Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4660-4671

  Li, Ze ^a   Khaliq, Mansoora ^b   Zhou, Zhigang ^a   Post, Carol Beth ^a   Kuhn, Richard J ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ((2 (4 CHLOROPHENYL)THIAZOL 4 YL)METHYLTHIO)ANILINE; 2 (3 (4 (1 (2 CARBAMIMIDOYLHYDRAZONO) ETHYL) PHENYL) UREIDO) N (2,4 DICHLOROBENZYL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; 2 (3 (4 (1 (2 CARBAMOYLHYDRAZONO) ETHYL) UREIDO) N (2,4 DICHLOROBENZYL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; 2 (3 (4 ACETYLPHENYL) UREIDO) N (2,4 DICHLOROBENZYL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; 2 (3 (4 ACETYLPHENYL) UREIDO) N (3,4 DICHLOROBENZYL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; 2 (3,5 DIPHENYL 1H PYRAZOL 1 YL) 4 METHYLTHIAZOLE 5 CARBOXYLIC ACID; 2 (4 CHLORO PHENYL) 4 DIBROMOMETHYL THIAZOLE 5 CARBOXYLIC ACID METHYL ESTER; 2 (4 CHLORO PHENYL) 4 METHYL THIAZOLE 5 CARBOXYLIC ACID ADAMANTAN 1 YLMETHYL ESTER; 2 (4 CHLOROPHENYL) 4 METHYLTHIAZOLE; 2 (4 CHOROPHEYNL) 4 METHYL THIAZOLE 5 CARBOXYLIC ACID METHYL ESTER; 2 (BIS(4 ACETYLBENZYL)AMINO) 4 METHYLTHIAZOLE 5 CARBOXYLIC ACID; 2 (BIS(4 ACETYLBENZYL)AMINO) N (2,4 DICHLOROBENZYL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; 2 [3 (4 ACETYLPHENYL) UREIDO] 4 METHYLTHIAZOLE 5 CARBOXYLIC ACID; 2 CHLORO 3 OXO BUTYRIC ACID METHYL ESTER; 4 (CHLOROMETHYL) 2 (4 CHLOROPHENYL)THIAZOLE; ANTIVIRUS AGENT; ETHYL 2 (3,5 DIPHENYL 1H PYRAZOL 1 YL) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 (3 (4 (1 (2 CARBAMIMIDOYLHYDRAZANO) ETHYL) PHENYL) UREIDO) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 (3 (4 (1 (2 CARBAMOYLHYDRAZANO) ETHYL) PHENYL) UREIDO) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 (3 (4 ACETYLPHENYL)UREIDO) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 (BIS(4 ACETYLBENZYL)AMINO) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 (N (4 ACETYLBENZYL)ACETAMIDO) 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 AMINO 4 METHYLTHIAZOLE 5 CARBOXYLATE; METHYL 2 BROMO 3 OXOBUTANOATE; N (3,4 DICHLOROBENZYL) 2 (3,5 DIPHENYL 1H PYRAZOL 1 YL) 4 METHYLTHIAZOLE 5 CARBOXAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; FLAVIVIRUS; HUMAN; HUMAN CELL;

ANTIVIRAL AGENTS; BINDING SITES; DRUG DESIGN; FLAVIVIRUS; GENE PRODUCTS, ENV; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49449094472     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800412d     Document Type: Article

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