The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 8021-8029

  Luo, Shanshan ^a   Blom, Anna M ^b   Rupp, Steffen ^c   Hipler, Uta Christina ^d   Hube, Bernhard ^a   Skerka, Christine ^a   Zipfel, Peter F ^a,d  

^a HANS KNÖLL INSTITUTE   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBICANS; BINDING DOMAIN; BINDING PROTEINS; BINDING SURFACE; CANDIDA ALBICANS; COFACTOR ACTIVITY; COMPLEMENT CONTROL PROTEINS; HUMAN SERUM; INHIBITORY ACTIVITY; ISOTHERMAL TITRATION CALORIMETRY; KNOCK OUTS; PHYSIOLOGICAL LEVELS; SURFACE DEPOSITION; WILD-TYPE STRAIN;

ANTIGENS; CANDIDA; PROTEINS;

YEAST;

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B BINDING PROTEIN; COMPLEMENT CONTROL PROTEIN DOMAIN 4; COMPLEMENT CONTROL PROTEIN DOMAIN 7; COMPLEMENT CONTROL PROTEIN DOMAIN 8; COMPLEMENT FACTOR H; FUNGAL PROTEIN; PH REGULATED ANTIGEN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CANDIDA ALBICANS; COMPLEMENT INHIBITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNGAL STRAIN; HUMAN; HUMAN CELL; IMMUNE EVASION; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; STRAIN DIFFERENCE; WILD TYPE;

CANDIDA ALBICANS; COMPLEMENT ACTIVATION; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; FUNGAL PROTEINS; GENE KNOCKDOWN TECHNIQUES; HISTOCOMPATIBILITY ANTIGENS; HUMANS; IMMUNE EVASION; PROTEIN BINDING;

CANDIDA; CANDIDA ALBICANS;

EID: 79953136593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.130138     Document Type: Article

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