Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 35, Issue 2, 2011, Pages 466-472

  Mick, Eric ^a   McGough, James J ^b   Middleton, Frank A ^c   Neale, Benjamin ^a,d   Faraone, Stephen V ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

ADHD; Blood pressure; Genome wide association study; Methylphenidate; Pharmacogenomic

Indexed keywords

FIBRONECTIN; IMMUNOGLOBULIN; METHYLPHENIDATE; SODIUM CALCIUM EXCHANGE PROTEIN;

ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; COMPUTER PROGRAM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG DOSE TITRATION; DRUG EFFICACY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE;

ADMINISTRATION, CUTANEOUS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; HYPERTENSION; MALE; METHYLPHENIDATE; POLYMORPHISM, SINGLE NUCLEOTIDE; SODIUM-CALCIUM EXCHANGER;

EID: 79952898117     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.11.037     Document Type: Article

References (68)

1. Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004, 114:555-576. (2 Suppl 4th Report).
2. Arimura T., Matsumoto Y., Okazaki O., Hayashi T., Takahashi M., Inagaki N., et al. Structural analysis of obscurin gene in hypertrophic cardiomyopathy. Biochem Biophys Res Commun 2007, 362(2):281-287.
3. Bersano A., Ballabio E., Bresolin N., Candelise L. Genetic polymorphisms for the study of multifactorial stroke. Hum Mutat 2008, 29(6):776-795.
4. Betzenhauser M.J., Marks A.R. Ryanodine receptor channelopathies. Pflugers Arch 2010.
5. Biederman J., Spencer T.J. Psychopharmacological interventions. Child Adolesc Psychiatr Clin N Am 2008, 17(2):439-458. xi.
6. Brueggemann L.I., Mackie A.R., Mani B.K., Cribbs L.L., Byron K.L. Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Mol Pharmacol 2009, 76(5):1053-1061.
7. Cappola T.P., Li M., He J., Ky B., Gilmore J., Qu L., et al. Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circ Cardiovasc Genet 2010.
8. Chambers J.C., Zhao J., Terracciano C.M., Bezzina C.R., Zhang W., Kaba R., et al. Genetic variation in SCN10A influences cardiac conduction. Nat Genet 2010, 42(2):149-152.
9. De Keulenaer G.W., Doggen K., Lemmens K. The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy. Circ Res 2010, 106(1):35-46.
10. Dennis G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003, 4(5):3.
11. Dmitrieva R.I., Hinojos C.A., Grove M.L., Bell R.J., Boerwinkle E., Fornage M., et al. Genome-wide identification of allelic expression in hypertensive rats. Circ Cardiovasc Genet 2009, 2(2):106-115.
12. Dong H., Jiang Y., Triggle C.R., Li X., Lytton J. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Am J Physiol Heart Circ Physiol 2006, 291(3):H1226-H1235.
13. Dudbridge F. UNPHASED user guide. Technical Report 2006/5. Cambridge, UK, MRC Biostatistics Unit 2006.
14. Fantin A., Maden C.H., Ruhrberg C. Neuropilin ligands in vascular and neuronal patterning. Biochem Soc Trans 2009, 37(Pt 6):1228-1232.
15. Faraone S.V., Biederman J., Morley C.P., Spencer T.J. Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 2008, 47(9):994-1009.
16. Faraone S.V., Buitelaar J. Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry 2009.
17. Faraone S.V., Glatt S.J. A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatry 2009.
18. Faraone S.V., Wilens T.E. Effect of stimulant medications on later substance use and the potential for misuse, abuse, and diversion. J Clin Psychiatry 2007, 68(suppl 11):15-22.
19. Ferreira M.A., Purcell S.M. A multivariate test of association. Bioinformatics 2009, 25(1):132-133.
20. Girolami A., Candeo N., Vettore S., Lombardi A.M., Girolami B. The clinical significance of the lack of arterial or venous thrombosis in patients with congenital prothrombin or FX deficiency. J Thromb Thrombolysis 2009, 29(3):299-302.
21. Gruber R., Joober R., Grizenko N., Leventhal B.L., Cook E.H., Stein M.A. Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2009, 19(3):233-239.
22. Hamidovic A., Dlugos A., Palmer A.A., de Wit H. Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of d-amphetamine: an exploratory pharmacogenetic study using healthy volunteers. Behav Genet 2010, 40(2):255-261.
23. Hammerness P., Wilens T., Mick E., Spencer T., Doyle R., McCreary M., et al. Cardiovascular effects of longer-term, high-dose OROS methylphenidate in adolescents with attention deficit hyperactivity disorder. J Pediatr 2009, 155(1):84-89. 89 e1.
24. Holm H., Gudbjartsson D.F., Arnar D.O., Thorleifsson G., Thorgeirsson G., Stefansdottir H., et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet 2010, 42(2):117-122.
25. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979, 6:65-70.
26. Horne B.D., Hauser E.R., Wang L., Muhlestein J.B., Anderson J.L., Carlquist J.F., et al. Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. Ann Hum Genet 2009, 73(Pt 6):551-558.
27. Huang D.W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4(1):44-57.
28. Koch W., Hoppmann P., Schomig A., Kastrati A. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. Int J Cardiol 2009.
29. Koop E.A., Gebbink M.F., Sweeney T.E., Mathy M.J., Heijnen H.F., Spaan J.A., et al. Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice. Am J Physiol Heart Circ Physiol 2005, 288(3):H1218-H1223.
30. Krug T.H., Krug T., Manso H., Gouveia L., Sobral J., Xavier J.M., et al. Kalirin: a novel genetic risk factor for ischemic stroke. Hum Genet 2010.
31. Lee G.S., Choi K.C., Jeung E.B. K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney. Am J Phys Ren Phys 2009, 297(2):F371-F379.
32. Levy D., Ehret G.B., Rice K., Verwoert G.C., Launer L.J., Dehghan A., et al. Genome-wide association study of blood pressure and hypertension. Nat Genet 2009.
33. Lott D.C., Kim S.J., Cook E.H., de Wit H. Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology 2005, 30(3):602-609.
34. Lu J.T., Kass R.S. Recent progress in congenital long QT syndrome. Curr Opin Cardiol 2010.
35. Luke M.M., O'Meara E.S., Rowland C.M., Shiffman D., Bare L.A., Arellano A.R., et al. Gene variants associated with ischemic stroke: the cardiovascular health study. Stroke 2009, 40(2):363-368.
36. Mackie A.R., Brueggemann L.I., Henderson K.K., Shiels A.J., Cribbs L.L., Scrogin K.E., et al. Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance. J Pharmacol Exp Ther 2008, 325(2):475-483.
37. Malarstig A., Buil A., Souto J.C., Clarke R., Blanco-Vaca F., Fontcuberta J., et al. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. Blood 2009, 114(7):1417-1422.
38. Masumiya H., Yamamoto H., Hemberger M., Tanaka H., Shigenobu K., Chen S.R., et al. The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors. FEBS Lett 2003, 553(1-2):141-144.
39. Matolweni L.O., Bardien S., Rebello G., Oppon E., Munclinger M., Ramesar R., et al. Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes. BMC Med Genet 2006, 7:29.
40. McGough J., McCracken J., Swanson J., Riddle M., Kollins S., Greenhill L., et al. Pharmacogenetics of methylphenidate response in preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 2006, 45(11):1314-1322.
41. McGough J.J., McCracken J.T., Loo S.K., Manganiello M., Leung M.C., Tietjens J.R., et al. A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2009.
42. Mick E., Biederman J., Spencer T., Faraone S.V., Sklar P. Absense of association with DAT1 polymorphism and response to methylphendate in a sample of adults with ADHD. Am J Med Genet Neuropsychiatr Genet 2006, 141B(8):890-894.
43. Mick E., Neale B., Middleton F.A., McGough J.J., Faraone S.V. Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2008, 147B(8):1412-1418.
44. Newton-Cheh C., Eijgelsheim M., Rice K.M., de Bakker P.I., Yin X., Estrada K., et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009, 41(4):399-406.
45. Newton-Cheh C., Johnson T., Gateva V., Tobin M.D., Bochud M., Coin L., et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009.
46. Oguri M., Kato K., Yokoi K., Yoshida T., Watanabe S., Metoki N., et al. Assessment of a polymorphism of SDK1 with hypertension in Japanese individuals. Am J Hypertens 2009, 23(1):70-77.
47. Pe'er I., Yelensky R., Altshuler D., Daly M.J. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 2008, 32(4):381-385.
48. Pennisi D.J., Mikawa T. FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation. Dev Biol 2009, 328(1):148-159.
49. Pfeufer A., Sanna S., Arking D.E., Muller M., Gateva V., Fuchsberger C., et al. Common variants at ten loci modulate the QT interval duration in the QTSCD study. Nat Genet 2009, 41(4):407-414.
50. Pfeufer A., van Noord C., Marciante K.D., Arking D.E., Larson M.G., Smith A.V., et al. Genome-wide association study of PR interval. Nat Genet 2010, 42(2):153-159.
51. Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006, 38(8):904-909.
52. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575.
53. Rapport M.D., Moffitt C. Attention deficit/hyperactivity disorder and methylphenidate. A review of height/weight, cardiovascular, and somatic complaint side effects. Clin Psychol Rev 2002, 22(8):1107-1131.
54. Reiner A.P., Lange L.A., Smith N.L., Zakai N.A., Cushman M., Folsom A.R. Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study. J Thromb Haemost 2009, 7(9):1499-1505.
55. Samani N.J. Genome scans for hypertension and blood pressure regulation. Am J Hypertens 2003, 16(2):167-171.
56. Samuels J.A., Franco K., Wan F., Sorof J.M. Effect of stimulants on 24-h ambulatory blood pressure in children with ADHD: a double-blind, randomized, cross-over trial. Pediatr Nephrol 2006, 21(1):92-95.
57. Shapiro M.S. An ion channel hypothesis to explain divergent cardiovascular safety of cyclooxygenase-2 inhibitors: the answer to a hotly debated puzzle?. Mol Pharmacol 2009, 76(5):942-945.
58. Spencer T.J. Pharmacology of adult ADHD with stimulants. CNS Spectr 2007, 12(4 Suppl 6):8-11.
59. Vasan R.S., Larson M.G., Aragam J., Wang T.J., Mitchell G.F., Kathiresan S., et al. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet 2007, 8(Suppl 1):S2.
60. Vetter V.L., Elia J., Erickson C., Berger S., Blum N., Uzark K., et al. Cardiovascular monitoring of children and adolescents with heart disease receiving stimulant drugs: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing. Circulation 2008, 117(18):2407-2423.
61. Volk T., Schwoerer A.P., Thiessen S., Schultz J.H., Ehmke H. A polycystin-2-like large conductance cation channel in rat left ventricular myocytes. Cardiovasc Res 2003, 58(1):76-88.
62. Wang L., Hauser E.R., Shah S.H., Pericak-Vance M.A., Haynes C., Crosslin D., et al. Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet 2007, 80(4):650-663.
63. Wang L., Hauser E.R., Shah S.H., Seo D., Sivashanmugam P., Exum S.T., et al. Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease. Ann Hum Genet 2008, 72(Pt 4):443-453.
64. Warshaw, E. M., L. Squires, Y. Li, R. Civil and A. S. Paller. Methylphenidate transdermal system: a multisite, open-label study of dermal reactions in pediatric patients diagnosed with ADHD. Prim Care Companion J Clin Psychiatry 2010;12(6):e1-9.
65. Yang H.C., Liang Y.J., Wu Y.L., Chung C.M., Chiang K.M., Ho H.Y., et al. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS ONE 2009, 4(5):e5459.
66. Yang Q., Kathiresan S., Lin J.P., Tofler G.H., O'Donnell C.J. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet 2007, (8 Suppl 1):S12.
67. Yeung S.Y., Pucovsky V., Moffatt J.D., Saldanha L., Schwake M., Ohya S., et al. Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. Br J Pharmacol 2007, 151(6):758-770.
68. Zhou Q., Li J., Wang H., Yin Y., Zhou J. Identification of nigral dopaminergic neuron-enriched genes in adult rats. Neurobiol Aging 2009.