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Volumn 18, Issue 24, 2010, Pages 8501-8511

Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives - A novel structural class of potent calcium-sensing receptor antagonists

(12) Yoshida, Masato a Mori, Akira a Inaba, Atsuhiro a Oka, Masahiro a Makino, Haruhiko a Yamaguchi, Masashi a Fujita, Hisashi a Kawamoto, Tomohiro a Goto, Mika a Kimura, Hiroyuki a Baba, Atsuo a Yasuma, Tsuneo a

a TAKEDA PHARMACEUTICAL COMPANY LIMITED (Japan)

Author keywords

Calcium sensing receptor (CaSR) antagonist; Osteoporosis; PTH; Tetrahydropyrazolopyrimidine

Indexed keywords

5 (2 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 (2 FURANYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 (3 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 (4 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 (4 ETHYPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 (4 METHOXYPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 5 PHENYL 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; 7 METHYL 5 PHENYL 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLIC ACID; CALCIUM SENSING RECEPTOR; ETHYL 5 (2 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (2 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (2 FURANYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (2 FURANYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXY LATE; ETHYL 5 (3 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (3 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (4 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (4 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (4 ETHYPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (4 ETHYPHENYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARB OXYLATE; ETHYL 5 (4 METHOXYPHENYL) 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 (4 METHOXYPHENYL) 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 METHYL 7 PHENYL 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 METHYL 7 PHENYLPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 PHENYL 7 (TRIFLUOROMETHYL) 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 5 PHENYL 7 (TRIFLUOROMETHYL) PYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 7 METHYL 5 PHENYL 4,5,6,7 TETRAHYDROPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; ETHYL 7 METHYL 5 PHENYLPYRAZOLO [1,5 A] PYRIMIDINE 3 CARBOXYLATE; PYRAZOLOPYRIMIDINE DERIVATIVE; TETRAHYDROPYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADAMANTANE; ANIMALS; INHIBITORY CONCENTRATION 50; PYRIMIDINES; RATS; RECEPTORS, CALCIUM-SENSING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649449205 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.10.035 Document Type: Article

Times cited : (28)

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