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Volumn 83, Issue 4, 2010, Pages 223-233

Methicillin-resistant Staphylococcus aureus: A pervasive pathogen highlights the need for new antimicrobial development

Author keywords

10 '20 initiative; Antibiotic development; Antibiotic resistance; Community associated MRSA; Methicillin resistant; Penicillin; Penicillin binding proteins; Staphylococcus aureus; Virulence factors

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BACTERIAL TOXIN; MEMBRANE PROTEIN; METICILLIN; PENICILLIN BINDING PROTEIN; PENICILLIN G; VIRULENCE FACTOR;

EID: 79953132492     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (81)

References (60)
  • 1
    • 0035282386 scopus 로고    scopus 로고
    • Infectious diseases: Considerations for the 21st century
    • Fauci AS. Infectious diseases: considerations for the 21st century. Clin Infect Dis. 2001;32:675- 85.
    • (2001) Clin Infect Dis , vol.32 , pp. 675-685
    • Fauci, A.S.1
  • 2
    • 43049112069 scopus 로고    scopus 로고
    • Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    • Gorwitz RJ, et al. Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004. J Infect Dis. 2008;197:1226-34.
    • (2008) J Infect Dis , vol.197 , pp. 1226-1234
    • Gorwitz, R.J.1
  • 3
    • 30544444128 scopus 로고    scopus 로고
    • Immune evasion by staphylococci
    • Foster TJ. Immune evasion by staphylococci. Nat Rev Microbiol. 2005;3:948-58.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 948-958
    • Foster, T.J.1
  • 4
    • 39749168427 scopus 로고    scopus 로고
    • Clinical practice: Colonization, fomites, and virulence: Rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection
    • Miller LG, Diep BA. Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. 2008;46:752-60.
    • (2008) Clin Infect Dis , vol.46 , pp. 752-760
    • Miller, L.G.1    Diep, B.A.2
  • 5
    • 69249083586 scopus 로고    scopus 로고
    • Waves of resistance: Staphylococcus aureus in the antibiotic era
    • Chambers HF, Deleo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 2009;7:629-41.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 629-641
    • Chambers, H.F.1    Deleo, F.R.2
  • 6
    • 0027960065 scopus 로고
    • MSCRAMM-mediated adherence of microorganisms to host tissues
    • Patti JM, et al. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol. 1994;48:585-617.
    • (1994) Annu Rev Microbiol , vol.48 , pp. 585-617
    • Patti, J.M.1
  • 7
    • 4444254793 scopus 로고    scopus 로고
    • Emerging problems in the management of infectious diseases: The biofilms
    • Sritharan M, Sritharan V. Emerging problems in the management of infectious diseases: the biofilms. Indian J Med Microbiol. 2004;22:140- 2.
    • (2004) Indian J Med Microbiol , vol.22 , pp. 140-142
    • Sritharan, M.1    Sritharan, V.2
  • 8
    • 78049354183 scopus 로고    scopus 로고
    • The Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus
    • Geoghegan JA, et al. The Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus. J Bacteriol. 2010;192(21):5663-73.
    • (2010) J Bacteriol , vol.192 , Issue.21 , pp. 5663-5673
    • Geoghegan, J.A.1
  • 9
    • 78649636709 scopus 로고    scopus 로고
    • Daptomycin and Rifampin Alone and in Combination Prevent Vascular Graft Biofilm Formation and Emergence of Antibiotic Resistance in a Subcutaneous Rat Pouch Model of Staphylococcal Infection
    • Forthcoming
    • Cirioni O, et al. Daptomycin and Rifampin Alone and in Combination Prevent Vascular Graft Biofilm Formation and Emergence of Antibiotic Resistance in a Subcutaneous Rat Pouch Model of Staphylococcal Infection. Eur J Vasc Endovasc Surg. Forthcoming 2010.
    • (2010) Eur J Vasc Endovasc Surg
    • Cirioni, O.1
  • 10
    • 2442442058 scopus 로고    scopus 로고
    • The molecular basis of fibronectin-mediated bacterial adherence to host cells
    • Schwarz-Linek U, et al. The molecular basis of fibronectin-mediated bacterial adherence to host cells. Mol Microbiol. 2004;52:631-41.
    • (2004) Mol Microbiol , vol.52 , pp. 631-641
    • Schwarz-Linek, U.1
  • 11
    • 77953328205 scopus 로고    scopus 로고
    • Staphylococcus aureus: An old pathogen with new weapons
    • Tang YW, Stratton CW. Staphylococcus aureus: An old pathogen with new weapons. Clin Lab Med. 2010;30:179-208.
    • (2010) Clin Lab Med , vol.30 , pp. 179-208
    • Tang, Y.W.1    Stratton, C.W.2
  • 12
    • 0033754023 scopus 로고    scopus 로고
    • Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrins
    • Fowler T, et al. Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrins. Eur J Cell Biol. 2000;79:672-9.
    • (2000) Eur J Cell Biol , vol.79 , pp. 672-679
    • Fowler, T.1
  • 13
    • 0019522383 scopus 로고
    • Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution
    • Deisenhofer J. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. Biochemistry. 1981;20:2361-70.
    • (1981) Biochemistry , vol.20 , pp. 2361-2370
    • Deisenhofer, J.1
  • 14
    • 1542343930 scopus 로고    scopus 로고
    • Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent
    • de Haas CJ, et al. Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent. J Exp Med. 2004;199:687- 95.
    • (2004) J Exp Med , vol.199 , pp. 687-695
    • de Haas, C.J.1
  • 16
    • 44149098644 scopus 로고    scopus 로고
    • Pathogenesis of methicillin- resistant Staphylococcus aureus infection
    • Gordon RJ, Lowy FD. Pathogenesis of methicillin- resistant Staphylococcus aureus infection. Clin Infect Dis. 2008;46(Suppl 5):S350-9.
    • (2008) Clin Infect Dis , vol.46 , Issue.SUPPL. 5
    • Gordon, R.J.1    Lowy, F.D.2
  • 17
    • 0018070935 scopus 로고
    • Toxic-shock syndrome associated with phage-group-I Staphylococci
    • Todd J, et al. Toxic-shock syndrome associated with phage-group-I Staphylococci. Lancet. 1978;2:1116-8.
    • (1978) Lancet , vol.2 , pp. 1116-1118
    • Todd, J.1
  • 18
    • 0032551901 scopus 로고    scopus 로고
    • Staphylococcus aureus infections
    • Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520-32.
    • (1998) N Engl J Med , vol.339 , pp. 520-532
    • Lowy, F.D.1
  • 19
    • 0015445486 scopus 로고
    • Serological detection of enterotoxin in foods implicated in staphylococcal food poisoning
    • Gilbert RJ, et al. Serological detection of enterotoxin in foods implicated in staphylococcal food poisoning. J Hyg (Lond). 1972;70:755-62.
    • (1972) J Hyg (Lond) , vol.70 , pp. 755-762
    • Gilbert, R.J.1
  • 20
    • 67649210248 scopus 로고    scopus 로고
    • Skin and soft tissue infection: Microbiology and epidemiology
    • Dryden MS. Skin and soft tissue infection: microbiology and epidemiology. Int J Antimicrob Agents. 2009;34(Suppl 1):S2-7.
    • (2009) Int J Antimicrob Agents , vol.34 , Issue.SUPPL. 1
    • Dryden, M.S.1
  • 22
    • 0742272595 scopus 로고    scopus 로고
    • Neutralization of Staphylococcus aureus Panton Valentine leukocidin by intravenous immunoglobulin in vitro
    • Gauduchon V, et al. Neutralization of Staphylococcus aureus Panton Valentine leukocidin by intravenous immunoglobulin in vitro. J Infect Dis. 2004;189:346-53.
    • (2004) J Infect Dis , vol.189 , pp. 346-353
    • Gauduchon, V.1
  • 23
    • 37349132468 scopus 로고    scopus 로고
    • Neutralization of staphylococcal exotoxins in vitro by humanorigin intravenous immunoglobulin
    • Yanagisawa C, et al. Neutralization of staphylococcal exotoxins in vitro by humanorigin intravenous immunoglobulin. J Infect Chemother. 2007;13:368-72.
    • (2007) J Infect Chemother , vol.13 , pp. 368-372
    • Yanagisawa, C.1
  • 24
    • 0036359208 scopus 로고    scopus 로고
    • Methicillin resistance in Staphylococcus aureus: Mechanisms and modulation
    • Stapleton PD, Taylor PW. Methicillin resistance in Staphylococcus aureus: mechanisms and modulation. Sci Prog. 2002;85:57-72.
    • (2002) Sci Prog , vol.85 , pp. 57-72
    • Stapleton, P.D.1    Taylor, P.W.2
  • 25
    • 0035091085 scopus 로고    scopus 로고
    • Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus
    • Wu SW, et al. Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus. J Bacteriol. 2001;183:2417-24.
    • (2001) J Bacteriol , vol.183 , pp. 2417-2424
    • Wu, S.W.1
  • 26
    • 0034038098 scopus 로고    scopus 로고
    • A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus
    • Katayama Y, et al. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2000;44:1549-55.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1549-1555
    • Katayama, Y.1
  • 27
    • 0027472248 scopus 로고
    • Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus
    • Kreiswirth B, et al. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science. 1993;259:227-30.
    • (1993) Science , vol.259 , pp. 227-230
    • Kreiswirth, B.1
  • 28
    • 0027381457 scopus 로고
    • Penicillin-binding proteins and bacterial resistance to beta-lactams
    • Georgopapadakou NH. Penicillin-binding proteins and bacterial resistance to beta-lactams. Antimicrob Agents Chemother. 1993;37:2045- 53.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2045-2053
    • Georgopapadakou, N.H.1
  • 30
    • 72849182077 scopus 로고
    • Methicillin-resistant staphylococci
    • Barber M. Methicillin-resistant staphylococci. J Clin Pathol. 1961;14:385-93.
    • (1961) J Clin Pathol , vol.14 , pp. 385-393
    • Barber, M.1
  • 31
    • 0014434278 scopus 로고
    • Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations
    • Barrett FF, et al. Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations. N Engl J Med. 1968;279:441-8.
    • (1968) N Engl J Med , vol.279 , pp. 441-448
    • Barrett, F.F.1
  • 32
    • 0036829003 scopus 로고    scopus 로고
    • Structural basis for the beta lactam resistance of PBP2a from methicillin- resistant Staphylococcus aureus
    • Lim D, Strynadka NC. Structural basis for the beta lactam resistance of PBP2a from methicillin- resistant Staphylococcus aureus. Nat Struct Biol. 2002;9:870-6.
    • (2002) Nat Struct Biol , vol.9 , pp. 870-876
    • Lim, D.1    Strynadka, N.C.2
  • 33
    • 24344466955 scopus 로고    scopus 로고
    • Beta-lactams against methicillin- resistant Staphylococcus aureus
    • Guignard B, et al. Beta-lactams against methicillin- resistant Staphylococcus aureus. Curr Opin Pharmacol. 2005;5:479-89.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 479-489
    • Guignard, B.1
  • 34
    • 0030003528 scopus 로고    scopus 로고
    • A cloud adult: The Staphylococcus aureus-virus interaction revisited
    • Sheretz RJ, et al. A cloud adult: the Staphylococcus aureus-virus interaction revisited. Ann Intern Med. 1996;124:539-47.
    • (1996) Ann Intern Med , vol.124 , pp. 539-547
    • Sheretz, R.J.1
  • 35
    • 33646833985 scopus 로고    scopus 로고
    • Managing methicillin-resistant staphylococci: A paradigm for preventing nosocomial transmission of resistant organisms
    • discussion S62-70
    • Henderson DK. Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms. Am J Med. 2006;119:S45-52, discussion S62-70.
    • (2006) Am J Med , vol.119
    • Henderson, D.K.1
  • 36
    • 31044456290 scopus 로고    scopus 로고
    • Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003
    • Klevens RM, et al. Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003. Clin Infect Dis. 2006;42:389-91.
    • (2006) Clin Infect Dis , vol.42 , pp. 389-391
    • Klevens, R.M.1
  • 37
    • 37049001066 scopus 로고    scopus 로고
    • Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
    • Klein E, et al. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005. Emerg Infect Dis. 2007;13:1840-6.
    • (2007) Emerg Infect Dis , vol.13 , pp. 1840-1846
    • Klein, E.1
  • 38
    • 35349019173 scopus 로고    scopus 로고
    • Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    • Klevens RM, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 2007;298:1763-71.
    • (2007) JAMA , vol.298 , pp. 1763-1771
    • Klevens, R.M.1
  • 39
    • 77951620048 scopus 로고    scopus 로고
    • Community-associated methicillin- resistant Staphylococcus aureus
    • Deleo FR, et al. Community-associated methicillin- resistant Staphylococcus aureus. Lancet. 2010;375:1557-68.
    • (2010) Lancet , vol.375 , pp. 1557-1568
    • Deleo, F.R.1
  • 40
    • 77955357246 scopus 로고    scopus 로고
    • Health care-associated invasive MRSA infections, 2005-2008
    • Kallen AJ, et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA. 2010;304:641-8.
    • (2010) JAMA , vol.304 , pp. 641-648
    • Kallen, A.J.1
  • 41
    • 71649106889 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus: Source control and surveillance organization
    • Tacconelli E. Methicillin-resistant Staphylococcus aureus: source control and surveillance organization. Clin Microbiol Infect. 2009;15(Suppl 7):31-8.
    • (2009) Clin Microbiol Infect , vol.15 , Issue.SUPPL. 7 , pp. 31-38
    • Tacconelli, E.1
  • 42
    • 60749089639 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007
    • Burton DC, et al. Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997-2007. JAMA. 2009;301:727-36.
    • (2009) JAMA , vol.301 , pp. 727-736
    • Burton, D.C.1
  • 43
    • 75649084906 scopus 로고    scopus 로고
    • Evolution of MRSA during hospital transmission and intercontinental spread
    • Harris SR, et al. Evolution of MRSA during hospital transmission and intercontinental spread. Science. 2010;327:469-74.
    • (2010) Science , vol.327 , pp. 469-474
    • Harris, S.R.1
  • 44
    • 0027497155 scopus 로고
    • Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia
    • Udo EE, et al. Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia. J Hosp Infect. 1993;25:97-108.
    • (1993) J Hosp Infect , vol.25 , pp. 97-108
    • Udo, E.E.1
  • 45
    • 0033595394 scopus 로고    scopus 로고
    • Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus- Minnesota and North Dakota, 1997- 1999
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus- Minnesota and North Dakota, 1997- 1999. JAMA. 1999;282:1123-5.
    • (1999) JAMA , vol.282 , pp. 1123-1125
  • 46
    • 0029149555 scopus 로고
    • Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities
    • Prevost G, et al. Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities. Infect Immun. 1995;63:4121-9.
    • (1995) Infect Immun , vol.63 , pp. 4121-4129
    • Prevost, G.1
  • 48
    • 42249101738 scopus 로고    scopus 로고
    • Guidelines for UK practice for the diagnosis and management of methicillin- resistant Staphylococcus aureus (MRSA) infections presenting in the community
    • Nathwani D, et al. Guidelines for UK practice for the diagnosis and management of methicillin- resistant Staphylococcus aureus (MRSA) infections presenting in the community. J Antimicrob Chemother. 2008;61:976-94.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 976-994
    • Nathwani, D.1
  • 50
    • 2342595765 scopus 로고    scopus 로고
    • Trends in antimicrobial drug development: Implications for the future
    • Spellberg B, et al. Trends in antimicrobial drug development: implications for the future. Clin Infect Dis. 2004;38:1279-86.
    • (2004) Clin Infect Dis , vol.38 , pp. 1279-1286
    • Spellberg, B.1
  • 51
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi JA, et al. The price of innovation: new estimates of drug development costs. J Health Econ. 2003;22:151-85.
    • (2003) J Health Econ , vol.22 , pp. 151-185
    • DiMasi, J.A.1
  • 53
    • 39449103059 scopus 로고    scopus 로고
    • The epidemic of antibioticresistant infections: A call to action for the medical community from the Infectious Diseases Society of America
    • Spellberg B, et al. The epidemic of antibioticresistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:155-64.
    • (2008) Clin Infect Dis , vol.46 , pp. 155-164
    • Spellberg, B.1
  • 54
    • 77950255824 scopus 로고    scopus 로고
    • The 10 x '20 Initiative: Pursuing a global commitment to develop 10 new antibacterial drugs by 2020
    • Infectious Diseases Society of America
    • Infectious Diseases Society of America. The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin Infect Dis. 2010;50:1081-3.
    • (2010) Clin Infect Dis , vol.50 , pp. 1081-1083
  • 55
    • 17244375099 scopus 로고    scopus 로고
    • A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics
    • Charest MG, et al. A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science. 2005;308:395-8.
    • (2005) Science , vol.308 , pp. 395-398
    • Charest, M.G.1
  • 56
    • 58249107405 scopus 로고    scopus 로고
    • A robust platform for the synthesis of new tetracycline antibiotics
    • Sun C, et al. A robust platform for the synthesis of new tetracycline antibiotics. J Am Chem Soc. 2008;130:17913-27.
    • (2008) J Am Chem Soc , vol.130 , pp. 17913-17927
    • Sun, C.1
  • 58
    • 17444421169 scopus 로고    scopus 로고
    • Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
    • Tu D, et al. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell. 2005;121:257-70.
    • (2005) Cell , vol.121 , pp. 257-270
    • Tu, D.1
  • 59
    • 79953136815 scopus 로고    scopus 로고
    • Nobelprize.org [Internet], cited, Oct 24. Available at
    • Nobelprize.org [Internet]. The Nobel Prize in Chemistry 2009 - Press Release. [cited 2010 Oct 24]. Available at: http://nobelprize.org/nobel_prizes/chemistry/laureates/2009/press.html.
    • (2010) The Nobel Prize in Chemistry 2009 - Press Release


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