Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: Evidence for activity on the level of substrate and/or enzyme

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 5, 2002, Pages 1231-1239

  Borowski, Peter ^a   Lang, Melanie ^a   Haag, Annemarie ^a   Schmitz, Herbert ^a   Choe, Joonho ^a   Chen, Huan Ming ^a   Hosmane, Ramachandra S ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2' DEOXY ALPHA DEXTRO RIBOFURANOSYL)IMIDAZO[4,5 D]PYRIDAZINE 4,7(5H,6H) DIONE; 1 (2' O METHYL BETA DEXTRO RIBOFURANOSYL)IMIDAZO[4,5 D]PYRIDAZINE 4,7(5H,6H) DIONE; 1 (BETA DEXTRO RIBOFURANOSYL)IMIDAZO[4,5 D]PYRIDAZINE 4,7(5H,6H) DIONE; ANTIVIRUS AGENT; HELICASE; IMIDAZO[4,5 D]PYRIDAZINE DERIVATIVE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; IC 50; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; VIRUS INHIBITION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS;

ACID ANHYDRIDE HYDROLASES; ANIMALS; CERCOPITHECUS AETHIOPS; DEOXYRIBONUCLEOSIDES; NUCLEOSIDE-TRIPHOSPHATASE; NUCLEOSIDES; PYRIDAZINES; RIBONUCLEOSIDES; RNA HELICASES; RNA, VIRAL; VERO CELLS; VIRUS REPLICATION; WEST NILE VIRUS;

EID: 0036237524     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.5.1231-1239.2002     Document Type: Article

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