Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells

Journal of Experimental and Clinical Cancer Research

Volumn 28, Issue 1, 2009, Pages

  Wei, Zhaohui ^a,b   Chen, Naiyao ^a   Guo, Hongxing ^b   Wang, Xueming ^a   Xu, Fangyun ^b   Ren, Qian ^b   Lu, Shihong ^b   Liu, Bin ^b   Zhang, Lei ^b   Zhao, Hui ^a,b  

^a NORTH CHINA COAL MEDICAL COLLEGE   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; BAD PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

APOPTOSIS; ARTICLE; BONE MARROW; CELL ASSAY; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL EXPANSION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN K 562; COCULTURE; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SERUM; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CELL COMMUNICATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CELL COMMUNICATION; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COCULTURE TECHNIQUES; CULTURE MEDIA, SERUM-FREE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MESENCHYMAL STEM CELLS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 72849137758     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-28-141     Document Type: Article

References (23)

1. PCR assessment of bone marrow status in "isolated" extramedullary relapse of childhood B-pre-cursor acute lymphoblastic leukemia. N Goulden K Langlands C Steward F Katz M Potter J Chessells A Oakhill, Br J Hematol 1994 87 282 5 10.1111/j.1365-2141.1994.tb04910.x
2. Hypoxia-induced resistance to cisplatin and doxorubicin in nonsmall cell lung cancer is inhibited by silencing of HIF-1 gene. X Song X Liu W Chi Y Liu L Wei X Wang J Yu, Cancer Chemotherapy and Pharmacology 2006 58 776 84 10.1007/s00280-006-0224-7 (Pubitemid 44351258)
3. Survival of B lineage leukemic cells: signals from the bone marrow microenvironment. LF Gibson, Leuk Lymphoma 2002 43 19 27 10.1080/10428190210188 11908727
4. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Y Tabe L Jin Y Tsutsumi-Ishii Y Xu T McQueen W Priebe GB Mills A Ohsaka I Nagaoka M Andreeff M Konopleva, Cancer Res 2007 67 684 94 10.1158/0008-5472.CAN-06-3166 17234779
5. Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt. L Wang JE Fortney LF Gibson, Leuk Res 2004 28 733 42 10.1016/j.leukres.2003.10.033 15158095
6. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. M Konopleva S Konoplev W Hu AY Zaritskey BV Afanasiev M Andreeff, Leukemia 2002 16 1713 24 10.1038/sj.leu.2402608 12200686
7. Survival of acute myeloid leukemia cells requires PI3-kinase activation. Q Xu SE Simpson TJ Scialla A Bagg M Carroll, Blood 2003 102 972 80 10.1182/blood-2002-11-3429 12702506
8. Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells:direct evidence of PI3K activation. Y Kubota H Ohnishi A Kitanaka T Ishida T Tanaka, Leukemia 2004 18 1438 40 10.1038/sj.leu.2403402 15175626
9. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. YH Min JI Eom JW Cheong HO Maeng JY Kim HK Jeung ST Lee MH Lee JS Hahn YW Ko, Leukemia 2003 17 995 7 10.1038/sj.leu.2402874 12750723
10. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici K Le Blanc I Mueller I Slaper-Cortenbach F Marini D Krause R Deans A Keating Dj Prockop E Horwitz, Cytotherapy 2006 8 315 7 10.1080/14653240600855905 16923606
11. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. R Ramasamy EW Lam I Soeiro V Tisato D Bonnet F Dazzi, Leukemia 2007 21 304 10 10.1038/sj.leu.2404489 17170725
12. In vivo induction of insulin-like growth factor-1 receptor and CD44v6 confers homing and adhesion to murine multiplemyeloma cells. K Asosingh U Günthert MH Bakkus H De Raeve E Goes I Van Riet B Van Camp K Vanderkerken, Cancer Res 2000 60 3096 104 10850462
13. Murine stem cell line HESS-5 maintains reconstituting ability of ex vivo generated hematopoietic stem cells from human bone marrow and cytokine-mobilized peripheral blood. Y Shimakura H Kawada K Ando T Sato Y Nakamura T Tsuji S Kato T Hotta, Stem Cells 2000 18 183 9 10.1634/stemcells.18-3-183 10840071
14. Direct contact between CD34+ lin-cells and stroma induces a soluble activity that specifically increases primitive hematopoietic cell production. MR Koller M Oxender TC Jensen KL Goltry AK Smith, Exp Hematol 1999 27 734 41 10.1016/S0301-472X(98)00080-0 10210331
15. Effects of leukemia bone marrow stem cells on resistance of co-cultured HL-60 to Idarubicin. X Zhang P Wang XH Cheng L Liu XG Peng QY Wang PY Kong H Liu y Zhang L Gao YM Zhong, J Exp Hematol 2004 12 163 5 (article in Chinese)
16. Intera ctions Between Human Mesenchymal Stem Cells and Natural Killer Cells. PA Sotiropoulou SA Perez AD Gritzapis CN Baxevanis M Papamichail, Stem Cells 2006 24 74 85 10.1634/stemcells.2004-0359 16099998
17. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. I Rasmusson O Ringdén B Sundberg K Le Blanc, Transplantation 2003 76 1208 13 10.1097/01.TP.0000082540.43730.80 14578755
18. + B lymphocyte. L Granziero P Circosta C Scielzo E Frisaldi S Stella M Geuna S Giordano P Ghia F Caligaris-Cappio, Blood 2003 101 1962 9 10.1182/blood-2002-05-1339 12406905
19. Interaction between leukemic cell VLA-4 and stem fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. T Matsunaga N Takemoto T Sato R Takimoto I Tanaka A Fujimi T Akiyama H Kuroda Y Kawano M Kobune J Kato Y Hirayama S Sakamaki K Kohda K Miyake Y Niitsu, Nat Med 2003 9 1158 65 10.1038/nm909 12897778
20. Bone marrow stem inhibits proliferation and apoptosis in leukemic cells through gap junction mediated cell communication. FH Paraguass-Braga R Borojevic LF Bouzas MA Barcinski A Bonomo, Cell Death Differ 2003 10 1101 8 10.1038/sj.cdd.4401279 12934084
21. PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway. ZY Cheng XL Guo XY Yang ZY Niu SH Li SY Wang H Chen L Pan, Journal of Experimental & Clinical Cancer Research 2008 27 87 10.1186/1756-9966-27-87
22. Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery. SR Datta H Dudek X Tao S Masters H Fu Y Gotoh ME Greenberg, Cell 1997 91 231 41 10.1016/S0092-8674(00)80405-5 9346240
23. A specific inhibitor of phospha-tidylin ositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). CJ Vlahos WF Matter KY Hui RF Brown, J Biol Chem 1994 269 5241 8 8106507