Impact of G2 checkpoint defect on centromeric instability

Oncogene

Volumn 30, Issue 11, 2011, Pages 1281-1289

  Deng, W ^a   Tsao, S W ^a   Mak, G W Y ^a   Tsang, C M ^a   Ching, Y P ^a   Guan, X Y ^a   Huen, M S Y ^a   Cheung, A L M ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

centromere; defect; G2 checkpoint; instability

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; CYCLIN B1; PUROMYCIN; TELOMERASE; 2 MORPHOLIN 4 YL 6 THIANTHREN 1 YL PYRAN 4 ONE; 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE; ATM PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MORPHOLINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRONE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; ATAXIA TELANGIECTASIA; CANCER CELL; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL LINE; CENTROMERE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOTHESIS; PHASE TRANSITION; PRIORITY JOURNAL; CASE CONTROL STUDY; CELL DIVISION; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ESOPHAGUS TUMOR; GAMMA RADIATION; GENE TRANSLOCATION; GENETICS; HELA CELL; METABOLISM; MITOSIS INDEX; NASOPHARYNX TUMOR; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA;

ATAXIA TELANGIECTASIA; CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CENTROMERE; CHROMOSOMAL INSTABILITY; CYCLIN B1; DNA-BINDING PROTEINS; ESOPHAGEAL NEOPLASMS; G2 PHASE; GAMMA RAYS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MITOTIC INDEX; MORPHOLINES; NASOPHARYNGEAL NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PYRONES; TELOMERASE; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 79952767681     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.508     Document Type: Article

References (43)

1. Abraham RT. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196. (Pubitemid 32843830)
2. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K et al. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870. (Pubitemid 40558993)
3. Beheshti B, Karaskova J, Park PC, Squire JA, Beatty BG. (2000). Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential giemsa banding and spectral karyotyping. Mol Diagn 5: 23-32.
4. Cheung PY, Deng W, Man C, Tse WW, Srivastava G, Law S et al. (2010). Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: implications for carcinogenesis. Cancer Lett 293: 41-51.
5. 2 checkpoint release. J Cell Biol 176: 749-755.
6. Deng W, Tsao SW, Guan XY, Cheung AL. (2007). Microtubule breakage is not a major mechanism for resolving end-to-end chromosome fusions generated by telomere dysfunction during the early process of immortalization. Chromosoma 116: 557-568. (Pubitemid 350120991)
7. Deng W, Tsao SW, Kwok YK, Wong E, Huang XR, Liu S et al. (2008). Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells. Cancer Res 68: 7200-7209.
8. Deng W, Tsao SW, Lucas JN, Leung CS, Cheung AL. (2003). A new method for improving metaphase chromosome spreading. Cytometry A 51: 46-51. (Pubitemid 37517310)
9. Dillon N, Festenstein R. (2002). Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet 18: 252-258. (Pubitemid 34607140)
10. Ehrlich M. (2002). DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements. J Nutr 132: 2424S-2429S. (Pubitemid 34848120)
11. Eichler EE, Sankoff D. (2003). Structural dynamics of eukaryotic chromosome evolution. Science 301: 793-797. (Pubitemid 36962611)
12. Glaser R, Zhang HY, Yao KT, Zhu HC, Wang FX, Li GY et al. (1989). Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas. Proc Natl Acad Sci USA 86: 9524-9528. (Pubitemid 20010459)
13. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T et al. (2005). Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913. (Pubitemid 40559004)
14. Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell 100: 57-70. (Pubitemid 30046295)
15. 2 checkpoint through cyclin B1. Proc Natl Acad Sci USA 96: 2147-2152. (Pubitemid 29117882)
16. Ito Y, Takeda T, Sakon M, Monden M, Tsujimoto M, Matsuura N. (2000). Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma. Oncology 59: 68-74. (Pubitemid 30435839)
17. Jin Y, Mertens F, Jin C, Akervall J, Wennerberg J, Gorunova L et al. (1995). Nonrandom chromosome abnormalities in short-term cultured primary squamous cell carcinomas of the head and neck. Cancer Res 55: 3204-3210.
18. Johansson M, Jin Y, Mandahl N, Hambraeus G, Johansson L, Mitelman F et al. (1995). Cytogenetic analysis of short-term cultured squamous cell carcinomas of the lung. Cancer Genet Cytogenet 81: 46-55.
19. 2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6. Cell Growth Differ 8: 1105-1114. (Pubitemid 27433299)
20. Kojis TL, Schreck RR, Gatti RA, Sparkes RS. (1989). Tissue specificity of chromosomal rearrangements in ataxia-telangiectasia. Hum Genet 83: 347-352. (Pubitemid 19276778)
21. Leach TJ, Chotkowski HL, Wotring MG, Dilwith RL, Glaser RL. (2000). Replication of heterochromatin and structure of polytene chromosomes. Mol Cell Biol 20: 6308-6316. (Pubitemid 30650217)
22. Li HM, Man C, Jin Y, Deng W, Yip YL, Feng HC et al. (2006). Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. Int J Cancer 119: 1567-1576. (Pubitemid 44258762)
23. 2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 7: 861-869. (Pubitemid 350006255)
24. Nakamura N, Yamamoto H, Yao T, Oda Y, Nishiyama K, Imamura M et al. (2005). Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol 36: 828-837. (Pubitemid 41112040)
25. Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M et al. (2001). Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosomes Cancer 30: 349-363. (Pubitemid 32216326)
26. Pandita TK. (2002). ATM function and telomere stability. Oncogene 21: 611-618. (Pubitemid 34146261)
27. Perrod S, Gasser SM. (2003). Long-range silencing and position effects at telomeres and centromeres: parallels and differences. Cell Mol Life Sci 60: 2303-2318. (Pubitemid 37487252)
28. 2 prophase in control and X-ray-irradiated human lymphocytes. Mutat Res 251: 71-77.
29. Rainey MD, Charlton ME, Stanton RV, Kastan MB. (2008). Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res 68: 7466-7474.
30. Santana C, Ortega E, Garcia-Carranca A. (2002). Oncogenic H-ras induces cyclin B1 expression in a p53-independent manner. Mutat Res 508: 49-58.
31. Stewenius Y, Gorunova L, Jonson T, Larsson N, Hoglund M, Mandahl N et al. (2005). Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc Natl Acad Sci USA 102: 5541-5546. (Pubitemid 40530294)
32. Struski S, Doco-Fenzy M, Cornillet-Lefebvre P. (2002). Compilation of published comparative genomic hybridization studies. Cancer Genet Cytogenet 135: 63-90. (Pubitemid 34605971)
33. Suzuki T, Urano T, Miki Y, Moriya T, Akahira J, Ishida T et al. (2007). Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor. Cancer Sci 98: 644-651. (Pubitemid 46563439)
34. Takata M, Sabe H, Hata A, Inazu T, Homma Y, Nukada T et al. (1994). Tyrosine kinases Lyn and Syk regulate B cell receptor- coupled Ca2+ mobilization through distinct pathways. EMBO J 13: 1341-1349.
35. Takeno S, Noguchi T, Kikuchi R, Uchida Y, Yokoyama S, Muller W. (2002). Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma. Cancer 94: 2874-2881. (Pubitemid 34547686)
36. Tang JC, Wan TS, Wong N, Pang E, Lam KY, Law SY et al. (2001). Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line SLMT-1 of Chinese origin. Cancer Genet Cytogenet 124: 36-41. (Pubitemid 32101470)
37. 2 compromises repair of chromosomal breaks in ataxia telangiectasia cells. Cancer Res 65: 11292-11296. (Pubitemid 41821685)
38. White JS, Choi S, Bakkenist CJ. (2008). Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle 7: 1277-1284. (Pubitemid 351749283)
39. Wong N, Lai P, Pang E, Leung TW, Lau JW, Johnson PJ. (2000). A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping. Hepatology 32: 1060-1068.
40. Xu B, Kim ST, Lim DS, Kastan MB. (2002). Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22: 1049-1059. (Pubitemid 34094842)
41. Yin XY, Grove L, Datta NS, Katula K, Long MW, Prochownik EV. (2001). Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression. Cancer Res 61: 6487-6493. (Pubitemid 32785287)
42. Yoshida T, Tanaka S, Mogi A, Shitara Y, Kuwano H. (2004). The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer. Ann Oncol 15: 252-256. (Pubitemid 38262624)
43. Zhu D, Ma MS, Zhao RZ, Li MY. (1995). Centromere spreading and centromeric aberrations in ovarian tumors. Cancer Genet Cytogenet 80: 63-65.