Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions

Journal of Parenteral and Enteral Nutrition

Volumn 30, Issue 6, 2006, Pages 467-473

  Holecek, Milan ^a   Muthny, Tomas ^a   Kovarik, Miroslav ^a   Sispera, Ludek ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUTAMINE;

ANIMAL; ARTICLE; DRUG COMBINATION; DRUG EFFECT; INFUSION; LIVER; MALE; METABOLISM; PROTEIN SYNTHESIS; RANDOMIZATION; RAT; SEPSIS; SKELETAL MUSCLE; SMALL INTESTINE; TREATMENT OUTCOME; WISTAR RAT;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; DRUG THERAPY, COMBINATION; GLUTAMINE; INFUSIONS, PARENTERAL; INTESTINE, SMALL; LIVER; MALE; MUSCLE, SKELETAL; PROTEIN BIOSYNTHESIS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEPSIS; TREATMENT OUTCOME;

EID: 39049177827     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607106030006467     Document Type: Article

References (31)

1. Harper AE, Miller RH, Block KP. Branched-chain amino acid metabolism. Annu Rev Nutr. 1984;4:409-454.
2. James JH. Branched chain amino acids in hepatic encephalopathy. Am J Surg. 2002;183:424-429.
3. Freund HR, Hanani M. The metabolic role of branched-chain amino acids. Nutrition. 2002;18:287-288.
4. Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. 2000;130:2413-2419.
5. De Bandt JP, Cynober LA. Amino acids with anabolic properties. Curr Opin Clin Nutr Metab Care. 1998;1:263-272.
6. Laviano A, Muscaritoli M, Cascino A, et al. Branched-chain amino acids: the best compromise to achieve anabolism? Curr Opin Clin Nutr Metab Care. 2005;8:408-414.
7. Cai JW, Hughes CS, Shen JW, Subjeck JR. Induction of heat-shock proteins by glutamine: the "feeding effect." FEBS Lett. 1991;288:229-232.
8. Wischmeyer PE. Glutamine and heat shock protein expression. Nutrition. 2002;18:225-228.
9. Stehle P, Zander J, Mertes N, et al. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet. 1989;i:231-233.
10. Wernerman J, Hammarqvist F, Vinnars E. α-Ketoglutarate and postoperative muscle catabolism. Lancet. 1990;335:701-703.
11. Newsholme E, Hardy G. Supplementation of diets with nutritional pharmaceuticals. Nutrition. 1997;13:837-839.
12. Holecek M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition. 2002;18:130-133.
13. Darmaun D, Dechelotte P. Role of leucine as a precursor of glutamine alpha-amino nitrogen in vivo in humans. Am J Physiol. 1991;260:E326-E329.
14. Holecek M, Skopec F, Skalska H, Sprongl L. Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats. JPEN J Parenter Enteral Nutr. 2000;24:215-222.
15. 3H]phenylalanine. Biochem J. 1980;192:719-723.
16. Holecek M, Sprongl L, Skopec F, Andrys C, Pecka M. Leucine metabolism in TNF-a- and endotoxin-treated rats: contribution of hepatic tissue. Am J Physiol. 1997;273:E1052-E1058.
17. McNurlan MA, Tomkins AM, Garlick PJ. The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J. 1979;178:373-379.
18. Welle S. Methods for studying protein metabolism in humans. In: Welle S, ed. Human Protein Metabolism. New York, NY: Springer-Verlag; 1999:29-71.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193: 265-275.
20. Wusteman M, Wight DGD, Elia M. Protein metabolism after injury with turpentine: a rat model for clinical trauma. Am J Physiol. 1990;259:E763-E769.
21. Biolo G, Zorat F, Antonione R, Ciocchi B. Muscle glutamine depletion in the intensive care unit. Int J Biochem Cell Biol. 2005;37:2169-2179.
22. Saadane A, Delautier D, Lestriez V, Feldmann G, Lardeux B, Bleiberg-Daniek F. Down-regulation of liver RNA breakdown by turpentine administration in the starved rat: autophagy and relevant factors. Inflamm Res. 1999;48:210-217.
23. Hasebe M, Suzuki H, Mori E, Furukawa J, Kobayashi K, Ueda Y. Glutamate in enteral nutrition: can glutamate replace glutamine in supplementation to enteral nutrition in burned rats? JPEN J Parenter Enteral Nutr. 1999;23(5 suppl):S78-S82.
24. Rutten EP, Engelen MP, Schols AM, Deutz NE. Skeletal muscle glutamate metabolism in health and disease: state of the art. Curr Opin Clin Nutr Metab Care. 2005;8:41-51.
25. Holecek M. Leucine metabolism in fasted and TNF treated rats. Clin Nutr. 1996;15:91-93.
26. 3VS on protein metabolism in septic rats. Int J Exp Pathol. 2004;85:365-371.
27. Baracos VE, Mackenzie ML. Investigations of branched-chain amino acids and their metabolites in animal models of cancer. J Nutr. 2006;136(1 suppl):237S-242S.
28. Rennie MJ, Bohe J, Smith K, Wackerhage H, Greenhaff P. Branched-chain amino acids as fuels and anabolic signals in human muscle. J Nutr. 2006;136(1 suppl):264S-268S.
29. Holecek M., Sprongl L, Tichy M, Pecka M. Leucine metabolism in rat liver after a bolus injection of endotoxin. Metabolism. 1998;47:681-685.
30. Gore DC, Wolfe RR. Glutamine supplementation fails to affect muscle protein kinetics in critically ill patients. JPEN J Parenter Enteral Nutr. 2002;26:342-349.
31. Holecek M, Rysava R, Safranek R, Kadlcikova J, Sprongl L. Acute effects of decreased glutamine supply on protein and amino acid metabolism in hepatic tissue: a study using isolated perfused rat liver. Metabolism. 2003;52:1062-1067.