Modelling and simulation of [18F]fluoromisonidazole dynamics based on histology-derived microvessel maps

Physics in Medicine and Biology

Volumn 56, Issue 7, 2011, Pages 2045-2057

  Mönnich, David ^a   Troost, Esther G C ^b   Kaanders, Johannes H A M ^b   Oyen, Wim J G ^b   Alber, Markus ^a   Thorwarth, Daniela ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSCOPIC MODELS; MICROSCOPIC PROCESS; MICROSCOPIC SCALE; MODELLING AND SIMULATIONS; MOLECULAR DISTRIBUTION; PARAMETER VALUES; PET DATA; REACTION DIFFUSION EQUATIONS; SIGNAL VARIABILITY; TIME-ACTIVITY CURVES; TISSUE OXYGENATION; TRACER MOLECULES; TWO DIMENSIONAL FINITE ELEMENT METHOD; VESSEL STRUCTURE;

COMPUTER SIMULATION; FINITE ELEMENT METHOD; HISTOLOGY; LINEAR EQUATIONS; OXYGEN; OXYGENATION; PARTIAL DIFFERENTIAL EQUATIONS;

POSITRON EMISSION TOMOGRAPHY;

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; DIAGNOSTIC AGENT; DRUG DERIVATIVE; MISONIDAZOLE; OXYGEN;

ANOXIA; ARTICLE; BIOLOGICAL MODEL; CYTOLOGY; DIFFUSION; FINITE ELEMENT ANALYSIS; METABOLISM; MICROVASCULATURE; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; STAINING;

ANOXIA; DIFFUSION; FINITE ELEMENT ANALYSIS; MICROVESSELS; MISONIDAZOLE; MODELS, BIOLOGICAL; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; STAINING AND LABELING;

EID: 79952950570     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/7/009     Document Type: Article

References (51)

1. Alber M, Paulsen F, Eschmann S M and Machulla H J 2003 On biologically conformal boost dose optimization Phys. Med. Biol. 48 N31-5
2. Bentzen S M 2005 Theragnostic imaging for radiation oncology: dose-painting by numbers Lancet. Oncol. 6 112-7 (Pubitemid 40197705)
3. Boucher Y and Jain R K 1992 Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse Cancer Res. 52 5110-4
4. Bowen S R, Flynn R T, Bentzen S M and Jeraj R 2009 On the sensitivity of IMRT dose optimization to the mathematical form of a biological imaging-based prescription function Phys. Med. Biol. 54 1483-501
5. Brizel D M, Klitzman B, Cook J M, Edwards J, Rosner G and Dewhirst M W 1993 A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model Int. J. Radiat. Oncol. Biol. Phys. 25 269-76 (Pubitemid 23048779)
6. Busk M, Horsman M R, Jakobsen S, Hansen K V, Bussink J, van der Kogel A and Overgaard J 2009 Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast? Radiother. Oncol. 92 429-36
7. Bussink J, Kaanders J H A M, Rijken P F J W, Raleigh J A and van der Kogel A J 2000 Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line Radiat. Res. 153 398-404 (Pubitemid 30185392)
8. Casciari J J, Graham M M and Rasey J S 1995 A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data Med. Phys. 22 1127-39
9. Chao K S et al 2001 A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity- modulated radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 49 1171-82 (Pubitemid 32184623)
10. Cowan D S M, Hicks K O and Wilson W R 1996 Multicellular membranes as an in vitro model for extravascular diffusion in tumours Br. J. Cancer 74 S28-31
11. 64Cu-ATSM for sub-target volume delineation in radiotherapy Phys. Med. Biol. 55 681-94
12. Dau A, Toma-Dau I and Karlsson M 2003 Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia Phys. Med. Biol. 48 2829-42 (Pubitemid 37121463)
13. Dehdashti D, Grigsby P W, Aintun M A, Lewis J S, Siegel B A and Welch M 2003 Assessing tumour hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report Int. J. Radiat. Oncol. Biol. Phys. 55 1233-8 (Pubitemid 36338289)
14. Dewhirst M W 1998 Concepts of oxygen transport at the microcirculatory level Semin. Radiat. Oncol. 8 143-50 (Pubitemid 28323473)
15. Eggleton C D, Vadapalli A, Roy T K and Popel A S 2000 Calculations of intracapillary oxygen tension distributions in muscle Math. Biosci. 167 123-43
16. Eschmann S-M, Paulsen F, Reimold M, Dittmann H, Welz S, Reischl G, Machulla H-J and Bares R 2005 Prognostic impact of hypoxia imaging with 18F-Misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy J. Nucl. Med. 46 253-60 (Pubitemid 43073432)
17. Goldman D 2008 Theoretical models of microvascular oxygen transport to tissue Microcirculation 15 795-811
18. Höckel M, Knoop C, Schlenger K, Vorndran B, Knapstein P G and Vaupel P 1993 Intratumoural pO2 predicts survival in advanced cancer of the uterine cervix Radiother. Oncol. 26 45-50 (Pubitemid 23063609)
19. Jain R K 1987a Transport of molecules across tumour vasculature Cancer Metastasis. Rev. 6 559-93
20. Jain R K 1987b Transport of molecules in the tumor interstitium: a review Cancer Res. 47 3039-51 (Pubitemid 17082621)
21. Jain R K 1988 Determinants of tumor blood flow: a review Cancer Res. 48 2641-58
22. Kelly C J and Brady M 2006 A model to simulate tumour oxygenation and dynamic [18F]-Fmiso PET data Phys. Med. Biol. 51 5859-73 (Pubitemid 46217672)
23. Koh W-J, Rasey J S, Evans M L, Grierson J R, Lewellen T K, Graham M M, Krohn K A and Griffin T W 1992 Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole Int. J. Radiat. Oncol. Biol. Phys. 22 199-212
24. Komar G, Seppanen M, Eskola O, Lindholm P, Gronroos T J, Forsback S, Sipila H, Evans S M, Solin O and Minn H 2008 18F-EF5: a new pet tracer for imaging hypoxia in head and neck cancer J. Nucl. Med. 49 1944-51
25. Ling C C, Humm J, Larson S, Amols H, Fuks Z, Leibel S and Koutcher J A 2000 Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality Int. J. Radiat. Oncol. Biol. Phys. 47 551-60 (Pubitemid 30317470)
26. Ljungkvist A S E, Bussink J, Rijken P F J W, Kaanders J H A M, van der Kogel A J and Denekamp J 2002 Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas Int. J. Radiat. Oncol. Biol. Phys. 54 215-28
27. Mahy P, Geets X, Lonneux M, Levque P, Christian N, De Bast M, Gillart J, Labar D, Lee J and Grgoire V 2008 Determination of tumour hypoxia with [18F]EF3 in patients with head and neck tumours: a phase I study to assess the tracer pharmacokinetics, biodistribution and metabolism Eur. J. Nucl. Med. Mol. Imaging. 35 1282-9
28. Mees G, Dierckx R, Vangestel C and Van de Wiele C 2009 Molecular imaging of hypoxia with radiolabelled agents Eur. J. Nucl. Med. Mol. Imaging 36 1674-86
29. Nordsmark M et al 2005 Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. an international multi-center study Radiother. Oncol. 77 18-24 (Pubitemid 41503384)
30. Piert M et al 2005 Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside J. Nucl. Med. 46 106-13 (Pubitemid 43086004)
31. Pogue B W, O'Hara J A, Wilmot C M, Paulsen K D and Swartz H M 2001 Estimation of oxygen distribution in RIF-1 tumors by diffusion model-based interpretation of pimonidazole hypoxia and eppendorf measurements Radiat. Res. 155 15-25 (Pubitemid 32125735)
32. Popel A S 1989 Theory of oxygen transport to tissue Crit. Rev. Biomed. Eng. 17 257-321
33. Rasey J S, Koh W J, Evans M L, Peterson L M, Lewellen T K, Graham M M and Krohn K A 1996 Quantifying regional hypoxia in human tumours with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients Int. J. Radiat. Oncol. Biol. Phys. 36 417-28
34. Rasey J S, Koh W-J, Grierson J R, Grunbaum Z and Krohn K A 1989 Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia Int. J. Radiat. Oncol. Biol. Phys. 17 985-91 (Pubitemid 19279502)
35. Rijken P F, Bernsen H J, Peters J P, Hodgkiss R J, Raleigh J A and van der Kogel A J 2000 Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis Int. J. Radiat. Oncol. Biol. Phys. 48 571-82
36. Schindler F J 1964 Oxygen kinetics in the cytochrome oxidase-oxygen reaction PhD Thesis University of Pennsylvania
37. Secomb T W, Hsu R, Park H. E Y and Dewhirst M W 2004 Green's function methods for analysis of oxygen delivery to tissues by microvascular networks Ann. Biomed. Eng. 32 1519-29 (Pubitemid 40044498)
38. 18F-FAZA PET in head and neck cancer patients: a pilot study Eur. J. Nucl. Med. Mol. Imaging 34 1566-75 (Pubitemid 47476913)
39. Søvik, Malinen E and Olsen D R 2009 Strategies for biologic image-guided dose escalation: a review Int. J. Radiat. Oncol. Biol. Phys. 73 650-8
40. Stohrer M, Boucher Y, Stangassinger M and Jain R K 2000 Oncotic pressure in solid tumors is elevated Cancer Res. 60 4251-5 (Pubitemid 30636613)
41. Tannock I F 1972 Oxygen diffusion and the distribution of cellular radiosensitivity in tumours Br. J. Radiol. 45 515-24
42. Thomlinson R H and Gray L H 1955 The histological structure of some human lung cancers and the possible implications for radiotherapy Br. J. Cancer. 9 539-49
43. Thorwarth D, Eschmann S M, Paulsen F and Alber M 2005b A kinetic model for dynamic 18F-Fmiso PET data to analyse tumour hypoxia Phys. Med. Biol. 50 2209-24 (Pubitemid 40767811)
44. Thorwarth D, Eschmann S M, Scheiderbauer J, Paulsen F and Alber M 2005a Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer Bio. Med. Cent. Cancer 5 152-60
45. Thorwarth D, Eschmann S M, Paulsen F and Alber M 2007 Hypoxia dose painting by numbers: a planning study Int. J. Radiat. Oncol. Biol. Phys. 68 291-300 (Pubitemid 46589864)
46. Thorwarth D, Geets X and Paiusco M 2010 Physical radiotherapy treatment planning based on functional PET/CT data Radiother. Oncol. 96 317-24
47. Toma-Dau I, Dau A and Brahme A 2009 Dose prescription and optimisation based on tumour hypoxia Acta. Oncol. 48 1181-92
48. 18F]HX4: a phase I trial Eur. J. Nucl. Med. Mol. Imaging 37 1663-8
49. Vaupel P 2004 Tumor microenvironmental physiology and its implication for radiation oncology Semin. Radiat. Oncol. 14 198-206 (Pubitemid 38903223)
50. Wang W, Lee N Y, Georgi J-C, Narayanan M, Guillem J, Schoder H and Humm J L 2010 Pharmacokinetic analysis of hypoxia 18F-Fluoromisonidazole dynamic PET in head and neck cancer J. Nucl. Med. 51 37-45
51. Wang W et al 2009 Evaluation of a compartmental model for estimating tumor hypoxia via FMISO dynamic PET imaging Phys. Med. Biol. 54 3083-99