Expression of p210 and p190 BCR-ABL due to alternative splicing in chronic myelogenous leukaemia

British Journal of Haematology

Volumn 103, Issue 3, 1998, Pages 711-715

  Lichty, Brian D ^a,b   Keating, Armand ^c   Callum, Jeannie ^c   Yee, Karen ^c   Croxford, Ruth ^d   Corpus, George ^c   Nwachukwu, Bevoline ^c   Kim, Peter ^c   Guo, Joyce ^c   Kamel Reid, Suzanne ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alternative splicing; BCR ABL; CML; P190; P210

Indexed keywords

BCR ABL PROTEIN; HYDROXYUREA; INTERFERON;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BLAST CELL; BLAST CELL CRISIS; CHILD; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; PHILADELPHIA 1 CHROMOSOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; CHILD; CHILD, PRESCHOOL; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM;

EID: 7844252267     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.01033.x     Document Type: Article

References (28)

1. Ben-Nariah, Y., Daley, G.Q., Mes-Masson, A.-M., Witte, O.N. & Baltimore, D. (1986) The chronic myelogenous leukemia-specific p210 protein is the product of the bcr-abl hybrid gene. Science. 233, 212-214.
2. de Klein, A., Geurts van Kessel, A., Grosveld, D., Bartram, C.R., Hagemeijer, A., Bootsma, D., Spurr, N.K., Heisterkamp, N., Groffen, J. & Stephenson, J.R. (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelogenous leukaemia. Nature, 300, 765-767.
3. BCR-ABL in chronic myelogenous leukemia may correlate with disease progression. Leukemia, 5, 191-195.
4. Gishizky, M.L., Johnson-White, J. & Witte, O.N. (1993) Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America, 90, 3755-3759.
5. Groffen, J., Stephenson, J.R., Heisterkamp, N., de Klein, A., Bartram, C.R. & Grosveld, G. (1984) Philadelphia chromosomal breakpoints are clustered within a limited region. bcr. on chromosome 22, Cell, 36, 93-99.
6. Hasford, J., Ansari, H., Pfirrmann, M., Hehlmann, R. & T.G.C.S. Group (1996) Analysis and validation of prognostic factors for CML. Bone Marrow Transplantation, (Suppl. 3), S49-S54.
7. Heisterkamp, N., Jenster, G., ten Hoeve, J., Zovich, D., Pattengale. P.K. & Groffen, J. (1990) Acute leukaemia in BCR/ABL transgenic mice. Nature, 344, 251-253.
8. Hermans, A., Heisterkamp, N., von Lindern, M., van Baal, S., Meijer, D., van der Plas, D., Wiedemann, L.M., Groffen, J., Bootsma, D. & Grosveld, G. (1987) Unique fusion of BCR and c-ABL genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell. 51, 33-40.
9. Hermans, A., Selleri, L., Gow, J. & Grosveld, G.C. (1988) Absence of alternative splicing in BCR-ABL mRNA in chronic myeloid cell lines. Blood, 72, 2066-2069.
10. Hooberman, A.L., Carrino, J.J., Leibowitz, D., Rowley, J.D., Le Beau, M.M., Arlin, Z.A. & Westbrook, C.A. (1989) Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 86, 4259-4263.
11. Kantarjian, H.M., Deisseroth, A., Kuzrock, R., Estrov, Z. & Talpaz, M. (1993) Chronic myelogenous leukemia: a concise update. Blood, 82, 691-703.
12. Kelliher, M.A., McLaughlin, J., Witte, O.N. & Rosenberg, N. (1990) Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proceedings of the National Academy of Sciences of the United States of America, 87, 6649-6653.
13. Kunieda, Y., Okabe, M., Kurosawa, M., Itaya, T., Kakinuma, M. & Miyazaki, T. (1994) Chronic myeloid leukemia presenting ALL-type BCR/ABL transcript. Annals of Hematology, 69, 189-193.
14. Laneuville, P., Heisterkamp, N. & Groffen, J. (1991) Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene, 6, 275-282.
15. Lugo, T.G., Pendergast, A., Muller, A.J. & Witte, O.N. (1990) Tyrosine kinase activity and transformation potency of BCR-ABL oncogene products. Science, 247, 1079-1082.
16. Maurer, J., Kinzel, H., Nentwig, T. & Thiel, E. (1990) Molecular diagnosis of the Philadelphia chromosome in chronic myelogenous and acute lymphoblastic leukemia. Disease Markers, 8, 211-218.
17. McLaughlin, J., Chianese, E. & Witte, O.N. (1987) In vitro transformation of immature hematopoietic cells by the p210 bcr/abl oncogene product of the Philadelphia chromosome. Proceedings of the National Academy of Sciences of the United States of America, 84, 6558-6562.
18. McLaughlin, J., Chianese, E. & Witte, O.N. (1989) Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Molecular and Cellular Biology, 9, 1866-1874.
19. Melo, J.V. (1996) The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood, 88, 2375-2384.
20. Morgan, G.J., Hernandez, A., Chan, L.C., Hughes, T., Martiat, P. & Wiedemann, L.M. (1990) The role of alternative splicing patterns of BCR/ABL transcripts in the generation of the blast crisis of chronic myeloid leukaemia. British Journal of Haematology, 76, 33-38.
21. Nowell, P.C. & Hungerford, D.A. (1960) A minute chromosome in human chronic granulocytic leukemia. Science, 132. 1497.
22. Rowley, J.D. (1973) A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine flourescence and Giemsa staining. Nature, 243, 290-293.
23. Saglio, G., Pane, F., Gottardi, E., Frigeri, F., Buonaiuto, M.R., Guerrasio, A., De Micheli, D., Parziale, A., Fornaci, M.N., Martinelli, G. & Salvatore, F. (1996) Consistent amounts of acute leukemia-associated p190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis. Blood. 87, 1075-1080.
24. Shtivelman, E., Lifshitz, B., Gale,. R.P. & Canaani, E. (1985) Fused transcript of ABL and BCR genes in chronic myelogenous leukaemia. Nature, 315, 550-554.
25. Suryanarayan, K., Hunger, S.P., Kohler, S., Carroll, A.J., Crist, W., Link, M.P. & Cleary, M.L. (1991) Consistent involvement of the BCR gene by 9:22 breakpoints in pediatric acute leukemia. Blood, 77, 324-330.
26. van Rhee, F., Hochhaus, A., Lin, F., Melo, J.V., Goldman, J.M. & Cross, N.C.P. (1996) p190 BCR-ABL mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias. Blood, 87, 5213-5217.
27. Voncken, J.W., Kaartinen, V. Pattengale, P.K., Germeraad, W.T.V., Groffen, J. & Heisterkamp, N. (1995) BCR/ABL p210 and p190 cause distinct leukemia in transgenic mice. Blood, 86, 4603-4611.
28. Westbrook, C.A., Hooberman, A.L., Spino, C., Dodge, R.K., Larson, R.A., Davey, F., Wurster-Hill, D.H., Sobol, R.E., Schiffer, C. & Bloomfield, C.D. (1992) Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B study. Blood, 80, 2983-2990.