Discovery of cyclicsulfonamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1065-1069

  Kim, Se Hoan ^a   Ramu, Ravirala ^b   Kwon, Sung Wook ^a   Lee, Su Hee ^b   Kim, Chi Hyun ^b   Kang, Seung Kyu ^b   Rhee, Sang Dal ^b   Bae, Myung Ae ^b   Ahn, Sung Hoon ^b   Ha, Duck Chan ^a   Cheon, Hyae Gyeong ^b   Kim, Ki Young ^b   Ahn, Jin Hee ^b  

^a Korea University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

11 Hydroxysteroid dehydrogenase 1; Cyclic sulfonamide; Diabetes; Inhibitor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; SULFONAMIDE;

ARTICLE; CHEMICAL STRUCTURE; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; COMPARATIVE STUDY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROSOME; MOUSE; PROCEDURES; SYNTHESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CELL LINE; DRUG DISCOVERY; HUMANS; MICE; MICROSOMES; SULFONAMIDES;

EID: 74049154856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.035     Document Type: Article

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