How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia

NeuroImage

Volumn 56, Issue 1, 2011, Pages 363-372

  Lueken, Ulrike ^a   Kruschwitz, Johann Daniel ^a   Muehlhan, Markus ^a   Siegert, Jens ^a   Hoyer, Jürgen ^a   Wittchen, Hans Ulrich ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Animal phobia; Anterior cingulate cortex; Anxiety; Blood injection injury phobia; Dental phobia; FMRI; Insula

Indexed keywords

ADULT; ANTERIOR CINGULATE; ANXIETY DISORDER; AROUSAL; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DENTAL PHOBIA; EMOTIONALITY; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INJECTION; INSULA; LIMBIC CORTEX; MALE; NERVE CELL NETWORK; NEUROBIOLOGY; ORBITAL CORTEX; PHOBIA; PREFRONTAL CORTEX; PRIORITY JOURNAL; SKIN CONDUCTANCE; SNAKE PHOBIA; THALAMUS; VISUAL STIMULATION;

BRAIN; BRAIN MAPPING; DENTAL ANXIETY; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; PHOBIC DISORDERS; YOUNG ADULT;

EID: 79953049198     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.02.015     Document Type: Article

References (47)

1. APA Diagnostic and Statistical Manual of Mental Disorders. text revision (DSM-IV-TR), Washington, DC 2000, 4th ed.
2. Benedek M., Kaernbach C. Decomposition of skin conductance data by means of nonnegative deconvolution. Psychophysiology 2010, 47:647-658.
3. Bradley M.M., Silakowski T., Lang P.J. Fear of pain and defensive activation. Pain 2008, 137:156-163.
4. Caseras X., Giampietro V., Lamas A., Brammer M., Vilarroya O., Carmona S., Rovira M., Torrubia R., Mataix-Cols D. The functional neuroanatomy of blood-injection-injury phobia: a comparison with spider phobics and healthy controls. Psychol. Med. 2010, 40:125-134.
5. Caseras X., Mataix-Cols D., Trasovares M.V., Lopez-Sola M., Ortriz H., Pujol J., Soriano-Mas C., Giampietro V., Brammer M.J., Torrubia R. Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes. Eur. J. Neurosci. 2010, 32:1414-1422.
6. Craig A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nature Rev Neurosci 2002, 3:655-666.
7. Deichmann R., Gottfried J.A., Hutton C., Turner R. Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 2003, 19:430-441.
8. Dilger S., Straube T., Mentzel H.J., Fitzek C., Reichenbach H.R., Hecht H., Krieschel S., Gutberlet I., Miltner W.H.R. Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study. Neurosci. Lett. 2003, 348:29-32.
9. Etkin A., Wager T.D. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry 2007, 164:1476-1488.
10. Genovese C.R., Lazar N.A., Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 2002, 15:870-878.
11. Glascher J. Visualization of group inference data in functional neuroimaging. Neuroinformatics 2009, 7:73-82.
12. Globisch J., Hamm A.O., Esteves F., Ohman A. Fear appears fast: temporal course of startle reflex potentiation in animal fearful subjects. Psychophysiology 1999, 36:66-75.
13. Goossens L., Sunaert S., Peeters R., Griez E.J.L., Schruers K.R.J. Amygdala hyperfunction in phobic fear normalizes after exposure. Biol. Psychiatry 2007, 62:1119-1125.
14. Hamm A.O. Spezifische Phobien 2008, Hogrefe, Göttingen.
15. Hamm A.O., Cuthbert B.N., Globisch J., Vaitl D. Fear and the startle reflex: blink modulation and autonomic response patterns in animal and mutilation fearful subjects. Psychophysiology 1997, 34:97-107.
16. Hermann A., Schafer A., Walter B., Stark R., Vaitl D., Schienle A. Diminished medial prefrontal cortex activity in blood-injection-injury phobia. Biol. Psychol. 2007, 75:124-130.
17. Klorman R., Weissberg R.P., Wiesenfeld A.R. Individual differences in fear and autonomic reactions to affective stimulation. Psychophysiology 1977, 14:45-51.
18. Kupfer D.J., First M.B., Regier D.A. A Research Agenda for DSM-V 2002, American Psychiatric Association, Washington, DC.
19. Larson C.L., Schaefer H.S., Siegle G.J., Jackson C.A.B., Anderle M.J., Davidson R.J. Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli. Biol. Psychiatry 2006, 60:410-417.
20. Lebeau R.T., Glenn D., Liao B., Wittchen H.U., Beesdo-Baum K., Ollendick T., Craske M.G. Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. Depress. Anxiety 2010, 27:148-167.
21. Lueken U., Hoyer J., Siegert J., Gloster A.T., Wittchen H.-U. Symptom provocation in dental anxiety using cross-phobic video stimulation. Eur. J. Oral Sci. 2011, 119:61-68.
22. Lykken D.T. Range correction applied to heart rate and to GSR data. Psychophysiology 1972, 9:373-379.
23. Maldjian J.A., Laurienti P.J., Kraft R.A., Burdette J.H. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003, 19:1233-1239.
24. Milad M.R., Rauch S.L. The role of the orbitofrontal cortex in anxiety disorders. Linking Affect to Action: Critical Contributions of the Orbitofrontal Cortex 2007, 546-561. Blackwell Publishing, Oxford. G. Schoenbaum, J.A. Gottfried, E.A. Murray, S.J. Rasmus (Eds.).
25. Ochsner K.N., Bunge S.A., Gross J.J., Gabrieli J.D.E. Rethinking feelings: an fMRI study of the cognitive regulation of emotion. J. Cogn. Neurosci. 2002, 14:1215-1229.
26. Ongur D., Price J.L. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb. Cortex 2000, 10:206-219.
27. Ongur D., Ferry A.T., Price J.L. Architectonic subdivision of the human orbital and medial prefrontal cortex. J. Comp. Neurol. 2003, 460:425-449.
28. Oosterink F.M.D., De Jongh A., Aartman I.H.A. What are people afraid of during dental treatment? Anxiety-provoking capacity of 67 stimuli characteristic of the dental setting. Eur. J. Oral Sci. 2008, 116:44-51.
29. Ost L.G., Sterner U., Lindahl I.L. Physiological responses in blood phobics. Behav. Res. Ther. 1984, 22:109-117.
30. Petrowski K., Herold U., Joraschky P., Wittchen H.U., Kirschbaum C. A striking pattern of cortisol non-responsiveness to psychosocial stress in patients with panic disorder with concurrent normal cortisol awakening responses. Psychoneuroendocrinology 2010, 35:414-421.
31. Rauch S.L., Drevets W.C. Neuroimaging and neuroanatomy of stress-induced and fear circuitry disorders. Stress-Induced and Fear Circuitry Disorders: Advancing the Research Agenda for DSM-V 2009, 215-254. American Psychiatric Association, Arlington, VA. G. Andrews, D.S. Charney, P.J. Sirovatka, D.A. Regier (Eds.).
32. Reiss S., Peterson R.A., Gursky D.M., McNally R.J. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav. Res. Ther. 1986, 24:1-8.
33. Schienle A., Schafer A., Stark R., Walter B., Kirsch P., Vaitl D. Disgust processing in phobia of blood-injection-injury - an fMRI study. J. Psychophysiol. 2003, 17:87-93.
34. Schienle A., Schafer A., Walter B., Stark R., Vaitl D. Brain activation of spider phobics towards disorder-relevant, generally disgust- and fear-inducing pictures. Neurosci. Lett. 2005, 388:1-6.
35. Schienle A., Schafer A., Hermann A., Rohrmann S., Vaitl D. Symptom provocation and reduction in patients suffering from spider phobia. Eur. Arch. Psychiatry Clin. Neurosci. 2007, 257:486-493.
36. Shin L.M., Liberzon I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 2010, 35:169-191.
37. Simmons A., Strigo I., Matthews S.C., Paulus M.P., Stein M.B. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biol. Psychiatry 2006, 60:402-409.
38. Stark R., Zimmermman M., Kagerer S., Schienle A., Walter B., Weygandt M., Vaitl D. Hemodynamic brain correlates of disgust and fear ratings. Neuroimage 2007, 37:663-673.
39. Stein M.B., Simmons A.N., Feinstein J.S., Paulus M.P. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. Am. J. Psychiatry 2007, 164:318-327.
40. Straube T., Glauer M., Dilger S., Mentzel H.J., Miltner W.H.R. Effects of cognitive-behavioral therapy on brain activation in specific phobia. Neuroimage 2006, 29:125-135.
41. Straube T., Mentzel H.J., Miltner W.H.R. Waiting for spiders: brain activation during anticipatory anxiety in spider phobics. Neuroimage 2007, 37:1427-1436.
42. Thyer B.A., Himle J., Curtis G.C. Blood-injury-illness phobia: a review. J. Clin. Psychol. 1985, 41:451-459.
43. Tönnies S., Mehrstedt M., Eisentraut I. Die Dental Anxiety Scale (DAS) und das Dental Fear Survey (DFS) - Zwei Messinstrumente zur Erfassung von Zahnbehandlungsängsten. Z. Med. Psychol. 2002, 11:63-72.
44. van Duinen M.A., Schruers K.R.J., Griez E.J.L. Desynchrony of fear in phobic exposure. J. Psychopharmacol. 2010, 24:695-699.
45. Wendt J., Lotze M., Weike A.I., Hosten N., Hamm A.O. Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia. Psychophysiology 2008, 45:205-215.
46. Wittchen H.-U., Pfister H. DIA-X Interview 1997, Swets & Zeitlinger, Frankfurt.
47. Wright C.I., Martis B., McMullin K., Shin L.M., Rauch S.L. Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. Biol. Psychiatry 2003, 54:1067-1076.