A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4485-4492

  Higashi, Kiyoshi ^a   Tomigahara, Yoshitaka ^a   Shiraki, Hiroaki ^a   Miyata, Kaori ^a   Mikami, Toshiyuki ^b   Kimura, Toru ^b   Moro, Tadashi ^c,d   Inagaki, Yutaka ^c   Kaneko, Hideo ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Minophagen Pharmaceutical Co   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; BINDING ASSAYS; BINDING PROTEINS; COLLAGEN GENE EXPRESSION; GLUTATHIONE-S-TRANSFERASE; HEPATIC STELLATE CELLS; IMMUNOPRECIPITATIONS; LIVER FIBROSIS; LIVER INJURIES; MAJOR FACTORS; MURINE MODEL; NUCLEAR TRANSLOCATIONS; ORAL ADMINISTRATION; PHARMACOLOGICAL EFFECTS; PROTEOMICS; PULLDOWN ASSAYS; PULMONARY FIBROSIS; TRANSFORMING GROWTH FACTORS;

AMINO ACIDS; CARBON TETRACHLORIDE; COLLAGEN; ENZYME INHIBITION; GENE EXPRESSION REGULATION; LIVER; MOLECULAR BIOLOGY; RESINS;

GENE EXPRESSION;

CARBON TETRACHLORIDE; GLUTATHIONE TRANSFERASE; HSC 025; LIVER PROTECTIVE AGENT; PLACEBO; POLYADENYLIC ACID BINDING PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1; ALKADIENE; COLLAGEN; DNA BINDING PROTEIN; HSC025; MADH3 PROTEIN, RAT; NUCLEAR PROTEIN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; YB 1 PROTEIN, MOUSE; YB-1 PROTEIN, MOUSE; YBX1 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER FIBROSIS; LIVER PROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SIGNAL TRANSDUCTION; STELLATE CELL; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL LIVER CIRRHOSIS; GENE EXPRESSION REGULATION; GENETICS; INTOXICATION; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE; RAT;

MURINAE; MUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ALKADIENES; ANIMALS; CARBON TETRACHLORIDE; CARBON TETRACHLORIDE POISONING; CELL NUCLEUS; COLLAGEN; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LIVER CIRRHOSIS, EXPERIMENTAL; MICE; NUCLEAR PROTEINS; POLY(A)-BINDING PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 79953011983     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.151936     Document Type: Article

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