10-Ketomorphinan and 3-Substituted-3-desoxymorphinan Analogues as Mixed κ and μ Opioid Ligands: Synthesis and Biological Evaluation of Their Binding Affinity at Opioid Receptors

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 165-174

  Zhang, Ao ^a   Xiong, Wennan ^a   Bidlack, Jean M ^b   Hilbert, James E ^b   Knapp, Brian I ^b   Wentland, Mark P ^c   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c Rensselaer Polytechnic Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1'H TETRAZOL 5' YL) N CYCLOBUTYLMETHYLMORPHINAN; 3 (1'H TETRAZOL 5' YL) N METHYLMORPHINAN; 3 AMINO N CYCLOBUTYLMETHYLMORPHINAN; 3 AMINO N CYCLOPROPYLMETHYLMORPHINAN; 3 AMINO N METHYLMORPHINAN; 3 AMINOMETHYL N CYCLOBUTYLMETHYLMORPHINAN; 3 AMINOMETHYL N METHYLMORPHINAN; 3 CARBOXAMIDO N CYCLOBUTYLMETHYLMORPHINAN; 3 CARBOXAMIDO N CYCLOPROPYLMETHYLMORPHINAN; 3 CARBOXAMIDO N METHYLMORPHINAN; 3 CYANO N METHYLMORPHINAN; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; LIGAND; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; INTERMETHOD COMPARISON; LIPID SOLUBILITY; MOLECULAR STABILITY; NONHUMAN; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; BRAIN; CHO CELLS; CRICETINAE; GUINEA PIGS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MORPHINANS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0347991961     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0304156     Document Type: Article

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