Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3531-3539

  Light, Samuel H ^a   Minasov, George ^a   Shuvalova, Ludmilla ^a   Duban, Mark Eugene ^a   Caffrey, Michael ^b   Anderson, Wayne F ^a   Lavie, Arnon ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AROMATIC AMINO ACID; BRANCH POINTS; CATALYTIC DEHYDRATION; CATALYTIC ROLE; CATALYZED REACTIONS; CHORISMATE; CLOSTRIDIUM DIFFICILE; DEHYDRATION REACTIONS; DEHYDROQUINATE; ENZYME INHIBITORS; INTERMEDIATE STATE; LEAVING GROUPS; SALMONELLA ENTERICA; SCHIFF BASE FORMATION; SCHIFF-BASE; SEQUENTIAL REACTION; SHIKIMATE PATHWAY; STATE-DEPENDENT;

AMINO ACIDS; CATALYSIS; CATALYSTS; CONFORMATIONS; DEHYDRATION; DEWATERING; ENZYMES; FUNCTIONAL GROUPS; SYNTHESIS (CHEMICAL);

REACTION INTERMEDIATES;

DEHYDROQUINATE DEHYDRATASE TYPE 1; HISTIDINE; HYDROLYASE; SHIKIMIC ACID; UNCLASSIFIED DRUG; 3 DEHYDROQUINIC ACID; 3 DEHYDROSHIKIMATE; 3-DEHYDROQUINIC ACID; 3-DEHYDROSHIKIMATE; BACTERIAL PROTEIN; DRUG DERIVATIVE; QUINIC ACID; SCHIFF BASE;

ARTICLE; CATALYSIS; CLOSTRIDIUM DIFFICILE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION; CHEMISTRY; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CLOSTRIDIUM DIFFICILE; SALMONELLA ENTERICA;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CLOSTRIDIUM DIFFICILE; CRYSTALLOGRAPHY, X-RAY; HYDRO-LYASES; PROTEIN BINDING; PROTEIN CONFORMATION; QUINIC ACID; SALMONELLA ENTERICA; SCHIFF BASES; SHIKIMIC ACID;

EID: 79952783908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.192831     Document Type: Article

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