Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer

ACS Nano

Volumn 4, Issue 4, 2010, Pages 2217-2227

  Simnick, Andrew J ^a   Valencia, C Alexander ^b   Liu, Rihe ^b   Chilkoti, Ashutosh ^a  

^a Duke University   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Block copolymer; Ligand receptor; Multivalency; Polypeptide; Self assembly

Indexed keywords

A-THERMAL; AFFINITY LIGANDS; AFFINITY MODULATION; ANTIBODY-ANTIGEN; BIO-INSPIRED MATERIALS; CELLULAR UPTAKE; DIBLOCK COPOLYMER; ELASTIN-LIKE POLYPEPTIDES; FUTURE APPLICATIONS; HYDROPHOBIC SEGMENT; IMAGING AGENT; IN-VITRO; LIGAND-RECEPTOR; LOW LEVEL; MEDIATED INTERACTION; MEMBRANE RECEPTORS; MORPHING; MULTIPLE LIGANDS; MULTIPLE RECEPTORS; MULTIVALENCY; MULTIVALENT INTERACTIONS; MULTIVALENT LIGANDS; NANO SCALE; NANOSCALE ARCHITECTURES; RATIONAL DESIGN PARAMETERS; RECEPTOR EXPRESSION; RECEPTOR INTERACTION; SELF-ASSEMBLE; TARGETED DELIVERY; TARGETED DRUG DELIVERY;

BLOCK COPOLYMERS; CELL MEMBRANES; COPOLYMERIZATION; CYTOLOGY; DAMS; DRUG DELIVERY; DRUG INTERACTIONS; MICELLES; NANOSTRUCTURED MATERIALS; POLYPEPTIDES; SELF ASSEMBLY; VIRUSES;

LIGANDS;

ELASTIN; LIGAND; NANOPARTICLE; PEPTIDE; VITRONECTIN RECEPTOR;

ARTICLE; CELL STRAIN K 562; CHEMISTRY; GENETICS; HUMAN; HYDROPHOBICITY; METABOLISM; MICELLE; TEMPERATURE;

ELASTIN; HUMANS; HYDROPHOBICITY; INTEGRIN ALPHAVBETA3; K562 CELLS; LIGANDS; MICELLES; NANOPARTICLES; PEPTIDES; TEMPERATURE;

EID: 77951723418     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn901732h     Document Type: Article

References (26)

1. Ehrlich, P. Collected Studies on Immunity; John Wiley & Sons: New York, 1906.
2. Adams, G. P.; Schier, R.; McCall, A. M.; Simmons, H. H.; Horak, E. M.; Alpaugh, R. K.; Marks, J. D.; Weiner, L. M. High Affinity Restricts the Localization and Tumor Penetration of Single-Chain Fv Antibody Molecules Cancer Res. 2001, 4750-4755
3. Caplan, M. R.; Rosca, E. V. Targeting Drugs to Combinations of Receptors: A Modeling Analysis of Potential Specificity Ann. Biomed. Eng. 2005, 1113-1124
4. Mauriz, J. L.; Gonzalez-Gallego, J. Antiangiogenic Drugs: Current Knowledge and New Approaches to Cancer Therapy J. Pharm. Sci. 2008, 4129-4154
5. Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors Angew. Chem., Int. Ed. 1998, 2754-2974
6. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 751-760
7. Meyer, D. E.; Chilkoti, A. Genetically Encoded Synthesis of Protein-Based Polymers with Precisely Specified Molecular Weight and Sequence by Recursive Directional Ligation: Examples from the Elastin-like Polypeptide System Biomacromolecules 2002, 357-367
8. Urry, D. W. Free Energy Transduction in Polypeptides and Proteins Based on Inverse Temperature Transitions Prog. Biophys. Mol. Biol. 1992, 23-57
9. Urry, D. W. Physical Chemistry of Biological Free Energy Transduction as Demonstrated by Elastic Protein-Based Polymers' J. Phys. Chem. B 1997, 11007-11028
10. Dreher, M. R.; Simnick, A. J.; Fischer, K.; Smith, R. J.; Patel, A.; Schmidt, M.; Chilkoti, A. Temperature Triggered Self-Assembly of Polypeptides into Multivalent Spherical Micelles J. Am. Chem. Soc. 2008, 687-694
11. Lee, T. A. T.; Cooper, A.; Apkarian, R. P.; Conticello, V. P. Thermo-Reversible Self-Assembly of Nanoparticles Derived from Elastin-Mimetic Polypeptides Adv. Mater. 2000, 1105-1110
12. Meyer, D. E.; Chilkoti, A. Purification of Recombinant Proteins by Fusion with Thermally-Responsive Polypeptides Nat. Biotechnol. 1999, 1112-1115
13. Koivunen, E.; Gay, D. A.; Ruoslahti, E. Selection of Peptides Binding to the α5β1 Integrin from Phage Display Library J. Biol. Chem. 1993, 20205-20210
14. 3 Integrin. Adhesion Mechanism for Transformed Glial Cells J. Clin. Invest. 1991, 1924-1932
15. 3 Expression on Tumor-Associated Vessels of Human Carcinomas Int. J. Cancer 1997, 320-324
16. Lindemann, S.; Kramer, B.; Seizer, P.; Gawaz, M. Platelets, Inflammation and Atherosclerosis J. Thromb. Haemostasis 2007, 203-211
17. 3-Integrin-Targeted Nanoparticles Circulation 2003, 2270-2274
18. Vagnucci, A. H.; Li, W. W. Alzheimer's Disease and Angiogenesis The Lancet 2003, 605-608
19. Ruoslahti, E. Rgd and Other Recognition Sequences for Integrins Annu. Rev. Cell Dev. Biol. 1996, 697-715
20. Giancotti, F. G.; Ruoslahti, E. Integrin Signaling Science 1999, 1028-1033
21. Dreher, M. R.; Raucher, D.; Balu, N.; Michael Colvin, O.; Ludeman, S. M.; Chilkoti, A. Evaluation of an Elastin-like Polypeptide-Doxorubicin Conjugate for Cancer Therapy J. Controlled Release 2003, 31-43
22. Maheshwari, G.; Brown, G.; Lauffenburger, D. A.; Wells, A.; Griffith, L. G. Cell Adhesion and Motility Depend on Nanoscale Rgd Clustering J. Cell. Sci. 2000, 1677-1686
23. 1 J. Cell Biol. 1994, 1129-1137
24. Raucher, D.; Chilkoti, A. Enhanced Uptake of a Thermally Responsive Polypeptide by Tumor Cells in Response to Its Hyperthermia-Mediated Phase Transition Cancer Res. 2001, 7163-7170
25. Maheshwari, G.; Brown, G.; Lauffenburger, D. A.; Wells, A.; Griffith, L. G. Cell Adhesion and Motility Depend on Nanoscale Rgd Clustering J. Cell Sci. 2000, 1677-1686
26. Urano, M. Invited Review: For the Clinical Application of Thermochemotherapy Given at Mild Temperatures Int. J. Hypertherm. 1999, 79-107