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Volumn 7, Issue 1, 2011, Pages 50-56

Branched-chain amino acid oxidation in skeletal muscle -physiological and clinical importance of its modulation by reactant availability

Author keywords

Branched chain amino acids; Cachexia; Glutamine; Leucine; Muscle; Nutrition

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUTAMINE;

EID: 79953043615     PISSN: 15734013     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340111794941139     Document Type: Article
Times cited : (5)

References (68)
  • 1
    • 0024547167 scopus 로고
    • Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat
    • Flores EA, Bistrian BR, Pomposelli JJ, et al. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. J Clin Invest 1989; 83: 1614-22.
    • (1989) J Clin Invest , vol.83 , pp. 1614-1622
    • Flores, E.A.1    Bistrian, B.R.2    Pomposelli, J.J.3
  • 2
    • 0025092141 scopus 로고
    • Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain α-keto acid dehydrogenase
    • Nawabi MD, Block KP, Chakrabarti MC, et al. Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain α-keto acid dehydrogenase. J Clin Invest 1990; 85: 256-63.
    • (1990) J Clin Invest , vol.85 , pp. 256-263
    • Nawabi, M.D.1    Block, K.P.2    Chakrabarti, M.C.3
  • 3
    • 0031426642 scopus 로고    scopus 로고
    • Leucine metabolism in TNF-α- and endotoxin-treated rats: Contribution of hepatic tissue
    • Holecek M, Sprongl L, Skopec F, et al. Leucine metabolism in TNF-α- and endotoxin-treated rats: contribution of hepatic tissue. Am J Physiol 1997; 273: E1052-8.
    • (1997) Am J Physiol , vol.273
    • Holecek, M.1    Sprongl, L.2    Skopec, F.3
  • 5
    • 33646674302 scopus 로고    scopus 로고
    • Cachexia: Pathophysiology and clinical relevance
    • Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 2006; 83: 735-43.
    • (2006) Am J Clin Nutr , vol.83 , pp. 735-743
    • Morley, J.E.1    Thomas, D.R.2    Wilson, M.M.3
  • 7
    • 0024555897 scopus 로고
    • An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition
    • Shaw JH, Wolfe RR An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition. Ann Surg 1989; 209: 63-72.
    • (1989) Ann Surg , vol.209 , pp. 63-72
    • Shaw, J.H.1    Wolfe, R.R.2
  • 8
    • 0025973318 scopus 로고
    • Nutritional support and cancer cachexia. Evolving concepts of mechanisms and adjunctive therapies
    • Ng EH, Lowry SF. Nutritional support and cancer cachexia. Evolving concepts of mechanisms and adjunctive therapies. Hematol Oncol Clin North Am 1991; 5: 161-84.
    • (1991) Hematol Oncol Clin North Am , vol.5 , pp. 161-184
    • Ng, E.H.1    Lowry, S.F.2
  • 10
    • 0035744467 scopus 로고    scopus 로고
    • Regulation of branched-chain amino acid catabolism: Nutritional and hormonal regulation of activity and expression of the branched-chain alphaketo acid dehydrogenase kinase
    • Shimomura Y, Obayashi M, Murakami T, et al. Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alphaketo acid dehydrogenase kinase. Curr Opin Clin Nutr Metab Care 2001; 4: 419-23.
    • (2001) Curr Opin Clin Nutr Metab Care , vol.4 , pp. 419-423
    • Shimomura, Y.1    Obayashi, M.2    Murakami, T.3
  • 11
    • 0345735297 scopus 로고    scopus 로고
    • Mechanisms responsible for regulation of branched-chain amino acid catabolism
    • Harris RA, Joshi M, Jeoung NH. Mechanisms responsible for regulation of branched-chain amino acid catabolism. Biochem Biophys Res Commun 2004; 313: 391-6.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 391-396
    • Harris, R.A.1    Joshi, M.2    Jeoung, N.H.3
  • 12
    • 31544475901 scopus 로고    scopus 로고
    • Assessment of branched-chain amino acid status and potential for biomarkers
    • Tom A, Nair KS. Assessment of branched-chain amino acid status and potential for biomarkers. J Nutr 2006; 136: 324S-30S.
    • (2006) J Nutr , vol.136
    • Tom, A.1    Nair, K.S.2
  • 13
    • 0015448896 scopus 로고
    • Some aspects of the regulation of fuel supply in omnivorous animals
    • Krebs HA. Some aspects of the regulation of fuel supply in omnivorous animals. Adv Enzyme Regul 1972; 10: 397-420.
    • (1972) Adv Enzyme Regul , vol.10 , pp. 397-420
    • Krebs, H.A.1
  • 14
    • 20344373417 scopus 로고    scopus 로고
    • Overview of the molecular and biochemical basis of branched-chain amino acid catabolism
    • Harris RA, Joshi M, Jeoung NH, et al. Overview of the molecular and biochemical basis of branched-chain amino acid catabolism. J Nutr 2005; 135: 1527S-30S.
    • (2005) J Nutr , vol.135
    • Harris, R.A.1    Joshi, M.2    Jeoung, N.H.3
  • 15
    • 31544458134 scopus 로고    scopus 로고
    • Branched-chain amino acids: Enzyme and substrate regulation
    • Brosnan JT, Brosnan ME. Branched-chain amino acids: enzyme and substrate regulation. J Nutr 2006; 136: 207S-11S.
    • (2006) J Nutr , vol.136
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 16
    • 0015440344 scopus 로고
    • Oxidation of leucine by rat skeletal muscle
    • Odessey R, Goldberg AL. Oxidation of leucine by rat skeletal muscle. Am J Physiol 1972; 223: 1376-83.
    • (1972) Am J Physiol , vol.223 , pp. 1376-1383
    • Odessey, R.1    Goldberg, A.L.2
  • 17
    • 0016286812 scopus 로고
    • The formation of glutamine and alanine in skeletal muscle
    • Ruderman NB, Berger M. The formation of glutamine and alanine in skeletal muscle. J Biol Chem 1974; 249: 5500-6.
    • (1974) J Biol Chem , vol.249 , pp. 5500-5506
    • Ruderman, N.B.1    Berger, M.2
  • 18
    • 0033816820 scopus 로고    scopus 로고
    • Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats
    • Holecek M, Skopec F, Skalska H, et al. Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats. J Parenter Enteral Nutr 2000; 24: 215-22.
    • (2000) J Parenter Enteral Nutr , vol.24 , pp. 215-222
    • Holecek, M.1    Skopec, F.2    Skalska, H.3
  • 19
    • 0036178861 scopus 로고    scopus 로고
    • Effect of alanyl-glutamine on leucine and protein metabolism in irradiated rats
    • Holecek M, Skopec F, Sprongl L, et al. Effect of alanyl-glutamine on leucine and protein metabolism in irradiated rats. Amino Acids 2002; 22: 95-108.
    • (2002) Amino Acids , vol.22 , pp. 95-108
    • Holecek, M.1    Skopec, F.2    Sprongl, L.3
  • 20
    • 33746789376 scopus 로고    scopus 로고
    • Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis
    • Safranek R, Holecek M, Sispera L, et al. Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis. Ann Nutr Metab 2006; 50: 361-7.
    • (2006) Ann Nutr Metab , vol.50 , pp. 361-367
    • Safranek, R.1    Holecek, M.2    Sispera, L.3
  • 21
    • 0033791641 scopus 로고    scopus 로고
    • Effect of hyperammonemia on leucine and protein metabolism in rats
    • Holecek M, Sprongl L, Tichy M. Effect of hyperammonemia on leucine and protein metabolism in rats. Metabolism 2000; 49: 1330-4.
    • (2000) Metabolism , vol.49 , pp. 1330-1334
    • Holecek, M.1    Sprongl, L.2    Tichy, M.3
  • 22
    • 0033119578 scopus 로고    scopus 로고
    • Role of the ubiquitin-proteasome pathway in sepsis- induced muscle catabolism
    • Hasselgren PO. Role of the ubiquitin-proteasome pathway in sepsis- induced muscle catabolism. Mol Biol Rep 1999; 26: 71-6.
    • (1999) Mol Biol Rep , vol.26 , pp. 71-76
    • Hasselgren, P.O.1
  • 24
    • 0030586073 scopus 로고    scopus 로고
    • Identification of altered gene expression in skeletal muscle during sepsis using differential display
    • Tiao GM, Hudson K, Lieberman MA, et al. Identification of altered gene expression in skeletal muscle during sepsis using differential display. J Surg Res 1996; 64: 63-7.
    • (1996) J Surg Res , vol.64 , pp. 63-67
    • Tiao, G.M.1    Hudson, K.2    Lieberman, M.A.3
  • 25
    • 0030951073 scopus 로고    scopus 로고
    • Intracellular regulation of protein degradation during sepsis is different in fast- and slowtwitch muscle
    • Tiao G, Lieberman M, Fischer JE, et al. Intracellular regulation of protein degradation during sepsis is different in fast- and slowtwitch muscle. Am J Physiol 1997; 272: R849-56.
    • (1997) Am J Physiol , vol.272
    • Tiao, G.1    Lieberman, M.2    Fischer, J.E.3
  • 26
    • 0017167707 scopus 로고
    • Metabolic adaptations for energy production during trauma and sepsis
    • Ryan NT. Metabolic adaptations for energy production during trauma and sepsis. Surg Clin North Am 1976; 56: 1073-90.
    • (1976) Surg Clin North Am , vol.56 , pp. 1073-1090
    • Ryan, N.T.1
  • 27
    • 0017083865 scopus 로고
    • Proteolysis associated with a deficit of peripheral energy fuel substrates in septic man
    • O'Donnel TF, Clowes GH Jr, Blackburn GL, et al. Proteolysis associated with a deficit of peripheral energy fuel substrates in septic man. Surgery 1976; 80: 192-200.
    • (1976) Surgery , vol.80 , pp. 192-200
    • O'Donnel, T.F.1    Clowes Jr., G.H.2    Blackburn, G.L.3
  • 28
    • 0020081889 scopus 로고
    • Does leucine, leucyltRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?
    • Tischler ME, Desautels M, Goldberg AL. Does leucine, leucyltRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J Biol Chem 1982; 257: 1613-21.
    • (1982) J Biol Chem , vol.257 , pp. 1613-1621
    • Tischler, M.E.1    Desautels, M.2    Goldberg, A.L.3
  • 29
    • 20344376194 scopus 로고    scopus 로고
    • The role of leucine in the regulation of protein metabolism
    • Garlick PJ. The role of leucine in the regulation of protein metabolism. J Nutr 2005; 135: 1553S-6S.
    • (2005) J Nutr , vol.135
    • Garlick, P.J.1
  • 30
    • 20344399405 scopus 로고    scopus 로고
    • Hormonal and signaling role of branched-chain amino acids
    • Nair KS, Short KR. Hormonal and signaling role of branched-chain amino acids. J Nutr 2005; 135: 1547S-52S.
    • (2005) J Nutr , vol.135
    • Nair, K.S.1    Short, K.R.2
  • 31
    • 58149199535 scopus 로고    scopus 로고
    • Effect of beta-hydroxybeta- methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues
    • Holecek M, Muthny T, Kovarik M, et al. Effect of beta-hydroxybeta- methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues. Food Chem Toxicol 2009; 47: 255-9.
    • (2009) Food Chem Toxicol , vol.47 , pp. 255-259
    • Holecek, M.1    Muthny, T.2    Kovarik, M.3
  • 32
    • 0021346659 scopus 로고
    • Branched chain metabolic support. A prospective, randomized, double-blind trial in surgical stress
    • Cerra FB, Mazuski JE, Chute E, et al. Branched chain metabolic support. A prospective, randomized, double-blind trial in surgical stress. Ann Surg 1984; 199: 286-91.
    • (1984) Ann Surg , vol.199 , pp. 286-291
    • Cerra, F.B.1    Mazuski, J.E.2    Chute, E.3
  • 33
    • 0025237815 scopus 로고
    • General and specialized parenteral amino acid formulations for nutrition support
    • Heyman MB. General and specialized parenteral amino acid formulations for nutrition support. J Am Diet Assoc 1990; 90: 401-8.
    • (1990) J Am Diet Assoc , vol.90 , pp. 401-408
    • Heyman, M.B.1
  • 34
    • 0025558936 scopus 로고
    • Failure of BCAA supplementation to promote nitrogen retention in injured patients
    • Scholten DJ, Morgan RE, Davis AT, et al. Failure of BCAA supplementation to promote nitrogen retention in injured patients. J Am Coll Nutr 1990; 9: 101-6.
    • (1990) J Am Coll Nutr , vol.9 , pp. 101-106
    • Scholten, D.J.1    Morgan, R.E.2    Davis, A.T.3
  • 35
    • 0025977967 scopus 로고
    • Prospective randomized double-blind trial of branched chain amino acid enriched versus standard parenteral nutrition solutions in traumatized and septic patients
    • Vente JP, Soeters PB, von Meyenfeldt MF, et al. Prospective randomized double-blind trial of branched chain amino acid enriched versus standard parenteral nutrition solutions in traumatized and septic patients. World J Surg 1991; 15: 128-32.
    • (1991) World J Surg , vol.15 , pp. 128-132
    • Vente, J.P.1    Soeters, P.B.2    von Meyenfeldt, M.F.3
  • 36
    • 0036197786 scopus 로고    scopus 로고
    • The metabolic role of branched-chain amino acids
    • Freund HR, Hanani M. The metabolic role of branched-chain amino acids. Nutrition 2002; 18: 287-8.
    • (2002) Nutrition , vol.18 , pp. 287-288
    • Freund, H.R.1    Hanani, M.2
  • 37
    • 31544449110 scopus 로고    scopus 로고
    • Therapeutic use of branched-chain amino acids in burn, trauma and sepsis
    • De Bandt JP, Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma and sepsis. J Nutr 2006; 136: 308S-13S.
    • (2006) J Nutr , vol.136
    • de Bandt, J.P.1    Cynober, L.2
  • 38
    • 11144338827 scopus 로고    scopus 로고
    • Pharmacological activities of branchedchain amino acids: Augmentation of albumin synthesis in liver and improvement of glucose metabolism in skeletal muscle
    • Nishitani S, Takehana K. Pharmacological activities of branchedchain amino acids: augmentation of albumin synthesis in liver and improvement of glucose metabolism in skeletal muscle. Hepatol Res 2004; 30S: 19-24.
    • (2004) Hepatol Res , vol.30 S , pp. 19-24
    • Nishitani, S.1    Takehana, K.2
  • 39
    • 20344404975 scopus 로고    scopus 로고
    • Branched-chain amino acid supplementation in patients with liver diseases
    • Marchesini G, Marzocchi R, Noia M, et al. Branched-chain amino acid supplementation in patients with liver diseases. J Nutr 2005; 135: 1596S-601S.
    • (2005) J Nutr , vol.135
    • Marchesini, G.1    Marzocchi, R.2    Noia, M.3
  • 40
    • 34247120492 scopus 로고    scopus 로고
    • Role of branched-chain amino acids in liver disease: The evidence for and against
    • Khanna S, Gopalan S. Role of branched-chain amino acids in liver disease: the evidence for and against. Curr Opin Clin Nutr Metab Care 2007; 10: 297-303.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 297-303
    • Khanna, S.1    Gopalan, S.2
  • 41
    • 33846206486 scopus 로고    scopus 로고
    • Hepatic Nutritional Therapy (HNT) Study Group. BCAA-enriched snack improves nutritional state of cirrhosis
    • Nakaya Y, Okita K, Suzuki K, et al. Hepatic Nutritional Therapy (HNT) Study Group. BCAA-enriched snack improves nutritional state of cirrhosis. Nutrition 2007; 23: 113-20.
    • (2007) Nutrition , vol.23 , pp. 113-120
    • Nakaya, Y.1    Okita, K.2    Suzuki, K.3
  • 42
    • 77951209222 scopus 로고    scopus 로고
    • Three targets of branched-chain amino acid supplementation in the treatment of liver disease
    • Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition 2010; 26: 482-90.
    • (2010) Nutrition , vol.26 , pp. 482-490
    • Holecek, M.1
  • 43
    • 0017106992 scopus 로고
    • Branched-chain amino acids, nitrogen excretion and injury in man
    • Wedge JH, De Campos R, Kerr A, et al. Branched-chain amino acids, nitrogen excretion and injury in man. Clin Sci Mol Med 1976; 50: 393-9.
    • (1976) Clin Sci Mol Med , vol.50 , pp. 393-399
    • Wedge, J.H.1    de Campos, R.2    Kerr, A.3
  • 44
    • 0026886375 scopus 로고
    • Variations in plasma amino acids in septic patients subjected to parenteral nutrition with a high proportion of branched-chain amino acids
    • Jiménez JFJ, Ortiz LC, Morales MS, et al. Variations in plasma amino acids in septic patients subjected to parenteral nutrition with a high proportion of branched-chain amino acids. Nutrition 1992; 8: 237-44.
    • (1992) Nutrition , vol.8 , pp. 237-244
    • Jiménez, J.F.J.1    Ortiz, L.C.2    Morales, M.S.3
  • 45
    • 0020818320 scopus 로고
    • Intracellular muscle free amino acids--their measurement and function
    • Fürst P. Intracellular muscle free amino acids--their measurement and function. Proc Nutr Soc 1983; 42: 451-62.
    • (1983) Proc Nutr Soc , vol.42 , pp. 451-462
    • Fürst, P.1
  • 46
    • 0016703172 scopus 로고
    • Influence of the postoperative state on the intracellular free amino acids in human muscle tissue
    • Vinnars E, Bergstöm J, Fürst P. Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann Surg 1975; 182: 665-71.
    • (1975) Ann Surg , vol.182 , pp. 665-671
    • Vinnars, E.1    Bergstöm, J.2    Fürst, P.3
  • 47
    • 14744267948 scopus 로고    scopus 로고
    • Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle
    • Lang CH, Frost RA. Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol 2005; 203: 144-55.
    • (2005) J Cell Physiol , vol.203 , pp. 144-155
    • Lang, C.H.1    Frost, R.A.2
  • 48
    • 0025165229 scopus 로고
    • Relationship of plasma cholesterol level to doses of branch-chain amino acids in sepsis
    • Chiarla C, Giovannini I, Siegel JH, et al. Relationship of plasma cholesterol level to doses of branch-chain amino acids in sepsis. Crit Care Med 1990; 18: 32-6.
    • (1990) Crit Care Med , vol.18 , pp. 32-36
    • Chiarla, C.1    Giovannini, I.2    Siegel, J.H.3
  • 49
    • 4244031940 scopus 로고
    • Oxidation of amino acids by isolated rat diaphragm and the influence of insulin
    • Manchester KL. Oxidation of amino acids by isolated rat diaphragm and the influence of insulin. Biochim Biophys Acta 1965; 100: 295-8.
    • (1965) Biochim Biophys Acta , vol.100 , pp. 295-298
    • Manchester, K.L.1
  • 50
    • 0022602879 scopus 로고
    • Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial
    • Tayek JA, Bistrian BR, Hehir DJ, et al. Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial. Cancer 1986; 58: 147-57.
    • (1986) Cancer , vol.58 , pp. 147-157
    • Tayek, J.A.1    Bistrian, B.R.2    Hehir, D.J.3
  • 51
    • 0023718289 scopus 로고
    • Inhibition of post-traumatic septic proteolysis and ureagenesis and stimulation of hepatic acutephase protein production by branched-chain amino acid TPN
    • Chiarla C, Siegel JH, Kidd S, et al. Inhibition of post-traumatic septic proteolysis and ureagenesis and stimulation of hepatic acutephase protein production by branched-chain amino acid TPN. J Trauma 1988; 28: 1145-72.
    • (1988) J Trauma , vol.28 , pp. 1145-1172
    • Chiarla, C.1    Siegel, J.H.2    Kidd, S.3
  • 52
    • 0023064384 scopus 로고
    • Stress-induced intracellular glutamine depletion. The potential use of glutamine-containing dipeptides in parenteral nutrition
    • Fürst P, Albers S, Stehle P. Stress-induced intracellular glutamine depletion. The potential use of glutamine-containing dipeptides in parenteral nutrition. Contr Infus Ther Clin Nutr 1978; 17: 117-36.
    • (1978) Contr Infus Ther Clin Nutr , vol.17 , pp. 117-136
    • Fürst, P.1    Albers, S.2    Stehle, P.3
  • 53
    • 0001956935 scopus 로고
    • Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle
    • Roth E, Funovics J, Mühlbacher F. Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle. Clin Nutr 1982; 1: 25-41.
    • (1982) Clin Nutr , vol.1 , pp. 25-41
    • Roth, E.1    Funovics, J.2    Mühlbacher, F.3
  • 55
    • 0025360991 scopus 로고
    • α-Ketoglutarate and postoperative muscle catabolism
    • Wernerman J, Hammarqvist F, Vinnars E. α-Ketoglutarate and postoperative muscle catabolism. Lancet 1990; 335: 701-3.
    • (1990) Lancet , vol.335 , pp. 701-703
    • Wernerman, J.1    Hammarqvist, F.2    Vinnars, E.3
  • 56
    • 0030772994 scopus 로고    scopus 로고
    • Supplementation of diets with nutritional pharmaceuticals
    • Newsholme E, Hardy G. Supplementation of diets with nutritional pharmaceuticals. Nutrition 1997; 13: 837-9.
    • (1997) Nutrition , vol.13 , pp. 837-839
    • Newsholme, E.1    Hardy, G.2
  • 57
    • 0024492090 scopus 로고
    • Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery
    • Stehle P, Zander J, Mertes N, et al. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 1989; i: 231-3.
    • (1989) Lancet , vol.i , pp. 231-233
    • Stehle, P.1    Zander, J.2    Mertes, N.3
  • 58
    • 0024580521 scopus 로고
    • Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance
    • Hammarqvist F, Wernerman J, Ali R, et al. Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Ann Surg 1989; 209: 455-61.
    • (1989) Ann Surg , vol.209 , pp. 455-461
    • Hammarqvist, F.1    Wernerman, J.2    Ali, R.3
  • 59
    • 0033985121 scopus 로고    scopus 로고
    • Dietary glutamine suppresses endogenous glutamine turnover in the rat
    • Watford M, Darcy-Vrillon B, Duée PH. Dietary glutamine suppresses endogenous glutamine turnover in the rat. Metabolism 2000; 49: 141-5.
    • (2000) Metabolism , vol.49 , pp. 141-145
    • Watford, M.1    Darcy-Vrillon, B.2    Duée, P.H.3
  • 60
    • 0034842396 scopus 로고    scopus 로고
    • The effect of glutamine supplementation in patients following elective surgery and accidental injury
    • DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr 2001; 131: 2543S-9S.
    • (2001) J Nutr , vol.131
  • 61
    • 0029862520 scopus 로고    scopus 로고
    • Effect of glutamine on leucine metabolism in humans
    • Hankard RG, Haymond MW, Darmaun D, et al. Effect of glutamine on leucine metabolism in humans. Am J Physiol 1996; 271: E748-54.
    • (1996) Am J Physiol , vol.271
    • Hankard, R.G.1    Haymond, M.W.2    Darmaun, D.3
  • 62
    • 0036134573 scopus 로고    scopus 로고
    • Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: A stable isotope study
    • des Robert C, Le Bacquer O, Piloquet H, et al. Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study. Pediatr Res 2002; 51: 87-93.
    • (2002) Pediatr Res , vol.51 , pp. 87-93
    • des Robert, C.1    le Bacquer, O.2    Piloquet, H.3
  • 63
    • 0031008508 scopus 로고    scopus 로고
    • Regulation of protein turnover by glutamine in heat-shocked skeletal myotubes
    • Zhou X, Thompson JR. Regulation of protein turnover by glutamine in heat-shocked skeletal myotubes. Biochim Biophys Acta 1997; 1357: 234-42.
    • (1997) Biochim Biophys Acta , vol.1357 , pp. 234-42
    • Zhou, X.1    Thompson, J.R.2
  • 64
    • 18144366579 scopus 로고    scopus 로고
    • Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants
    • Kalhan SC, Parimi PS, Gruca LL, et al. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr 2005; 146: 642-7.
    • (2005) J Pediatr , vol.146 , pp. 642-647
    • Kalhan, S.C.1    Parimi, P.S.2    Gruca, L.L.3
  • 65
    • 0025755232 scopus 로고
    • Absorption and metabolic effects of enterally administered glutamine in humans
    • Déchelotte P, Darmaun D, Rongier M, et al. Absorption and metabolic effects of enterally administered glutamine in humans. Am J Physiol 1991; 260: G677-82.
    • (1991) Am J Physiol , vol.260
    • Déchelotte, P.1    Darmaun, D.2    Rongier, M.3
  • 66
    • 0036194103 scopus 로고    scopus 로고
    • Glutamine and heat shock protein expression
    • Wischmeyer PE. Glutamine and heat shock protein expression. Nutrition 2002; 18: 225-8.
    • (2002) Nutrition , vol.18 , pp. 225-228
    • Wischmeyer, P.E.1
  • 67
    • 0038645316 scopus 로고    scopus 로고
    • Glutamine starvation of monocytes inhibits the ubiquitin-proteasome proteolytic pathway
    • Zellner M, Gerner C, Eliasen MM, et al. Glutamine starvation of monocytes inhibits the ubiquitin-proteasome proteolytic pathway. Biochim Biophys Acta 2003; 1638: 138-48.
    • (2003) Biochim Biophys Acta , vol.1638 , pp. 138-48
    • Zellner, M.1    Gerner, C.2    Eliasen, M.M.3
  • 68
    • 39049177827 scopus 로고    scopus 로고
    • Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions
    • Holecek M, Muthny T, Kovarik M, et al. Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions. J Parenter Enteral Nutr 2006; 30: 467-73.
    • (2006) J Parenter Enteral Nutr , vol.30 , pp. 467-73
    • Holecek, M.1    Muthny, T.2    Kovarik, M.3


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