, 342-359
43. Wohlfert, E. A., Gorelik, L., Mittler, R., Flavell, R. A., and Clark, R. B. (2006) J. Immunol. 176, 1316-1320
44. Tsui, H. W., Siminovitch, K. A., de Souza, L., and Tsui, F. W. (1993) Nat. Genet. 4, 124-129
45. Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y. Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P. S., Sarosi, I., Nishina, H., Lipkowitz, S., and Penninger, J. M. (2000) Nature 403, 211-216
46. Guo, R., Wan, C. K., Carpenter, J. H., Mousallem, T., Boustany, R. M., Kuan, C. T., Burks, A. W., and Zhong, X. P. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 11909-11914