Minimum Infective Dose of the Major Human Respiratory and Enteric Viruses Transmitted Through Food and the Environment

Food and Environmental Virology

Volumn 3, Issue 1, 2011, Pages 1-30

  Yezli, Saber ^a   Otter, Jonathan A ^a  

^a Bioquell UK Ltd   (United Kingdom)

Author keywords

Enteric viruses; Infection; Minimum infectious dose; Respiratory viruses

Indexed keywords

ADENOVIRUS; ADENOVIRUS INFECTION; ANTIBODY TITER; CALICIVIRUS INFECTION; COXSACKIE VIRUS INFECTION; ECHO VIRUS; ECHOVIRUS INFECTION; ENTERIC VIRUS; ENVIRONMENTAL FACTOR; FOOD CONTAMINATION; FOOD PROCESSING; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; INFLUENZA; INFLUENZA VIRUS; INTESTINE INFECTION; MINIMUM INFECTIVE DOSE; NONHUMAN; NOROVIRUS; POLIOMYELITIS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; REINFECTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RESPIRATORY VIRUS; REVIEW; RHINOVIRUS; RHINOVIRUS INFECTION; RISK ASSESSMENT; ROTAVIRUS; ROTAVIRUS INFECTION; SEROCONVERSION; VIRAL CONTAMINATION; VIRAL RESPIRATORY TRACT INFECTION; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS PLAQUE; VIRUS REPLICATION; VIRUS SHEDDING; VIRUS TRANSMISSION; WATER TREATMENT;

ADENOVIRIDAE; ECHOVIRUS; HEPATITIS A VIRUS; NOROVIRUS; ORTHOMYXOVIRIDAE; POLIOVIRUS; RHINOVIRUS; ROTAVIRUS;

EID: 79952835307     PISSN: 18670334     EISSN: 18670342     Source Type: Journal    
DOI: 10.1007/s12560-011-9056-7     Document Type: Review

References (285)

1. Abzug, M. J., Beam, A. C., Gyorkos, E. A., & Levin, M. J. (1990). Viral pneumonia in the first month of life. Pediatric Infectious Disease Journal, 9, 881-885.
2. Adair, B. M. (2009). Nanoparticle vaccines against respiratory viruses. Wiley Interdisciplinary Review of Nanomedicine and Nanobiotechnology, 1, 405-414.
3. Adler, J. L., & Zickl, R. (1969). Winter vomiting disease. Journal of Infectious Diseases, 119, 668-673.
4. Aich, P., Wilson, H. L., Kaushik, R. S., Potter, A. A., Babiuk, L. A., & Griebel, P. (2007). Comparative analysis of innate immune responses following infection of newborn calves with bovine rotavirus and bovine coronavirus. Journal of General Virology, 88, 2749-2761.
5. Alexander, J. P., Jr., Gary, H. E., Jr., & Pallansch, M. A. (1997). Duration of poliovirus excretion and its implications for acute flaccid paralysis surveillance: a review of the literature. Journal of Infectious Diseases, 175(Suppl 1), S176-S182.
6. Alford, R. H., Kasel, J. A., Gerone, P. J., & Knight, V. (1966). Human influenza resulting from aerosol inhalation. Proceedings of the Society for Experimental Biology and Medicine, 122, 800-804.
7. Alford, R. H., Kasel, J. A., Lehrich, J. R., & Knight, V. (1967a). Human responses to experimental infection with influenza A/Equi 2 virus. American Journal of Epidemiology, 86, 185-192.
8. Alford, R. H., Rossen, R. D., Butler, W. T., & Kasel, J. A. (1967b). Neutralizing and hemagglutination-inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus. Journal of Immunology, 98, 724-731.
9. Al-Nakib, W., Higgins, P. G., Willman, J., Tyrrell, D. A., Swallow, D. L., Hurst, B. C., et al. (1986). Prevention and treatment of experimental influenza A virus infection in volunteers with a new antiviral ICI 130, 685. Journal of Antimicrobial Chemotherapy, 18, 119-129.
10. Amado, L. A., Marchevsky, R. S., de Paula, V. S., Hooper, C., Freire, M. S., Gaspar, A. M., et al. (2010). Experimental hepatitis A virus (HAV) infection in cynomolgus monkeys (Macaca fascicularis): evidence of active extrahepatic site of HAV replication. International Journal of Experimental Pathology, 91, 87-97.
11. Anderson, E. L., Newman, F. K., Maassab, H. F., & Belshe, R. B. (1992). Evaluation of a cold-adapted influenza B/Texas/84 reassortant virus (CRB-87) vaccine in young children. Journal of Clinical Microbiology, 30, 2230-2234.
12. Andre, F. E., D'Hondt, E., Delem, A., & Safary, A. (1992). Clinical assessment of the safety and efficacy of an inactivated hepatitis A vaccine: Rationale and summary of findings. Vaccine, 10(Suppl. 1), S160-S168.
13. Arnon, R., Naor, N., Davidson, S., Katz, K., & Mor, C. (1991). Fatal outcome of neonatal echovirus 19 infection. Pediatric Infectious Disease Journal, 10, 788-789.
14. Arola, M., Ziegler, T., Ruuskanen, O., Mertsola, J., Nanto-Salonen, K., & Halonen, P. (1988). Rhinovirus in acute otitis media. Journal of Pediatrics, 113, 693-695.
15. Arroyo, M., Beare, A. S., Reed, S. E., & Craig, J. W. (1975). A therapeutic study of an adamantane spiro compound in experimental influenza A infection in man. Journal of Antimicrobial Chemotherapy, 1, 87-93.
16. Atkinson, M. P., & Wein, L. M. (2008). Quantifying the routes of transmission for pandemic influenza. Bulletin of Mathematical Biology, 70, 820-867.
17. Atmar, R. L., & Estes, M. K. (2001). Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses. Clinical Microbiology Reviews, 14, 15-37.
18. Atmar, R. L., Opekun, A. R., Gilger, M. A., Estes, M. K., Crawford, S. E., Neill, F. H., et al. (2008). Norwalk virus shedding after experimental human infection. Emerging Infectious Diseases, 14, 1553-1557.
19. Ball, J. M., Graham, D. Y., Opekun, A. R., Gilger, M. A., Guerrero, R. A., & Estes, M. K. (1999). Recombinant Norwalk virus-like particles given orally to volunteers: phase I study. Gastroenterology, 117, 40-48.
20. Bancroft, C. T., & Parslow, T. G. (2002). Evidence for segment-nonspecific packaging of the influenza a virus genome. Journal of Virology, 76, 7133-7139.
21. Barker, J., Vipond, I. B., & Bloomfield, S. F. (2004). Effects of cleaning and disinfection in reducing the spread of Norovirus contamination via environmental surfaces. Journal of Hospital Infection, 58, 42-49.
22. Barroso, L., Treanor, J., Gubareva, L., & Hayden, F. G. (2005). Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment. Antiviral therapy, 10, 901-910.
23. Bell, J. A., Huebner, R. J., Paffenbarger, R. S., Jr., Rowe, W. P., Suskind, R. G., & Ward, T. G. (1956). Studies of adenoviruses (APC) in volunteers. American Journal of Public Health and the Nations Health, 46, 1130-1146.
24. Bertino, J. S., Jr., Thoelen, S., VanDamme, P., Bryan, J. P., Becherer, P. R., Frey, S., et al. (1998). A dose response study of hepatitis A vaccine in healthy adults who are & or = 30 years old and weigh & or = 77 kg. Journal of Infectious Diseases, 178, 1181-1184.
25. Bishop, R. F. (1996). Natural history of human rotavirus infection. Archives of Virology. Supplementum, 12, 119-128.
26. Bishop, R. F. & Kirkwood, C. D. (2008). Enteric viruses. Encyclopedia of Virology, 116-123.
27. Blacklow, N. R., Cukor, G., Bedigian, M. K., Echeverria, P., Greenberg, H. B., Schreiber, D. S., et al. (1979). Immune response and prevalence of antibody to Norwalk enteritis virus as determined by radioimmunoassay. Journal of Clinical Microbiology, 10, 903-909.
28. Blacklow, N. R., & Greenberg, H. B. (1991). Viral gastroenteritis. The New England Journal of Medicine, 325, 252-264.
29. Bloom, H. H., Johnson, K. M., Mufson, M. A., & Chanock, R. M. (1962). Acute respiratory disease associated with Coxsackie A-21 virus infection. II. Incidence in military personnel: Observations in a nonrecruit population. JAMA, 179, 120-125.
30. Bloomfield, S. S., Gaffney, T. E., & Schiff, G. M. (1970). A design for the evaluation of antiviral drugs in human influenza. American Journal of Epidemiology, 91, 568-574.
31. Blount, R. E., Jr., Morris, J. A., & Savage, R. E. (1956). Recovery of cytopathogenic agent from chimpanzees with coryza. Proceedings of the Society for Experimental Biology and Medicine, 92, 544-549.
32. Bohl, E. H., Theil, K. W., & Saif, L. J. (1984). Isolation and serotyping of porcine rotaviruses and antigenic comparison with other rotaviruses. Journal of Clinical Microbiology, 19, 105-111.
33. Brankston, G., Gitterman, L., Hirji, Z., Lemieux, C., & Gardam, M. (2007). Transmission of influenza A in human beings. The Lancet Infectious Diseases, 7, 257-265.
34. Breitbart, M., & Rohwer, F. (2005). Here a virus, there a virus, everywhere the same virus? Trends in Microbiology, 13, 278-284.
35. Buchman, C. A., Doyle, W. J., Pilcher, O., Gentile, D. A., & Skoner, D. P. (2002). Nasal and otologic effects of experimental respiratory syncytial virus infection in adults. American Journal of Otolaryngology, 23, 70-75.
36. Buckland, F. E., Bynoe, M. L., Philipson, L., & Tyrrell, D. A. (1959). Experimental infection of human volunteers with the U-virus-a strain of ECHO virus type 11. Journal of Hygiene, 57, 274-284.
37. Bynoe, M. L., Hobson, D., Horner, J., Kipps, A., Schild, G. C., & Tyrrell, D. A. (1961). Inoculation of human volunteers with a strain of virus isolated from a common cold. Lancet, 1, 1194-1196.
38. Calfee, D. P., Peng, A. W., Cass, L. M., Lobo, M., & Hayden, F. G. (1999). Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection. Antimicrobial Agents and Chemotherapy, 43, 1616-1620.
39. Cameron, J. D. S. (1943). Infective hepatitis. The Quarterly Journal of Medicine, 12, 139.
40. Carpenter, C. M., & Boak, R. A. (1952). Coxsackie viruses; a review of pathologic, epidemiologic, diagnostic and etiologic observations. California Medicine, 77, 127-130.
41. Cate, T. R., Couch, R. B., Fleet, W. F., Griffith, W. R., Gerone, P. J., & Knight, V. (1965). Production of tracheobronchitis in volunteers with rhinovirus in a small-particle aerosol. American Journal of Epidemiology, 81, 95-105.
42. Cate, T. R., Couch, R. B., & Johnson, K. M. (1964). Studies with rhinoviruses in volunteers: Production of illness, effect of naturally acquired antibody, and demonstration of a protective effect not associated with serum antibody. Journal of Clinical Investigation, 43, 56-67.
43. Caul, E. O. (1994). Small round structured viruses: airborne transmission and hospital control. Lancet, 343, 1240-1242.
44. Caul, E. O. (1996a). Viral gastroenteritis: Small round structured viruses, caliciviruses and astroviruses. Part I. The clinical and diagnostic perspective. Journal of Clinical Pathology, 49, 874-880.
45. Caul, E. O. (1996b). Viral gastroenteritis: Small round structured viruses, caliciviruses and astroviruses. Part II. The epidemiological perspective. Journal of Clinical Pathology, 49, 959-964.
46. Chan, M. C., Sung, J. J., Lam, R. K., Chan, P. K., Lee, N. L., Lai, R. W., et al. (2006). Fecal viral load and norovirus-associated gastroenteritis. Emerging Infectious Diseases, 12, 1278-1280.
47. Chaproniere, D. M., Pereira, H. G., & Roden, A. T. (1956). Infection of volunteers by a virus (A. P. C. type 1) isolated from human adenoid tissue. Lancet, 271, 592-596.
48. Clemens, R., Safary, A., Hepburn, A., Roche, C., Stanbury, W. J., & Andre, F. E. (1995). Clinical experience with an inactivated hepatitis A vaccine. Journal of Infectious Diseases, 171(Suppl 1), S44-S49.
49. Clements, M. L., Betts, R. F., Maassab, H. F., & Murphy, B. R. (1984). Dose response of influenza A/Washington/897/80 (H3N2) cold-adapted reassortant virus in adult volunteers. Journal of Infectious Diseases, 149, 814-815.
50. Clements, M. L., O'Donnell, S., Levine, M. M., Chanock, R. M., & Murphy, B. R. (1983). Dose response of A/Alaska/6/77 (H3N2) cold-adapted reassortant vaccine virus in adult volunteers: Role of local antibody in resistance to infection with vaccine virus. Infection and Immunity, 40, 1044-1051.
51. Clements, M. L., Snyder, M. H., Sears, S. D., Maassab, H. F., & Murphy, B. R. (1990). Evaluation of the infectivity, immunogenicity, and efficacy of live cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in adult volunteers. Journal of Infectious Diseases, 161, 869-877.
52. Cliver, D. O. (1981). Experimental infection by waterborne viruses. Journal of Food Protection, 44, 861-865.
53. Cohen, A., Togo, Y., Khakoo, R., Waldman, R., & Sigel, M. (1976). Comparative clinical and laboratory evaluation of the prophylactic capacity of ribavirin, amantadine hydrochloride, and placebo in induced human influenza type A. Journal of Infectious Diseases, 133(Suppl), A114-A120.
54. Committee on the ECHO viruses. (1955). ENTERIC cytopathogenic human orphan (ECHO) viruses. Science, 122, 1187-1188.
55. Couch, R. B., Cate, T. R., Douglas, R. G., Jr., Gerone, P. J., & Knight, V. (1966). Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission. Bacteriological Reviews, 30, 517-529.
56. Couch, R. B., Cate, T. R., Gerone, P. J., Fleet, W. F., Lang, D. J., Griffith, W. R., et al. (1965). Production of illness with a small-particle aerosol of coxsackie a21. Journal of Clinical Investigation, 44, 535-542.
57. Couch, R. B., Douglas, R. G., Jr., Fedson, D. S., & Kasel, J. A. (1971). Correlated studies of a recombinant influenza-virus vaccine. 3. Protection against experimental influenza in man. Journal of Infectious Diseases, 124, 473-480.
58. Couch, R. B., Douglas, R. G., Jr., Lindgren, K. M., Gerone, P. J., & Knight, V. (1970). Airborne transmission of respiratory infection with coxsackievirus A type 21. American Journal of Epidemiology, 91, 78-86.
59. Couch, R. B., Knight, V., Douglas, R. G., Jr., Black, S. H., & Hamory, B. H. (1969). The minimal infectious dose of adenovirus type 4: The case for natural transmission by viral aerosol. Transactions of the American Clinical and Climatological Association, 80, 205-211.
60. Cukor, G., & Blacklow, N. R. (1984). Human viral gastroenteritis. Microbiological Reviews, 48, 157-179.
61. D'Alessio, D. J., Meschievitz, C. K., Peterson, J. A., Dick, C. R., & Dick, E. C. (1984). Short-duration exposure and the transmission of rhinoviral colds. Journal of Infectious Diseases, 150, 189-194.
62. Dalldorf, G., & Sickles, G. M. (1948). An unidentified, filtrable agent isolated from the feces of children with paralysis. Science, 108, 61-62.
63. Davidson, M., Krugman, S., & Sandman, L. A. (1992). Inactivated hepatitis A vaccine: A safety and immunogenicity study in health professionals. Vaccine, 10(Suppl. 1), S119-S120.
64. Davison, A. J., Benko, M., & Harrach, B. (2003). Genetic content and evolution of adenoviruses. Journal of General Virology, 84, 2895-2908.
65. De, S. A., Zara, F., Terulla, V., Brerra, R., Zucca, S., & Belloni, C. (2006). Immunogenicity of hepatitis A-inactivated vaccine administered to seronegative infants, and serological follow-up 12 months after second dose. Acta Paediatrica, 95, 1582-1585.
66. Dick, E. C. (1968). Experimental infections of chimpanzees with human rhinovirus types 14 and 43. Proceedings of the Society for Experimental Biology and Medicine, 127, 1079-1081.
67. Dick, E. C., & Dick, C. R. (1968). A subclinical outbreak of human rhinovirus 31 infection in chimpanzees. American Journal of Epidemiology, 88, 267-272.
68. Dienstag, J. L. (1981). Hepatitis A virus: Virologic, clinical, and epidemiologic studies. Human Pathology, 12, 1097-1106.
69. Dienstag, J. L., Feinstone, S. M., Purcell, R. H., Hoofnagle, J. H., Barker, L. F., London, W. T., et al. (1975). Experimental infection of chimpanzees with hepatitis A virus. Journal of Infectious Diseases, 132, 532-545.
70. Dolin, R., Blacklow, N. R., DuPont, H., Buscho, R. F., Wyatt, R. G., Kasel, J. A. et al. (1972). Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis. Proceedings of the Society for Experimental Biology and Medicine, 140, 578-583.
71. Dolin, R., Blacklow, N. R., DuPont, H., Formal, S., Buscho, R. F., Kasel, J. A., et al. (1971). Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. Journal of Infectious Diseases, 123, 307-312.
72. Douglas, R. G. (1975). Influenza in man. In E. D. Kilbourne (Ed.), The influenza viruses and influenza (pp. 375-447). New York: Academic Press.
73. Douglas, R. G., Jr., Betts, R. F., Simons, R. L., Hogan, P. W., & Roth, F. K. (1975). Evaluation of a topical interferon inducer in experimental influenza infection in volunteers. Antimicrobial Agents and Chemotherapy, 8, 684-687.
74. Douglas, R. G., Jr., & Couch, R. B. (1969). Attenuation of rhinovirus type 15 for humans. Nature, 223, 213-214.
75. Doyle, W. J., Skoner, D. P., Alper, C. M., Allen, G., Moody, S. A., Seroky, J. T., et al. (1998). Effect of rimantadine treatment on clinical manifestations and otologic complications in adults experimentally infected with influenza A (H1N1) virus. Journal of Infectious Diseases, 177, 1260-1265.
76. Drake, M. E., Kitts, A. W., Blanchard, M. C., Farquhar, J. D., Stokes, J., Jr., & Henle, W. (1950). Studies on the agent of infectious hepatitis; the disease produced in human volunteers by the agent cultivated in tissue culture or embryonated hen's eggs. Journal of Experimental Medicine, 92, 283-297.
77. Drake, C. L., Roehrs, T. A., Royer, H., Koshorek, G., Turner, R. B., & Roth, T. (2000). Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness. Physiology & Behavior, 71, 75-81.
78. Dudding, B. A., Bartelloni, P. J., Scott, R. M., Top, F. H., Jr., Russell, P. K., & Buescher, E. L. (1972). Enteric immunization with live adenovirus type 21 vaccine. I. Tests for safety, infectivity, immunogenicity, and potency in volunteers. Infection and Immunity, 5, 295-299.
79. Enami, M., Sharma, G., Benham, C., & Palese, P. (1991). An influenza virus containing nine different RNA segments. Virology, 185, 291-298.
80. Erdman, D. D., Gary, G. W., & Anderson, L. J. (1989). Serum immunoglobulin A response to Norwalk virus infection. Journal of Clinical Microbiology, 27, 1417-1418.
81. Evans, A. S. (1982). Viral infections of humans: Epidemiology and control. New York: Plenum Press.
82. Falsey, A. R., & Walsh, E. E. (2000). Respiratory syncytial virus infection in adults. Clinical Microbiology Reviews, 13, 371-384.
83. Findlay, G. M., & Willcox, R. R. (1945). Infective hepatitis: Transmission by faeces and urine. Lancet, 2, 594-597.
84. Findor, J. A., Canero Velasco, M. C., Mutti, J., & Safary, A. (1996). Response to hepatitis A vaccine in children after a single dose with a booster administration 6 months later. Journal of Travel Medicine, 3, 156-159.
85. Fiore, A. E. (2004). Hepatitis A transmitted by food. Clinical Infectious Diseases, 38, 705-715.
86. Fisch, A., Cadilhac, P., Vidor, E., Prazuck, T., Dublanchet, A., & Lafaix, C. (1996). Immunogenicity and safety of a new inactivated hepatitis A vaccine: A clinical trial with comparison of administration route. Vaccine, 14, 1132-1136.
87. Flack, A., Hummeler, K., Hunt, A. D., Jr., Jervis, G. A., Koprowski, H., Norton, T. W., et al. (1956). Immunization of infants with living attenuated poliomyelitis virus; laboratory investigations of alimentary infection and antibody response in infants under six months of age with congenitally acquired antibodies. JAMA, 162, 1281-1288.
88. Flewett, T. H. (1983). Rotavirus in the home and hospital nursery. British Medical Journal (Clinical Research Ed), 287, 568-569.
89. Fulton, R. W., Johnson, C. A., Pearson, N. J., & Woode, G. N. (1981). Isolation of a rotavirus from a newborn dog with diarrhea. American Journal of Veterinary Research, 42, 841-843.
90. Garner, J. S. (1996). Guideline for isolation precautions in hospitals. Part I. Evolution of isolation practices, Hospital Infection Control Practices Advisory Committee. American Journal of Infection Control, 24, 24-31.
91. Gentile, D., Doyle, W., Whiteside, T., Fireman, P., Hayden, F. G., & Skoner, D. (1998). Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infection. Clinical and Diagnostic Laboratory Immunology, 5, 604-608.
92. Glass, R. I., Parashar, U. D., & Estes, M. K. (2009). Norovirus gastroenteritis. The New England Journal of Medicine, 361, 1776-1785.
93. Goncalves, M. A., & de Vries, A. A. (2006). Adenovirus: from foe to friend. Reviews in Medical Virology, 16, 167-186.
94. Goubau, P., van Gerven, V., Safary, A., Delem, A., Knops, J., D'Hondt, E., et al. (1992). Effect of virus strain and antigen dose on immunogenicity and reactogenicity of an inactivated hepatitis A vaccine. Vaccine, 10(Suppl. 1), S114-S118.
95. Grabow, W. O. K. (1997). Hepatitis viruses in water: Update on risk and control. Water SA, 23, 379-386.
96. Graham, D. Y. (1987). Minimal infectious dose of rotavirus in volunteers: Safety issues. Journal of Infectious Diseases, 156, 416-418.
97. Graham, D. Y., Dufour, G. R., & Estes, M. K. (1987). Minimal infective dose of rotavirus. Archives of Virology, 92, 261-271.
98. Graham, D. Y., Jiang, X., Tanaka, T., Opekun, A. R., Madore, H. P., & Estes, M. K. (1994). Norwalk virus infection of volunteers: New insights based on improved assays. Journal of Infectious Diseases, 170, 34-43.
99. Graham, D. Y., Sackman, J. W., & Estes, M. K. (1984). Pathogenesis of rotavirus-induced diarrhea. Preliminary studies in miniature swine piglet. Digestive Diseases and Sciences, 29, 1028-1035.
100. Gratacap-Cavallier, B., Genoulaz, O., Brengel-Pesce, K., Soule, H., Innocenti-Francillard, P., Bost, M., et al. (2000). Detection of human and animal rotavirus sequences in drinking water. Applied and Environmental Microbiology, 66, 2690-2692.
101. Green, J., Wright, P. A., Gallimore, C. I., Mitchell, O., Morgan-Capner, P., & Brown, D. W. (1998). The role of environmental contamination with small round structured viruses in a hospital outbreak investigated by reverse-transcriptase polymerase chain reaction assay. Journal of Hospital Infection, 39, 39-45.
102. Greenberg, H. B., Wyatt, R. G., & Kapikian, A. Z. (1979). Norwalk virus in vomitus. Lancet, 1, 55.
103. Greenberg, H. B., Wyatt, R. G., Valdesuso, J., Kalica, A. R., London, W. T., Chanock, R. M., et al. (1978). Solid-phase microtiter radioimmunoassay for detection of the Norwalk strain of acute nonbacterial, epidemic gastroenteritis virus and its antibodies. Journal of Medical Virology, 2, 97-108.
104. Guix, S., Asanaka, M., Katayama, K., Crawford, S. E., Neill, F. H., Atmar, R. L., et al. (2007). Norwalk virus RNA is infectious in mammalian cells. Journal of Virology, 81, 12238-12248.
105. Guo, Y. J., Jin, F. G., Wang, P., Wang, M., & Zhu, J. M. (1983). Isolation of influenza C virus from pigs and experimental infection of pigs with influenza C virus. Journal of General Virology, 64(Pt 1), 177-182.
106. Gust, I. D. (1992). Epidemiological patterns of hepatitis A in different parts of the world. Vaccine, 10(Suppl. 1), S56-S58.
107. Gutekunst, R. R., White, R. J., Edmondson, W. P., & Chanock, R. M. (1967). Immunization with live type 4 adenovirus: Determination of infectious virus dose and protective effect of enteric infection. American Journal of Epidemiology, 86, 341-349.
108. Gwaltney, J. M., Jr., & Hendley, J. O. (1982). Transmission of experimental rhinovirus infection by contaminated surfaces. American Journal of Epidemiology, 116, 828-833.
109. Haas, C. N. (1983). Estimation of risk due to low doses of microorganisms: A comparison of alternative methodologies. American Journal of Epidemiology, 118, 573-582.
110. Haas, C. N., Rose, J. B., Gerba, C., & Regli, S. (1993). Risk assessment of virus in drinking water. Risk Analysis, 13, 545-552.
111. Hall, C. B. (2001). Respiratory syncytial virus and parainfluenza virus. The New England Journal of Medicine, 344, 1917-1928.
112. Hall, C. B., Douglas, R. G., Jr., & Geiman, J. M. (1976). Respiratory syncytial virus infections in infants: Quantitation and duration of shedding. Journal of Pediatrics, 89, 11-15.
113. Hall, C. B., Douglas, R. G., Jr., Schnabel, K. C., & Geiman, J. M. (1981). Infectivity of respiratory syncytial virus by various routes of inoculation. Infection and Immunity, 33, 779-783.
114. Hamory, B. H., Couch, R. B., Douglas, R. G., Jr., Black, S. H., & Knight, V. (1972). Characterization of the infectious unit for man of two respiratory viruses. Proceedings of the Society for Experimental Biology and Medicine, 139, 890-893.
115. Havens, W. P., Jr. (1946a). Immunity in experimentally induced infectious hepatitis. Journal of Experimental Medicine, 84, 403-406.
116. Havens, W. P., Jr. (1946b). Period of infectivity of patients with experimentally induced infectious hepatitis. Journal of Experimental Medicine, 83, 251-258.
117. Havens, W. P., Jr. (1948). Infectious hepatitis. Medicine (Baltimore), 27, 279-326.
118. Hay, A. J., Gregory, V., Douglas, A. R., & Lin, Y. P. (2001). The evolution of human influenza viruses. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 356, 1861-1870.
119. Hayden, F. G., Jennings, L., Robson, R., Schiff, G., Jackson, H., Rana, B., et al. (2000). Oral oseltamivir in human experimental influenza B infection. Antiviral therapy, 5, 205-213.
120. Hayden, F. G., Treanor, J. J., Betts, R. F., Lobo, M., Esinhart, J. D., & Hussey, E. K. (1996). Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza. JAMA, 275, 295-299.
121. Hayden, F. G., Treanor, J. J., Fritz, R. S., Lobo, M., Betts, R. F., Miller, M., et al. (1999). Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: Randomized controlled trials for prevention and treatment. JAMA, 282, 1240-1246.
122. Hayden, F. G., Tunkel, A. R., Treanor, J. J., Betts, R. F., Allerheiligen, S., & Harris, J. (1994). Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrobial Agents and Chemotherapy, 38, 1178-1181.
123. Hendley, J. O., Edmondson, W. P., Jr., & Gwaltney, J. M., Jr. (1972). Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. Journal of Infectious Diseases, 125, 243-248.
124. Hendley, J. O., Wenzel, R. P., & Gwaltney, J. M., Jr. (1973). Transmission of rhinovirus colds by self-inoculation. The New England Journal of Medicine, 288, 1361-1364.
125. Higgins, P. G., Barrow, G. I., Tyrrell, D. A., Isaacs, D., & Gauci, C. L. (1990). The efficacy of intranasal interferon alpha-2a in respiratory syncytial virus infection in volunteers. Antiviral Research, 14, 3-10.
126. Hill, W. M. (1996). Are echoviruses still orphans? British Journal of Biomedical Science, 53, 221-226.
127. Hilleman, M. R., Hodges, R. E., Warfield, M. S., & Anderson, S. A. (1957). Acute respiratory illness in volunteers following intramuscular administration of live adenovirus. Journal of Clinical Investigation, 36, 1072-1080.
128. Hilleman, M. R., & Werner, J. H. (1954). Recovery of new agent from patients with acute respiratory illness. Proceedings of the Society for Experimental Biology and Medicine, 85, 183-188.
129. Hilleman, M. R., Werner, J. H., Dascomb, H. E., & Butler, R. L. (1955). Epidemiologic investigations with respiratory disease virus RI-67. American Journal of Public Health and the Nations Health, 45, 203-210.
130. Hollinger, F. B., & Emerson, S. U. (2001). Hepatitis A virus. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, et al. (Eds.), Fields virology (pp. 799-840). Philadelphia: Lippincott-Raven Publishers.
131. Holmes, M. J., Reed, S. E., Stott, E. J., & Tyrrell, D. A. (1976). Studies of experimental rhinovirus type 2 infections in polar isolation and in England. Journal of Hygiene, 76, 379-393.
132. Hood, A. M. (1963). Infectivity of influenza virus aerosols. Journal of Hygiene, 61, 331-335.
133. Hornei, B., Kammerer, R., Moubayed, P., Frings, W., Gauss-Muller, V., & Dotzauer, A. (2001). Experimental hepatitis A virus infection in guinea pigs. Journal of Medical Virology, 64, 402-409.
134. Horstmann, D. M., Paul, J. R., Melnick, J. L., & Deutsch, J. V. (1957). Infection induced by oral administration of attenuated poliovirus to persons possessing homotypic antibody. Journal of Experimental Medicine, 106, 159-177.
135. Hoshino, Y., Wyatt, R. G., Scott, F. W., & Appel, M. J. (1982). Isolation and characterization of a canine rotavirus. Archives of Virology, 72, 113-125.
136. Huebner, R. J., Ransom, S. E., & Beeman, E. A. (1950). Studies of Coxsackie virus; adaptation of a strain to chick embryos. Public Health Reports, 65, 803-806.
137. Huebner, R. J., Rowe, W. P., Schatten, W. E., Smith, R. R., & Thomas, L. B. (1956). Studies on the use of viruses in the treatment of carcinoma of the cervix. Cancer, 9, 1211-1218.
138. Huebner, R. J., Rowe, W. P., Ward, T. G., Parrott, R. H., & Bell, J. A. (1954). Adenoidal-pharyngeal-conjunctival agents: a newly recognized group of common viruses of the respiratory system. The New England Journal of Medicine, 251, 1077-1086.
139. Hutson, A. M., Airaud, F., LePendu, J., Estes, M. K., & Atmar, R. L. (2005). Norwalk virus infection associates with secretor status genotyped from sera. Journal of Medical Virology, 77, 116-120.
140. Innis, B. L., Snitbhan, R., Kunasol, P., Laorakpongse, T., Poopatanakool, W., Kozik, C. A., et al. (1994). Protection against hepatitis A by an inactivated vaccine. JAMA, 271, 1328-1334.
141. Isaacs, A., Negroni, G., & Tyrrell, D. A. (1957). Infection of volunteers with Asian influenza virus. Lancet, 273, 886-887.
142. Jackson, G. G., & Muldoon, R. L. (1973). Viruses causing common respiratory infections in man. Journal of Infectious Diseases, 127, 328-355.
143. Jao, R. L., Wheelock, E. F., & Jackson, G. G. (1970). Production of interferon in volunteers infected with Asian influenza. Journal of Infectious Diseases, 121, 419-426.
144. Jarjour, N. N., Gern, J. E., Kelly, E. A., Swenson, C. A., Dick, C. R., & Busse, W. W. (2000). The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils. Journal of Allergy and Clinical Immunology, 105, 1169-1177.
145. Johnson, K. M., Bloom, H. H., Mufson, A., & Chanock, R. M. (1962). Acute respiratory disease associated with Coxsackie A-21 virus infection. I. Incidence in military personnel: Observations in a recruit population. JAMA, 179, 112-119.
146. Johnson, K. M., Chanock, R. M., Rifkind, D., Kravetz, H. M., & Knight, V. (1961). Respiratory syncytial virus. IV. Correlation of virus shedding, serologic response, and illness in adult volunteers. JAMA, 176, 663-667.
147. Johnson, P. C., Mathewson, J. J., Dupont, H. L., & Greenberg, H. B. (1990). Multiple-challenge study of host susceptibility to Norwalk gastroenteritis in US adults. Journal of Infectious Diseases, 161, 18-21.
148. Johnston, S. L. (2005). Overview of virus-induced airway disease. Proceedings of the American Thoracic Society, 2, 150-156.
149. Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., et al. (1995). Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. British Medical Journal, 310, 1225-1229.
150. Kahn, J. S. (2007). Newly identified respiratory viruses. Pediatric Infectious Disease Journal, 26, 745-746.
151. Kapikian, A. Z., Wyatt, R. G., Dolin, R., Thornhill, T. S., Kalica, A. R., & Chanock, R. M. (1972). Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. Journal of Virology, 10, 1075-1081.
152. Kapikian, A. Z., Wyatt, R. G., Levine, M. M., Black, R. E., Greenberg, H. B., Flores, J., et al. (1983). Studies in volunteers with human rotaviruses. Developments in Biological Standardization, 53, 209-218.
153. Kasel, J. A., Alford, R. H., Knight, V., Waddell, G. H., & Sigel, M. M. (1965a). Experimental infection of human volunteers with equine influenza virus. Nature, 206, 41-43.
154. Kasel, J. A., Rosen, L., Loda, F., & Fleet, W. (1965b). ECHO virus type 25, infection in adult volunteers. Proceedings of the Society for Experimental Biology and Medicine, 118, 381-384.
155. Katayama, K., Hansman, G. S., Oka, T., Ogawa, S., & Takeda, N. (2006). Investigation of norovirus replication in a human cell line. Archives of Virology, 151, 1291-1308.
156. Katz, M., & Plotkin, S. A. (1967). Minimal infective dose of attenuated poliovirus for man. American Journal of Public Health and the Nations Health, 57, 1837-1840.
157. Kawaoka, Y. (2006). Influenza virology: Current topics. Norfolk: Caister Academic Press.
158. Keitel, W. A., Couch, R. B., Cate, T. R., Six, H. R., & Baxter, B. D. (1990). Cold recombinant influenza B/Texas/1/84 vaccine virus (CRB 87): Attenuation, immunogenicity, and efficacy against homotypic challenge. Journal of Infectious Diseases, 161, 22-26.
159. Keswick, B. H., Satterwhite, T. K., Johnson, P. C., Dupont, H. L., Secor, S. L., Bitsura, J. A., et al. (1985). Inactivation of Norwalk virus in drinking water by chlorine. Applied and Environmental Microbiology, 50, 261-264.
160. Kim, H. W., Arrobio, J. O., Brandt, C. D., Wright, P., Hodes, D., Chanock, R. M., et al. (1973). Safety and antigenicity of temperature sensitive (TS) mutant respiratory syncytial virus (RSV) in infants and children. Pediatrics, 52, 56-63.
161. Knight, V., Kasel, J. A., Alford, R. H., Loda, F., Morris, J. A., Davenport, F. M., et al. (1965). New research on influenza: Studies with normal volunteers. Combined clinical staff conference at the national institutes of health. Annals of Internal Medicine, 62, 1307-1325.
162. Kojaoghlanian, T., Flomenberg, P., & Horwitz, M. S. (2003). The impact of adenovirus infection on the immunocompromised host. Reviews in Medical Virology, 13, 155-171.
163. Koprowski, H., Norton, T. W., Jervis, G. A., Nelson, T. L., Chadwick, D. L., Nelsen, D. J., et al. (1956). Clinical investigations on attenuated strains of poliomyelitis virus; use as a method of immunization of children with living virus. JAMA, 160, 954-966.
164. Kraft, L. M. (1957). Studies on the etiology and transmission of epidemic diarrhea of infant mice. Journal of Experimental Medicine, 106, 743-755.
165. Kravetz, H. M., Knight, V., Chanock, R. M., Morris, J. A., Johnson, K. M., Rifkind, D., et al. (1961). Respiratory syncytial virus. III. Production of illness and clinical observations in adult volunteers. JAMA, 176, 657-663.
166. Krous, H. F., Dietzman, D., & Ray, C. G. (1973). Fatal infections with echovirus types 6 and 11 in early infancy. American Journal of Diseases of Children, 126, 842-846.
167. Krugman, S., & Giles, J. P. (1970). Viral hepatitis. New light on an old disease. JAMA, 212, 1019-1029.
168. Krugman, S., & WARD, R. (1958). Clinical and experimental studies of infectious hepatitis. Pediatrics, 22, 1016-1022.
169. Krugman, S., WARD, R., & Giles, J. P. (1962). The natural history of infectious hepatitis. American Journal of Medicine, 32, 717-728.
170. Lagos, R., Munoz, A., Dumas, R., Pichon, S., Zambrano, B., Levine, M., et al. (2003). Immunological priming of one dose of inactivated hepatitis A vaccine given during the first year of life in presence of maternal antibodies. Vaccine, 21, 3730-3733.
171. Landsteiner, K. & Popper, E. (1908). Mikroscopische präparate von einem menschlichen und zwei affentückermarker. Wein klin Wschr, 21.
172. Lang, D. J., Cate, T. R., Couch, R. B., Knight, V., & Johnson, K. M. (1965). Response of volunteers to inoculation with hemagglutinin-positive and hemagglutinin-negative variants of coxsackie a21 virus. Journal of Clinical Investigation, 44, 1125-1131.
173. LeDuc, J. W., Lemon, S. M., Keenan, C. M., Graham, R. R., Marchwicki, R. H., & Binn, L. N. (1983). Experimental infection of the New World owl monkey (Aotus trivirgatus) with hepatitis A virus. Infection and Immunity, 40, 766-772.
174. Lee, F. E., Walsh, E. E., Falsey, A. R., Betts, R. F., & Treanor, J. J. (2004). Experimental infection of humans with A2 respiratory syncytial virus. Antiviral Research, 63, 191-196.
175. Lemon, S. M., Jansen, R. W., & Brown, E. A. (1992). Genetic, antigenic and biological differences between strains of hepatitis A virus. Vaccine, 10(Suppl. 1), S40-S44.
176. Lindesmith, L., Moe, C., Marionneau, S., Ruvoen, N., Jiang, X., Lindblad, L., et al. (2003). Human susceptibility and resistance to Norwalk virus infection. Nature Medicine, 9, 548-553.
177. Liu, G., Kahan, S. M., Jia, Y., & Karst, S. M. (2009). Primary high-dose murine norovirus 1 infection fails to protect from secondary challenge with homologous virus. Journal of Virology, 83, 6963-6968.
178. Lopman, B. A., Brown, D. W., & Koopmans, M. (2002). Human caliciviruses in Europe. Journal of Clinical Virology, 24, 137-160.
179. Maccallum, F. O., & Bradley, W. H. (1944). Transmission of infective hepatitis to human volunteers. Lancet, 2, 228.
180. Mackie, P. L. (2003). The classification of viruses infecting the respiratory tract. Paediatric Respiratory Reviews, 4, 84-90.
181. Madore, H. P., Treanor, J. J., Buja, R., & Dolin, R. (1990). Antigenic relatedness among the Norwalk-like agents by serum antibody rises. Journal of Medical Virology, 32, 96-101.
182. Magnussen, C. R., Douglas, R. G., Jr., Betts, R. F., Roth, F. K., & Meagher, M. P. (1977). Double-blind evaluation of oral ribavirin (Virazole) in experimental influenza A virus infection in volunteers. Antimicrobial Agents and Chemotherapy, 12, 498-502.
183. Makela, M. J., Puhakka, T., Ruuskanen, O., Leinonen, M., Saikku, P., Kimpimaki, M., et al. (1998). Viruses and bacteria in the etiology of the common cold. Journal of Clinical Microbiology, 36, 539-542.
184. Mallia, P., Message, S. D., Kebadze, T., Parker, H. L., Kon, O. M., & Johnston, S. L. (2006). An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study. Respiratory research, 7, 116.
185. Mann, J. J., Waldman, R. H., Togo, Y., Heiner, G. G., Dawkins, A. T., & Kasel, J. A. (1968). Antibody response in respiratory secretions of volunteers given live and dead influenza virus. Journal of Immunology, 100, 726-735.
186. Matsuzaki, Y., Mizuta, K., Kimura, H., Sugawara, K., Tsuchiya, E., Suzuki, H., et al. (2000). Characterization of antigenically unique influenza C virus strains isolated in Yamagata and Sendai cities, Japan, during 1992-1993. Journal of General Virology, 81, 1447-1452.
187. McKay, E., Higgins, P., Tyrrell, D., & Pringle, C. (1988). Immunogenicity and pathogenicity of temperature-sensitive modified respiratory syncytial virus in adult volunteers. Journal of Medical Virology, 25, 411-421.
188. Mead, P. S., Slutsker, L., Griffin, P. M., & Tauxe, R. V. (1999). Food-related illness and death in the United States reply to Dr. Hedberg. Emerging Infectious Diseases, 5, 841-842.
189. Midthun, K., Ellerbeck, E., Gershman, K., Calandra, G., Krah, D., McCaughtry, M., et al. (1991). Safety and immunogenicity of a live attenuated hepatitis A virus vaccine in seronegative volunteers. Journal of Infectious Diseases, 163, 735-739.
190. Mills, J., van Kirk, J. E., Wright, P. F., & Chanock, R. M. (1971). Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. Journal of Immunology, 107, 123-130.
191. Minor, T. E., Allen, C. I., Tsiatis, A. A., Nelson, D. B., & D'Alessio, D. J. (1981). Human infective dose determinations for oral poliovirus type 1 vaccine in infants. Journal of Clinical Microbiology, 13, 388-389.
192. Moe, K., & Shirley, J. A. (1982). The effects of relative humidity and temperature on the survival of human rotavirus in faeces. Archives of Virology, 72, 179-186.
193. Mufson, M. A., Ludwig, W. M., James, H. D., Jr., Gauld, L. W., Rourke, J. A., Holper, J. C., et al. (1963). Effect of neutralizing antibody on experimental rhinovirus infection. JAMA, 186, 578-584.
194. Murphy, B. R., Chalhub, E. G., Nusinoff, S. R., Kasel, J., & Chanock, R. M. (1973). Temperature-sensitive mutants of influenza virus. 3. Further characterization of the ts-1(E) influenza A recombinant (H3N2) virus in man. Journal of Infectious Diseases, 128, 479-487.
195. Murphy, B. R., Clements, M. L., Tierney, E. L., Black, R. E., Stienberg, J., & Chanock, R. M. (1985). Dose response of influenza A/Washington/897/80 (H3N2) avian-human reassortant virus in adult volunteers. Journal of Infectious Diseases, 152, 225-229.
196. Murphy, A. W., Platts-Mills, T. A., Lobo, M., & Hayden, F. (1998). Respiratory nitric oxide levels in experimental human influenza. Chest, 114, 452-456.
197. Murphy, B. R., Rennels, M. B., Douglas, R. G., Jr., Betts, R. F., Couch, R. B., Cate, T. R., Jr., et al. (1980). Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers. Infection and Immunity, 29, 348-355.
198. Neefe, J. R., & Strokes, J. J. R. (1945). An epidemic of infectious hepatitis apparently due to a water borne agent. JAMA, 128, 1063.
199. Nicas, M., Nazaroff, W. W., & Hubbard, A. (2005). Toward understanding the risk of secondary airborne infection: Emission of respirable pathogens. Journal of Occupational and Environmental Hygiene, 2, 143-154.
200. Nichols, W. G., Peck Campbell, A. J., & Boeckh, M. (2008). Respiratory viruses other than influenza virus: impact and therapeutic advances. Clinical Microbiology Reviews, 21, 274-290 (Table).
201. Nicholson, K. G., Kent, J., & Ireland, D. C. (1993). Respiratory viruses and exacerbations of asthma in adults. British Medical Journal, 307, 982-986.
202. Nicholson, K. G., Wood, J. M., & Zambon, M. (2003). Influenza. Lancet, 362, 1733-1745.
203. Noah, T. L., & Becker, S. (2000). Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus. Clinical Immunology, 97, 43-49.
204. Offit, P. A., Clark, H. F., Kornstein, M. J., & Plotkin, S. A. (1984). A murine model for oral infection with a primate rotavirus (simian SA11). Journal of Virology, 51, 233-236.
205. Ozawa, K., Oka, T., Takeda, N., & Hansman, G. S. (2007). Norovirus infections in symptomatic and asymptomatic food handlers in Japan. Journal of Clinical Microbiology, 45, 3996-4005.
206. Pachuta, D. M., Togo, Y., Hornick, R. B., Schwartz, A. R., & Tominaga, S. (1974). Evaluation of isoprinosine in experimental human rhinovirus infection. Antimicrobial Agents and Chemotherapy, 5, 403-408.
207. Parrino, T. A., Schreiber, D. S., Trier, J. S., Kapikian, A. Z., & Blacklow, N. R. (1977). Clinical immunity in acute gastroenteritis caused by Norwalk agent. The New England Journal of Medicine, 297, 86-89.
208. Parrott, R. H., Kim, H. W., Brandt, C. D., & Chanock, R. M. (1975). Potential of attenuated respiratory syncytial virus vaccine for infants and children. Developments in Biological Standardization, 28, 389-399.
209. Payment, P., & Morin, E. (1990). Minimal infective dose of the OSU strain of porcine rotavirus. Archives of Virology, 112, 277-282.
210. Perkins, J. C., Tucker, D. N., Knopf, H. L., Wenzel, R. P., Kapikian, A. Z., & Chanock, R. M. (1969). Comparison of protective effect of neutralizing antibody in serum and nasal secretions in experimental rhinovirus type 13 illness. American Journal of Epidemiology, 90, 519-526.
211. Peterson, K. M., O'Shea, M., Stam, W., Mohede, I. C., Patrie, J. T., & Hayden, F. G. (2009). Effects of dietary supplementation with conjugated linoleic acid on experimental human rhinovirus infection and illness. Antiviral therapy, 14, 33-43.
212. Philipson, L. (1958). Experiments in human adults with a recently isolated virus associated with respiratory disease. Archiv fur Die Gesamte Virusforschung, 8, 318-331.
213. Philipson, L., & Wesslen, T. (1958). Recovery of a cytopathogenic agent from patients with non-diphtheritic croup and from day-nursery children. I. Properties of the agent. Archiv fur Die Gesamte Virusforschung, 8, 76-94.
214. Pindak, F. F. & Clapper, W. E. (1965). Experimental infection of beagles with ECHO virus type 6. LF-25. Fission Product Inhalation Project, 69, 1-11.
215. Pinto, C. A., & Haff, R. F. (1969). Experimental infection of gibbons with rhinovirus. Nature, 224, 1310-1311.
216. Pinto, M. A., Marchevsky, R. S., Baptista, M. L., de Lima, M. A., Pelajo-Machado, M., Vitral, C. L., et al. (2002). Experimental hepatitis A virus (HAV) infection in Callithrix jacchus: Early detection of HAV antigen and viral fate. Experimental and Toxicologic Pathology, 53, 413-420.
217. Pitkaranta, A., Arruda, E., Malmberg, H., & Hayden, F. G. (1997). Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR. Journal of Clinical Microbiology, 35, 1791-1793.
218. Plotkin, S. A., Koprowski, H., & Stokes, J., Jr. (1959). Clinical trials in infants of orally administered attenuated poliomyelitis viruses. Pediatrics, 23, 1041-1062.
219. Purcell, R. H., Wong, D. C., & Shapiro, M. (2002). Relative infectivity of hepatitis A virus by the oral and intravenous routes in 2 species of nonhuman primates. Journal of Infectious Diseases, 185, 1668-1671.
220. Quigley, J. J. (1949). Ultrafiltration and ultracentrifugation studies of Coxsackie virus. Proceedings of the Society for Experimental Biology and Medicine, 72, 434.
221. Racaniello, V. R. (2006). One hundred years of poliovirus pathogenesis. Virology, 344, 9-16.
222. Ramig, R. F. (1988). The effects of host age, virus dose, and virus strain on heterologous rotavirus infection of suckling mice. Microbial Pathogenesis, 4, 189-202.
223. Reid, J. A., Caul, E. O., White, D. G., & Palmer, S. R. (1988). Role of infected food handler in hotel outbreak of Norwalk-like viral gastroenteritis: Implications for control. Lancet, 2, 321-323.
224. Ren, A., Feng, F., Ma, J., Xu, Y., & Liu, C. (2002). Immunogenicity and safety of a new inactivated hepatitis A vaccine in young adults: A comparative study. Chinese Medical Journal, 115, 1483-1485.
225. Rosenblum, L. S., Villarino, M. E., Nainan, O. V., Melish, M. E., Hadler, S. C., Pinsky, P. P., et al. (1991). Hepatitis A outbreak in a neonatal intensive care unit: Risk factors for transmission and evidence of prolonged viral excretion among preterm infants. Journal of Infectious Diseases, 164, 476-482.
226. Rotbart, H. A., & Hayden, F. G. (2000). Picornavirus infections: A primer for the practitioner. Archives of Family Medicine, 9, 913-920.
227. Rowe, W. P., Huebner, R. J., Gilmore, L. K., Parrott, R. H., & Ward, T. G. (1953). Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proceedings of the Society for Experimental Biology and Medicine, 84, 570-573.
228. Sabin, A. B. (1957). Present status of attenuated live virus poliomyelitis vaccine. Bulletin of the New York Academy of Medicine, 33, 17-39.
229. Sabin, A. B., Hennessen, W. A., & Winsser, J. (1954). Studies on variants of poliomyelitis virus. I. Experimental segregation and properties of avirulent variants of three immunologic types. Journal of Experimental Medicine, 99, 551-576.
230. Sair, A. I., D'Souza, D. H., & Jaykus, L. A. (2002). Human enteric viruses as causes of foodborne disease. Comprehensive reviews in food science and food safety, 1, 73-89.
231. Saliba, G. S., Franklin, S. L., & Jackson, G. G. (1968). ECHO-11 as a respiratory virus: Quantitation of infection in man. Journal of Clinical Investigation, 47, 1303-1313.
232. Sato, K., Inaba, Y., Miura, Y., Tokuhisa, S., & Matumoto, M. (1982). Isolation of lapine rotavirus in cell cultures. Brief report. Archives of Virology, 71, 267-271.
233. Savolainen, C., Blomqvist, S., & Hovi, T. (2003). Human rhinoviruses. Paediatric Respiratory Reviews, 4, 91-98.
234. Schiff, G. M., Stefanovic, G. M., Young, E. C., Sander, D. S., Pennekamp, J. K., & Ward, R. L. (1984a). Studies of echovirus-12 in volunteers: Determination of minimal infectious dose and the effect of previous infection on infectious dose. Journal of Infectious Diseases, 150, 858-866.
235. Schiff, G. M., Stefanovic', G. M., Yung, B., & Pennekemp, J. K. (1984b). Minimum human infectious dose of enteric virus (Echo-virus-12) in drinking wate. Monographs in Virology, 15, 222-228.
236. Schoub, B. D. (1981). Enteric adenoviruses and rotaviruses in infantile gastroenteritis in developing countries. Lancet, 2, 925.
237. Sears, S. D., & Clements, M. L. (1987). Protective efficacy of low-dose amantadine in adults challenged with wild-type influenza A virus. Antimicrobial Agents and Chemotherapy, 31, 1470-1473.
238. Sears, S. D., Clements, M. L., Betts, R. F., Maassab, H. F., Murphy, B. R., & Snyder, M. H. (1988). Comparison of live, attenuated H1N1 and H3N2 cold-adapted and avian-human influenza A reassortant viruses and inactivated virus vaccine in adults. Journal of Infectious Diseases, 158, 1209-1219.
239. Selivanov, A. A., Kovaleva, T. P., & Smorodintsev, A. A. (1972). Specific humoral immunity among volunteers with experimental adenovirus infection. Archiv fur Die Gesamte Virusforschung, 36, 36-42.
240. Sjogren, M. H., Purcell, R. H., McKee, K., Binn, L., Macarthy, P., Ticehurst, J., et al. (1992). Clinical and laboratory observations following oral or intramuscular administration of a live attenuated hepatitis A vaccine candidate. Vaccine, 10(Suppl 1), S135-S137.
241. Snyder, M. H., Clements, M. L., Betts, R. F., Dolin, R., Buckler-White, A. J., Tierney, E. L., et al. (1986a). Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers. Journal of Clinical Microbiology, 23, 852-857.
242. Snyder, M. H., Stephenson, E. H., Young, H., York, C. G., Tierney, E. L., London, W. T., et al. (1986b). Infectivity and antigenicity of live avian-human influenza A reassortant virus: Comparison of intranasal and aerosol routes in squirrel monkeys. Journal of Infectious Diseases, 154, 709-711.
243. Southam, C. M., Hilleman, M. R., & Werner, J. H. (1956). Pathogenicity and oncolytic capacity of RI virus strain RI-67 in man. Journal of Laboratory and Clinical Medicine, 47, 573-582.
244. Spickard, A., Evans, H., Knight, V., & Johnson, K. (1963). Acute respiratory disease in normal volunteers associated with Coxsackie A-21 viral infection. III. Response to nasopharyngeal and enteric inoculation. Journal of Clinical Investigation, 42, 840-852.
245. Steinhoff, M. C., Halsey, N. A., Fries, L. F., Wilson, M. H., King, J., Burns, B. A., et al. (1991). The A/Mallard/6750/78 avian-human, but not the A/Ann Arbor/6/60 cold-adapted, influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine retains partial virulence for infants and children. Journal of Infectious Diseases, 163, 1023-1028.
246. Steinhoff, M. C., Halsey, N. A., Wilson, M. H., Burns, B. A., Samorodin, R. K., Fries, L. F., et al. (1990). Comparison of live attenuated cold-adapted and avian-human influenza A/Bethesda/85 (H3N2) reassortant virus vaccines in infants and children. Journal of Infectious Diseases, 162, 394-401.
247. Tacket, C. O., Mason, H. S., Losonsky, G., Estes, M. K., Levine, M. M., & Arntzen, C. J. (2000). Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes. Journal of Infectious Diseases, 182, 302-305.
248. Tacket, C. O., Sztein, M. B., Losonsky, G. A., Wasserman, S. S., & Estes, M. K. (2003). Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clinical Immunology, 108, 241-247.
249. Tang, J. W., & Li, Y. (2007). Transmission of influenza A in human beings. The Lancet Infectious Diseases, 7, 758.
250. Tellier, R. (2006). Review of aerosol transmission of influenza A virus. Emerging Infectious Diseases, 12, 1657-1662.
251. Teunis, P. F., & Havelaar, A. H. (2000). The Beta Poisson dose-response model is not a single-hit model. Risk Analysis, 20, 513-520.
252. Teunis, P. F., Moe, C. L., Liu, P., Miller, S. E., Lindesmith, L., Baric, R. S., et al. (2008). Norwalk virus: How infectious is it? Journal of Medical Virology, 80, 1468-1476.
253. Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., et al. (2003). Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA, 289, 179-186.
254. Thornhill, T. S., Kalica, A. R., Wyatt, R. G., Kapikian, A. Z., & Chanock, R. M. (1975). Pattern of shedding of the Norwalk particle in stools during experimentally induced gastroenteritis in volunteers as determined by immune electron microscopy. Journal of Infectious Diseases, 132, 28-34.
255. Tjon, G. M., Coutinho, R. A., van den Hoek, A., Esman, S., Wijkmans, C. J., Hoebe, C. J., et al. (2006). High and persistent excretion of hepatitis A virus in immunocompetent patients. Journal of Medical Virology, 78, 1398-1405.
256. Togo, Y., Hornick, R. B., & Dawkins, A. T., Jr. (1968). Studies on induced influenza in man. I. Double-blind studies designed to assess prophylactic efficacy of amantadine hydrochloride against a2/Rockville/1/65 strain. JAMA, 203, 1089-1094.
257. Togo, Y., & McCracken, E. A. (1976). Double-blind clinical assessment of ribavirin (virazole) in the prevention of induced infection with type B influenza virus. Journal of Infectious Diseases, 133(Suppl.), A109-A113.
258. Togo, Y., Schwartz, A. R., Tominaga, S., & Hornick, R. B. (1972). Cyclooctylamine in the prevention of experimental human influenza. JAMA, 220, 837-841.
259. Treanor, J. J., Kotloff, K., Betts, R. F., Belshe, R., Newman, F., Iacuzio, D., et al. (1999). Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses. Vaccine, 18, 899-906.
260. Turner, R. B., Bauer, R., Woelkart, K., Hulsey, T. C., & Gangemi, J. D. (2005). An evaluation of Echinacea angustifolia in experimental rhinovirus infections. The New England Journal of Medicine, 353, 341-348.
261. Turner, R. B., Riker, D. K., & Gangemi, J. D. (2000). Ineffectiveness of echinacea for prevention of experimental rhinovirus colds. Antimicrobial Agents and Chemotherapy, 44, 1708-1709.
262. van Blerkom, L. M. (2003). Role of viruses in human evolution. American Journal of Physical Anthropology, Suppl, 37, 14-46.
263. van Elden, L. J., Nijhuis, M., Schipper, P., Schuurman, R., & van Loon, A. M. (2001). Simultaneous detection of influenza viruses A and B using real-time quantitative PCR. Journal of Clinical Microbiology, 39, 196-200.
264. Vasickova, P., Dvorska, L., Lorencova, A., & Pavlik, I. (2005). Viruses as a cause of foodborne diseases: a review of the literature. Veterinary medicine, 50, 89-104.
265. Vasilenko, S., & Atsev, S. (1965). Experimental infection of mice with ECHO-6 virus. Acta Virologica, 9, 541-545.
266. Vasilenko, S., Atsev, S., & Bradvarova, A. (1967). Experimental infection of mice induced by ECHO virus types 7, 8, 11 and 13 adapted to them. Voprosy Virusologii, 12, 485-491.
267. Venter, J. M., van, H. J., Vivier, J. C., Grabow, W. O., & Taylor, M. B. (2007). Hepatitis A virus in surface water in South Africa: What are the risks? Journal of Water and Health, 5, 229-240.
268. Ventura, K. C., Hawkins, H., Smith, M. B., & Walker, D. H. (2001). Fatal neonatal echovirus 6 infection: Autopsy case report and review of the literature. Modern Pathology, 14, 85-90.
269. Vipond, I. B. (2001). The role of viruses in gastrointestinal disease in the home. Journal of Infection, 43, 38-40.
270. Voegt, H. (1942). Zur Aetiologie der Hepatitis epidemica. Munchener Medizinische Wochenschrift, 89, 76.
271. Vogels, R., Zuijdgeest, D., van, R. R., Hartkoorn, E., Damen, I., de Bethune, M. P., et al. (2003). Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: Efficient human cell infection and bypass of preexisting adenovirus immunity. Journal of Virology, 77, 8263-8271.
272. Wang, X. Y., Xu, Z. Y., Ma, J. C., von, S. L., Zhang, Y., Hao, Z. Y., et al. (2007). Long-term immunogenicity after single and booster dose of a live attenuated hepatitis A vaccine: Results from 8-year follow-up. Vaccine, 25, 446-449.
273. Ward, R. L., Akin, E. W., & D'Alessio, D. J. (1984a). Minimum infective dose of animal viruses. CRC Critical Reviews in Environmental Control, 14, 297-310.
274. Ward, R. L., Bernstein, D. I., Young, E. C., Sherwood, J. R., Knowlton, D. R., & Schiff, G. M. (1986). Human rotavirus studies in volunteers: Determination of infectious dose and serological response to infection. Journal of Infectious Diseases, 154, 871-880.
275. Ward, R. L., Knowlton, D. R., & Pierce, M. J. (1984b). Efficiency of human rotavirus propagation in cell culture. Journal of Clinical Microbiology, 19, 748-753.
276. Warren, R. J., Lepow, M. L., Bartsch, G. E., & Robbins, F. C. (1964). The relationship of maternal antibody, breast feeding, and age to the susceptibility of newborn infants to infection with attenuated polioviruses. Pediatrics, 34, 4-13.
277. Weber, T. P., & Stilianakis, N. I. (2008). Inactivation of influenza A viruses in the environment and modes of transmission: a critical review. Journal of Infection, 57, 361-373.
278. Wei, Z., McEvoy, M., Razinkov, V., Polozova, A., Li, E., Casas-Finet, J., et al. (2007). Biophysical characterization of influenza virus subpopulations using field flow fractionation and multiangle light scattering: correlation of particle counts, size distribution and infectivity. Journal of Virological Methods, 144, 122-132.
279. Wenner, H. A. (1982). The enteroviruses: Recent advances. Yale Journal of Biology and Medicine, 55, 277-282.
280. Westblom, T. U., Gudipati, S., DeRousse, C., Midkiff, B. R., & Belshe, R. B. (1994). Safety and immunogenicity of an inactivated hepatitis A vaccine: Effect of dose and vaccination schedule. Journal of Infectious Diseases, 169, 996-1001.
281. Winther, B., Gwaltney, J. M., Jr., Mygind, N., Turner, R. B., & Hendley, J. O. (1986). Sites of rhinovirus recovery after point inoculation of the upper airway. JAMA, 256, 1763-1767.
282. Woode, G. N. (1976). Pathogenic rotaviruses isolated from pigs and calves, Ciba foundation symposium series (pp. 251-271). Amsterdam: Elsevier.
283. Wright, P. F., Belshe, R. B., Kim, H. W., van Voris, L. P., & Chanock, R. M. (1982). Administration of a highly attenuated, live respiratory syncytial virus vaccine to adults and children. Infection and Immunity, 37, 397-400.
284. Wyatt, R. G., Dolin, R., Blacklow, N. R., Dupont, H. L., Buscho, R. F., Thornhill, T. S., et al. (1974). Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. Journal of Infectious Diseases, 129, 709-714.
285. Zambrano, J. C., Carper, H. T., Rakes, G. P., Patrie, J., Murphy, D. D., Platts-Mills, T. A., et al. (2003). Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE. Journal of Allergy and Clinical Immunology, 111, 1008-1016.