Human DBS sampling with LC-MS/MS for enantioselective determination of metoprolol and its metabolite O-desmethyl metoprolol

Bioanalysis

Volumn 2, Issue 8, 2010, Pages 1437-1448

  Liang, Xiaorong ^a   Jiang, Hongliang ^a   Chen, Xi ^b  

^a 206 Carnegie Center   (United States)

^b Albany Molecular Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; METOPROLOL; NORMETOPROLOL; UNCLASSIFIED DRUG; DRUG DERIVATIVE; O DESMETHYL METOPROLOL; O-DESMETHYL METOPROLOL;

ACCURACY; ARTICLE; BIOASSAY; BLOOD SAMPLING; CONTROLLED STUDY; DRIED BLOOD SPOT; DRUG DETERMINATION; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ENANTIOSELECTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; BLOOD; BLOOD ANALYSIS; BLOOD VOLUME; CHEMISTRY; DESICCATION; METABOLISM; METHODOLOGY; QUALITY CONTROL; STATISTICAL MODEL; STEREOISOMERISM; TEMPERATURE;

BLOOD CHEMICAL ANALYSIS; BLOOD SPECIMEN COLLECTION; BLOOD VOLUME; CHROMATOGRAPHY, LIQUID; DESICCATION; DRUG STABILITY; HUMANS; LINEAR MODELS; METOPROLOL; QUALITY CONTROL; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 79953130704     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.107     Document Type: Article

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