Aminothiazolomorphinans with mixed κ and μ opioid activity

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1903-1913

  Zhang, Tangzhi ^a   Yan, Zhaohua ^a   Sromek, Anna ^a   Knapp, Brian I ^b   Scrimale, Thomas ^b   Bidlack, Jean M ^b   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BROMO THIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; AMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMORPHINAN; AMINOTHIAZOLO[5,4 B] N TETRAHYDROFURYLMETHYLMORPHINAN; KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; N' (3 HYDROXYBENZYL)AMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' (3 METHOXYBENZYL)AMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' (PIPERAZIN 1 YL)AMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' (PYRIDIN 2 YL)AMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ACETYL N' ETHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ACETYL N' METHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ACETYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ACETYLAMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMORPHINAN; N' BENZYLMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ETHYLAMINOTHIAZOLO[5,4 B] N CYCLOBUTYLMETHYLMORPHINAN; N' ETHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' ETHYLAMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMORPHINAN; N' ETHYLTHIOUREA THIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' METHYLAMINOTHIAZOLO[5,4 B] N CYCLOBUTYLMETHYLMORPHINAN; N' METHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' METHYLAMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMORPHINAN; N' PHENYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' PROPYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N' PROPYLAMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMORPHINAN; N' TRIFLUOROETHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N',N' DIMETHYLAMINOTHIAZOLO[5,4 B] N CYCLOPROPYLMETHYLMORPHINAN; N',N' DIMETHYLAMINOTHIAZOLO[5,4 B] N FLUOROPROPYLMETHYLMORPHINAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MORPHINANS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79952803684     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101542c     Document Type: Article

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