Long-term β-carotene supplementation and risk of type 2 diabetes mellitus: A randomized controlled trial

JAMA

Volumn 282, Issue 11, 1999, Pages 1073-1075

  Liu, Simin ^a   Ajani, Umed ^b   Chae, Claudia ^b   Hennekens, Charles ^b   Buring, Julie E ^b   Manson, JoAnn E ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; BETA CAROTENE; CAROTENOID; MULTIVITAMIN; PLACEBO;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FOLLOW UP; HUMAN; HUMAN EXPERIMENT; INCIDENCE; LONG TERM CARE; MALE; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHYSICIAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK; UNITED STATES;

EID: 0033568481     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.282.11.1073     Document Type: Article

References (18)

1. Paolisso G, D'Amore A, Di Maro G, et al. Evidence for a relationship between free radicals and insulin action in the elderly. Metabolism. 1993;42:659-663.
2. Golay A, Felber J. Evolution from obesity to diabetes. Diabet Metab. 1994;20:3-14.
3. Oberley LW. Free radicals and diabetes. Free Radic Biol Med. 1988;5:113-124.
4. Krinsky NI. Actions of carotenoids in biological systems. Ann Rev Nutr. 1993;13:561-587.
5. Burton GW, Ingold KU. Beta-carotene: an unusual type of lipid antioxidant. Science. 1984;224: 569-573.
6. Paolisso D, D'Amore A, Ceriello A, Varrichio M, D'Onofrio F. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr. 1993; 57:650-656.
7. Ford ES, Will JC, Bowman BA, Narayan KM. Diabetes mellitus and serum carotenoids: findings from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 1999;149:168-176.
8. Colditz G, Manson J, Stampfer M, Rosner B, Willett W, Speizer F. Diet and risk of clinical diabetes in women. Am J Clin Nutr. 1992;55:1018-1023.
9. Feskens EJ, Virtanen SM, Rasanen L, et al. Dietary factors determining diabetes and impaired glucose tolerance. Diabetes Care. 1995;18:1104-1112.
10. Snowdon DA, Phillips RL. Does a vegetarian diet reduce the occurrence of diabetes? Am J Public Health. 1985;75:507-512.
11. Pan X, Cao H, Li G, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. Diabetes Care. 1997;20:537-544.
12. Rothman KJ, Greenland S. Modern Epidemiology, 2nd ed. Philadelphia, Pa: Lippincott-Raven Publishers; 1998.
13. Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing Physicians' Health Study. N Engl J Med. 1989;321:129-135.
14. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334:1145-1149.
15. Satterfield S, Greco P, Goldhaber S, et al. Biochemical markers of compliance in the Physicians' Health Study. Am J Prev Med. 1990;6:290-294.
16. Manson JE, Rimm EB, Stampfer MJ, et al. A prospective study of physical activity and the incidence of non-insulin-dependent diabetes mellitus in women. Lancet. 1991;338:774-778.
17. Rock C, Jahnke M, Gorenflo D, Swartz R, Messana J. Racial group differences in plasma concentrations of antioxidant vitamins and carotenoids in hemodialysis patients. Am J Clin Nutr. 1997;65:844-850.
18. Reunanen A, Knekt P, Aaran RK, Aromaa A. Serum antioxidants and risk of non-insulin dependent diabetes mellitus. Eur J Clin Nutr. 1998;52:89-93.