메뉴 건너뛰기




Volumn 226, Issue 6, 2011, Pages 1510-1518

Testosterone attenuates morpho-functional alterations by 2-methoxyestradiol exposure and induces differentiation in C6 cells

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ACETYLATED TUBULIN; ALPHA TUBULIN; CATALASE; GLIAL FIBRILLARY ACIDIC PROTEIN; TESTOSTERONE; TUBULIN; TYROSINATED TUBULIN; UNCLASSIFIED DRUG;

EID: 79952717537     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22480     Document Type: Article
Times cited : (3)

References (57)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. 1984. Catalase in vitro. Methods Enzymol 105: 121-126.
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 0035936944 scopus 로고    scopus 로고
    • Testosterone protects cerebellar granules from oxidative stress-induced cell death through a receptor mediated mechanism
    • Ahlbom E, Prins GS, Ceccatelli S. 2001. Testosterone protects cerebellar granules from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res 892: 225-262.
    • (2001) Brain Res , vol.892 , pp. 225-262
    • Ahlbom, E.1    Prins, G.S.2    Ceccatelli, S.3
  • 7
    • 33646390930 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2
    • Bu SZ, Huang Q, Jiang YM, Min HB, Hou Y, Guo ZY, Wei JF, Wang JW, Ni X, Zheng SS. 2006. p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2. Apoptosis 11: 413-425.
    • (2006) Apoptosis , vol.11 , pp. 413-425
    • Bu, S.Z.1    Huang, Q.2    Jiang, Y.M.3    Min, H.B.4    Hou, Y.5    Guo, Z.Y.6    Wei, J.F.7    Wang, J.W.8    Ni, X.9    Zheng, S.S.10
  • 8
    • 0034884320 scopus 로고    scopus 로고
    • Androgen up-regulation of tubulin isoforms in neuroblastoma cells
    • Butler R, Leigh PN, Gallo JM. 2001. Androgen up-regulation of tubulin isoforms in neuroblastoma cells. J Neurochem 78: 854-861.
    • (2001) J Neurochem , vol.78 , pp. 854-861
    • Butler, R.1    Leigh, P.N.2    Gallo, J.M.3
  • 9
    • 69249234726 scopus 로고    scopus 로고
    • Effects of morphine on testosterone levels in rat C6 glioma cells: Modulation by anastazole
    • Ceccarelli I, Rossi A, Melinda M, Weber E, Aloisi AM. 2009. Effects of morphine on testosterone levels in rat C6 glioma cells: Modulation by anastazole. J Cell Physiol 221: 1-4.
    • (2009) J Cell Physiol , vol.221 , pp. 1-4
    • Ceccarelli, I.1    Rossi, A.2    Melinda, M.3    Weber, E.4    Aloisi, A.M.5
  • 10
    • 21244482124 scopus 로고    scopus 로고
    • Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton
    • Chamaon K, Stojek J, Kanakis D, Braeuninger S, Kirches E, Krause G, Mawrin C, Dietzmann K. 2005. Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton. J Neurooncol 72: 11-26.
    • (2005) J Neurooncol , vol.72 , pp. 11-26
    • Chamaon, K.1    Stojek, J.2    Kanakis, D.3    Braeuninger, S.4    Kirches, E.5    Krause, G.6    Mawrin, C.7    Dietzmann, K.8
  • 11
    • 33846415077 scopus 로고    scopus 로고
    • Effects of testosterone on differentiation and oxidative stress resistance in C1300 neuroblastoma cells
    • Chisu V, Manca P, Zedda M, Lepore G, Gadau S, Farina V. 2006. Effects of testosterone on differentiation and oxidative stress resistance in C1300 neuroblastoma cells. Neuroendocrinol Lett 27: 808-812.
    • (2006) Neuroendocrinol Lett , vol.27 , pp. 808-812
    • Chisu, V.1    Manca, P.2    Zedda, M.3    Lepore, G.4    Gadau, S.5    Farina, V.6
  • 12
    • 0028842744 scopus 로고
    • Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein (GFAP) mRna and immunoreactive levels in the rat hippocampus
    • Chowen JA, Businguina S, Garcia-Segura LM. 1995. Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein (GFAP) mRna and immunoreactive levels in the rat hippocampus. Neuroscience 69: 519-532.
    • (1995) Neuroscience , vol.69 , pp. 519-532
    • Chowen, J.A.1    Businguina, S.2    Garcia-Segura, L.M.3
  • 13
    • 0032516063 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: A potential signaling molecule for neocortical organization during development
    • Compagnone NA, Mellon SH. 1998. Dehydroepiandrosterone: A potential signaling molecule for neocortical organization during development. Proc Natl Acad Sci 95: 4678-4683.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 4678-4683
    • Compagnone, N.A.1    Mellon, S.H.2
  • 14
    • 0033959187 scopus 로고    scopus 로고
    • Tubulin carboxypeptidase/microtubules association can be detected in the distal region of neuronal processes
    • Contin MA, Arce CA. 2000. Tubulin carboxypeptidase/microtubules association can be detected in the distal region of neuronal processes. Neurochem Res 25: 27-36.
    • (2000) Neurochem Res , vol.25 , pp. 27-36
    • Contin, M.A.1    Arce, C.A.2
  • 15
    • 0025899234 scopus 로고
    • Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in cultures
    • Cory AH, Owen TC, Barltrop JA, Cory JG. 1991. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in cultures. Cancer Commun 3: 207-212.
    • (1991) Cancer Commun , vol.3 , pp. 207-212
    • Cory, A.H.1    Owen, T.C.2    Barltrop, J.A.3    Cory, J.G.4
  • 16
    • 0029008622 scopus 로고
    • Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicines binding site
    • Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. 1995. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicines binding site. J Med Chem 38: 2041-2049.
    • (1995) J Med Chem , vol.38 , pp. 2041-2049
    • Cushman, M.1    He, H.M.2    Katzenellenbogen, J.A.3    Lin, C.M.4    Hamel, E.5
  • 17
    • 0028331925 scopus 로고
    • 2-methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicines binding site
    • D'Amato CM, Lin E, Flynn J, Folkman H, Hamel E. 1994. 2-methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicines binding site. Proc Natl Acad Sci 91: 3964-3968.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 3964-3968
    • D'Amato, C.M.1    Lin, E.2    Flynn, J.3    Folkman, H.4    Hamel, E.5
  • 18
    • 0002292234 scopus 로고
    • Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats
    • Del Cerro S, Garcia-Estrada J, Garcia-Segura LM. 1995. Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats. Glia 14: 65-71.
    • (1995) Glia , vol.14 , pp. 65-71
    • Del Cerro, S.1    Garcia-Estrada, J.2    Garcia-Segura, L.M.3
  • 19
    • 0037793319 scopus 로고    scopus 로고
    • Diurnal rhythms of serum total, free and bioavailable testosterone and SHBG in middle-aged men compared with those in young men
    • Diver MJ, Imtiaz KE, Ahmad AM, Vora JP, Fraser WD. 2003. Diurnal rhythms of serum total, free and bioavailable testosterone and SHBG in middle-aged men compared with those in young men. Clin Endrocr 58: 710-717.
    • (2003) Clin Endrocr , vol.58 , pp. 710-717
    • Diver, M.J.1    Imtiaz, K.E.2    Ahmad, A.M.3    Vora, J.P.4    Fraser, W.D.5
  • 20
    • 0021849021 scopus 로고
    • GFAP: The major protein of glial intermediate filaments in differentiated astrocytes
    • Eng LF. 1985. GFAP: The major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol 8: 203-214.
    • (1985) J Neuroimmunol , vol.8 , pp. 203-214
    • Eng, L.F.1
  • 23
    • 76049085862 scopus 로고    scopus 로고
    • Different nitrosative-induced microtubular modifications of testosterone neuroprotective effects on high-D-glucose-exposed neuroblastoma and glioma cells
    • Gadau S, Lepore G, Zedda M, Mura A, Farina V. 2009. Different nitrosative-induced microtubular modifications of testosterone neuroprotective effects on high-D-glucose-exposed neuroblastoma and glioma cells. Neuroendocrinol Lett 30: 515-524.
    • (2009) Neuroendocrinol Lett , vol.30 , pp. 515-524
    • Gadau, S.1    Lepore, G.2    Zedda, M.3    Mura, A.4    Farina, V.5
  • 24
    • 19844369277 scopus 로고    scopus 로고
    • 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and aAkt-dependent process
    • Gao N, Rahmani M, Dent P, Grant S. 2005. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and aAkt-dependent process. Oncogene 23: 3797-3809.
    • (2005) Oncogene , vol.23 , pp. 3797-3809
    • Gao, N.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 25
    • 0027520373 scopus 로고
    • Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating injury
    • Garcia-Estrada J, Del Rio JA, Luquin S, Soriano E, Garcia Segura LM. 1993. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating injury. Brain Res 628: 271-278.
    • (1993) Brain Res , vol.628 , pp. 271-278
    • Garcia-Estrada, J.1    Del Rio, J.A.2    Luquin, S.3    Soriano, E.4    Garcia Segura, L.M.5
  • 27
    • 0023765747 scopus 로고    scopus 로고
    • The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids
    • Garcia-Segura LM, Suarez I, Segovia S, Tranque PA, Cales JM, Aguilera P, Olmos G, Guillamón A. 1998. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Res 456: 357-363.
    • (1998) Brain Res , vol.456 , pp. 357-363
    • Garcia-Segura, L.M.1    Suarez, I.2    Segovia, S.3    Tranque, P.A.4    Cales, J.M.5    Aguilera, P.6    Olmos, G.7    Guillamón, A.8
  • 28
    • 79952732060 scopus 로고    scopus 로고
    • Neurons induced glia fibrillary acidic protein (GFAP) gene promoter of astrocytes derived from transgenice mice
    • Gomes FCA, Garcia-Abreu J, Gaou M, Paulin D, Moura Neto V. 1999. Neurons induced glia fibrillary acidic protein (GFAP) gene promoter of astrocytes derived from transgenice mice. Glia 26: 96-108.
    • (1999) Glia , vol.26 , pp. 96-108
    • Gomes, F.C.A.1    Garcia-Abreu, J.2    Gaou, M.3    Paulin, D.4    Moura Neto, V.5
  • 29
    • 0023371190 scopus 로고
    • Postpolymerization, detyrosination of α-tubulin: A mechanism for subcellular differentiation of microtubules
    • Gundersen GG, Khawaja S, Bulinski JC. 1987. Postpolymerization, detyrosination of α-tubulin: A mechanism for subcellular differentiation of microtubules. J Cell Biol 105: 251-264.
    • (1987) J Cell Biol , vol.105 , pp. 251-264
    • Gundersen, G.G.1    Khawaja, S.2    Bulinski, J.C.3
  • 30
    • 0035006622 scopus 로고    scopus 로고
    • Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons
    • Hammond J, Le Q, Goodyer C, Gelfand M, Trifiro M, Blanc A. 2001. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. J Neurochem 77: 1319-1326.
    • (2001) J Neurochem , vol.77 , pp. 1319-1326
    • Hammond, J.1    Le, Q.2    Goodyer, C.3    Gelfand, M.4    Trifiro, M.5    Blanc, A.6
  • 31
    • 0035253195 scopus 로고    scopus 로고
    • Colocalization of androgen, estrogen and cholinergic receptors on cultured astrocytes of rat central nervous system
    • Hösli E, Jurasin K, Rühl W, Lüthy R, Hösli I. 2001. Colocalization of androgen, estrogen and cholinergic receptors on cultured astrocytes of rat central nervous system. Int J Dev Neurosci 19: 243-251.
    • (2001) Int J Dev Neurosci , vol.19 , pp. 243-251
    • Hösli, E.1    Jurasin, K.2    Rühl, W.3    Lüthy, R.4    Hösli, I.5
  • 32
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for selective killing of cancer cells
    • Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. 2000. Superoxide dismutase as a target for selective killing of cancer cells. Nature 407: 309-395.
    • (2000) Nature , vol.407 , pp. 309-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 33
    • 0033860681 scopus 로고    scopus 로고
    • Common mechanism underlying growth cone guidance and axon branching
    • Kalil K, Gyorgyi S, Dent EW. 2000. Common mechanism underlying growth cone guidance and axon branching. Neurobiology 44: 145-158.
    • (2000) Neurobiology , vol.44 , pp. 145-158
    • Kalil, K.1    Gyorgyi, S.2    Dent, E.W.3
  • 34
    • 33749578369 scopus 로고    scopus 로고
    • 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
    • Kamath K, Okouneva T, Larson G, Panda D, Wilson L, Jordan MA. 2006. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther 6: 2225-2233.
    • (2006) Mol Cancer Ther , vol.6 , pp. 2225-2233
    • Kamath, K.1    Okouneva, T.2    Larson, G.3    Panda, D.4    Wilson, L.5    Jordan, M.A.6
  • 35
    • 0038545476 scopus 로고    scopus 로고
    • Estradiol and testosterone have opposite effects on microtubule polymerization
    • Kipp JL, Ramirez VD. 2003. Estradiol and testosterone have opposite effects on microtubule polymerization. Neuroendocrinology 4: 258-272.
    • (2003) Neuroendocrinology , vol.4 , pp. 258-272
    • Kipp, J.L.1    Ramirez, V.D.2
  • 36
    • 3442881059 scopus 로고    scopus 로고
    • + conductance in differentiated C6-glioma cells
    • + conductance in differentiated C6-glioma cells. Neurochem Res 29: 1453-1459.
    • (2004) Neurochem Res , vol.29 , pp. 1453-1459
    • Kuo, T.-C.1    Lin-Shiau, S.-Y.2
  • 37
    • 0028104020 scopus 로고
    • Glial fibrillary acidic protein: Regulation by hormones, cytokines and growth factors
    • Laping NJ, Teter B, Nichols NR, Rozovsky I, Finch CE. 1994. Glial fibrillary acidic protein: Regulation by hormones, cytokines and growth factors. Brain Pathol 4: 259-275.
    • (1994) Brain Pathol , vol.4 , pp. 259-275
    • Laping, N.J.1    Teter, B.2    Nichols, N.R.3    Rozovsky, I.4    Finch, C.E.5
  • 39
    • 4344659253 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death in vitro
    • Lis A, Ciesielski MJ, Barone TA, Scott BE, Fenstermaker RA, Plunkett RJ. 2004. 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death in vitro Cancer Lett 213: 57-65.
    • (2004) Cancer Lett , vol.213 , pp. 57-65
    • Lis, A.1    Ciesielski, M.J.2    Barone, T.A.3    Scott, B.E.4    Fenstermaker, R.A.5    Plunkett, R.J.6
  • 40
    • 59149085565 scopus 로고    scopus 로고
    • Neuroprotective effects of testosterone on the morphology and functions of somatic motoneurons following the death of neighboring motorneurons
    • Little CM, Coons KD, Sengelaup DR. 2008. Neuroprotective effects of testosterone on the morphology and functions of somatic motoneurons following the death of neighboring motorneurons. J Comp Neurol 512: 359-372.
    • (2008) J Comp Neurol , vol.512 , pp. 359-372
    • Little, C.M.1    Coons, K.D.2    Sengelaup, D.R.3
  • 41
    • 0028225403 scopus 로고
    • An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 Cell
    • Lustig RH, Hua P, Yu W, Ahmad FJ, Baas PW. 1994. An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 Cell. J Neurosci 14: 3945-3957.
    • (1994) J Neurosci , vol.14 , pp. 3945-3957
    • Lustig, R.H.1    Hua, P.2    Yu, W.3    Ahmad, F.J.4    Baas, P.W.5
  • 43
    • 0031039519 scopus 로고    scopus 로고
    • Tubulin post-translational modifications: Enzymes and their mechanisms of action
    • MacRae TH. 1997. Tubulin post-translational modifications: Enzymes and their mechanisms of action. Eur J Biochem 244: 265-278.
    • (1997) Eur J Biochem , vol.244 , pp. 265-278
    • MacRae, T.H.1
  • 44
    • 77950844371 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces morpho-functional changes and impairs the microtubular system in mouse neuroblastoma and rat glioma
    • Manca P, Chisu V. 2010. 2-Methoxyestradiol induces morpho-functional changes and impairs the microtubular system in mouse neuroblastoma and rat glioma. Arch Ital Biol 148: 11-21.
    • (2010) Arch Ital Biol , vol.148 , pp. 11-21
    • Manca, P.1    Chisu, V.2
  • 45
    • 0024326484 scopus 로고
    • Early and late passage C6-glioma cell growth, similarities with primary glial cells in culture
    • Mangoura D, Sakellaridis N, Jones J, Vernadakis A. 1989. Early and late passage C6-glioma cell growth, similarities with primary glial cells in culture. Neurochem Res 14: 941-947.
    • (1989) Neurochem Res , vol.14 , pp. 941-947
    • Mangoura, D.1    Sakellaridis, N.2    Jones, J.3    Vernadakis, A.4
  • 47
    • 0033557656 scopus 로고    scopus 로고
    • Gonadal steroids promote cell differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner
    • Mong JA, Glaser E, McCarty MM. 1999. Gonadal steroids promote cell differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner. J Neurosci 19: 1464-1472.
    • (1999) J Neurosci , vol.19 , pp. 1464-1472
    • Mong, J.A.1    Glaser, E.2    McCarty, M.M.3
  • 48
    • 15844415314 scopus 로고    scopus 로고
    • Sexual differentiation of the brain: Role of estrogen and its active metabolites
    • Negri-Cesi Colciago A, Celotti F, Motta M. 2004. Sexual differentiation of the brain: Role of estrogen and its active metabolites. J Endocrinol Invest 27: 120-127.
    • (2004) J Endocrinol Invest , vol.27 , pp. 120-127
    • Negri-Cesi Colciago, A.1    Celotti, F.2    Motta, M.3
  • 49
    • 0035662941 scopus 로고    scopus 로고
    • Estradiol, in the CNS, targets several physiologically relevant membrane-associated protein
    • Ramirez VD, Kipp JL, Joe I. 2001. Estradiol, in the CNS, targets several physiologically relevant membrane-associated protein. Brain Res Rev 37: 141-152.
    • (2001) Brain Res Rev , vol.37 , pp. 141-152
    • Ramirez, V.D.1    Kipp, J.L.2    Joe, I.3
  • 51
    • 0029990387 scopus 로고    scopus 로고
    • Microtubule stability decreases axon elongation but no axoplasm production
    • Rochlin MW, Wickline KM, Bridgman PC. 1996. Microtubule stability decreases axon elongation but no axoplasm production. J Neurosci 16: 3236-3246.
    • (1996) J Neurosci , vol.16 , pp. 3236-3246
    • Rochlin, M.W.1    Wickline, K.M.2    Bridgman, P.C.3
  • 53
    • 0038011249 scopus 로고    scopus 로고
    • Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis
    • Shimada K, Nakamura M, Ishida E, Kishi M, Konishi N. 2003. Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24: 1067-1075.
    • (2003) Carcinogenesis , vol.24 , pp. 1067-1075
    • Shimada, K.1    Nakamura, M.2    Ishida, E.3    Kishi, M.4    Konishi, N.5
  • 54
    • 0034982058 scopus 로고    scopus 로고
    • Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence
    • Skogh C, Eriksson C, Kokaia M, Meijer XC, Wahlberg LU, Wictorin K, Campbell K. 2001. Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence. Mol Cell Neurosci 17: 811-820.
    • (2001) Mol Cell Neurosci , vol.17 , pp. 811-820
    • Skogh, C.1    Eriksson, C.2    Kokaia, M.3    Meijer, X.C.4    Wahlberg, L.U.5    Wictorin, K.6    Campbell, K.7
  • 55
    • 0842299490 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein expression in the hamster red nucleus: Effects of axotomy and testosterone treatment
    • Storer PD, Jones KJ. 2003. Glial fibrillary acidic protein expression in the hamster red nucleus: Effects of axotomy and testosterone treatment. Exp Neurol 184: 939-946.
    • (2003) Exp Neurol , vol.184 , pp. 939-946
    • Storer, P.D.1    Jones, K.J.2
  • 57
    • 79952732300 scopus 로고    scopus 로고
    • Androgen replacement therapy in aging male-A critical evaluation
    • Vermeulen A. 2001. Androgen replacement therapy in aging male-A critical evaluation. J Clin Endocr Metab 81: 1821-1826.
    • (2001) J Clin Endocr Metab , vol.81 , pp. 1821-1826
    • Vermeulen, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.