Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease

Annals of Human Genetics

Volumn 72, Issue 4, 2008, Pages 443-453

  Wang, L ^a   Hauser, E R ^b   Shah, S H ^b   Seo, D ^a   Sivashanmugam, P ^b   Exum, S T ^b   Gregory, S G ^b   Granger, C B ^b   Haines, J L ^c   Jones, C J H ^d   Crossman, D ^e   Haynes, C ^b   Kraus, W E ^b   Freedman, N J ^b   Pericak vance, M A ^a   Goldschmidt Clermont, P J ^a   Vance, Jeffery M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Association; Atherosclerosis; Coronary artery disease; Genetics; LSAMP

Indexed keywords

DNA; LIMBIC SYSTEM ASSOCIATED MEMBRANE PROTEIN; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; AORTA ATHEROSCLEROSIS; ARTERY WALL; ARTICLE; BODY MASS; CASE CONTROL STUDY; CELL PROLIFERATION; CHROMOSOME 3Q; CIGARETTE SMOKING; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; DNA SYNTHESIS; DOWN REGULATION; DYSLIPIDEMIA; FAMILY STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MAPPING; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; HAPLOTYPE; HEART CATHETERIZATION; HUMAN; HUMAN CELL; HYPERTENSION; LEFT CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE FIBER; VALIDATION STUDY;

AGE OF ONSET; AGED; AORTA; ATHEROSCLEROSIS; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES, NEURONAL; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 3; CORONARY ARTERY DISEASE; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 45149093160     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2008.00433.x     Document Type: Article

References (31)

1. Abecasis, G. R. & Cookson, W. O. (2000) GOLD-graphical overview of linkage disequilibrium. BioInformatics 16, 182-183.
2. Benjamini, Y. & Hochberg, Y. (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of Royal Statistical Society 57, 289-300.
3. Boucher, P., Gotthardt, M., Li, W. P., Anderson, R. G. & Herz, J. (2003) LRP: Role in vascular wall integrity and protection from atherosclerosis. Science 300, 329-332.
4. Bowden, D. W., Rudock, M., Ziegler, J., Lehtinen, A. B., Xu, J., Wagenknecht, L. E., Herrington, D., Rich, S. S., Freedman, B. I., Carr, J. J. & Langefeld, C. D. (2006) Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study. Diabetes 55, 1985-1994.
5. Chen, J., Lui, W. O., Vos, M. D., Clark, G. J., Takahashi, M., Schoumans, J., Khoo, S. K., Petillo, D., Lavery, T., Sugimura, J., Astuti, D., Zhang, C., Kagawa, S., Maher, E. R., Larsson, C., Alberts, A. S., Kanayama, H. O. & Teh, B. T. (2003) The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell 4, 405-413.
6. Connelly, J. J., Wang, T., Cox, J. E., Haynes, C., Wang, L., Shah, S. H., Crosslin, D. R., Hale, A. B., Nelson, S., Crossman, D. C., Granger, C. B., Haines, J. L., Jones, C. J., Vance, J. M., Goldschmidt-Clermont, P. J., Kraus, W. E., Hauser, E. R. & Gregory, S. G. (2006) GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease. PLoS Genet 2, e139.
7. de Kok, Y. J., Vossenaar, E. R., Cremers, C. W., Dahl, N., Laporte, J., Hu, L. J., Lacombe, D., Fischel-Ghodsian, N., Friedman, R. A., Parnes, L. S., Thorpe, P., Bitner-Glindzicz, M., Pander, H. J., Heilbronner, H., Graveline, J., Den Dunnen, J. T., Brunner, H. G., Ropers, H. H. & Cremers, F. P. (1996) Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4. Hum Mol Genet 5, 1229-1235.
8. Eagleson, K. L., Pimenta, A. F., Burns, M. M., Fairfull, L. D., Cornuet, P. K., Zhang, L. & Levitt, P. (2003) Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth. Mol Cell Neurosci 24, 725-740.
9. Fischer, M., Broeckel, U., Holmer, S., Baessler, A., Hengstenberg, C., Mayer, B., Erdmann, J., Klein, G., Riegger, G., Jacob, H. J. & Schunkert, H. (2005) Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation 111, 855-862.
10. Fischer, M., Mayer, B., Holmer, S., Baessler, A., Riegger, G. Erdmann, J., Hengstenberg, C & Schunkert, H. (2007) Familial aggregation of left main coronary artery disease and future risk of coronary events in asymptomatic siblings of affected patients. Eur Heart J 28, 2432-2437.
11. Hansson, G. K. (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352, 1685-1695.
12. Hauser, E. R., Crossman, D. C., Granger, C. B., Haines, J. L., Jones, C. J., Mooser, V., McAdam, B., Winkelmann, B. R., Wiseman, A. H., Muhlestein, J. B., Bartel, A. G., Dennis, C. A., Dowdy, E., Estabrooks, S., Eggleston, K., Francis, S., Roche, K., Clevenger, P. W., Huang, L., Pedersen, B. et al. (2004) A genomewide scan for early-onset coronary artery disease in 438 families: The GENECARD Study. Am J Hum Genet 75, 436-447.
13. Kleinjan, D. A. & van, H., V. (2005) Long-range control of gene expression: Emerging mechanisms and disruption in disease. Am J Hum Genet 76, 8-32.
14. Levitt, P. (1984) A monoclonal antibody to limbic system neurons. Science 223, 299-301.
15. Martin, E. R., Bass, M. P., Gilbert, J. R., Pericak-Vance, M. A. & Hauser, E. R. (2003a) Genotype-based association test for general pedigrees: The genotype-PDT. Genet Epidemiol 25, 203-213.
16. Martin, E. R., Bass, M. P., Hauser, E. R. & Kaplan, N. L. (2003b) Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet 73, 1016-1026.
17. McNamee, C. J., Reed, J. E., Howard, M. R., Lodge, A. P. & Moss, D. J. (2002) Promotion of neuronal cell adhesion by members of the IgLON family occurs in the absence of either support or modification of neurite outgrowth. J Neurochem 80, 941-948.
18. Murabito, J. M., Pencina, M. J., Nam, B. H., D'Agostino, R. B., Sr., Wang, T. J., Lloyd-Jones, D., Wilson, P. W. & O'Donnell, C. J. (2005) Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA 294, 3117-3123.
19. Ntougkos, E., Rush, R., Scott, D., Frankenberg, T., Gabra, H., Smyth, J. F. & Sellar, G. C. (2005) The IgLON family in epithelial ovarian cancer: Expression profiles and clinicopathologic correlates. Clin Cancer Res 11, 5764-5768.
20. Peppel, K., Jacobson, A., Huang, X., Murray, J. P., Oppermann, M. & Freedman, N. J. (2000) Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. Circulation 102, 793-799.
21. Pimenta, A. F. & Levitt, P. (2004) Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene. Genomics 83, 790-801.
22. Pimenta, A. F., Zhukareva, V., Barbe, M. F., Reinoso, B. S., Grimley, C., Henzel, W., Fischer, I. & Levitt, P. (1995) The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting. Neuron 15, 287-297.
23. Seo, D., Wang, T., Dressman, H., Herderick, E. E., Iversen, E. S., Dong, C., Vata, K., Milano, C. A., Rigat, F., Pittman, J., Nevins, J. R., West, M. & Goldschmidt-Clermont, P. J. (2004) Gene Expression Phenotypes of Atherosclerosis. Arterioscler Thromb Vasc Biol 24, 1922-1927.
24. Shea, S., Ottman, R., Gabrieli, C., Stein, Z. & Nichols, A. (1984) Family history as an independent risk factor for coronary artery disease. J Am Coll Cardiol 4, 793-801.
25. Shephard, N., John, S., Cardon L., McCarthy, M. I. & Zeggini, E. (2005) Will the real disease gene please stand up? BMC Genet 6 Suppl 1, S66.
26. Skol, A. D., Scott, L. J., Abecasis, G. R. & Boehnke, M. (2006) Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38, 209-213.
27. Ten Kate, L. P., Boman, H., Daiger, S. P. & Motulsky, A. G. (1982) Familial aggregation of coronary heart disease and its relation to known genetic risk factors. Am J Cardiol 50, 945-953.
28. Teng, E. L. & Chui, H. C. (1987) The modified Mini-Mental State (3MS) examination. Journal of Clinical Psychiatry 48, 314-318.
29. Wang, L., Hauser, E. R., Shah, S. H., Pericak-Vance, M. A., Haynes, C., Crosslin, D., Harris, M., Nelson, S., Hale, A. B., Granger, C. B., Haines, J. L., Jones, C. J., Crossman, D., Seo, D., Gregory, S. G., Kraus, W. E., Goldschmidt-Clermont, P. J. & Vance, J. M. (2007) Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet 80, 650-663.
30. Xu, H., Gregory, S. G., Hauser, E. R., Stenger, J. E., Pericak-Vance, M. A., Vance, J. M., Zuchner, S. & Hauser, M. A. (2005) SNPselector: A web tool for selecting SNPs for genetic association studies. BioInformatics 21, 4181-4186.
31. Zhang, L., Peppel, K., Sivashanmugam, P., Orman, E. S., Brian, L., Exum, S. T. & Freedman, N. J. (2007) Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 27, 1087-1094.