Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 3, 2000, Pages 231-234

  Parker, Emily J ^a   Bello, Concepción González ^a   Coggins, John R ^b   Hawkins, Alastair R ^c   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; FLUORINE; IMINE; QUINIC ACID; SHIKIMIC ACID;

ARTICLE; ASPERGILLUS NIDULANS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REACTION ANALYSIS;

CYCLOHEXANECARBOXYLIC ACIDS; CYCLOHEXANONES; HYDRO-LYASES; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; STEREOISOMERISM;

ASPERGILLUS; EMERICELLA NIDULANS; ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0343938469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00660-5     Document Type: Article

References (14)

1. Bentley R. CRC Crit. Rev. Biochem. 25:1990;307.
2. Kleanthous C., Deka R., Davis K., Kelly S.M., Cooper A., Harding S.E., Price N.C., Hawkins A.R., Coggins J.R. Biochem, J. 282:1992;687.
3. Butler J.R., Alworth W.L., Nugent M.J. J. Am. Chem. Soc. 96:1974;1617.
4. Chaudhuri S., Duncan K., Coggins J.R. Methods Enzymol. 142:1987;320.
5. Shneier A., Harris J., Kleanthous C., Coggins J.R., Hawkins A.R., Abell C. Bioorg. Med. Chem. Lett. 3:1993;1399.
6. Harris, J.; Kleanthous, C.; Coggins, J. R.; Hawkins, A. R.; Abell, C. J. Chem. Soc., Chem. Commun. 1993, 1080.
7. Harris J.M., González-Bello C., Kleanthous C., Hawkins A.R., Coggins J.R., Abell C. Biochem, J. 319:1996;333.
8. Duggan P.J., Parker E., Coggins J.R., Abell C. Bioorg. Med. Chem. Lett. 5:1995;2347.
9. E. coli dehydroquinase was purified as described by Chaudhuri, S.; Lambert, J. M.; McColl, L. A.; Coggins, J. R. Biochem. J. 1986, 239, 699.
10. A. nidulans dehydroquinase was purified as described by Beri, R. K.; Grant, S.; Roberts, C. F.; Smith, M.; Hawkins, A. R. Biochem. J. 1990, 265, 337.
11. M. tuberculosis dehydroquinase was purified as described by Garbe, T.; Servos, S.; Hawkins, A. R.; Dimitradis, G.; Young, D.; Dougan, G.; Charles, I. Mol. & Gen. Genet. 1991, 228, 385.
12. Mitsuhashi S., Davis B.D. Biochim. Biophys. Acta. 15:1954;54.
13. Shneier A., Kleanthous C., Deka R., Coggins J.R., Abell C. J. Am. Chem. Soc. 113:1991;9416.
14. -1).