Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: Applications for compounds with low solubility

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 1, 2011, Pages 102-106

  Argikar, Upendra A ^a   Liang, Guiqing ^a   Bushee, Jennifer L ^a   Hosagrahara, Vinayak P ^a   Lee, Wendy ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Excipients; Glucuronidation; HLMs; Kinetics; UGTs

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; CREMOPHOR; EXCIPIENT; HYMECROMONE; HYMECROMONE GLUCURONIDE; MACROGOL 200; MACROGOL 400; N,N DIMETHYLACETAMIDE; SOLUTOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION KINETICS; CLEARANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SOLUBILITY; GLUCURONIDATION; HUMAN; IN VITRO STUDY; INCUBATION TIME; LIVER MICROSOME;

EID: 79952767834     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-SH-086     Document Type: Article

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