Structural basis for reductive radical formation and electron recycling in (R)-2-hydroxyisocaproyl-CoA dehydratase

Journal of the American Chemical Society

Volumn 133, Issue 12, 2011, Pages 4342-4347

  Knauer, Stefan H ^a,b   Buckel, Wolfgang ^c,d   Dobbek, Holger ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF BAYREUTH   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; ACTIVATOR PROTEINS; ACTIVE ELECTRONS; ACTIVE SITE; BENZOYL-COA REDUCTASE; BIOTIN SYNTHASE; CATALYZED REACTIONS; CLASS II; CLOSTRIDIUM DIFFICILE; COFACTORS; HETERODIMERIC PROTEINS; HIGH-ENERGY ELECTRON; KETYL RADICALS; L-LEUCINE; METALLOENZYMES; ONE-TERMINAL; PATHOGENIC BACTERIUM; RADICAL ENZYMES; RADICAL FORMATION; RADICAL GENERATION; S-ADENOSYLMETHIONINE; SIDE REACTIONS; SINGLE ELECTRON; STRUCTURAL BASIS; THIOESTER GROUP;

AMINO ACIDS; BACTERIA; CATALYSIS; DEHYDRATION; DEWATERING; ELECTRONS; ENZYMES; LIGANDS; OXYGEN; RECYCLING;

CRYSTAL STRUCTURE;

2 HYDROXYISOCAPROYL COA DEHYDRATASE; CARBONYL DERIVATIVE; COBAMAMIDE; CYSTEINE; ENZYME; OXYGEN; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; WATER;

ALPHA HELIX; ARTICLE; BETA SHEET; CATALYSIS; CRYSTAL STRUCTURE; ELECTRON; ENZYME STRUCTURE; PROTEIN STRUCTURE; RADICAL REACTION;

BACTERIAL PROTEINS; BIOCATALYSIS; CLOSTRIDIUM DIFFICILE; ELECTRONS; FERMENTATION; FREE RADICALS; HYDRO-LYASES; LEUCINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STEREOISOMERISM;

EID: 79953053845     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1076537     Document Type: Article

References (43)

1. Buckel, W.; Golding, B. T. Annu. Rev. Microbiol. 2006, 60, 27-49
2. Banerjee, R.; Vlasie, M. Biochem. Soc. Trans. 2002, 30, 621-4
3. Licht, S.; Gerfen, G. J.; Stubbe, J. Science 1996, 271, 477-81
4. Frey, P. A.; Hegeman, A. D.; Ruzicka, F. J. Crit. Rev. Biochem. Mol. Biol. 2008, 43, 63-88
5. Berkovitch, F.; Nicolet, Y.; Wan, J. T.; Jarrett, J. T.; Drennan, C. L. Science 2004, 303, 76-9
6. Knappe, J.; Wagner, A. F. Adv. Protein Chem. 2001, 58, 277-315
7. Buckel, W.; Hetzel, M.; Kim, J. Curr. Opin. Chem. Biol. 2004, 8, 462-7
8. Kim, J.; Hetzel, M.; Boiangiu, C. D.; Buckel, W. FEMS Microbiol. Rev. 2004, 28, 455-68
9. Kim, J.; Darley, D.; Buckel, W. FEBS J. 2005, 272, 550-61
10. Parthasarathy, A.; Buckel, W.; Smith, D. M. FEBS J. 2010, 277, 1738-46
11. Kim, J.; Darley, D. J.; Buckel, W.; Pierik, A. J. Nature 2008, 452, 239-42
12. Müller, U.; Buckel, W. Eur. J. Biochem. 1995, 230, 698-704
13. Reitzer, R.; Gruber, K.; Jogl, G.; Wagner, U. G.; Bothe, H.; Buckel, W.; Kratky, C. Structure 1999, 7, 891-902
14. Lepore, B. W.; Ruzicka, F. J.; Frey, P. A.; Ringe, D. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 13819-24
15. Holm, L.; Kaariainen, S.; Rosenstrom, P.; Schenkel, A. Bioinformatics 2008, 24, 2780-1
16. Rees, D. C. Annu. Rev. Biochem. 2002, 71, 221-46
17. Page, C. C.; Moser, C. C.; Chen, X.; Dutton, P. L. Nature 1999, 402, 47-52
18. Beinert, H.; Kennedy, M. C.; Stout, C. D. Chem. Rev. 1996, 96, 2335-2374
19. Dey, A.; Jenney, F. E., Jr.; Adams, M. W.; Babini, E.; Takahashi, Y.; Fukuyama, K.; Hodgson, K. O.; Hedman, B.; Solomon, E. I. Science 2007, 318, 1464-8
20. Nicolet, Y.; Amara, P.; Mouesca, J. M.; Fontecilla-Camps, J. C. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 14867-71
21. Kim, J., Pierik, A. J., and Buckel, W. ChemPhysChem 2010, 11, 1307-12
22. Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. J. Mol. Biol. 1994, 237, 437-51
23. Smith, D. M.; Buckel, W.; Zipse, H. Angew. Chem., Int. Ed. 2003, 42, 1867-70
24. Hofmeister, A. E.; Buckel, W. Eur. J. Biochem. 1992, 206, 547-52
25. Pitsch, C.; Simon, H. Hoppe-Seyler's Z. Physiol. Chem. 1982, 363, 1253-7
26. Buckel, W. Eur. J. Biochem. 1980, 106, 439-47
27. Herrmann, G.; Jayamani, E.; Mai, G.; Buckel, W. J. Bacteriol. 2008, 190, 784-91
28. Lees, N. S.; Chen, D.; Walsby, C. J.; Behshad, E.; Frey, P. A.; Hoffman, B. M. J. Am. Chem. Soc. 2006, 128, 10145-54
29. Boll, M.; Fuchs, G.; Heider, J. Curr. Opin. Chem. Biol. 2002, 6, 604-11
30. Kabsch, W. J. Appl. Crystallogr. 1993, 26, 795-800
31. Sheldrick, G. M. Acta Crystallogr., Sect. A: Found. Crystallogr. 2008, 64, 112-22
32. DeLaFortelle, E.; Irwing, J. J.; Bricogne, G. Methods Enzymol. 1997, 276, 472-494
33. Perrakis, A.; Morris, R.; Lamzin, V. S. Nat. Struct. Biol. 1999, 6, 458-63
34. Emsley, P.; Lohkamp, B.; Scott, W.; Cowtan, K. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2010, 66
35. Brunger, A. T.; Adams, P. D.; Clore, G. M.; DeLano, W. L.; Gros, P.; Grosse-Kunstleve, R. W.; Jiang, J. S.; Kuszewski, J.; Nilges, M.; Pannu, N. S.; Read, R. J.; Rice, L. M.; Simonson, T.; Warren, G. L. Acta Crystallogr., Sect. D: Biol. Crystallogr. 1998, 54, 905-21
36. Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallogr., Sect. D: Biol. Crystallogr. 1997, 53, 240-55
37. Adams, P. D. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2010, 66, 213-21
38. McCoy, A. J.; Grosse-Kunstleve, R. W.; Adams, P. D.; Winn, M. D.; Storoni, L. C.; Read, R. J. J. Appl. Crystallogr. 2007, 40, 658-674
39. Kleywegt, G. J.; Jones, T. A. Methods Enzymol. 1997, 277, 525-45
40. Ho, B. K.; Gruswitz, F. BMC Struct. Biol. 2008, 8, 49
41. Schrodinger, LLC 2010.
42. Thompson, J. D.; Higgins, D. G.; Gibson, T. J. Nucleic Acid Res. 1994, 22, 4673-4680
43. http://www.psc.edu/biomed/genedoc.