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Volumn 27, Issue 4, 2007, Pages 291-302

Alpha-cobratoxin as a possible therapy for multiple sclerosis: A review of the literature leading to its development for this application

Author keywords

Antiviral; Autoimmune; Myelin; Neurological; Neurotoxin; Nicotinic; Receptor

Indexed keywords

4 AMINOPYRIDINE; ANCROD; BATROXOBIN; BETA1A INTERFERON; CAPTOPRIL; CARDIOTOXIN; COBROTOXIN; CONOTOXIN; CROTOXIN; DISINTEGRIN; ESCOZUL; FRAMPRIDINE; GLATIRAMER; INTERFERON; INTERFERON BETA SERINE; MARIMASTAT; MITOXANTRONE; NATALIZUMAB; OMEGA CONOTOXIN MVIIA; PEPTERON; SCORPION VENOM; SNAKE VENOM; SOLUBLE CD4 ANTIGEN; THYMOPENTIN; TIROFIBAN; UNCLASSIFIED DRUG; XIMELAGATRAN; ZICONITIDE;

EID: 38049050658     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (36)

References (107)
  • 2
    • 33745184310 scopus 로고
    • 5th ed. Cotran RS, Kumar V, Robbins SL, editors. Philadelphia: W. B. Saunders;
    • DeGirolami U, Frosch MP, Anthony DC. Pathologic basis of disease. 5th ed. Cotran RS, Kumar V, Robbins SL, editors. Philadelphia: W. B. Saunders; 1994. p. 174-208.
    • (1994) Pathologic basis of disease , pp. 174-208
    • DeGirolami, U.1    Frosch, M.P.2    Anthony, D.C.3
  • 3
    • 38049016657 scopus 로고    scopus 로고
    • Netter FH, The CIBA collection of medical illustrations: nervous system. I. Summit (NJ): CIBA; 1986. p. 174-80.
    • Netter FH, The CIBA collection of medical illustrations: nervous system. Vol I. Summit (NJ): CIBA; 1986. p. 174-80.
  • 4
    • 33749330705 scopus 로고    scopus 로고
    • Multiple sclerosis is linked to Epstein-Barr virus infection
    • Haahr S, Hollsberg P. Multiple sclerosis is linked to Epstein-Barr virus infection. Rev Med Virol. 2006;16(5):297-310.
    • (2006) Rev Med Virol , vol.16 , Issue.5 , pp. 297-310
    • Haahr, S.1    Hollsberg, P.2
  • 5
    • 0033807935 scopus 로고    scopus 로고
    • Viruses and multiple sclerosis
    • Cermelli C, Jacobson S. Viruses and multiple sclerosis. Viral Immunol. 2000;13(3):255-67.
    • (2000) Viral Immunol , vol.13 , Issue.3 , pp. 255-267
    • Cermelli, C.1    Jacobson, S.2
  • 8
    • 0028241742 scopus 로고
    • A putative new retrovirus associated with multiple sclerosis and the possible involvement of Epstein-Barr virus in this disease
    • Haahr S, Sommerlund M, Christensen T, Jensen AW, Hansen HJ, Moller-Larsen A. A putative new retrovirus associated with multiple sclerosis and the possible involvement of Epstein-Barr virus in this disease. Ann NY Acad Sci. 1994;724:148-56.
    • (1994) Ann NY Acad Sci , vol.724 , pp. 148-156
    • Haahr, S.1    Sommerlund, M.2    Christensen, T.3    Jensen, A.W.4    Hansen, H.J.5    Moller-Larsen, A.6
  • 10
    • 33746905455 scopus 로고    scopus 로고
    • Current status and future prospective of immunointervention in multiple sclerosis.Curr
    • Cavaletti G. Current status and future prospective of immunointervention in multiple sclerosis.Curr Med Chem. 2006;13(19):2329-43.
    • (2006) Med Chem , vol.13 , Issue.19 , pp. 2329-2343
    • Cavaletti, G.1
  • 11
    • 0017846792 scopus 로고
    • Reduced neuromuscular transmission safety factor in multiple sclerosis
    • Eisen A, Yufe R, Rop D, Campbell I. Reduced neuromuscular transmission safety factor in multiple sclerosis. Neurology. 1978;28(6):598-602.
    • (1978) Neurology , vol.28 , Issue.6 , pp. 598-602
    • Eisen, A.1    Yufe, R.2    Rop, D.3    Campbell, I.4
  • 14
    • 20444386558 scopus 로고    scopus 로고
    • General mechanisms of axonal damage and its prevention
    • Stys PK. General mechanisms of axonal damage and its prevention. J Neurol Sci. 2005;233(1-2):3-13.
    • (2005) J Neurol Sci , vol.233 , Issue.1-2 , pp. 3-13
    • Stys, P.K.1
  • 15
    • 0035094894 scopus 로고    scopus 로고
    • Nicotine protects against arachidonic acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons
    • Garrido R, Mattson MP, Hennig B, Toborek M. Nicotine protects against arachidonic acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Neurochem. 2001;76(5):1395-403.
    • (2001) Neurochem , vol.76 , Issue.5 , pp. 1395-1403
    • Garrido, R.1    Mattson, M.P.2    Hennig, B.3    Toborek, M.4
  • 16
    • 0344585351 scopus 로고    scopus 로고
    • Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced neurotrophic factors
    • Garrido R, Springer JE, Hennig B, Toborek M. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced neurotrophic factors. Neurotrauma. 2003;20(11):1201-13.
    • (2003) Neurotrauma , vol.20 , Issue.11 , pp. 1201-1213
    • Garrido, R.1    Springer, J.E.2    Hennig, B.3    Toborek, M.4
  • 17
    • 0142074815 scopus 로고    scopus 로고
    • Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons
    • Garrido R, King-Pospisil K, Son KW, Hennig B, Toborek M, Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons. Neurosci Res. 2003;47(3):349-55.
    • (2003) Neurosci Res , vol.47 , Issue.3 , pp. 349-355
    • Garrido, R.1    King-Pospisil, K.2    Son, K.W.3    Hennig, B.4    Toborek, M.5
  • 18
    • 33645661281 scopus 로고    scopus 로고
    • Naloxone precipitates nicotine abstinence syndrome and attenuates nicotine-induced antinociception in mice
    • Biala G, Budzynska B, Kruk M. Naloxone precipitates nicotine abstinence syndrome and attenuates nicotine-induced antinociception in mice. Pharmacol Rep. 2005;57(6):755-60.
    • (2005) Pharmacol Rep , vol.57 , Issue.6 , pp. 755-760
    • Biala, G.1    Budzynska, B.2    Kruk, M.3
  • 19
    • 0026465111 scopus 로고
    • Effects of cigarette smoking on motor functions in patients with multiple sclerosis
    • Emre M, de Decker C. Effects of cigarette smoking on motor functions in patients with multiple sclerosis. Arch Neurol. 1992;49(12):1243-7.
    • (1992) Arch Neurol , vol.49 , Issue.12 , pp. 1243-1247
    • Emre, M.1    de Decker, C.2
  • 20
    • 0021592979 scopus 로고
    • Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis
    • Raine CS. Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab Invest. 1984;50(6):608-35.
    • (1984) Lab Invest , vol.50 , Issue.6 , pp. 608-635
    • Raine, C.S.1
  • 21
    • 0020700751 scopus 로고
    • Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein
    • Fritz RB, Chou CH, McFarlin DE. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J Immunol. 1983;130(3):1024-6.
    • (1983) J Immunol , vol.130 , Issue.3 , pp. 1024-1026
    • Fritz, R.B.1    Chou, C.H.2    McFarlin, D.E.3
  • 23
    • 33847774004 scopus 로고
    • Experimental and clinical study of cobra venom as an analgesic
    • Macht DI. Experimental and clinical study of cobra venom as an analgesic. Proc Natl Acad Sci USA. 1936;22(1):61-71.
    • (1936) Proc Natl Acad Sci USA , vol.22 , Issue.1 , pp. 61-71
    • Macht, D.I.1
  • 24
    • 33847792321 scopus 로고
    • Preparation of "Cobratoxin" for clinical purposes, especially for the treatment of cancer pains
    • Van Esveld LW. Preparation of "Cobratoxin" for clinical purposes, especially for the treatment of cancer pains. Biochem Zeitschrift 1936;283:343-57.
    • (1936) Biochem Zeitschrift , vol.283 , pp. 343-357
    • Van Esveld, L.W.1
  • 25
    • 38049060103 scopus 로고
    • The use of more potent cobra venom for intractable pain
    • Hills RG, Firor WM. The use of more potent cobra venom for intractable pain. Am Surg. 1952;18(9):875-9.
    • (1952) Am Surg , vol.18 , Issue.9 , pp. 875-879
    • Hills, R.G.1    Firor, W.M.2
  • 26
    • 38049081820 scopus 로고
    • A clinical evaluation of cobra venom extracts for control of pain
    • Taren JA. A clinical evaluation of cobra venom extracts for control of pain. Med Bull (Ann Arbor). 1953;19(8):206-11.
    • (1953) Med Bull (Ann Arbor) , vol.19 , Issue.8 , pp. 206-211
    • Taren, J.A.1
  • 27
    • 33645211467 scopus 로고
    • The cobra neurotoxin; pharmacology and clinical applications in the treatment of pain
    • Grasset E., The cobra neurotoxin; pharmacology and clinical applications in the treatment of pain. Med Hyg (Geneve). 1952;10(212):55-8.
    • (1952) Med Hyg (Geneve) , vol.10 , Issue.212 , pp. 55-58
    • Grasset, E.1
  • 28
    • 38049071253 scopus 로고
    • The treatment of chronic arthritis with a combination of cobra venom, formic acid, and silicic acid
    • Bryson KD. The treatment of chronic arthritis with a combination of cobra venom, formic acid, and silicic acid. Am Surg. 1954;20(7):751-5.
    • (1954) Am Surg , vol.20 , Issue.7 , pp. 751-755
    • Bryson, K.D.1
  • 29
    • 38049068449 scopus 로고
    • Treatment of trigeminal neuralgia with cobra venom
    • Williams EY. Treatment of trigeminal neuralgia with cobra venom. J Natl Med Assoc. 1960;52:327-8.
    • (1960) J Natl Med Assoc , vol.52 , pp. 327-328
    • Williams, E.Y.1
  • 30
    • 0014272163 scopus 로고
    • Anti-asthmatic effects of immunization with cobra venom
    • Singh I, Srivastava MC. Anti-asthmatic effects of immunization with cobra venom. Br J Dis Chest. 1968;62(2):107-9.
    • (1968) Br J Dis Chest , vol.62 , Issue.2 , pp. 107-109
    • Singh, I.1    Srivastava, M.C.2
  • 32
    • 38049045302 scopus 로고
    • Cobra venom therapy in the neuroses; a preliminary report
    • Jackman AI. Cobra venom therapy in the neuroses; a preliminary report. Dis Nerv Syst. 1954;15(4):99-102.
    • (1954) Dis Nerv Syst , vol.15 , Issue.4 , pp. 99-102
    • Jackman, A.I.1
  • 33
    • 38049036060 scopus 로고
    • Preparation of venom and its analgesic activity
    • Wang S, He Y, Peng S. Preparation of venom and its analgesic activity. Zhongcaoyo. 1986;17(1): 7-9.
    • (1986) Zhongcaoyo , vol.17 , Issue.1 , pp. 7-9
    • Wang, S.1    He, Y.2    Peng, S.3
  • 34
    • 38049040554 scopus 로고
    • The effect of nyloxin on the pain of arthritis
    • Meiselas LE, Schlecker AA. The effect of nyloxin on the pain of arthritis. NY State J Med. 1957;57(12):2067-8.
    • (1957) NY State J Med , vol.57 , Issue.12 , pp. 2067-2068
    • Meiselas, L.E.1    Schlecker, A.A.2
  • 35
    • 50749125134 scopus 로고
    • On the action of venoms of different species of poisonous snakes on the nervous system
    • Lamb G, Hunter W. On the action of venoms of different species of poisonous snakes on the nervous system. Lancet. 1904;1:20.
    • (1904) Lancet , vol.1 , pp. 20
    • Lamb, G.1    Hunter, W.2
  • 36
    • 33745220385 scopus 로고
    • Neurotoxoid interference with two human strains of poliomyelitis in rhesus monkeys
    • Sanders M, Soret MG, Akin B. Neurotoxoid interference with two human strains of poliomyelitis in rhesus monkeys. Ann NY Acad Sci. 1953;58:1-12.
    • (1953) Ann NY Acad Sci , vol.58 , pp. 1-12
    • Sanders, M.1    Soret, M.G.2    Akin, B.3
  • 37
    • 33745218397 scopus 로고
    • Naja Flava neurotoxoid interference late in experimental poliomyelitis
    • Sanders M, Soret MG, Akin B. Naja Flava neurotoxoid interference late in experimental poliomyelitis, J Path Bact. 1954;68:1267.
    • (1954) J Path Bact , vol.68 , pp. 1267
    • Sanders, M.1    Soret, M.G.2    Akin, B.3
  • 38
    • 33745205715 scopus 로고
    • Neurotoxoid interference in Macacus rhesus infected intramuscularly with poliovirus
    • Sanders M, Soret MG, Akin BA, Roizin L. Neurotoxoid interference in Macacus rhesus infected intramuscularly with poliovirus. Science. 1958;127:594-6.
    • (1958) Science , vol.127 , pp. 594-596
    • Sanders, M.1    Soret, M.G.2    Akin, B.A.3    Roizin, L.4
  • 39
    • 33745187435 scopus 로고
    • The use of sanders neurotoxoid i (modified snake venom) in the treatment of recurrent herpes simplex of the cornea: Progress report
    • Clark WB, Baldone JA, Thomas CI. The use of sanders neurotoxoid i (modified snake venom) in the treatment of recurrent herpes simplex of the cornea: progress report. South Med J. 1962;55( 9):947-51.
    • (1962) South Med J , vol.55 , Issue.9 , pp. 947-951
    • Clark, W.B.1    Baldone, J.A.2    Thomas, C.I.3
  • 40
    • 0000936302 scopus 로고
    • Studies in human subjects on active immunization against poliomyelitis. I. A preliminary report of experiments in progress
    • Salk JE. Studies in human subjects on active immunization against poliomyelitis. I. A preliminary report of experiments in progress. JAMA. 1953;151(13):1081-98.
    • (1953) JAMA , vol.151 , Issue.13 , pp. 1081-1098
    • Salk, J.E.1
  • 41
    • 0002380311 scopus 로고
    • Behavior of chimpanzee avirulent poliomyelitis viruses in experimentally infected human volunteers
    • Sabin AB. Behavior of chimpanzee avirulent poliomyelitis viruses in experimentally infected human volunteers. Am J Med Sci. 1955;230(1):1-8.
    • (1955) Am J Med Sci , vol.230 , Issue.1 , pp. 1-8
    • Sabin, A.B.1
  • 42
    • 0016679597 scopus 로고
    • Use of detoxified snake neurotoxin as a partial treatment for amyotrophic lateral sclerosis
    • Sanders M, Fellowes ON. Use of detoxified snake neurotoxin as a partial treatment for amyotrophic lateral sclerosis. Cancer Cytol. 1975;15:26-30.
    • (1975) Cancer Cytol , vol.15 , pp. 26-30
    • Sanders, M.1    Fellowes, O.N.2
  • 43
    • 0018317741 scopus 로고
    • Double-blind study of modified neurotoxin in motor neuron disease
    • Tyler HR. Double-blind study of modified neurotoxin in motor neuron disease. Neurology. 1979;29:77-81.
    • (1979) Neurology , vol.29 , pp. 77-81
    • Tyler, H.R.1
  • 45
    • 0017131593 scopus 로고
    • Patient resistance and prognosis in amyotrophic lateral sclerosis
    • Mulder DW, Howard FM. Patient resistance and prognosis in amyotrophic lateral sclerosis. Mayo Clin Proc. 1976;51(9):537-41.
    • (1976) Mayo Clin Proc , vol.51 , Issue.9 , pp. 537-541
    • Mulder, D.W.1    Howard, F.M.2
  • 46
    • 0017581414 scopus 로고
    • Inhibition of virus-induced plaque formation by atoxic derivatives of purified cobra neurotoxins
    • Miller KD, Miller GG, Sanders M, Fellowes O. Inhibition of virus-induced plaque formation by atoxic derivatives of purified cobra neurotoxins. Biochim Biophys Acta. 1977;496:192-6.
    • (1977) Biochim Biophys Acta , vol.496 , pp. 192-196
    • Miller, K.D.1    Miller, G.G.2    Sanders, M.3    Fellowes, O.4
  • 47
    • 0023757777 scopus 로고
    • Neurotoxin-binding site on the acetylcholine receptor
    • Lentz TC, Wilson M. Neurotoxin-binding site on the acetylcholine receptor. Int Rev Neurobiol. 1988;29:117-60.
    • (1988) Int Rev Neurobiol , vol.29 , pp. 117-160
    • Lentz, T.C.1    Wilson, M.2
  • 48
    • 0029133807 scopus 로고
    • Diversity and patterns of regulation of nicotinic receptor subtypes
    • Lukas RJ. Diversity and patterns of regulation of nicotinic receptor subtypes. Ann NY Acad Sci. 1995;757:153-168.
    • (1995) Ann NY Acad Sci , vol.757 , pp. 153-168
    • Lukas, R.J.1
  • 49
    • 0030627685 scopus 로고    scopus 로고
    • Pharmacology of neuronal nicotinic acetylcholine receptor subtypes
    • Colquhoun LM, Patrick JW. Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmac. 1997;39:191-220.
    • (1997) Adv Pharmac , vol.39 , pp. 191-220
    • Colquhoun, L.M.1    Patrick, J.W.2
  • 50
    • 0024109534 scopus 로고
    • Denervation alters the size, number and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons
    • Sargent PB, Pang DZ. Denervation alters the size, number and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons. Neuron. 1988;1:866-77.
    • (1988) Neuron , vol.1 , pp. 866-877
    • Sargent, P.B.1    Pang, D.Z.2
  • 51
    • 0023175767 scopus 로고
    • Marked up-regulation of the beta-bungarotoxin site in adrenal chromaffin cells by specific nicotinic antagonists
    • Quik M, Geertsen S, Trifaro JM. Marked up-regulation of the beta-bungarotoxin site in adrenal chromaffin cells by specific nicotinic antagonists, Mol Pharmacol. 1987;3(1):385-91.
    • (1987) Mol Pharmacol , vol.3 , Issue.1 , pp. 385-391
    • Quik, M.1    Geertsen, S.2    Trifaro, J.M.3
  • 52
    • 0024505711 scopus 로고
    • Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum
    • Schultz DW, Zigmond RE. Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum. Neurosci Lett. 1989;98:310-16.
    • (1989) Neurosci Lett , vol.98 , pp. 310-316
    • Schultz, D.W.1    Zigmond, R.E.2
  • 53
    • 0030611558 scopus 로고    scopus 로고
    • Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus
    • Lena C, Changeux JP. Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus, J Neurosci. 1997;17:576-85.
    • (1997) J Neurosci , vol.17 , pp. 576-585
    • Lena, C.1    Changeux, J.P.2
  • 54
    • 38049039009 scopus 로고
    • Proteins with epitopes of the acetylcholine receptor in epithelial cell cultures of thymomas in myasthenia gravis
    • Marx A, Kirckner T, Hoppe F, O'Connor R, Schalke B, Tzartos S, Muller-Hermelink HK. Proteins with epitopes of the acetylcholine receptor in epithelial cell cultures of thymomas in myasthenia gravis. Am J Pathol. 1989;34(4):65-75.
    • (1989) Am J Pathol , vol.34 , Issue.4 , pp. 65-75
    • Marx, A.1    Kirckner, T.2    Hoppe, F.3    O'Connor, R.4    Schalke, B.5    Tzartos, S.6    Muller-Hermelink, H.K.7
  • 55
    • 0018516383 scopus 로고
    • Nicotinic acetylcholine receptor: Evidence for a functionally distinct receptor on human lymphocytes
    • Richman DP, Arnason BG. Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes. Proc Natl Acad Sci USA. 1979;76(9):4632-5.
    • (1979) Proc Natl Acad Sci USA , vol.76 , Issue.9 , pp. 4632-4635
    • Richman, D.P.1    Arnason, B.G.2
  • 56
    • 0025144459 scopus 로고
    • Adult thymus expresses an embryonic nicotinic acetylcholine receptor-like protein
    • Nelson S, Conti-Tronconi BM. Adult thymus expresses an embryonic nicotinic acetylcholine receptor-like protein. J Neuroimmunol. 1990;29:81-92.
    • (1990) J Neuroimmunol , vol.29 , pp. 81-92
    • Nelson, S.1    Conti-Tronconi, B.M.2
  • 57
    • 0023680515 scopus 로고
    • Effect of ace-inhibitors, calmodulin antagonists, acetylcholine receptor blocking, and alpha receptor blocking agents on motility of human sperm
    • Placzek R, Krassnigg F, Schill WB. Effect of ace-inhibitors, calmodulin antagonists, acetylcholine receptor blocking, and alpha receptor blocking agents on motility of human sperm. Arch Androl. 1988;21:1-10.
    • (1988) Arch Androl , vol.21 , pp. 1-10
    • Placzek, R.1    Krassnigg, F.2    Schill, W.B.3
  • 58
    • 0029347808 scopus 로고
    • Localisation of two classes of acetylcholine receptor-like molecules in sperms of different animal species
    • Baccetti B, Burrini AG, Collodel G, Falugi C, Moretti E, Piomboni P. Localisation of two classes of acetylcholine receptor-like molecules in sperms of different animal species. Zygote. 1995;3:207-17.
    • (1995) Zygote , vol.3 , pp. 207-217
    • Baccetti, B.1    Burrini, A.G.2    Collodel, G.3    Falugi, C.4    Moretti, E.5    Piomboni, P.6
  • 59
    • 0023613528 scopus 로고    scopus 로고
    • Lentz TC, Hawrot E, Wilson M. Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor: proteins: structure, function and genetics. 1987;2:298-307.
    • Lentz TC, Hawrot E, Wilson M. Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor: proteins: structure, function and genetics. 1987;2:298-307.
  • 60
    • 0025028790 scopus 로고
    • Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Is the nicotinic acetylcholine receptor an HIV receptor?
    • Neri P, Bracci L, Rustici M, Santucci A. Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Is the nicotinic acetylcholine receptor an HIV receptor? Arch Virol. 1990;114:265-69.
    • (1990) Arch Virol , vol.114 , pp. 265-269
    • Neri, P.1    Bracci, L.2    Rustici, M.3    Santucci, A.4
  • 61
    • 4444254469 scopus 로고    scopus 로고
    • Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells
    • Lalo U, Pankratov Y, Krishtal O, North RA. Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells. Br J Pharmacol. 2004;142(8):1227-32.
    • (2004) Br J Pharmacol , vol.142 , Issue.8 , pp. 1227-1232
    • Lalo, U.1    Pankratov, Y.2    Krishtal, O.3    North, R.A.4
  • 62
    • 0015722899 scopus 로고
    • Modification of the invariant tryptophan residue of two naja naja neurotoxins
    • Karlsson E, Eaker D, Drevin H. Modification of the invariant tryptophan residue of two naja naja neurotoxins. Biochim Biophys Acta. 1973;328:510-9.
    • (1973) Biochim Biophys Acta , vol.328 , pp. 510-519
    • Karlsson, E.1    Eaker, D.2    Drevin, H.3
  • 63
    • 0020693270 scopus 로고
    • Experimental allergic encephalomyelitis: Prevention with a nontoxic derivative of a cobra neurotoxin
    • Hudson RA, Montgomery IN, Rauch HC. Experimental allergic encephalomyelitis: prevention with a nontoxic derivative of a cobra neurotoxin. Mol Immunol. 1983;20(2):229-32.
    • (1983) Mol Immunol , vol.20 , Issue.2 , pp. 229-232
    • Hudson, R.A.1    Montgomery, I.N.2    Rauch, H.C.3
  • 64
    • 0020967564 scopus 로고
    • The sites of neurotoxicity in a-cobratoxin
    • Martin BM, Chibber BA, Maelicke A. The sites of neurotoxicity in a-cobratoxin. J Biol Chem. 1983;258(14):8714-22.
    • (1983) J Biol Chem , vol.258 , Issue.14 , pp. 8714-8722
    • Martin, B.M.1    Chibber, B.A.2    Maelicke, A.3
  • 65
    • 0025064615 scopus 로고
    • The role of an invariant tryptophan reside in alpha-bungarotoxin and cobrotoxin. Investigation of active derivatives with the invariant tryptophan replaced by kynurenine
    • Chang CC, Kawata Y, Sakiyama F, Hayashi K. The role of an invariant tryptophan reside in alpha-bungarotoxin and cobrotoxin. Investigation of active derivatives with the invariant tryptophan replaced by kynurenine. Eur J Biochem, 1990;193:567-72.
    • (1990) Eur J Biochem , vol.193 , pp. 567-572
    • Chang, C.C.1    Kawata, Y.2    Sakiyama, F.3    Hayashi, K.4
  • 66
    • 0030020271 scopus 로고    scopus 로고
    • Chemical modification of cationic residues in toxin a from king cobra (ophiophagus hannah) venom
    • Lin SR., Chi SH., Chang LS, Kuo KW, Chang CC. Chemical modification of cationic residues in toxin a from king cobra (ophiophagus hannah) venom. J Protein Chem. 1996;15:95-101.
    • (1996) J Protein Chem , vol.15 , pp. 95-101
    • Lin, S.R.1    Chi, S.H.2    Chang, L.S.3    Kuo, K.W.4    Chang, C.C.5
  • 67
    • 33646813930 scopus 로고    scopus 로고
    • Natalizumab and progressive multifocal leukoencephalopathy: Migrating towards safe adhesion molecule therapy in multiple sclerosis
    • Bennett JL. Natalizumab and progressive multifocal leukoencephalopathy: migrating towards safe adhesion molecule therapy in multiple sclerosis. Neurol Res. 2006;28(3):291-8.
    • (2006) Neurol Res , vol.28 , Issue.3 , pp. 291-298
    • Bennett, J.L.1
  • 69
    • 0020993694 scopus 로고
    • Apparent motor neuron disease following the use of pneumatic tools
    • Gallagher JP, Sanders M. Apparent motor neuron disease following the use of pneumatic tools. Anal Neurol. 1983;14(6):694-5.
    • (1983) Anal Neurol , vol.14 , Issue.6 , pp. 694-695
    • Gallagher, J.P.1    Sanders, M.2
  • 70
    • 0020546549 scopus 로고
    • Inhibition of herpes simplex virus replication by cobra a-neurotoxin
    • Yourist JE, Haines HG, Miller KD. Inhibition of herpes simplex virus replication by cobra a-neurotoxin. J Gen Virol. 1983;64:1475-81.
    • (1983) J Gen Virol , vol.64 , pp. 1475-1481
    • Yourist, J.E.1    Haines, H.G.2    Miller, K.D.3
  • 71
    • 33847776139 scopus 로고    scopus 로고
    • Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom
    • Zhang HL, Han R, Chen ZX, Gu ZL, Reid PF, Raymond LN, Qin ZH. Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom. Neurosci Bull. 2006;22(5):267-73.
    • (2006) Neurosci Bull , vol.22 , Issue.5 , pp. 267-273
    • Zhang, H.L.1    Han, R.2    Chen, Z.X.3    Gu, Z.L.4    Reid, P.F.5    Raymond, L.N.6    Qin, Z.H.7
  • 73
    • 33745183653 scopus 로고
    • Primera experiencia en el tratamiento de infecciones herpeticas con neuevo antiviral (peptido-E o immunoquina)
    • in Spanish
    • Vargas F, Cortes M. Primera experiencia en el tratamiento de infecciones herpeticas con neuevo antiviral (peptido-E o immunoquina). Rev Chil Urol. 1995;60:242-6 (in Spanish).
    • (1995) Rev Chil Urol , vol.60 , pp. 242-246
    • Vargas, F.1    Cortes, M.2
  • 74
    • 0041931042 scopus 로고    scopus 로고
    • A randomized controlled trial of modified cobratoxin in adrenomyeloneuropathy
    • Mundy HR, Jones SJ, Hobart JC, Hanna MG, Lee PJ, A randomized controlled trial of modified cobratoxin in adrenomyeloneuropathy. Neurology. 2003;61:528-30.
    • (2003) Neurology , vol.61 , pp. 528-530
    • Mundy, H.R.1    Jones, S.J.2    Hobart, J.C.3    Hanna, M.G.4    Lee, P.J.5
  • 75
    • 38049083235 scopus 로고    scopus 로고
    • Sanders M , Soret MG, Akin BA. Neurotoxoid interference principle in pseudorabies infection, in vivo inactivation of Aujeszky virus. Proceedings of the 7th International Congress of Microbiology; Stockholm, Sweden; 1958. p. 299.
    • Sanders M , Soret MG, Akin BA. Neurotoxoid interference principle in pseudorabies infection, in vivo inactivation of Aujeszky virus. Proceedings of the 7th International Congress of Microbiology; Stockholm, Sweden; 1958. p. 299.
  • 76
    • 38049049966 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication in mononuclear cells and thymus explant cultures by a purified, detoxified cobra venom protein. Abstract. Novel biological fusion inhibitors of HIV
    • April 7; Colorado
    • Patterson B, Flener Z, Yogev R, Kabat W. Inhibition of HIV-1 replication in mononuclear cells and thymus explant cultures by a purified, detoxified cobra venom protein. Abstract. Novel biological fusion inhibitors of HIV; 2000 April 7; Keystone Conference; Colorado.
    • (2000) Keystone Conference
    • Patterson, B.1    Flener, Z.2    Yogev, R.3    Kabat, W.4
  • 78
    • 0036094490 scopus 로고    scopus 로고
    • Differential use of the nicotinic receptor by rabies virus based upon substrate origin
    • Castaneda-Castellanos DR, Castellanos JE, Hurtado H. Differential use of the nicotinic receptor by rabies virus based upon substrate origin. J Neurovirol. 2002;8(2):150-4.
    • (2002) J Neurovirol , vol.8 , Issue.2 , pp. 150-154
    • Castaneda-Castellanos, D.R.1    Castellanos, J.E.2    Hurtado, H.3
  • 79
    • 0032820260 scopus 로고    scopus 로고
    • Sequence determinants of modified cobra venom neurotoxin which induce immune resistance to experimental allergic encephalomyelitis: Molecular mechanisms for immunologic action
    • Hinman CL, Stevens-Truss R, Schwarz C, Hudson RA. Sequence determinants of modified cobra venom neurotoxin which induce immune resistance to experimental allergic encephalomyelitis: molecular mechanisms for immunologic action. Immunopharmacol Immunotoxicol. 1999;21(3):483-506.
    • (1999) Immunopharmacol Immunotoxicol , vol.21 , Issue.3 , pp. 483-506
    • Hinman, C.L.1    Stevens-Truss, R.2    Schwarz, C.3    Hudson, R.A.4
  • 80
    • 70449091509 scopus 로고    scopus 로고
    • Amelioration of acute and relapsing stages of the experimental allergic encephalomyelitis by cobra toxins
    • Mohamed A, Reid PF, Raymond L, Dufan T. Amelioration of acute and relapsing stages of the experimental allergic encephalomyelitis by cobra toxins. Biomed Sci Instrum. 2006;42:399-404.
    • (2006) Biomed Sci Instrum , vol.42 , pp. 399-404
    • Mohamed, A.1    Reid, P.F.2    Raymond, L.3    Dufan, T.4
  • 81
    • 38049011108 scopus 로고    scopus 로고
    • Montsdeoca G, Stoik R. Human clinical trials on the effect of Pepteron in rheumatoid arthritis. SE Sect, 10. Charleston, SC: Soc Exp Biol Med; 1985.
    • Montsdeoca G, Stoik R. Human clinical trials on the effect of Pepteron in rheumatoid arthritis. SE Sect, Vol 10. Charleston, SC: Soc Exp Biol Med; 1985.
  • 82
    • 0020335073 scopus 로고
    • Carbamycholine modulation of E-rosette formation: Identification of nicotinic acetylcholine receptors on a subpopulation of human T lymphocytes
    • Mizuno Y, Dosch HM, Gelfand EW. Carbamycholine modulation of E-rosette formation: identification of nicotinic acetylcholine receptors on a subpopulation of human T lymphocytes. J Clin Immunol. 1982;2(4):303-8.
    • (1982) J Clin Immunol , vol.2 , Issue.4 , pp. 303-308
    • Mizuno, Y.1    Dosch, H.M.2    Gelfand, E.W.3
  • 83
    • 0029887551 scopus 로고    scopus 로고
    • Activation of voltage-dependent sodium channels in cultured cerebellar poffule cells induces neurotoxicity that is not mediated by glutamate release
    • Dargent B, Arsac C, Tricaud N, Couraud F. Activation of voltage-dependent sodium channels in cultured cerebellar poffule cells induces neurotoxicity that is not mediated by glutamate release. Neuroscience. 1996;73(1):209-16.
    • (1996) Neuroscience , vol.73 , Issue.1 , pp. 209-216
    • Dargent, B.1    Arsac, C.2    Tricaud, N.3    Couraud, F.4
  • 84
    • 0029818801 scopus 로고    scopus 로고
    • Inhibitory effect of MS-153 on elevated brain glutamate level induced by rat middle cerebral artery occlusion
    • Umemura K, Gemba T, Mizuno A, Nakashima M. Inhibitory effect of MS-153 on elevated brain glutamate level induced by rat middle cerebral artery occlusion. Stroke. 1996;27:1624-8.
    • (1996) Stroke , vol.27 , pp. 1624-1628
    • Umemura, K.1    Gemba, T.2    Mizuno, A.3    Nakashima, M.4
  • 85
    • 0031970726 scopus 로고    scopus 로고
    • Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway
    • Carlson NG, Bacchi A, Rogers SW, Gahring LC. Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway. J Neurobiol. 1998;35(1):29-36.
    • (1998) J Neurobiol , vol.35 , Issue.1 , pp. 29-36
    • Carlson, N.G.1    Bacchi, A.2    Rogers, S.W.3    Gahring, L.C.4
  • 86
    • 0018724813 scopus 로고
    • Cell death of motoneurons in the chick embryo spinal cord. IV. Evidence that a functional neuromuscular interaction is involved in the regulation of naturally occurring cell death and the stabilization of synapses
    • Pittman R, Oppenheim RW. Cell death of motoneurons in the chick embryo spinal cord. IV. Evidence that a functional neuromuscular interaction is involved in the regulation of naturally occurring cell death and the stabilization of synapses. J Comp Neurol. 1979;187(2):425-46.
    • (1979) J Comp Neurol , vol.187 , Issue.2 , pp. 425-446
    • Pittman, R.1    Oppenheim, R.W.2
  • 87
    • 0027286275 scopus 로고
    • Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: Implications for the toxin-induced arrest of naturally occurring motoneuron death
    • Renshaw G, Rigby P, Self G, Lamb A, Goldie R. Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: implications for the toxin-induced arrest of naturally occurring motoneuron death. Neuroscience. 1993;53:1163-72.
    • (1993) Neuroscience , vol.53 , pp. 1163-1172
    • Renshaw, G.1    Rigby, P.2    Self, G.3    Lamb, A.4    Goldie, R.5
  • 88
    • 0028169009 scopus 로고
    • 125I]-alpha-bungarotoxin binding covaries with motoneurone density during apoptosis
    • Renshaw GM. [125I]-alpha-bungarotoxin binding covaries with motoneurone density during apoptosis. Neuroreport. 1994;5(15):1949-52.
    • (1994) Neuroreport , vol.5 , Issue.15 , pp. 1949-1952
    • Renshaw, G.M.1
  • 89
    • 0028894896 scopus 로고
    • The nicotinic blocking agents d-tubocurare and a-bungarotoxin save motoneurons from naturally occurring death in the absence of neuromuscular blockade
    • Hory-Lee F, Frank E, The nicotinic blocking agents d-tubocurare and a-bungarotoxin save motoneurons from naturally occurring death in the absence of neuromuscular blockade. J Neurosci. 1995;15(10):6453-60.
    • (1995) J Neurosci , vol.15 , Issue.10 , pp. 6453-6460
    • Hory-Lee, F.1    Frank, E.2
  • 90
    • 0024425285 scopus 로고
    • Cell death of motoneurons in the chick embryo spinal cord. XI. Acetylcholine receptors and synaptogenesis in skeletal muscle following the reduction of motoneuron death by neuromuscular blockade
    • Oppenheim RW, Bursztajn S, Prevette D. Cell death of motoneurons in the chick embryo spinal cord. XI. Acetylcholine receptors and synaptogenesis in skeletal muscle following the reduction of motoneuron death by neuromuscular blockade. Development. 1989;107(2):331-41.
    • (1989) Development , vol.107 , Issue.2 , pp. 331-341
    • Oppenheim, R.W.1    Bursztajn, S.2    Prevette, D.3
  • 91
    • 0034663169 scopus 로고    scopus 로고
    • Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic-blocking agents
    • Oppenheim RW, Prevette D, D'Costa A, Wang S, Houenou LJ, McIntosh JM. Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic-blocking agents. J Neurosci. 2000;20(16):6117-24.
    • (2000) J Neurosci , vol.20 , Issue.16 , pp. 6117-6124
    • Oppenheim, R.W.1    Prevette, D.2    D'Costa, A.3    Wang, S.4    Houenou, L.J.5    McIntosh, J.M.6
  • 92
    • 0026032594 scopus 로고
    • A non-radioactive receptor assay for snake venom postsynaptic neurotoxins
    • Stiles BG. A non-radioactive receptor assay for snake venom postsynaptic neurotoxins. Toxicon. 1991;29:503-10.
    • (1991) Toxicon , vol.29 , pp. 503-510
    • Stiles, B.G.1
  • 94
    • 0000874961 scopus 로고
    • Absorption and distribution of i-labeled cobra venom and its purified toxins
    • Tseng LF, Chiu TH, Lee CY. Absorption and distribution of i-labeled cobra venom and its purified toxins. Toxicol Appl Pharmacol. 1968;12:526-35.
    • (1968) Toxicol Appl Pharmacol , vol.12 , pp. 526-535
    • Tseng, L.F.1    Chiu, T.H.2    Lee, C.Y.3
  • 95
    • 33644921478 scopus 로고    scopus 로고
    • Managing specific symptoms in people with multiple sclerosis
    • Henze T., Managing specific symptoms in people with multiple sclerosis. Int MS J. 2005;12(2):60-8.
    • (2005) Int MS J , vol.12 , Issue.2 , pp. 60-68
    • Henze, T.1
  • 96
    • 0025676439 scopus 로고
    • Effect of cholinergic manipulations on the analgesic response to Cobrotoxin in mice
    • Chen R, Robinson SE. Effect of cholinergic manipulations on the analgesic response to Cobrotoxin in mice. Life Sci. 1990;47:1949-54.
    • (1990) Life Sci , vol.47 , pp. 1949-1954
    • Chen, R.1    Robinson, S.E.2
  • 97
    • 84866617898 scopus 로고    scopus 로고
    • Paradiso A randomized, double-blind, placebo-controlled, parallel multicenter trial of Cobrotoxin-containing compound analgesic in the treatment of postoperative pain
    • Abstract
    • Xu JM, Song ST, Yu CZ, Yang Y, Cui M, Wang WU, Xiong YL, Paradiso A randomized, double-blind, placebo-controlled, parallel multicenter trial of Cobrotoxin-containing compound analgesic in the treatment of postoperative pain. Europain. 2002;2(2) [Abstract].
    • (2002) Europain , vol.2 , Issue.2
    • Xu, J.M.1    Song, S.T.2    Yu, C.Z.3    Yang, Y.4    Cui, M.5    Wang, W.U.6    Xiong, Y.L.7
  • 99
    • 0024554466 scopus 로고
    • Electrophysiological investigations in adoptively transferred experimental autoimmune encephalomyelitis in the Lewis rat
    • Heininger K, Fierz W, Schafer B, Hartung HP, Wehling P, Toyka KV. Electrophysiological investigations in adoptively transferred experimental autoimmune encephalomyelitis in the Lewis rat. Brain. 1989;112( Pt 2):537-52.
    • (1989) Brain , vol.112 , Issue.PART 2 , pp. 537-552
    • Heininger, K.1    Fierz, W.2    Schafer, B.3    Hartung, H.P.4    Wehling, P.5    Toyka, K.V.6
  • 101
    • 0023791654 scopus 로고
    • Thymopoietins and long postsynaptic neurotoxins share common information in their primary structures
    • Skerl V, Pavlovic M. Thymopoietins and long postsynaptic neurotoxins share common information in their primary structures. FEBS Lett. 1988;239(1):141-6.
    • (1988) FEBS Lett , vol.239 , Issue.1 , pp. 141-146
    • Skerl, V.1    Pavlovic, M.2
  • 103
    • 0027984158 scopus 로고
    • Management of viral infections with thymopentin
    • Review
    • Sundal E, Bertelletti D. Management of viral infections with thymopentin. Arzneimittelforschung. 1994;44(7):866-71. Review.
    • (1994) Arzneimittelforschung , vol.44 , Issue.7 , pp. 866-871
    • Sundal, E.1    Bertelletti, D.2
  • 104
    • 0025944302 scopus 로고
    • Effect of thymopentin on peripheral blood T-lymphocytes subsets and on the clinical course of the disease in patients affected by multiple sclerosis
    • Cognazzo A, Seliak D, Fruttero A. Effect of thymopentin on peripheral blood T-lymphocytes subsets and on the clinical course of the disease in patients affected by multiple sclerosis. Rev Neurol. 1991;61(3):110-5.
    • (1991) Rev Neurol , vol.61 , Issue.3 , pp. 110-115
    • Cognazzo, A.1    Seliak, D.2    Fruttero, A.3
  • 105
    • 0029080633 scopus 로고
    • Multiple sclerosis: A report of a case treated with thymopentin
    • Borromei A, Draghetti M, Guerra L, Lozito A, Vargiu B. Multiple sclerosis: a report of a case treated with thymopentin. Minerva Med. 1995;86(5):227-32.
    • (1995) Minerva Med , vol.86 , Issue.5 , pp. 227-232
    • Borromei, A.1    Draghetti, M.2    Guerra, L.3    Lozito, A.4    Vargiu, B.5
  • 106
    • 0022394963 scopus 로고
    • Thymopentin: Safety overview
    • Friedmann N. Thymopentin: safety overview. Surv Immunol Res. 1985;4(Suppl 1):139-48.
    • (1985) Surv Immunol Res , vol.4 , Issue.SUPPL. 1 , pp. 139-148
    • Friedmann, N.1
  • 107
    • 0025663013 scopus 로고
    • Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function
    • Ochoa EL, Li LA, Plummer A, McNamee MG. Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function. Mol Pharmacol. 1990;38(6):863-71.
    • (1990) Mol Pharmacol , vol.38 , Issue.6 , pp. 863-871
    • Ochoa, E.L.1    Li, L.A.2    Plummer, A.3    McNamee, M.G.4


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