The relationship between the serum free light chain assay and serum immunofixation electrophoresis, and the definition of concordant and discordant free light chain ratios

Blood

Volumn 114, Issue 1, 2009, Pages 38-39

  Singhal, Seema ^a   Vickrey, Eric ^a   Krishnamurthy, Jairam ^a   Singh, Veerpal ^a   Allen, Sharon ^a   Mehta, Jayesh ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; PARAPROTEIN;

ARTICLE; BLOOD; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOLOGY; METHODOLOGY; MULTIPLE MYELOMA; PROTEIN ELECTROPHORESIS; REMISSION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; STATISTICS; TUMOR VOLUME;

BLOOD PROTEIN ELECTROPHORESIS; HUMANS; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN LIGHT CHAINS; MULTIPLE MYELOMA; MYELOMA PROTEINS; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TUMOR BURDEN;

EID: 67651046994     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-02-205807     Document Type: Article

References (7)

1. Drayson M, Tang LX, Drew R, Mead GP, Carr-Smith H, Bradwell AR. Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood. 2001;97(9):2900-2902.
2. Katzmann JA, Abraham RS, Dispenzieri A, Lust JA, Kyle RA. Diagnostic performance of quantitative kappa and lambda free light chain assays in clinical practice. Clin Chem. 2005;51:878-881.
3. Moesbauer U, Schieder H, Renges H, Ayuk F, Zander A, Kröger N. Serum free light chain [FLC] assay in multiple myeloma patients who achieved negative immunofixation after allogeneic stem cell transplantation [abstract]. Blood. 2005;106(11):Abstract 2023.
4. Durie BGM, Harousseau JL, Miguel JS, et al. International uniform response criteria for multiple myeloma. Leukemia. 2006;20:1467-1473.
5. Blade J, Samson D, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102:1115-1123.
6. Allen S, Vickrey E, Mehta J, Singhal S. The relationship between serum free light chain levels and serum immunofixation electrophoresis: implications for the definition of "stringent CR" in myeloma [abstract]. Blood. 2008;112(11):Abstract 2724.
7. Singhal S, Stein R, Vickrey E, Mehta J. The serum free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias. Blood. 2007;109(8):3611-3612.