Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1704-1714

  Mayhoub, Abdelrahman S ^a   Khaliq, Mansoora ^b   Kuhn, Richard J ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 CHLOROPHENYL) 4 METHYLTHIAZOL 5 YL]ETHANONE; 1 [4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOL 5 YL] 3 (DIMETHYLAMINO)PROP 2 EN 1 ONE; 1 [4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOL 5 YL]ETHANONE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N (2 HYDROXYETHYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N (2,3 DIHYDROXYPROPYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N (DEXTRO GLUCOSYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N (PROP 2 YNYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N (RIBITYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N ETHYLTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N METHOXYTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N METHYLTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N,N DIETHYLTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL) N,N DIMETHYLTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 4 (METHOXYMETHYL) N METHYLTHIAZOLE 5 CARBOXAMIDE; 4 (DIBROMOMETHYL) 5 CHLOROCARBONYL 2 (4 CHLOROPHENYL)THIAZOLE; ALKYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXYLIC ACID; ETHYL 2 (4 CHLOROPHENYL) 4 (FURAN 2 YL)THIAZOLE 5 CARBOXYLIC ACID; ETHYL 2 CHLORO 3 (FURAN 2 YL) 3 OXOPROPANOATE; ETHYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXYLIC ACID; ISOPROPYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOTHIOATE; ISOPROPYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXYLIC ACID; METHYL 2 (4 CHLOROPHENYL) 4 ETHYLTHIAZOLE 5 CARBOXYLIC ACID; METHYL 2 (4 CHLOROPHENYL) 4 ISOPROPYLTHIAZOLE 5 CARBOXYLIC ACID; METHYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOTHIOATE; METHYL 4 TERT BUTYL 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXYLIC ACID; N ALLYL 4 (DIBROMOMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE 5 CARBOXAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS ENVELOPE PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN BHK; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; YELLOW FEVER FLAVIVIRUS;

AMIDES; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE; CRICETINAE; DENGUE VIRUS; DRUG DESIGN; DRUG STABILITY; ESTERS; FLAVIVIRUS; KETONES; MESOCRICETUS; MODELS, MOLECULAR; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRAL ENVELOPE PROTEINS; YELLOW FEVER VIRUS;

EID: 79952812935     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013538     Document Type: Article

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