Nanoparticles targeting dendritic cell surface molecules effectively block T cell conjugation and shift response

ACS Nano

Volumn 5, Issue 3, 2011, Pages 1693-1702

  Chittasupho, Chuda ^a   Shannon, Laura ^b   Siahaan, Teruna J ^a   Vines, Charlotte M ^b   Berkland, Cory ^a,c  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c University of Kansas   (United States)

Author keywords

dendritic cells; nanoparticles; peptides; T cell; targeted delivery

Indexed keywords

ANTIGEN PRESENTING CELLS; CYTOKINE PRODUCTION; DENDRITIC CELLS; FREE LIGANDS; GLYCOLIC ACIDS; OVALBUMINS; T CELL ACTIVATION; T CELL PROLIFERATION; T CELLS; T-CELL RESPONSE; TARGETED DELIVERY;

ANTIBODIES; CELL MEMBRANES; CELL PROLIFERATION; PEPTIDES;

NANOPARTICLES;

MEMBRANE PROTEIN; NANOMATERIAL;

ARTICLE; CELL CULTURE; CYTOLOGY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFECT; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; T LYMPHOCYTE;

CELLS, CULTURED; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; HUMANS; MEMBRANE PROTEINS; NANOSTRUCTURES; T-LYMPHOCYTES;

EID: 79952980085     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102159g     Document Type: Article

References (41)

1. Dustin, M. L.; Shaw, A. S. Costimulation: Building an Immunological Synapse Science 1999, 283, 649-650
2. Dustin, M. L. T-Cell Activation through Immunological Synapses and Kinapses Immunol. Rev. 2008, 221, 77-89 (Pubitemid 351230116)
3. Bachmann, M. F.; McKall-Faienza, K.; Schmits, R.; Bouchard, D.; Beach, J.; Speiser, D. E.; Mak, T. W.; Ohashi, P. S. Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation Immunity 1997, 7, 549-557 (Pubitemid 27508706)
4. Van Seventer, G. A.; Shimizu, Y.; Horgan, K. J.; Shaw, S. The LFA-1 Ligand ICAM-1 Provides an Important Costimulatory Signal for T Cell Receptor-Mediated Activation of Resting T Cells J. Immunol. 1990, 144, 4579-4586 (Pubitemid 20224088)
5. Springer, T. A.; Dustin, M. L.; Kishimoto, T. K.; Marlin, S. D. The Lymphocyte Function-Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System Annu. Rev. Immunol. 1987, 5, 223-252
6. Lunsford, K. E.; Koester, M. A.; Eiring, A. M.; Horne, P. H.; Gao, D.; Bumgardner, G. L. Targeting LFA-1 and CD154 Suppresses the In Vivo Activation and Development of Cytolytic (CD4-Independent) CD8+ T Cells J. Immunol. 2005, 175, 7855-7866 (Pubitemid 41798346)
7. Simnick, A. J.; Valencia, A.; Liu, R.; Chilkoti, A. Morphing Low-Affinity Ligands into High-Avidity Nanoparticles by Thermally Triggered Self Assembly of a Genetically Enclosed Polymer ACS Nano 2010, 4, 2217-2227
8. Stukel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R. Two-Step Synthesis of Multivalent Cancer-Targeting Constructs Biomacromolecules 2010, 11, 160-167
9. Hong, A.; Leroueil, P. R.; Majoros, I. J.; Orr, B. G.; Baker, J. R., Jr.; Banaszak Holl, M. M. The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform Chem. Biol. 2007, 14, 107-115 (Pubitemid 46124068)
10. Johnson, R. N.; Kopeckova, P.; Kopecek, J. Synthesis and Evaluation of Multivalent Branched HPMA Copolymer-Fab Conjugates Targeted to the B-Cell Antigen CD20 Bioconjugate Chem. 2009, 20, 129-137
11. Ding, H.; Prodinger, W. M.; Kopecek, J. Identification of CD21-Binding Peptides with Phage Display and Investigation of Binding Properties of HPMA Copolymer-Peptide Conjugates Bioconjugate Chem. 2006, 17, 514-523
12. Carlson, C. B.; Mowery, P.; Owen, R. M.; Dykhuizen, E. C.; Kiessling, L. L. Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions ACS Chem. Biol. 2007, 2, 119-127 (Pubitemid 47490233)
13. Puffer, E. B.; Pontrello, J. K.; Hollenbeck, J. J.; Kink, J. A.; Kiessling, L. L. Activating B Cell Signaling with Defined Multivalent Ligands ACS Chem. Biol. 2007, 2, 252-262 (Pubitemid 47629213)
14. Gordon, E. J.; Sanders, W. J.; Keissling, L. L. Synthetic Ligands Point to Cell Surface Strategies Nature 1998, 392, 30-31 (Pubitemid 28150577)
15. Mowery, P.; Yang, Z. Q.; Gordon, E. J.; Dwir, O.; Spencer, A. G.; Alon, R.; Kiessling, L. L. Synthetic Glycoprotein Mimics Inhibit l -Selectin Mediated Rolling and Promote l -Selectin Shedding Chem. Biol. 2004, 11, 725-732 (Pubitemid 38708841)
16. Lebedeva, T.; Dustin, M. L.; Sykulev, Y. ICAM-1 Co-stimulates Target Cells To Facilitate Antigen Presentation Curr. Opin. Immunol. 2005, 17, 251-258 (Pubitemid 40692659)
17. Hogg, N.; Laschinger, M.; Giles, K.; McDowall, A. T-Cell Integrins: More Than Just Sticking Points J. Cell. Sci. 2003, 116, 4695-4705 (Pubitemid 37541213)
18. Anderson, M. E.; Siahaan, T. J. Targeting ICAM-1/LFA-1 Interaction for Controlling Autoimmune Diseases: Designing Peptide and Small Molecule Inhibitors Peptides 2003, 24, 487-501 (Pubitemid 36561224)
19. Anderson, M. E.; Siahaan, T. J. Mechanism of Binding and Internalization of ICAM-1-Derived Cyclic Peptides by LFA-1 on the Surface of T Cells: A Potential Method for Targeted Drug Delivery Pharm. Res. 2003, 20, 1523-1532 (Pubitemid 37268263)
20. Jois, S. D. S.; Siahaan, T. J. A Peptide Derived from LFA-1 That Modulates T-Cell Adhesion Binds to Soluble ICAM-1 Protein J. Biomol. Struc. Dyn. 2003, 20, 635-644 (Pubitemid 36428063)
21. Tibbetts, S. A.; Seetharama, J. D.; Siahaan, T. J.; Benedict, S. H.; Chan, M. A. Linear and Cyclic LFA-1 and ICAM-1 Peptides Inhibit T Cell Adhesion and Function Peptides 2000, 21, 1161-1167
22. Tibbetts, S. A.; Chirathaworn, C.; Nakashima, M.; Jois, D. S.; Siahaan, T. J.; Chan, M. A.; Benedict, S. H. Peptides Derived from ICAM-1 and LFA-1 Modulate T Cell Adhesion and Immune Function in a Mixed Lymphocyte Culture Transplantation 1999, 68, 685-692 (Pubitemid 29453447)
23. Chittasupho, C.; Manikwar, P.; Krise, J. P.; Siahaan, T. J.; Berkland, C. cIBR Effectively Targets Nanoparticles to LFA-1 on Acute Lymphoblastic T Cells Mol. Pharmaceutics 2010, 7, 146-155
24. Zhang, N.; Chittasupho, C.; Duangrat, C.; Siahaan, T. J.; Berkland, C. PLGA Nanoparticle-Peptide Conjugate Effectively Targets Intercellular Cell-Adhesion Molecule-1 Bioconjugate Chem. 2008, 19, 145-152 (Pubitemid 351213845)
25. Chittasupho, C.; Xie, S.; Baoum, A.; Yakovleva, T.; Siahaan, T. J.; Berkland, C. ICAM-1 Targeting of Doxorubicin-Loaded PLGA Nanoparticles to Lung Epithelial Cells Eur. J. Pharm. Sci. 2009, 37, 141-150
26. Commins, S. P.; Borish, L.; Steinke, J. W. Immunologic Messenger Molecules: Cytokines, Interferons, and Chemokines J. Allergy Clin. Immunol. 2010, 125, S53-72
27. Zhu, J.; Yamane, H.; Paul, W. E. Differentiation of Effector CD4 T Cell Populations Annu. Rev. Immunol. 2010, 28, 445-489
28. Miossec, P.; Korn, T.; Kunchroo, V. K. Interleukin-17 and Type 17 Helper T Cells N. Engl. J. Med. 2009, 361, 888-898
29. Dustin, M. L. A Dynamic View of the Immunological Synapse Semin. Immunol. 2005, 17, 400-410 (Pubitemid 41654692)
30. Dustin, M. L. Modular Design of Immunological Synapses and Kinapses Cold Spring Harbor Perspect. Biol. 2009, 1, a002873
31. Rothlein, R.; Dustin, M. L.; Marlin, S. D.; Springer, T. A. A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1 J. Immunol. 1986, 137, 1270-1274 (Pubitemid 16041114)
32. Dustin, M. L.; Springer, T. A. T-Cell Receptor Cross-Linking Transiently Stimulates Adhesiveness through LFA-1 Nature 1989, 341, 619-624 (Pubitemid 19257309)
33. Muro, S.; Wiewrodt, R.; Thomas, A.; Koniaris, L.; Albelda, S. M.; Muzykantov, V. R.; Koval, M. A Novel Endocytic Pathway Induced by Clustering Endothelial ICAM-1 or PECAM-1 J. Cell. Sci. 2003, 116, 1599-1609 (Pubitemid 36527505)
34. Welder, C. A.; Lee, D. H. S.; Takei, F. Inhibition of Cell Adhesion by Microspheres Coated with Recombinant Soluble ICAM-1 J. Immunol. 1993, 150, 2203-2210 (Pubitemid 23127465)
35. Yoshida, M.; Babensee, J. E. Molecular Aspects of Microparticle Phagocytosis by Dendritic Cells J. Biomater. Sci. Polym. 2006, 17, 893-907
36. Semete, B.; Booysen, L. I. J.; Kalombo, L.; Venter, J. D.; Katata, B.; Ramalapa, J. A.; Verschoor, J. A.; Swai, H. In Vivo Uptake and Acute Immune Response to Orally Administered Chitosan and PEG Coated PLGA Nanoparticles Toxicol. Appl. Pharmacol. 2010, 249, 158-165
37. Molavi, O.; Mahmud, A.; Hamdy, S.; Hung, R. W.; Lai, R.; Samuel, J.; Lavasanifar, A. Development of a Poly(d, l -lactic- co -glycolic acid) Nanoparticle Formulation of STAT3 Inhibitor JSI-124: Implication for Cancer Immunotherapy Mol. Pharmaceutics 2009, 7, 364-374
38. Steenblock, E.; Fahmy, T. M. A Comprehensive Platform for Ex Vivo T Cell Expansion Based on Biodegradable Polymeric Artificial Antigen Presenting Cells Mol. Ther. 2008, 16, 765-772 (Pubitemid 351426179)
39. Lutz, M. B; Kukutsch, N.; Ogilvie, A. L; Rössner, S.; Koch, F.; Romani, N.; Schuler, G. An Advanced Culture Method for Generating Large Quantities of Highly Pure Dendritic Cells from Mouse Bone Marrow J. Immunol. Methods 1999, 223, 77-92 (Pubitemid 29096240)
40. Guerrouache, M.; Karakasyan, C.; Gaillet, C.; Canva, M.; Millot, M. C. Immobilization of a Functionalized Poly(ethylene glycol) onto β-Cyclodextrin-Coated Surfaces by Formation of Inclusion Complexes: Application to the Coupling of Proteins J. Appl. Polym. Sci. 2006, 100, 2362-2370
41. Vines, C. M.; Potter, J. W.; Xu, Y.; Geahlen, R. L.; Costello, P. S.; Tybulewicz, V. L.; Lowell, C. A.; Chang, P. W.; Gresham, H. D.; Willman, C. L. Inhibition of Beta 2 Integrin Receptor and Syk Kinase Signaling in Monocytes by The Src Family Kinase Fgr Immunity 2001, 15, 507-519 (Pubitemid 33016437)