Antioxidants and diabetes mellitus: Review of the evidence;Antioxidantes y diabetes mellitus: Revisión de la evidencia

Nutricion Hospitalaria

Volumn 26, Issue 1, 2011, Pages 68-78

  Cuerda, C ^a   Luengo, L M ^b   Valero, M A ^c   Vidal, A ^d   Burgos, R ^e   Calvo, F L ^f   Martinez C ^g  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL INFANTA CRISTINA   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d Complejo Asistencial Universitario de León   (Spain)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^g HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Antioxidant; Diabetes mellitus; Oxidative stress; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; VITAMIN;

DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; HUMAN; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANTIOXIDANTS; ASCORBIC ACID; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHIES; HUMANS; OXIDATIVE STRESS; VITAMIN E; VITAMINS;

EID: 79952967970     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2011.26.1.5115     Document Type: Review

References (74)

1. Evans JL, Goldfine IP, Maddus BA, Grodsky GM. Are oxidative stress-activated signalling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003; 52: 1-8. (Pubitemid 36042100)
2. Robertson R, Harmon J, Oanh P, Poitout V. Beta cell glucose toxicity, lipotoxicity and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 53 (Suppl. 1): S119-24. (Pubitemid 38168703)
3. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996; 19: 257-67. (Pubitemid 26070354)
4. Orasanu G, Plutzky J. The pathologic continuum of diabetes vascular disease. J Am Coll Cardiol 2009; 53 (5 Suppl.): S35-42.
5. Yu Y, Lyons TJ. A lethal tread in diabetes, hyperglucemia, dyslipemia, oxidative stress and endothelial dysfunction. Am J Med Sci 2005; 330: 227-32. (Pubitemid 41689451)
6. Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008; 57: 1446-54.
7. Brown AA, Hu FB. Dietary modulation on endothelial function: implications for cardiovascular disease. Am J Clin Nutr 2001; 71: 673-86. (Pubitemid 32239221)
8. Ceriello A, Testa R. Antioxidant anti-inflammatory treatment in type 2 diabetes. Diabetes Care 2009; 32: S32-6.
9. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004; 24: 816-23. (Pubitemid 38620857)
10. Stamper MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993; 328: 1444-9. (Pubitemid 23143846)
11. Rimm EB, Stamper MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993; 328: 1450-60.
12. Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromma A. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994; 139: 1180-9. (Pubitemid 24184411)
13. Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu J, Bostick RM. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996; 334: 115-62.
14. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiolgic Studies of the Elderly. Am J Clin Nutr 1996; 64: 190-6. (Pubitemid 26250838)
15. Lee IM, Cook NR, Gaziano JM et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005; 294: 56-65. (Pubitemid 41002839)
16. Stephens NG, Parsons A, Schoefield PM et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996; 347: 781-6. (Pubitemid 26091640)
17. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results from the GISSI-Prevenzione trial. Lancet 1999; 354: 447-55.
18. HOPE investigators. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med 2000; 342: 154-60.
19. The HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer. A randomized controlled trial. JAMA 2005; 293: 1338-47.
20. Liu S, Lee I, Song Y, et al. Vitamin E and risk of type 2 diabetes in the Women's Health Study Randomized Control Trial. Diabetes 2006; 55: 2856-62. (Pubitemid 44923687)
21. Devaraj S, Li D, Jialal I. The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1beta, and monocyte adhesion to endothelium. J Clin Invest 1996; 98: 756-63. (Pubitemid 26349181)
22. Davi G, Romano M, Mezzetti A et al. Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 1998; 97: 953-7. (Pubitemid 28125466)
23. Devaraj S, Cahan AV, Jialal J. Alpha-tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients. Diabetes Care 2002.
24. Simons LA, von Konigsmark M, Simons J, Stocker R, Celermajer DS. Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults. Atherosclerosis 1999; 143: 193-9. (Pubitemid 29138718)
25. Kugiyama K, Motoyama T, Doi H et al. Improvement of endothelial vasomotor disfunction by treatment with alphatocopherol in patients with high remmant lipoproteins levels. J Am Coll Cardiol 1999; 33: 1512-8
26. Neunteufl T, Priglinger U, Heher S et al. Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. J Am Coll Cardiol 2000; 35: 277-83. (Pubitemid 30125514)
27. Motoyama T, Kawano H, Kugiyama K et al. Vitamin E administration improves impairment of endothelium-dependent vasodilatation in patients with coronary spastic angina. J Am Coll Cardiol 1998; 32: 1672-9. (Pubitemid 28545207)
28. Skyrme-Jones RA, O'Brien RC, Barry KL, Meredith IT. Vitamin E supplementation improves endothelial function in type 1 diabetes mellitus: a randomized, placebo-controlled study. J Am Coll Cardiol 2000; 36: 94-102. (Pubitemid 30466118)
29. Economides PA, Khaodhiar L, Caselli A et al. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in Type 1 and type 2 diabetic patients. Diabetes 2005; 54: 204-11.
30. Paolisso G et al. Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type 2 diabetic patients. JCEM 2000; 85: 109-15. (Pubitemid 32268799)
31. Clarke et al. Supplementation with mixed tocopherols increases blood serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. Am J Clin Nutr 2006; 83: 94-102.
32. Gisinger C, Jeremy J, Mikhailidis D, et al. Effect of vitamin E supplementation on platelet thromboxane A2 production in type 1 diabetic patients. Double-blind crossover trial. Diabetes 1988; 37 (9): 1260-4. (Pubitemid 19035059)
33. Colette C, Pares-Herbute N, Monnier L, Cartry E. Platelet function in type I diabetes: effect of supplementation with large doses of vitamin E. Am J Clin Nutr 1988; 47: 256-61. (Pubitemid 18091573)
34. Manzella D, Barbieri M, Ragno E, Paolisso G. Chronic administration of pharmacological doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes. Am J Clin Nutr 2001; 73 (6): 1052-7. (Pubitemid 32496944)
35. Wu JH, Ward NC, Indrawan AP et al. Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clinical Chemistry 2007.
36. Engelen W, Keenoy BM, Vertommen J, De Leeuw I. Effects of long-term supplementation with moderate pharmacologic doses of vitamin E are saturable and reversible in patients with type 1 diabetes. Am J Clin Nutr 2000; 72: 1142-9.
37. Ward NC, Wu JHY, Clarke MW et al. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens 2007; 25: 227-34. (Pubitemid 44885685)
38. Park S, Choi SB. Effects of alpha tocoferol supplementation and continuous subcutaneous insulin infusion on oxidative stress in Korean patients with type 2 diabetes. Am J Clin Nutr 2002; 75: 728-33. (Pubitemid 34250687)
39. Fuller CJ, Chandalia M, Garg A, Grundy SM, Jialal I. RRRalpha- tocopheryl acetate supplementation at pharmacologic doses decreases low-density- lipoprotein oxidative susceptibil- ity but not protein glycation in patients with diabetes mellitus. Am J Clin Nutr 1996; 63 (5): 753-9. (Pubitemid 26126596)
40. Ble-Castillo JL, Carmona-Diaz E, Mendez JD, et al. Effect of alpha-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics. Biomedicine & Pharmacotherapy 2005.
41. Mark SD, Wang W, Fraumeni JF Jr et al. Do nutritional supplements lower the risk of stroke or hypertension? Epidemiology 1998; 9: 9-15. (Pubitemid 28030484)
42. Hercberg S, Galan P, Preziosi P et al. The SUVIMAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamin and minerals. Arch Intern Med 2004; 164: 2335-42. (Pubitemid 39532244)
43. Virtamo J, Rapola JM, Ripatti S et al. Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease. Arch Intern Med 1998; 158: 668-75. (Pubitemid 28144826)
44. Heart Protection Study collaborative group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomized placebo-controlled trial. The Lancet 2002; 360 (6): 23-33.
45. Belch J, MacCuish A, Campbell I et al. The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease. BMJ 2008; 337: a1840 doi:10.1136/bmj.a1840.
46. Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effects of vitamin C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled study. Am J Clin Nutr 2009; 90: 429-37.
47. Czernichov S, Couthouis A, Bertrais S, et al. Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SUVIMAX) study in France: association with dietary intake and plasma concentrations. Am J Clin Nutr 2006; 84: 395-9. (Pubitemid 44699151)
48. Seljeflot I, Arnesen H, Brude IR, Nenseter MS, Drevon CA, Hjermann I. Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers. Eur J Clin Invest 1998; 28: 629-35. (Pubitemid 28380359)
49. Neri S, Signorelli SS, Torrissi B et al. Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls. Clinical therapeutics 2005; 27 (11): 1764-73. (Pubitemid 41815227)
50. Nappo F, Esposito K, Cioffi M et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 2002; 39: 1145-50. (Pubitemid 34267417)
51. Chui MH, Greenwood CE. Antioxidant vitamins reduce acute meal-induced memory deficits in adults with type 2 diabetes. Nutrition Research 2008; 28: 423-9. (Pubitemid 351802291)
52. Anderson JW, Gowri MS, Turner J et al. Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with type 2 diabetes mellitus. J Am Coll Nutrition 1999; 18: 451-61. (Pubitemid 29455718)
53. Vincent HK, Bourguignon CM, Weltman AL et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism Clinical and Experimental 2009; 58: 254-62.
54. Pohl M, Mayr P, Mert-Roetzer M et al. Glycemic control in patients with type 2 diabetes with a disease-specific enteral formula: Stage II of a randomized, controlled multicenter trial. JPEN 2009; 33: 37-49.
55. Liu S, Ajan U, Chae C, Hennekens C, Buring JE, Manson JE. Long-term beta-carotene supplementation and risk of type 2 diabetes mellitus: a randomized controlled trial. JAMA 1999; 282 (11): 1073-5. (Pubitemid 29436456)
56. Stranges S, Marshall JR, Natarajan R et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Arch Intern Med 2007; 147 (4): 217-23. (Pubitemid 351664577)
57. Brown AA, Hu FB. Dietary modulation of endothelial function: implications for cardiovascular disease. Am J Clin Nutr 2001; 73: 673-86. (Pubitemid 32239221)
58. Weber C, Erl W, Weber K,Weber PC. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation 1996; 93: 1488-92. (Pubitemid 26115411)
59. Anderson RA, Evans LM, Ellis GR et al. Prolonged deterioration of endothelial dysfunction in response to postprandial lipemia is attenuated by vitamin C in Type 2 diabetes. Diabet Med 2006; 23 (3): 258-64.
60. Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM, Anderson RA. Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr 2003; 22 (4): 316-21. (Pubitemid 36927768)
61. Cheng HH, Lai MH, Hou WC, Huang CL. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. J Agric Food Chem 2004; 52 (5): 1385-9.
62. Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am Coll Nutr 2001; 20 (3): 212-8. (Pubitemid 32606167)
63. Neyestani TR, Shariatzadeh N, Gharavi A, Kalayi A, Khalaji N. Physiological dose of lycopene suppressed oxidative stress and enhanced serum levels of immunoglobulin M in patients with Type 2 diabetes mellitus: a possible role in the prevention of long-term complications. J Endocrinol Invest 2007; 30 (10): 833-8. (Pubitemid 351166305)
64. Mittermayer F, Pleiner J, Francesconi M, Woltz M. Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus. Transl Res 2010; 155 (1): 6-9.
65. Hornig B, Arakawa N, Kohler C, Drexler H. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998; 97: 363-8. (Pubitemid 28074337)
66. Gocke N, Keaney JF, Frei B et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999; 99: 3234-40. (Pubitemid 29293432)
67. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999; 99:1156-60. (Pubitemid 29120086)
68. Raitakari OT, Adams MR, McCredie RJ, Griffiths KA, Stocker R, Celermajer DS. Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. J Am Coll Cardiol 2000; 35: 1616-21. (Pubitemid 30307508)
69. Drossos GE, Toumpoulis IK, Katritsis DG et al. Is vitamin C superior to diltiazem for radial artery vasodilatation in patients awaiting coronary artery bypass grafting? J Thorac Cardiovasc Surg 2003; 125 (2): 330-5. (Pubitemid 36228310)
70. Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilatation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997; 95: 2617-22. (Pubitemid 27255489)
71. Lu Q, BjÖrkhem I, Wretlind B, Diczfalusy U, Henriksson P, Freyschuss A. Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study. Clin Sci (Lond) 2005; 108 (6): 507-13. (Pubitemid 40827558)
72. Anderson RA, Cheng N, Bryden NA et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997; 46 (11): 1786-91. (Pubitemid 27456412)
73. Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci 2007; 333 (3): 145-53. (Pubitemid 47181613)
74. Levy Y, Zaltsberg H, Ben-Amotz A, Kanter Y, Aviram M. Dietary supplementation of a natural isomer mixture of betacarotene inhibits oxidation of LDL derived from patients with diabetes mellitus. Ann Nutr Metab 2000; 44 (2): 54-60.